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A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors
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    A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors
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    Journal of Medicinal Chemistry

    Cite this: J. Med. Chem. 1995, 38, 23, 4730–4738
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    https://doi.org/10.1021/jm00023a013
    Published November 1, 1995

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    This article is cited by 12 publications.

    1. Margaret M. Mc Gee,, Sandra Gemma,, Stefania Butini,, Anna Ramunno,, Daniela M. Zisterer,, Caterina Fattorusso,, Bruno Catalanotti,, Gagan Kukreja,, Isabella Fiorini,, Claudio Pisano,, Carla Cucco,, Ettore Novellino,, Vito Nacci,, D. Clive Williams, and, Giuseppe Campiani. Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target. Journal of Medicinal Chemistry 2005, 48 (13) , 4367-4377. https://doi.org/10.1021/jm049402y
    2. Giuseppe Campiani,, Anna Ramunno,, Isabella Fiorini,, Vito Nacci,, Elena Morelli,, Ettore Novellino,, Mara Goegan,, Tiziana Mennini,, Stephen Sullivan,, Daniela M. Zisterer, and, Clive D. Williams. Synthesis of New Molecular Probes for Investigation of Steroid Biosynthesis Induced by Selective Interaction with Peripheral Type Benzodiazepine Receptors (PBR). Journal of Medicinal Chemistry 2002, 45 (19) , 4276-4281. https://doi.org/10.1021/jm020849l
    3. Guillermo Moyna,, Gonzalo Hernandez,, Howard J. Williams,, Ronald J. Nachman, and, A. I. Scott. Development of Weiner et al. Force Field Parameters Suitable for Conformational Studies of [1,4]-Benzodiazepines and Related Compounds. Journal of Chemical Information and Computer Sciences 1997, 37 (5) , 951-956. https://doi.org/10.1021/ci9700236
    4. Andrea Cappelli,, Maurizio Anzini,, Salvatore Vomero,, Pier G. De Benedetti,, Maria Cristina Menziani,, Gianluca Giorgi, and, Cristina Manzoni. Mapping the Peripheral Benzodiazepine Receptor Binding Site by Conformationally Restrained Derivatives of 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195). Journal of Medicinal Chemistry 1997, 40 (18) , 2910-2921. https://doi.org/10.1021/jm960516m
    5. Giuseppe Campiani,, Vito Nacci,, Isabella Fiorini,, Maria P. De Filippis,, Antonio Garofalo,, Silvia M. Ciani,, Giovanni Greco,, Ettore Novellino,, D. Clive Williams,, Daniela M. Zisterer,, Margaret J. Woods,, Camelia Mihai,, Cristina Manzoni, and, Tiziana Mennini. Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands. Journal of Medicinal Chemistry 1996, 39 (18) , 3435-3450. https://doi.org/10.1021/jm960251b
    6. Simona Daniele, Sabrina Taliani, Eleonora Da Pozzo, Chiara Giacomelli, Barbara Costa, Maria Letizia Trincavelli, Leonardo Rossi, Valeria La Pietra, Elisabetta Barresi, Alfonso Carotenuto, Antonio Limatola, Anna Lamberti, Luciana Marinelli, Ettore Novellino, Federico Da Settimo, Claudia Martini. Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma. Scientific Reports 2014, 4 (1) https://doi.org/10.1038/srep04749
    7. Barbara Cosimelli, Francesca Simorini, Sabrina Taliani, Concettina La Motta, Federico Da Settimo, Elda Severi, Giovanni Greco, Ettore Novellino, Barbara Costa, Eleonora Da Pozzo, Sara Bendinelli, Claudia Martini. Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. European Journal of Medicinal Chemistry 2011, 46 (9) , 4506-4520. https://doi.org/10.1016/j.ejmech.2011.07.025
    8. W. Dehaen, T.H. Ngo. 1,4-Oxazepines and 1,4-Thiazepines. 2008, 255-298. https://doi.org/10.1016/B978-008044992-0.01209-8
    9. D.O. Tymoshenko. Chapter 1 Benzoheteropines with Fused Pyrrole, Furan and Thiophene Rings. 2008, 1-80. https://doi.org/10.1016/S0065-2725(07)00001-3
    10. Tahmineh Akbarzadeh, Sayyed A Tabatabai, Mohammad J Khoshnoud, Bijan Shafaghi, Abbas Shafiee. Design and synthesis of 4H-3-(2-Phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists. Bioorganic & Medicinal Chemistry 2003, 11 (5) , 769-773. https://doi.org/10.1016/S0968-0896(02)00469-8
    11. G Campiani, V Nacci, I Fiorini, MP De Filippis, A Garofalo, SM Ciani, G Greco, E Novellino, C Manzoni, T Mennini. New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site. European Journal of Medicinal Chemistry 1997, 32 (3) , 241-251. https://doi.org/10.1016/S0223-5234(97)83975-X
    12. Arup K. Ghose, John J. Wendoloski. Pharmacophore Modelling: Methods,Experimental Verification and Applications. , 253-271. https://doi.org/10.1007/0-306-46857-3_14

    Journal of Medicinal Chemistry

    Cite this: J. Med. Chem. 1995, 38, 23, 4730–4738
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jm00023a013
    Published November 1, 1995

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