N-.omega.-Fluoroalkyl Analogs of (1R)-2.beta.-Carbomethoxy-3.beta.-(4-iodophenyl)tropane (.beta.-CIT): Radiotracers for Positron Emission Tomography and Single Photon Emission Computed Tomography Imaging of Dopamine Transporters

This article is cited by 127 publications.

1. Jiang Wang, María Sánchez-Roselló, José Luis Aceña, Carlos del Pozo, Alexander E. Sorochinsky, Santos Fustero, Vadim A. Soloshonok, and Hong Liu . Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011). Chemical Reviews 2014, 114 (4) , 2432-2506. https://doi.org/10.1021/cr4002879
2. Anna W. Sromek, Yu-Gui Si, Tangzhi Zhang, Susan R. George, Philip Seeman, and John L. Neumeyer . Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors. ACS Medicinal Chemistry Letters 2011, 2 (3) , 189-194. https://doi.org/10.1021/ml1001689
3. Peter C. Meltzer,, Paul Blundell,, Thomas Zona,, Lihua Yang,, Hong Huang,, Ali A. Bonab,, Eli Livni,, Alan Fischman, and, Bertha K. Madras. A Second-Generation 99mTechnetium Single Photon Emission Computed Tomography Agent That Provides in Vivo Images of the Dopamine Transporter in Primate Brain. Journal of Medicinal Chemistry 2003, 46 (16) , 3483-3496. https://doi.org/10.1021/jm0301484
4. Satendra Singh. Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists. Chemical Reviews 2000, 100 (3) , 925-1024. https://doi.org/10.1021/cr9700538
5. Sanath K. Meegalla,, Karl Plössl,, Mei-Ping Kung,, D. Andrew Stevenson,, Mu Mu,, Steven Kushner,, Louise M. Liable-Sands,, Arnold L. Rheingold, and, Hank F. Kung. Specificity of Diastereomers of [99mTc]TRODAT-1 as Dopamine Transporter Imaging Agents. Journal of Medicinal Chemistry 1998, 41 (4) , 428-436. https://doi.org/10.1021/jm970742b
6. Simon M. N. Efange,, Ashok P. Kamath,, Anil B. Khare,, Mei-Ping Kung,, Robert H. Mach, and, Stanley M. Parsons. N-Hydroxyalkyl Derivatives of 3β-Phenyltropane and 1-Methylspiro[1H-indoline-3,4‘-piperidine]:  Vesamicol Analogues with Affinity for Monoamine Transporters. Journal of Medicinal Chemistry 1997, 40 (24) , 3905-3914. https://doi.org/10.1021/jm970326r
7. Patrick Emond,, Lucette Garreau,, Sylvie Chalon,, Miriam Boazi,, Mireille Caillet,, Jacques Bricard,, Yves Frangin,, Laurent Mauclaire,, Jean-Claude Besnard, and, Denis Guilloteau. Synthesis and Ligand Binding of Nortropane Derivatives:  N-Substituted 2β-Carbomethoxy-3β-(4‘-iodophenyl)nortropane and N-(3-Iodoprop-(2E)-enyl)-2β-carbomethoxy-3β-(3‘,4‘-disubstituted phenyl)nortropane. New High-Affinity and Selective Compounds for the Dopamine Transporter. Journal of Medicinal Chemistry 1997, 40 (9) , 1366-1372. https://doi.org/10.1021/jm960795d
8. Sanath K. Meegalla,, Karl Plössl,, Mei-Ping Kung,, Sumalee Chumpradit,, D. Andrew Stevenson,, Steven A. Kushner,, William T. McElgin,, P. David Mozley, and, Hank F. Kung. Synthesis and Characterization of Technetium-99m-Labeled Tropanes as Dopamine Transporter-Imaging Agents. Journal of Medicinal Chemistry 1997, 40 (1) , 9-17. https://doi.org/10.1021/jm960532j
9. Sanath Meegalla,, Karl Plössl,, Mei-Ping Kung,, Sumalee Chumpradit,, D. Andrew Stevenson,, Dana Frederick, and, Hank F. Kung. Tc-99m-Labeled Tropanes as Dopamine Transporter Imaging Agents. Bioconjugate Chemistry 1996, 7 (4) , 421-429. https://doi.org/10.1021/bc960029l
10. John L. Neumeyer,, Gilles Tamagnan,, Shaoyin Wang,, Yigong Gao,, Richard A. Milius,, Nora S. Kula, and, Ross J. Baldessarini. N-Substituted Analogs of 2β-Carbomethoxy-3β-(4‘-iodophenyl)tropane (β-CIT) with Selective Affinity to Dopamine or Serotonin Transporters in Rat Forebrain. Journal of Medicinal Chemistry 1996, 39 (2) , 543-548. https://doi.org/10.1021/jm9505324
11. Jamir Pitton Rissardo, Ana Letícia Fornari Caprara. Neuroimaging Techniques in Differentiating Parkinson’s Disease from Drug-Induced Parkinsonism: A Comprehensive Review. Clinics and Practice 2023, 13 (6) , 1427-1448. https://doi.org/10.3390/clinpract13060128
12. Susanne Nikolaus, Owen Y. Chao, Markus Beu, Jan Henke, Christina Antke, An-Li Wang, Benedetta Fazari, Eduards Mamlins, Joseph P. Huston, Frederik L. Giesel. The 5-HT1A receptor agonist 8-OH-DPAT modulates motor/exploratory activity, recognition memory and dopamine transporter binding in the dorsal and ventral striatum. Neurobiology of Learning and Memory 2023, 205 , 107848. https://doi.org/10.1016/j.nlm.2023.107848
13. Yoonsuk Huh, Javier Caravaca, Jaehyuk Kim, Yonggang Cui, Qiu Huang, Grant Gullberg, Youngho Seo. Simulation studies of a full‐ring, CZT SPECT system for whole‐body imaging of 99m Tc and 177 Lu. Medical Physics 2023, 50 (6) , 3726-3737. https://doi.org/10.1002/mp.16360
14. Shankar Vallabhajosula. Radiohalogens for Molecular Imaging (Fluorine and Iodine). 2023, 213-242. https://doi.org/10.1007/978-3-031-23205-3_10
15. Ola A.M. Ghoneim, Raymond G. Booth. Therapeutic and Diagnostic Agents for Parkinson's Disease. 2021, 1-46. https://doi.org/10.1002/0471266949.bmc105.pub3
16. Andy Welch, Adriana A. S. Tavares, Sally Pimlott, Andrew Sutherland. PET and SPECT in Drug Development. 2021, 1-18. https://doi.org/10.1002/0471266949.bmc254.pub2
17. Jan Booij, Marina A. J. Tijssen, Henk W. Berendse. Clinical Applications of [123I]FP-CIT SPECT Imaging. 2021, 849-870. https://doi.org/10.1007/978-3-030-53168-3_31
18. Edoardo Rosario de Natale, Heather Wilson, Marios Politis. Serotonergic imaging in Parkinson's disease. 2021, 303-338. https://doi.org/10.1016/bs.pbr.2020.11.001
19. Rachid Fahmi, Günther Platsch, Alexandre Bani Sadr, Sylvain Gouttard, Stephane Thobois, Sven Zuehlsdorff, Christian Scheiber. Single-site 123I-FP-CIT reference values from individuals with non-degenerative parkinsonism—comparison with values from healthy volunteers. European Journal of Hybrid Imaging 2020, 4 (1) https://doi.org/10.1186/s41824-020-0074-2
20. Thilo van Eimeren, Joseph Claßen, Alexander Drzezga, Carsten Eggers, Rüdiger Hilker-Roggendorf, Jochen Klucken, Jiri Koschel, Philipp Tobias Meyer, Christoph Redecker, Hendrik Theis, Carsten Buhmann. Empfehlung zum differenzierten Einsatz nuklearmedizinischer Diagnostik bei Parkinson-Syndromen. Fortschritte der Neurologie · Psychiatrie 2020, 88 (09) , 609-619. https://doi.org/10.1055/a-1207-0515
21. Ralph Buchert, Carsten Buhmann, Ivayla Apostolova, Philipp T. Meyer, Jürgen Gallinat. Nuclear Imaging in the Diagnosis of Clinically Uncertain Parkinsonian Syndromes. Deutsches Ärzteblatt international 2019, https://doi.org/10.3238/arztebl.2019.0747
22. Inki Lee, Jin Su Kim, Joon Yeun Park, Byung Hyun Byun, Su Yeon Park, Joon Ho Choi, Hansol Moon, Jung Young Kim, Kyo Chul Lee, Dae Yoon Chi, Kyeong Min Kim, Ilhan Lim, Joo Hyun Kang, Soon Hyuk Ahn, Byung Il Kim, Jeong Ho Ha, Sang Moo Lim. Head‐to‐head comparison of 18 F‐FP‐CIT and 123 I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study. Synapse 2018, 72 (7) https://doi.org/10.1002/syn.22032
23. Weihua Li, Nick P. Lao‐Kaim, Andreas A. Roussakis, Antonio Martín‐Bastida, Natalie Valle‐Guzman, Gesine Paul, Clare Loane, Håkan Widner, Marios Politis, Tom Foltynie, Roger A. Barker, Paola Piccini. 11 C‐PE2I and 18 F‐Dopa PET for assessing progression rate in Parkinson's: A longitudinal study. Movement Disorders 2018, 33 (1) , 117-127. https://doi.org/10.1002/mds.27183
24. Kosuke Hida, Masanari Nonokuma, Yasuo Kuwabara, Tomonobu Tani, Koichi Takano, Kengo Yoshimitsu. Creation and validation of an I-123 FP-CIT template for statistical image analysis using high-resolution SPECT for parkinsonian patients. Annals of Nuclear Medicine 2016, 30 (7) , 477-483. https://doi.org/10.1007/s12149-016-1085-8
25. Stefanie Geisler, Nicola Beindorff, Markus Cremer, Kerstin Hoffmann, Winfried Brenner, Paul Cumming, Philipp T. Meyer, Karl‐Josef Langen, Eberhard Fuchs, Ralph Buchert. Characterization of [ 123 I]FP‐CIT binding to the dopamine transporter in the striatum of tree shrews by quantitative in vitro autoradiography. Synapse 2015, 69 (10) , 497-504. https://doi.org/10.1002/syn.21838
26. Manuela C. Matesan, Donna J. Cross, David H. Lewis, Satoshi Minoshima. Differential Alterations of Dopamine Transporter in the Striatum and Midbrain in Patients With Parkinsonian Syndrome. Clinical Nuclear Medicine 2015, 40 (3) , 191-194. https://doi.org/10.1097/RLU.0000000000000638
27. T.C. Booth, M. Nathan, A.D. Waldman, A.-M. Quigley, A.H. Schapira, J. Buscombe. The Role of Functional Dopamine-Transporter SPECT Imaging in Parkinsonian Syndromes, Part 1. American Journal of Neuroradiology 2015, 36 (2) , 229-235. https://doi.org/10.3174/ajnr.A3970
28. Yoshifumi Shirakami. Radioactive Iodine. 2014, 603-624. https://doi.org/10.1002/9781118909911.ch34
29. Mostafa Erfani, Mohammad Shafiei. Preparation of 99mTc-TRODAT-1 with high labeling yield in boiling water bath: A new formulation. Nuclear Medicine and Biology 2014, 41 (4) , 317-321. https://doi.org/10.1016/j.nucmedbio.2014.01.003
30. S. R. Suwijn, H. W. Berendse, C. V. M. Verschuur, R. M. A. de Bie, J. Booij. Serotonin Transporter Availability in Early Stage Parkinson’s Disease and Multiple System Atrophy. ISRN Neurology 2014, 2014 , 1-4. https://doi.org/10.1155/2014/345132
31. Jan Booij, Marina A. J. Tijssen, Henk W. Berendse. Clinical Applications of [123I]FP-CIT SPECT Imaging. 2014, 719-736. https://doi.org/10.1007/978-3-642-54307-4_33
32. Devaki Shilpa Surasi, Patrick J. Peller, Zsolt Szabo, Gustavo Mercier, Rathan M. Subramaniam. Dopamine Transporter SPECT Imaging in Parkinson Disease and Dementia. PET Clinics 2013, 8 (4) , 459-467. https://doi.org/10.1016/j.cpet.2013.08.006
33. P. J. Riss, K. Stockhofe, F. Roesch. Tropane‐derived 11 C‐labelled and 18 F‐labelled DAT ligands. Journal of Labelled Compounds and Radiopharmaceuticals 2013, 56 (3-4) , 149-158. https://doi.org/10.1002/jlcr.3018
34. Sven R Suwijn, Henk W Berendse, Constant VM Verschuur, Ania Winogrodzka, Rob MA de Bie, Jan Booij. SERT-to-DAT ratios in early Parkinson’s disease do not correlate with the development of dyskinesias. EJNMMI Research 2013, 3 (1) , 44. https://doi.org/10.1186/2191-219X-3-44
35. Enrique Garea-Rodríguez, Christina Schlumbohm, Boldizsár Czéh, Jessica König, Gunther Helms, Cornelia Heckmann, Birgit Meller, Johannes Meller, Eberhard Fuchs. Visualizing dopamine transporter integrity with iodine-123-FP-CIT SPECT in combination with high resolution MRI in the brain of the common marmoset monkey. Journal of Neuroscience Methods 2012, 210 (2) , 195-201. https://doi.org/10.1016/j.jneumeth.2012.07.009
36. Ioannis U Isaias, Giorgio Marotta, Gianni Pezzoli, Osama Sabri, Swen Hesse. [ 123 I]FP-CIT SPECT in atypical degenerative parkinsonism. Imaging in Medicine 2012, 4 (4) , 411-421. https://doi.org/10.2217/iim.12.21
37. Anna Costa, Michael Riedel, Ulrich Müller, Hans‐Jürge Möller, Ulrich Ettinger. Relationship between SLC6A3 genotype and striatal dopamine transporter availability: A meta‐analysis of human single photon emission computed tomography studies. Synapse 2011, 65 (10) , 998-1005. https://doi.org/10.1002/syn.20927
38. Remco J. J. Knol, Jan C. van den Bos, Anton G. M. Janssen, Kora de Bruin, Berthe L. F. van Eck-Smit, Jan Booij. Synthesis and In Vitro Evaluation of Novel Nortropane Derivatives as Potential Radiotracers for Muscarinic M 2 Receptors. International Journal of Molecular Imaging 2011, 2011 , 1-7. https://doi.org/10.1155/2011/709416
39. Jingying Liu, Lin Zhu, Karl Plössl, Brian P. Lieberman, Hank F. Kung. Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters 2011, 21 (10) , 2962-2965. https://doi.org/10.1016/j.bmcl.2011.03.051
40. Susanne Nikolaus, Rolf Larisch, Henning Vosberg, Markus Beu, Andreas Wirrwar, Christina Antke, Konstantin Kley, Maria Angelica De Souza Silva, Joseph P. Huston, Hans-Wilhelm Müller. Pharmacological challenge and synaptic response – assessing dopaminergic function in the rat striatum with small animal single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Reviews in the Neurosciences 2011, 22 (6) https://doi.org/10.1515/RNS.2011.054
41. Morten Ziebell, Signe Holm-Hansen, Gerda Thomsen, Aase Wagner, Peter Jensen, Lars H. Pinborg, Gitte Moos Knudsen. Serotonin Transporters in Dopamine Transporter Imaging: A Head-to-Head Comparison of Dopamine Transporter SPECT Radioligands 123 I-FP-CIT and 123 I-PE2I. Journal of Nuclear Medicine 2010, 51 (12) , 1885-1891. https://doi.org/10.2967/jnumed.110.078337
42. Raymond G. Booth, John L. Neumeyer, Ross J. Baldessarini. Therapeutic and Diagnostic Agents for Parkinson's Disease. 2010, 529-568. https://doi.org/10.1002/0471266949.bmc105.pub2
43. Andy Welch, Sally Pimlott. PET and SPECT in Drug Development. 2010, 737-748. https://doi.org/10.1002/0471266949.bmc254
44. Francesco Roselli, Nicola M. Pisciotta, Michele Pennelli, Maria S. Aniello, Angelo Gigante, Maria F. De Caro, Ermanno Ferrannini, Bruno Tartaglione, Artor Niccoli‐Asabella, Giovanni Defazio, Paolo Livrea, Giuseppe Rubini. Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study. Movement Disorders 2010, 25 (12) , 1853-1859. https://doi.org/10.1002/mds.23179
45. Päivi Marjamäki, Merja Haaparanta, Sarita Forsback, Veronica Fagerholm, Olli Eskola, Tove Grönroos, Teija Koivula, Olof Solin. Comparison of 2β-Carbomethoxy-3β-(4-[18F]Fluorophenyl)Tropane and N-(3-[18F]Fluoropropyl)-2β-Carbomethoxy-3β-(4-Fluorophenyl)Nortropane, Tracers for Imaging Dopamine Transporter in Rat. Molecular Imaging and Biology 2010, 12 (3) , 269-277. https://doi.org/10.1007/s11307-009-0278-0
46. Susanne Nikolaus, Christina Antke, Konstantin Kley, Markus Beu, Andreas Wirrwar, Hans-Wilhelm Müller. Pretreatment with Haloperidol Reduces 123 I-FP-CIT Binding to the Dopamine Transporter in the Rat Striatum: An In Vivo Imaging Study with a Dedicated Small-Animal SPECT Camera. Journal of Nuclear Medicine 2009, 50 (7) , 1147-1152. https://doi.org/10.2967/jnumed.109.061952
47. Jeffrey S. Stehouwer, Mark M. Goodman. Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine. PET Clinics 2009, 4 (1) , 101-128. https://doi.org/10.1016/j.cpet.2009.05.006
48. Patrick Johannes Riss, René Hummerich, Patrick Schloss. Synthesis and monoamine uptake inhibition of conformationally constrained 2β-carbomethoxy-3β-phenyl tropanes. Organic & Biomolecular Chemistry 2009, 7 (13) , 2688. https://doi.org/10.1039/b902863c
49. Jae Seung Kim, Seung Jun Oh, Dae Hyuk Moon. Molecular Imaging in Neurodegenerative Diseases. Journal of the Korean Medical Association 2009, 52 (2) , 151. https://doi.org/10.5124/jkma.2009.52.2.151
50. Philipp T. Meyer, Dagmar Salber, Johannes Schiefer, Markus Cremer, Wolfgang M. Schaefer, Christoph M. Kosinski, Karl-Josef Langen. Cerebral kinetics of the dopamine D2 receptor ligand [123I]IBZM in mice. Nuclear Medicine and Biology 2008, 35 (4) , 467-473. https://doi.org/10.1016/j.nucmedbio.2008.01.002
51. Jan Booij, Paul Kemp. Dopamine transporter imaging with [123I]FP-CIT SPECT: potential effects of drugs. European Journal of Nuclear Medicine and Molecular Imaging 2008, 35 (2) , 424-438. https://doi.org/10.1007/s00259-007-0621-0
52. Gunnar Antoni, Jens Sörensen, Håkan Hall. Molecular Imaging of Transporters with Positron Emission Tomography. 2008, 155-186. https://doi.org/10.1007/7355_2008_025
53. B Vastenhouw, F van der Have, A J A van der Linden, L von Oerthel, J Booij, J P H Burbach, M P Smidt, F J Beekman. Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT. Molecular Psychiatry 2007, 12 (11) , 984-987. https://doi.org/10.1038/sj.mp.4002028
54. Ingeborg Goethals, André Dobbeleir, Hamphrey Ham, Patrick Santens, Yves D'Asseler. Validation of a resolution-independent method for the quantification of 123I-FP-CIT SPECT scans. Nuclear Medicine Communications 2007, 28 (10) , 771-774. https://doi.org/10.1097/MNM.0b013e32829152c9
55. Birte Drewes, Wiebke Sihver, Sabine Willbold, Ray A. Olsson, Heinz H. Coenen. New 2α-tropane amides as potential PET ligands for the dopamine transporter. Nuclear Medicine and Biology 2007, 34 (5) , 531-539. https://doi.org/10.1016/j.nucmedbio.2007.04.007
56. H. Umesha Shetty, Sami S. Zoghbi, Jeih-San Liow, Masanori Ichise, Jinsoo Hong, John L. Musachio, Christer Halldin, Jurgen Seidel, Robert B. Innis, Victor W. Pike. Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I. European Journal of Nuclear Medicine and Molecular Imaging 2007, 34 (5) , 667-678. https://doi.org/10.1007/s00259-006-0277-1
57. W. Sihver, B. Drewes, A. Schulze, R.A. Olsson, H.H. Coenen. Evaluation of novel tropane analogues in comparison with the binding characteristics of [18F]FP-CIT and [131I]β-CIT. Nuclear Medicine and Biology 2007, 34 (2) , 211-219. https://doi.org/10.1016/j.nucmedbio.2006.11.005
58. Françoise Riché, Fadi Masri, Monique Lopez. Diastereoselective synthesis of polyfunctionalized piperidines as precursors of dopamine transporter imaging agents. Tetrahedron Letters 2007, 48 (9) , 1609-1612. https://doi.org/10.1016/j.tetlet.2006.12.141
59. M. Laura Parnas, Roxanne Vaughan. DAT, Dopamine Transporter. 2007, 1-10. https://doi.org/10.1016/B978-008055232-3.60441-6
60. Davy M. Kieffer, Bernard J. Cleynhens, Hubert P. Vanbilloen, Dirk Rattat, Christelle Y. Terwinghe, Luc Mortelmans, Guy M. Bormans, Alfons M. Verbruggen. Synthesis and biological evaluation of a technetium-99m(I)-tricarbonyl-labelled phenyltropane derivative. Bioorganic & Medicinal Chemistry Letters 2006, 16 (2) , 382-386. https://doi.org/10.1016/j.bmcl.2005.09.071
61. Xuemei Peng, Ao Zhang, Nora S. Kula, Ross J. Baldessarini, John L. Neumeyer. Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. Bioorganic & Medicinal Chemistry Letters 2004, 14 (22) , 5635-5639. https://doi.org/10.1016/j.bmcl.2004.08.049
62. Ana M. Catafau, Eduardo Tolosa. Impact of dopamine transporter SPECT using 123 I‐Ioflupane on diagnosis and management of patients with clinically uncertain parkinsonian syndromes. Movement Disorders 2004, 19 (10) , 1175-1182. https://doi.org/10.1002/mds.20112
63. Tatsuro Tsuchida, James R. Ballinger, Douglass Vines, Yun J. Kim, Keita Utsunomiya, Anthony E. Lang, Masanori Ichise. Reproducibility of dopamine transporter density measured with123I-FPCIT SPECT in normal control and Parkinson’s disease patients. Annals of Nuclear Medicine 2004, 18 (7) , 609-616. https://doi.org/10.1007/BF02984583
64. Fadi Masri, Françoise Riche, Andre Durif, Christian Philouze, Yannick Vallée. Synthesis of stereoisomers of 6β- and 7β-(benzylthio)-3-( p -tolyl) tropane-2-carboxylic acid methyl ester. Journal of Sulfur Chemistry 2004, 25 (4) , 259-268. https://doi.org/10.1080/17415990412331282459
65. J. Serra‐Mestres, H. A. Ring, D. C. Costa, S. Gacinovic, Z. Walker, A. J. Lees, M. M. Robertson, M. R. Trimble. Dopamine transporter binding in Gilles de la Tourette syndrome: a [ 123 I]FP‐CIT/SPECT study. Acta Psychiatrica Scandinavica 2004, 109 (2) , 140-146. https://doi.org/10.1111/j.0001-690X.2004.00214.x
66. David L. Roman, Shannon N. Saldaña, David E. Nichols, F. Ivy Carroll, Eric L. Barker. Distinct Molecular Recognition of Psychostimulants by Human and Drosophila Serotonin Transporters. Journal of Pharmacology and Experimental Therapeutics 2004, 308 (2) , 679-687. https://doi.org/10.1124/jpet.103.057836
67. Thomas Chaly, R.M. Baldwin, John L. Neumeyer, Matthew J. Hellman, Vijay Dhawan, Pradeep K. Garg, Gilles Tamagnan, Julie K. Staley, Mohammed S. Al-Tikriti, Yankun Hou, Sami S. Zoghbi, Xiao-Hui Gu, R. Zong, David Eidelberg. Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-β-Carbomethoxy-3-β-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET. Nuclear Medicine and Biology 2004, 31 (1) , 125-131. https://doi.org/10.1016/S0969-8051(03)00110-0
68. Byoung Se Lee, Soyoung Chu, Kyo Chul Lee, Bon-Su Lee, Dae Yoon Chi, Yearn Seong Choe, Sang Eun Kim, Yun Seon Song, Changbae Jin. Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. † †Part 2. See ref 1. A potential 5-HT transporter imaging agent, 3-(3-[ 18 F]fluoropropyl)-6-nitroquipazine. Bioorganic & Medicinal Chemistry 2003, 11 (23) , 4949-4958. https://doi.org/10.1016/j.bmc.2003.09.009
69. John L. Neumeyer, Ross J. Baldessarini, Raymond G. Booth. Therapeutic and Diagnostic Agents for Parkinson's Disease. 2003, 711-741. https://doi.org/10.1002/0471266949.bmc105
70. A. Semih Dogan, A.M. Catafau. PET y SPECT de neurotransmisión cerebral. Revista Española de Medicina Nuclear 2003, 22 (2) , 109-121. https://doi.org/10.1016/S0212-6982(03)72158-2
71. Susanne Asenbaum. Nuclear Medicine in Neurodegenerative Disorders. Imaging Decisions MRI 2002, 6 (s1) , 19-28. https://doi.org/10.1046/j.1617-0830.6.s1.3.x
72. Amy Hauck Newman, Santosh Kulkarni. Probes for the dopamine transporter: New leads toward a cocaine‐abuse therapeutic—A focus on analogues of benztropine and rimcazole. Medicinal Research Reviews 2002, 22 (5) , 429-464. https://doi.org/10.1002/med.10014
73. F. Turpin, F. Masri, F. Riché, E. Berthommier, P. Emond, M. Vidal, P. Auzeloux, C. Loc'h, N. Neuquelman, L. Mauclaire. Synthesis of two novel oxocyclam‐binding technetium complexes containing an analogue of cocaine. Journal of Labelled Compounds and Radiopharmaceuticals 2002, 45 (5) , 379-393. https://doi.org/10.1002/jlcr.560
74. Kyoo-Hyun Chung, Choong Hwan Lim, Dong Reyoul Lee, Changbae Jin, Dae Yoon Chi. Synthesis and binding affinities of 2β-(3-iodoallyloxycarbonyl)-3β-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies. Bioorganic & Medicinal Chemistry Letters 2001, 11 (23) , 3077-3080. https://doi.org/10.1016/S0960-894X(01)00625-4
75. Xiao-Hui Gu, Rushi Zong, Nora S Kula, Ross J Baldessarini, John L Neumeyer. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters 2001, 11 (23) , 3049-3053. https://doi.org/10.1016/S0960-894X(01)00626-6
76. Thomas Poyot, Françoise Condé, Marie-Claude Grégoire, Vincent Frouin, Christine Coulon, Chantal Fuseau, Françoise Hinnen, Frédéric Dollé, Philippe Hantraye, Michel Bottlaender. Anatomic and Biochemical Correlates of the Dopamine Transporter Ligand 11 C-PE2I in Normal and Parkinsonian Primates: Comparison with 6-[ 18 F]Fluoro-L-Dopa. Journal of Cerebral Blood Flow & Metabolism 2001, 21 (7) , 782-792. https://doi.org/10.1097/00004647-200107000-00003
77. K. TATSCH. Imaging of the dopaminergic system in parkinsonism with SPET. Nuclear Medicine Communications 2001, 22 (7) , 819-827. https://doi.org/10.1097/00006231-200107000-00015
78. Alan J. Fischman, Ali A. Bonab, John W. Babich, E. Livni, Nathaniel M. Alpert, Peter C. Meltzer, Bertha K. Madras. [11C,127I] Altropane: A highly selective ligand for PET imaging of dopamine transporter sites. Synapse 2001, 39 (4) , 332-342. https://doi.org/10.1002/1098-2396(20010315)39:4<332::AID-SYN1017>3.0.CO;2-X
79. Jan Booij, Paul Bergmans, Ania Winogrodzka, Johannes D. Speelman, Erik Ch. Wolters. Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease. Synapse 2001, 39 (2) , 101-108. https://doi.org/10.1002/1098-2396(200102)39:2<101::AID-SYN1>3.0.CO;2-1
80. E. G. EISING, Th. MÜLLER, L. FREUDENBERG, S. P. MÜLLER, K. DUTSCHKA, W. SONNENSCHEIN, H. PRZUNTEK, A. BOCKISCH. SPECT imaging with [123I]-β-CIT in Parkinsonism: comparison of SPECT images obtained by a single-headed and a three-headed gamma camera. Nuclear Medicine Communications 2001, 22 (2) , 145-130. https://doi.org/10.1097/00006231-200102000-00005
81. Bernard Gaudilliere, Patrick Bernardelli, Patrick Berna. Chapter 28. To market, to market — 2000. 2001, 293-318. https://doi.org/10.1016/S0065-7743(01)36068-2
82. Qi-Huang Zheng, G. Keith Mulholland. Isomerization Study of Aryltropane Analogs of Cocaine. Synthetic Communications 2000, 30 (2) , 333-340. https://doi.org/10.1080/00397910008087326
83. Nora S Kula, Ross J Baldessarini, Frank I Tarazi, Raoul Fisser, Shaoyin Wang, Joseph Trometer, John L Neumeyer. [3H]β-CIT: a radioligand for dopamine transporters in rat brain tissue. European Journal of Pharmacology 1999, 385 (2-3) , 291-294. https://doi.org/10.1016/S0014-2999(99)00695-0
84. David Stout, Andrej Petric, N. Satyamurthy, Quan Nguyen, Sung-Cheng Huang, Mohammad Namavari, Jorge R. Barrio. 2β-carbomethoxy-3β-(4- and 2-[18F]fluoromethylphenyl)tropanes: specific probes for in vivo quantification of central dopamine transporter sites. Nuclear Medicine and Biology 1999, 26 (8) , 897-903. https://doi.org/10.1016/S0969-8051(99)00073-6
85. Thomas Chaly, Ralph Matacchieri, Robert Dahl, Vijay Dhawan, David Eidelberg. Radiosynthesis of [ ] N-3-fluoropropyl-2-β-carbomethoxy-3-β(4′ methylphenyl) nortropane (FPCMT). Applied Radiation and Isotopes 1999, 51 (3) , 299-305. https://doi.org/10.1016/S0969-8043(99)00044-5
86. H. Hall, C. Halldin, D. Guilloteau, S. Chalon, P. Emond, J.-C. Besnard, L. Farde, G. Sedvall. Visualization of the Dopamine Transporter in the Human Brain Postmortem with the New Selective Ligand [125I]PE2I. NeuroImage 1999, 9 (1) , 108-116. https://doi.org/10.1006/nimg.1998.0366
87. Bertha K. Madras, Peter C. Meltzer, Anna Y. Liang, David R. Elmaleh, John Babich, Alan J. Fischman. Altropane, a SPECT or PET imaging probe for dopamine neurons: I. dopamine transporter binding in primate brain. Synapse 1998, 29 (2) , 93-104. https://doi.org/10.1002/(SICI)1098-2396(199806)29:2<93::AID-SYN1>3.0.CO;2-5
88. Denis Guilloteau, Patrick Emond, Jean-Louis Baulieu, Lucette Garreau, Yves Frangin, Léandre Pourcelot, Laurent Mauclaire, Jean-Claude Besnard, Sylvie Chalon. Exploration of the Dopamine Transporter: In Vitro and In Vivo Characterization of a High-Affinity and High-Specificity Iodinated Tropane Derivative (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy- 3β-(4′-methylphenyl)nortropane (PE2I). Nuclear Medicine and Biology 1998, 25 (4) , 331-337. https://doi.org/10.1016/S0969-8051(97)00224-2
89. John L. Neumeyer, Ross J. Baldessarini, Nora S. Kula, Gilles Tamagnan. Novel Phenyltropanes: Affinity to Monoamine Transporters in Rat Forebrain. 1998, 739-745. https://doi.org/10.1007/978-1-4615-5337-3_105
90. Tomoya Okada, Masahiro Fujita, Shoichi Shimada, Kohji Sato, Patrick Schloss, Yoshiyuki Watanabe, Yasushi Itoh, Masaya Tohyama, Tsunehiko Nishimura. Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines. Nuclear Medicine and Biology 1998, 25 (1) , 53-58. https://doi.org/10.1016/S0969-8051(97)00156-X
91. Jan Booij, Gerda Andringa, Leonie J.M. Rijks, R. Jeroen Vermeulen, Kora De Bruin, Gerard J. Boer, Anton G.M. Janssen, Eric A. Van Royen. [123I]FP-CIT binds to the dopamine transporter as assessed by biodistribution studies in rats and SPECT studies in MPTP-lesioned monkeys. Synapse 1997, 27 (3) , 183-190. https://doi.org/10.1002/(SICI)1098-2396(199711)27:3<183::AID-SYN4>3.0.CO;2-9
92. Camilla Lundkvist, Christer Halldin, Nathalie Ginovart, Carl-Gunnar Swahn, Lars Farde. [18F]β-CIT-FP is superior to [11C]β-CIT-FP for quantitation of the dopamine transporter. Nuclear Medicine and Biology 1997, 24 (7) , 621-627. https://doi.org/10.1016/S0969-8051(97)00077-2
93. Ionka Günther, Håkan Hall, Christer Halldin, Carl-Gunnar Swahn, Lars Farde, Göran Sedvall. [125I]β-CIT-FE and [125I]β-CIT-FP are superior to [125I]β-CIT for dopamine transporter visualization: Autoradiographic evaluation in the human brain. Nuclear Medicine and Biology 1997, 24 (7) , 629-634. https://doi.org/10.1016/S0969-8051(97)00081-4
94. P. Emond, M Boazi, A. Duchêne, S. Chalon, J. C. Besnard, D. Guilloteau, Y. Frangin. Synthesis of iodinated and radioiodinated (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy-3β-(3′,4′-dichlorophenyl) nortropane (β-CDIT): a ligand for the dopamine transporter. Journal of Labelled Compounds and Radiopharmaceuticals 1997, 39 (9) , 757-772. https://doi.org/10.1002/(SICI)1099-1344(199709)39:9<757::AID-JLCR24>3.0.CO;2-J
95. Annette Andersen, Shaoyin Wang, Robert D. Thompson, John L. Neumeyer. Synthesis of potential metabolites of the brain imaging agents methyl (1 R ,2 S ,3 S ,5 S )‐3‐(4‐Iodophenyl)‐8‐alkyl‐8‐azabicyclo[3.2.1]octane‐2‐carboxylate. Journal of Heterocyclic Chemistry 1997, 34 (5) , 1633-1636. https://doi.org/10.1002/jhet.5570340541
96. . XIIth international symposium on radiopharmaceutical chemistry: Abstracts and programme. Journal of Labelled Compounds and Radiopharmaceuticals 1997, 515-594. https://doi.org/10.1002/jlcr.2580400801
97. Ursula Scheffel, John R. Lever, Philip Abraham, Karol R. Parham, William B. Mathews, Theresa Kopajtic, F. Ivy Carroll, Michael J. Kuhar. N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter. Synapse 1997, 25 (4) , 345-349. https://doi.org/10.1002/(SICI)1098-2396(199704)25:4<345::AID-SYN5>3.0.CO;2-A
98. Mei-Ping Kung, D. Andrew Stevenson, Karl Pl�ssl, Sanath K. Meegalla, Andrew Beckwith, William D. Essman, Mu Mu, Irwin Lucki, Hank F. Kung. [99mTc]TRODAT-1: A novel technetium-99m complex as a dopamine transporter imaging agent. European Journal of Nuclear Medicine 1997, 24 (4) , 372-380. https://doi.org/10.1007/BF00881808
99. Juha O. Rinne, Jyrki T. Kuikka, Kim A. Bergström, Jukka Hiltunen, Hannu Kilpelainen. Striatal Dopamine transporter in Parkinson's disease: A Study With a New Radioligand, [123I]B-CIT-FP. Parkinsonism & Related Disorders 1997, 3 (2) , 77-81. https://doi.org/10.1016/S1353-8020(96)00046-6
100. Gilles Tamagnan, John L. Neumeyer, Yigong Gao, Shaoyin Wang, Nora S. Kula, Ross J. Baldessarini. N-Phthalimidoalkyl derivatives of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT): Brain monoamine transporter affinity. Bioorganic & Medicinal Chemistry Letters 1997, 7 (3) , 337-340. https://doi.org/10.1016/S0960-894X(97)00009-7