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2-Aralkynyl and 2-Heteroalkynyl Derivatives of Adenosine-5'-N-Ethyluronamide as Selective A2a Adenosine Receptor Agonists

Cite this: J. Med. Chem. 1995, 38, 9, 1462–1472
Publication Date (Print):April 1, 1995
https://doi.org/10.1021/jm00009a007
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    Cited By

    This article is cited by 45 publications.

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    2. Rosaria Volpini,, Diego Dal Ben,, Catia Lambertucci,, Sara Taffi,, Sauro Vittori,, Karl-Norbert Klotz, and, Gloria Cristalli. N6-Methoxy-2-alkynyladenosine Derivatives as Highly Potent and Selective Ligands at the Human A3 Adenosine Receptor. Journal of Medicinal Chemistry 2007, 50 (6) , 1222-1230. https://doi.org/10.1021/jm060963u
    3. Rosaria Volpini,, Stefano Costanzi,, Catia Lambertucci,, Sara Taffi,, Sauro Vittori,, Karl-Norbert Klotz, and, Gloria Cristalli. N6-Alkyl-2-alkynyl Derivatives of Adenosine as Potent and Selective Agonists at the Human Adenosine A3 Receptor and a Starting Point for Searching A2B Ligands. Journal of Medicinal Chemistry 2002, 45 (15) , 3271-3279. https://doi.org/10.1021/jm0109762
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    11. He Ni, Yue‐Hong Li, Rui‐Lin Hao, Hui Li, Song‐Qing Hu, Hai‐Hang Li. Identification of adenosine deaminase inhibitors from Tofu wastewater and litchi peel and their synergistic anticancer and antibacterial activities with cordycepin. International Journal of Food Science & Technology 2016, 51 (5) , 1168-1176. https://doi.org/10.1111/ijfs.13064
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    18. Gloria Cristalli, Christa E. Müller, Rosaria Volpini. Recent Developments in Adenosine A2A Receptor Ligands. 2009, 59-98. https://doi.org/10.1007/978-3-540-89615-9_3
    19. Cheng-Wu Liang, Won Jun Choi, Lak Shin Jeong. Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors. Archives of Pharmacal Research 2008, 31 (8) , 973-977. https://doi.org/10.1007/s12272-001-1254-x
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    23. M.P. González, C. Terán, M. Teijeira, M.J. González-Moa. GETAWAY descriptors to predicting A2A adenosine receptors agonists. European Journal of Medicinal Chemistry 2005, 40 (11) , 1080-1086. https://doi.org/10.1016/j.ejmech.2005.04.014
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    31. Rosaria Volpini, Stefano Costanzi, Catia Lambertucci, Sauro Vittori, K.-N Klotz, Anna Lorenzen, Gloria Cristalli. Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A 3 adenosine receptor. Bioorganic & Medicinal Chemistry Letters 2001, 11 (14) , 1931-1934. https://doi.org/10.1016/S0960-894X(01)00347-X
    32. S. Vittori, S. Costanzi, C. Lambertucci, R. Volpini, G. Cristalli. COUPLING OF 2,6-DISUBSTITUTED PURINES TO RIBOSE-MODIFIED SUGARS. Nucleosides, Nucleotides and Nucleic Acids 2001, 20 (4-7) , 771-774. https://doi.org/10.1081/NCN-100002427
    33. R. Volpini, S. Costanzi, C. Lambertucci, S. Vittori, G. Cristalli. SYNTHETIC PROCEDURE FOR THE PREPARATION OF NOVEL POTENT AND SELECTIVE A 3 ADENOSINE RECEPTOR RADIOLIGANDS. Nucleosides, Nucleotides and Nucleic Acids 2001, 20 (4-7) , 775-779. https://doi.org/10.1081/NCN-100002428
    34. C. Lambertucci, S. Costanzi, S. Vittori, R. Volpini, G. Cristalli. SYNTHESIS AND ADENOSINE RECEPTOR AFFINITY AND POTENCY OF 8-ALKYNYL DERIVATIVES OF ADENOSINE. Nucleosides, Nucleotides and Nucleic Acids 2001, 20 (4-7) , 1153-1157. https://doi.org/10.1081/NCN-100002509
    35. Bruce T. Liang, Douglas Stewart, Kenneth A. Jacobson. Adenosine A 1 and A 3 receptors: Distinct cardioprotection. Drug Development Research 2001, 52 (1-2) , 366-378. https://doi.org/10.1002/ddr.1136
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