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Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogs of methotrexate and tetrahydrofolic acid

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    Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogs of methotrexate and tetrahydrofolic acid
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    Journal of Medicinal Chemistry

    Cite this: J. Med. Chem. 1990, 33, 2, 673–677
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    https://doi.org/10.1021/jm00164a033
    Published February 1, 1990
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    This article is cited by 20 publications.

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    7. Mahmoud A. Mohamed. Synthesis of some new bipyridines, thieno[2,3‐ b ]pyridines, and pyrazolo[3,4‐ b ]pyridines. Journal of Heterocyclic Chemistry 2012, 49 (1) , 200-203. https://doi.org/10.1002/jhet.802
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    14. Galal E.H. Elgemeie, Badria A.W. Hussain. A convenient synthesis of 5-deaza nonclassical antifolates: Reaction of cyanothioacetamide with sodium salts of 2-(hydroxymethylene)-1-cycloalkanones. Tetrahedron 1994, 50 (1) , 199-204. https://doi.org/10.1016/S0040-4020(01)80745-6
    15. Robert J. Mullin, Barry R. Keith, Eric C. Bigham, David S. Duch, Robert Ferone, Louise S. Heath, Sara Singer, Kathleen A. Waters, H.Robert Wilson. In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues. Biochemical Pharmacology 1992, 43 (7) , 1627-1634. https://doi.org/10.1016/0006-2952(92)90222-5
    16. Richard G. Moran. Folate antimetabolites inhibitory to de novo purine synthesis. 1992, 65-87. https://doi.org/10.1007/978-1-4615-3876-9_4
    17. Aleem Gangjee, Rajesh Devraj, Fu‐Tyan Lin. Synthesis of 2,4‐diamino‐5,10‐dideaza nonclassical antifolates. Journal of Heterocyclic Chemistry 1991, 28 (7) , 1747-1751. https://doi.org/10.1002/jhet.5570280717
    18. E. M. Birinberg, I. P. Rudakova. Search for new anti-tumor drugs among compounds inhibiting enzymes involved in folic acid metabolism (a review). Pharmaceutical Chemistry Journal 1991, 25 (9) , 611-622. https://doi.org/10.1007/BF00777683
    19. Gerrit Jansen, G. Robbin Westerhof, Ietje Kathmann, Gert Rijksen, Jan H. Schornagel. Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds. Cancer Chemotherapy and Pharmacology 1991, 28 (2) , 115-117. https://doi.org/10.1007/BF00689699
    20. J. I. DEGRAW, P. H. CHRISTIE, R. L. KISLIUK, Y. GAUMONT, F. M. SIROTNAK. ChemInform Abstract: Synthesis and Antifolate Properties of 10‐Alkyl‐5,10‐dideaza Analogues of Methotrexate and Tetrahydrofolic Acid.. ChemInform 1990, 21 (25) https://doi.org/10.1002/chin.199025188
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    Journal of Medicinal Chemistry

    Cite this: J. Med. Chem. 1990, 33, 2, 673–677
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jm00164a033
    Published February 1, 1990
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