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The benzodiazepine story

Cite this: J. Med. Chem. 1979, 22, 1, 1–7
Publication Date (Print):January 1, 1979
https://doi.org/10.1021/jm00187a001
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  2. Qiwen Pang, Jin Zhou, Yuling Wu, Wu-Jingyun Zhou, Wei-Fang Zuo, Gu Zhan, Bo Han. Construction of Oxo-Bridged Diazocines via Rhodium-Catalyzed (4+3) Cycloaddition of Carbonyl Ylides with Azoalkenes. Organic Letters 2022, 24 (6) , 1362-1366. https://doi.org/10.1021/acs.orglett.2c00076
  3. Kashif Majeed, Lingna Wang, Bangjie Liu, Zijian Guo, Fengtao Zhou, Qiuyu Zhang. Metal-Free Tandem Approach for Triazole-Fused Diazepinone Scaffolds via [3 + 2]Cycloaddition/C–N Coupling Reaction. The Journal of Organic Chemistry 2021, 86 (1) , 207-222. https://doi.org/10.1021/acs.joc.0c02022
  4. Samuele Maramai, Mohamed Benchekroun, Simon E. Ward, John R. Atack. Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update. Journal of Medicinal Chemistry 2020, 63 (7) , 3425-3446. https://doi.org/10.1021/acs.jmedchem.9b01312
  5. Gerard K. M. Verzijl, Jorma Hassfeld, André H. M. de Vries, Laurent Lefort. Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation. Organic Process Research & Development 2020, 24 (2) , 255-260. https://doi.org/10.1021/acs.oprd.9b00519
  6. Juan Feng, Meng Zhou, Xuanzi Lin, An Lu, Xiaoyi Zhang, Ming Zhao. Base-Mediated [3 + 4]-Cycloaddition of Anthranils with Azaoxyallyl Cations: A New Approach to Multisubstituted Benzodiazepines. Organic Letters 2019, 21 (16) , 6245-6248. https://doi.org/10.1021/acs.orglett.9b02118
  7. Constantinos G. Neochoritis, Ting Zhao, Alexander Dömling. Tetrazoles via Multicomponent Reactions. Chemical Reviews 2019, 119 (3) , 1970-2042. https://doi.org/10.1021/acs.chemrev.8b00564
  8. Matthew L. Maddess, Chaomin Li. Metal Catalyzed Synthesis of Dihydropyridobenzodiazepines. Organometallics 2019, 38 (1) , 81-84. https://doi.org/10.1021/acs.organomet.8b00322
  9. Dean G. Brown, Jonas Boström. Where Do Recent Small Molecule Clinical Development Candidates Come From?. Journal of Medicinal Chemistry 2018, 61 (21) , 9442-9468. https://doi.org/10.1021/acs.jmedchem.8b00675
  10. Schuyler A. Chambers, Jenna M. DeSousa, Eric D. Huseman, Steven D. Townsend. The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production. ACS Chemical Neuroscience 2018, 9 (10) , 2307-2330. https://doi.org/10.1021/acschemneuro.7b00528
  11. Eneko Larrañeta. Incorporating Stories of Sedatives, Spoiled Sweet Clover Hay, and Plants from the Amazon Rainforest into a Pharmaceutical Chemistry Course To Engage Students and Introduce Drug Design Strategies. Journal of Chemical Education 2018, 95 (10) , 1778-1786. https://doi.org/10.1021/acs.jchemed.8b00063
  12. Antoine Douchez, Etienne Billard, Terence E. Hébert, David Chatenet, and William D. Lubell . Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics. Journal of Medicinal Chemistry 2017, 60 (23) , 9838-9859. https://doi.org/10.1021/acs.jmedchem.7b01525
  13. Dean G. Brown and Jonas Boström . Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?. Journal of Medicinal Chemistry 2016, 59 (10) , 4443-4458. https://doi.org/10.1021/acs.jmedchem.5b01409
  14. Matthias G. J. Baud, Enrique Lin-Shiao, Michael Zengerle, Cynthia Tallant, and Alessio Ciulli . New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. Journal of Medicinal Chemistry 2016, 59 (4) , 1492-1500. https://doi.org/10.1021/acs.jmedchem.5b01135
  15. Antoine Douchez and William D. Lubell . Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates. Organic Letters 2015, 17 (24) , 6046-6049. https://doi.org/10.1021/acs.orglett.5b03046
  16. Aurélie A. Dörr and William D. Lubell . γ-Turn Mimicry with Benzodiazepinones and Pyrrolobenzodiazepinones Synthesized from a Common Amino Ketone Intermediate. Organic Letters 2015, 17 (14) , 3592-3595. https://doi.org/10.1021/acs.orglett.5b01679
  17. Jonghoon Kim, Heejun Kim, and Seung Bum Park . Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces. Journal of the American Chemical Society 2014, 136 (42) , 14629-14638. https://doi.org/10.1021/ja508343a
  18. Nicholas E. Calcaterra and James C. Barrow . Classics in Chemical Neuroscience: Diazepam (Valium). ACS Chemical Neuroscience 2014, 5 (4) , 253-260. https://doi.org/10.1021/cn5000056
  19. Nurettin Menges, Ozlem Sari, Yusif Abdullayev, Safiye Sağ Erdem, and Metin Balci . Design and Synthesis of Pyrrolotriazepine Derivatives: An Experimental and Computational Study. The Journal of Organic Chemistry 2013, 78 (11) , 5184-5195. https://doi.org/10.1021/jo4001228
  20. Veronika Fülöpová, Tomáš Gucký, Martin Grepl, and Miroslav Soural . Solid-Phase Synthesis of Trisubstituted Benzo[1,4]-Diazepin-5-one Derivatives. ACS Combinatorial Science 2012, 14 (12) , 651-656. https://doi.org/10.1021/co300124q
  21. Yijun Huang, Kareem Khoury, Tyler Chanas, and Alexander Dömling . Multicomponent Synthesis of Diverse 1,4-Benzodiazepine Scaffolds. Organic Letters 2012, 14 (23) , 5916-5919. https://doi.org/10.1021/ol302837h
  22. James R. Donald, Rebekah R. Wood, and Stephen F. Martin . Application of a Sequential Multicomponent Assembly Process/Huisgen Cycloaddition Strategy to the Preparation of Libraries of 1,2,3-Triazole-Fused 1,4-Benzodiazepines. ACS Combinatorial Science 2012, 14 (2) , 135-143. https://doi.org/10.1021/co2002087
  23. Eliezer J. Barreiro, Arthur E. Kümmerle, and Carlos A. M. Fraga . The Methylation Effect in Medicinal Chemistry. Chemical Reviews 2011, 111 (9) , 5215-5246. https://doi.org/10.1021/cr200060g
  24. Nicolas Boutard, Julien Dufour-Gallant, Philippe Deaudelin, and William D. Lubell . Pyrrolo[3,2-e][1,4]diazepin-2-one Synthesis: A Head-to-Head Comparison of Soluble versus Insoluble Supports. The Journal of Organic Chemistry 2011, 76 (11) , 4533-4545. https://doi.org/10.1021/jo200424q
  25. Gunaji S. Bayes, Y. S. Lakshmi Narasimham, Sambhaji S. Raut, Vishwanath R. Patil, and Rama S. Lokhande . Automated Potentiometric Titration Method for Determination of pK Values: An Application to Benzodiazepines. Journal of Chemical & Engineering Data 2011, 56 (5) , 1787-1792. https://doi.org/10.1021/je100738h
  26. Kimihito Matsushita, Chieko Okamoto, Mayumi Yoshimoto, Kenichi Harada, Miwa Kubo, Yoshiyasu Fukuyama and Hideaki Hioki. Novel Alkoxyamine Linker to Load Ketones for Solid-Phase Synthesis: Application of the Synthesis of 1,4-Benzodiazepine-2-ones. Journal of Combinatorial Chemistry 2010, 12 (3) , 311-314. https://doi.org/10.1021/cc9001795
  27. Jin-Yuan Wang,, Xue-Fei Guo,, De-Xiang Wang,, Zhi-Tang Huang, and, Mei-Xiang Wang. A New Strategy for the Synthesis of 1,4-Benzodiazepine Derivatives Based on the Tandem N-Alkylation−Ring Opening−Cyclization Reactions of Methyl 1-Arylaziridine-2-carboxylates with N-[2-Bromomethyl(phenyl)]trifluoroacetamides. The Journal of Organic Chemistry 2008, 73 (5) , 1979-1982. https://doi.org/10.1021/jo7024306
  28. Yong-Sok Lee,, Victor W. Pike, and, Milan Hodoscek. Identification of the Transition States in the Inversion of 1,4-Benzodiazepines with the Ab Initio Replica Path Method. The Journal of Physical Chemistry A 2008, 112 (7) , 1604-1611. https://doi.org/10.1021/jp077738o
  29. Line S. Laustsen and Christian K. Sams. Parallel Synthesis of 1,3-Dihydro-1,4-benzodiazepine-2-ones Employing Catch and Release. Journal of Combinatorial Chemistry 2007, 9 (6) , 1094-1103. https://doi.org/10.1021/cc0700647
  30. Jitendra Kumar Mishra and, Gautam Panda. Diversity-Oriented Synthetic Approach to Naturally Abundant S-Amino Acid Based Benzannulated Enantiomerically Pure Medium Ring Heterocyclic Scaffolds Employing Inter- and Intramolecular Mitsunobu Reactions. Journal of Combinatorial Chemistry 2007, 9 (2) , 321-338. https://doi.org/10.1021/cc0601480
  31. Matthew D. Surman,, Mark J. Mulvihill, and, Marvin J. Miller. Novel 1,4-Benzodiazepines from Acylnitroso-Derived Hetero-Diels−Alder Cycloadducts. Organic Letters 2002, 4 (1) , 139-141. https://doi.org/10.1021/ol017036w
  32. Adel Nefzi,, John M. Ostresh, and, Richard A. Houghten. The Current Status of Heterocyclic Combinatorial Libraries. Chemical Reviews 1997, 97 (2) , 449-472. https://doi.org/10.1021/cr960010b
  33. Thomas A. Keating and, Robert W. Armstrong. Postcondensation Modifications of Ugi Four-Component Condensation Products:  1-Isocyanocyclohexene as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture. Journal of the American Chemical Society 1996, 118 (11) , 2574-2583. https://doi.org/10.1021/ja953868b
  34. John S. Winn. A systematic look at weakly bound diatomics. Accounts of Chemical Research 1981, 14 (11) , 341-348. https://doi.org/10.1021/ar00071a003
  35. Victor Snieckus and Jacques Streith. 1,2-Diazepines: a new vista in heterocyclic chemistry. Accounts of Chemical Research 1981, 14 (11) , 348-355. https://doi.org/10.1021/ar00071a004
  36. Meenu Devi, Shivangi Jaiswal, Neetu Yaduvanshi, Sonika Jain, Smita Jain, Kanika Verma, Rahul Verma, Dharma Kishore, Jaya Dwivedi, Swapnil Sharma. Design, Synthesis, Molecular docking, and Antibacterial Study of Aminomethyl Triazolo Substituted Analogues of Benzimidazolo [1,4]-benzodiazepine. Journal of Molecular Structure 2023, 1286 , 135571. https://doi.org/10.1016/j.molstruc.2023.135571
  37. Azeem Iqbal, Filip Ložek, Ismael Soto, Davinder Kaur, Kateřina Grabicová, Iryna Kuklina, Tomáš Randák, Viktoriia Malinovska, Miloš Buřič, Pavel Kozák. Effect of psychoactive substances on cardiac and locomotory activity of juvenile marbled crayfish Procambarus virginalis. Ecotoxicology and Environmental Safety 2023, 260 , 115084. https://doi.org/10.1016/j.ecoenv.2023.115084
  38. Maria Ivanova, Thomas Poisson, Philippe Jubault, Julien Legros. Flow platform for the synthesis of benzodiazepines. Journal of Flow Chemistry 2023, 13 (1) , 45-52. https://doi.org/10.1007/s41981-022-00243-z
  39. Nicolas Singewald, Simone B. Sartori, Andreas Reif, Andrew Holmes. Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder. Neuropharmacology 2023, 226 , 109418. https://doi.org/10.1016/j.neuropharm.2023.109418
  40. Michaele Abrantes de Oliveira Lima, Cicera Amanda Mota Seabra, Kassandra Lins Braga, Ankilma do Nascimento Andrade Feitosa, Bruna Raquel Gomes de Oliveira, Ingrid Barbosa Duete Xenofonte. USO DE BENZODIAZEPÍNICOS POR IDOSOS: UMA REVISÃO INTEGRATIVA DE LITERATURA. Revista interdisciplinar em saúde 2023, 10 (Único) , 60-67. https://doi.org/10.35621/23587490.v10.n1.p60-67
  41. Norman J. Temple. Research strategies in nutrition in health and disease: The failure of mechanistic research. Frontiers in Nutrition 2023, 10 https://doi.org/10.3389/fnut.2023.1082182
  42. Seyede Khadije Ghadiri, Seyed Meysam Baghbanian, Samad Khaksar. Mild and highly efficient method for synthesis of 1,5-benzodiazepine using pentafluorobenzenaminium hexafluorophosphate as a novel organocatalyst. Journal of Molecular Structure 2023, 1272 , 134057. https://doi.org/10.1016/j.molstruc.2022.134057
  43. Marcel P. Goldschen-Ohm. Benzodiazepine Modulation of GABAA Receptors: A Mechanistic Perspective. Biomolecules 2022, 12 (12) , 1784. https://doi.org/10.3390/biom12121784
  44. Neelanjana Srivastava, Monika Verma, Ajay Thakur, Ruchi Bharti, Renu Sharma. Contemporary Progress in the Applications of Iron-based Magnetic Nanoparticles in Multicomponent Synthesis: A Review. Current Organic Chemistry 2022, 26 (23) , 2122-2142. https://doi.org/10.2174/1385272827666230126124704
  45. . From Antiquity to the Age of Artificial Intelligence. 2022, 438-455. https://doi.org/10.1002/9781119589181.ch18
  46. Fengxuan Jiang, Menghua Xu, Wenfeng Bei, Kai Cheng, Lehao Huang. Palladium-catalyzed native α-amino acid derivative-directed arylation/oxidation of benzylic C–H bonds: synthesis of 5-aryl-1,4-benzodiazepin-2-ones. Chemical Communications 2022, 58 (69) , 9638-9641. https://doi.org/10.1039/D2CC03266J
  47. Paweł Kozyra, Monika Pitucha. Terminal Phenoxy Group as a Privileged Moiety of the Drug Scaffold—A Short Review of Most Recent Studies 2013–2022. International Journal of Molecular Sciences 2022, 23 (16) , 8874. https://doi.org/10.3390/ijms23168874
  48. Anirudh Singh Bhathiwal, Anjaneyulu Bendi, Aditi Tiwari. A study on synthesis of benzodiazepine scaffolds using biologically active chalcones as precursors. Journal of Molecular Structure 2022, 1258 , 132649. https://doi.org/10.1016/j.molstruc.2022.132649
  49. Fatemeh Molaei Yielzoleh, Kobra Nikoofar. Metal-bio functionalized bismuthmagnetite [Fe 3− x Bi x O 4 /SiO 2 @ l -ArgEt 3 + I − /Zn( ii )]: a novel bionanocomposite for the synthesis of 1,2,4,5-tetrahydro-2,4-dioxobenzo[ b ][1,4]diazepine malononitriles and malonamides at room temperature and under sonication. RSC Advances 2022, 12 (17) , 10219-10236. https://doi.org/10.1039/D2RA00212D
  50. Michael Evans-Brown, Brendan Hughes, Roumen Sedefov. Legal classification and international systems for monitoring and responding to novel psychoactive substances. 2022, 3-56. https://doi.org/10.1016/B978-0-12-818788-3.00016-4
  51. Branko Stanovnik. 1,2-Diazepines. 2022, 181-203. https://doi.org/10.1016/B978-0-12-818655-8.00099-8
  52. Farzad Zamani, Ramin Javahershenas, Fatemeh M. Arlan, Christopher J.T. Hyland, Esmail Doustkhah. Synthesis of 1,4-benzodiazepines and 1,4-benzothiazepines. 2022, 35-77. https://doi.org/10.1016/B978-0-12-824516-3.00004-5
  53. Farzad Zamani, Esmail Doustkhah. An introduction to benzodiazepines and benzothiazepines. 2022, 1-8. https://doi.org/10.1016/B978-0-12-824516-3.00007-0
  54. Alexey V. Rossokhin, Irina N. Sharonova. Structural pharmacology of GABAА receptors. Annals of Clinical and Experimental Neurology 2021, 15 (4) , 44-53. https://doi.org/10.54101/ACEN.2021.4.5
  55. Thorsteinn Loftsson. 1,4-Benzodiazepines: Chemical stability and cyclodextrin solubilization. Journal of Drug Delivery Science and Technology 2021, 66 , 102936. https://doi.org/10.1016/j.jddst.2021.102936
  56. Zhen Huang, Li Niu. RNA aptamers for AMPA receptors. Neuropharmacology 2021, 199 , 108761. https://doi.org/10.1016/j.neuropharm.2021.108761
  57. Xiaoyong Huang, Xiaole Zhao, Xin Zhang, Peng Wang, Kui Zhu, Bing Shao. Chlorinated disinfection byproducts of diazepam perturb cell metabolism and induce behavioral toxicity in zebrafish larvae. Ecotoxicology and Environmental Safety 2021, 220 , 112416. https://doi.org/10.1016/j.ecoenv.2021.112416
  58. Gavin J. Kilpatrick. Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent. Frontiers in Pharmacology 2021, 12 https://doi.org/10.3389/fphar.2021.690875
  59. Yohan Malki, Jean Martinez, Nicolas Masurier. 1,3‐Diazepine: A privileged scaffold in medicinal chemistry. Medicinal Research Reviews 2021, 41 (4) , 2247-2315. https://doi.org/10.1002/med.21795
  60. Gerhard Gründer, Henrik Jungaberle. The Potential Role of Psychedelic Drugs in Mental Health Care of the Future. Pharmacopsychiatry 2021, 54 (04) , 191-199. https://doi.org/10.1055/a-1486-7386
  61. Ashish Sarangi, Terry McMahon, Jayasudha Gude. Benzodiazepine Misuse: An Epidemic Within a Pandemic. Cureus 2021, 37 https://doi.org/10.7759/cureus.15816
  62. Jeong Joo Kim, Ryan E. Hibbs. Direct Structural Insights into GABAA Receptor Pharmacology. Trends in Biochemical Sciences 2021, 46 (6) , 502-517. https://doi.org/10.1016/j.tibs.2021.01.011
  63. Ravi Kumar. Drug Discovery (Lead Identification and High Throughput Screening). Research Journal of Pharmacology and Pharmacodynamics 2021, , 46-50. https://doi.org/10.52711/2321-5836.2021.00010
  64. Xiao‐Zu Fan, Hui‐Hui Wu, Zhe Tang, Heng Zhang, Lu‐Yu Cai, Xiao‐Fan Bi, Hong‐Wu Zhao. Formal [3+2] Cycloaddition Between in situ Formed 1,4‐Benzodiazepin‐2‐One‐Based Azomethine Ylides and Azodicarboxylic Acid Derivatives: Diastereoselective Synthesis of Spiro‐1,4‐Benzodiazepin‐2‐Ones. Advanced Synthesis & Catalysis 2021, 363 (5) , 1379-1389. https://doi.org/10.1002/adsc.202001486
  65. Suresh Kumar Maury, Dhirendra Kumar, Arsala Kamal, Himanshu Kumar Singh, Savita Kumari, Sundaram Singh. A facile and efficient multicomponent ultrasound-assisted “on water” synthesis of benzodiazepine ring. Molecular Diversity 2021, 25 (1) , 131-142. https://doi.org/10.1007/s11030-019-10031-y
  66. Imtiaz Khan, Aliya Ibrar, Sumera Zaib. Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges. Topics in Current Chemistry 2021, 379 (1) https://doi.org/10.1007/s41061-020-00316-4
  67. Latifeh Navidpour, Shabnam Shabani, Alireza Heidari, Manouchehr Bashiri, Azadeh Ebrahim-Habibi, Soraya Shahhosseini, Hamed Shafaroodi, Sayyed Abbas Tabatabai, Mahsa Toolabi. 5-[Aryloxypyridyl (or nitrophenyl)]-4H-1,2,4-triazoles as novel flexible benzodiazepine analogues: Synthesis, receptor binding affinity and lipophilicity-dependent anti-seizure onset of action. Bioorganic Chemistry 2021, 106 , 104504. https://doi.org/10.1016/j.bioorg.2020.104504
  68. P. -L. Chau, Jonathan Herring. Sickness. 2021, 195-210. https://doi.org/10.1007/978-3-030-60208-6_6
  69. Angela Di Capua, Annalisa Reale, Marco Paolino, Giulia Chemi, Simone Brogi, Andrea Cappelli, Gianluca Giorgi, Fedora Grande, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Rosanna Matucci, Antonio Garofalo, Maurizio Anzini. Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents. European Journal of Medicinal Chemistry 2020, 200 , 112405. https://doi.org/10.1016/j.ejmech.2020.112405
  70. Rajesh K. Singh, Sadhna Sharda, Shikha Sharma, Sahil Kumar, Deo Nandan Prasad. Multicomponent Catalytic Synthesis of 1,5-Benzodiazepines: An Update. Mini-Reviews in Organic Chemistry 2020, 17 (4) , 465-484. https://doi.org/10.2174/1570193X16666190509074109
  71. Tarak Saied, Mohamed L. Efrit, Yves Fort, Corinne Comoy. Elaboration of Benzoxadiazepine and Benzotriazocine Scaffolds. ChemistrySelect 2020, 5 (19) , 5604-5614. https://doi.org/10.1002/slct.202001467
  72. Dino Luethi, Matthias E. Liechti. Designer drugs: mechanism of action and adverse effects. Archives of Toxicology 2020, 94 (4) , 1085-1133. https://doi.org/10.1007/s00204-020-02693-7
  73. Marie-Christine Tonon, Hubert Vaudry, Julien Chuquet, Florent Guillebaud, Jinjiang Fan, Olfa Masmoudi-Kouki, David Vaudry, Damien Lanfray, Fabrice Morin, Vincent Prevot, Vassilios Papadopoulos, Jean-Denis Troadec, Jérôme Leprince. Endozepines and their receptors: Structure, functions and pathophysiological significance. Pharmacology & Therapeutics 2020, 208 , 107386. https://doi.org/10.1016/j.pharmthera.2019.06.008
  74. Nidhi Arora, Prashant Dhiman, Shubham Kumar, Gurpreet Singh, Vikramdeep Monga. Recent advances in synthesis and medicinal chemistry of benzodiazepines. Bioorganic Chemistry 2020, 97 , 103668. https://doi.org/10.1016/j.bioorg.2020.103668
  75. Laura E. Vossen, Daniel Červený, Oly Sen Sarma, Per-Ove Thörnqvist, Fredrik Jutfelt, Jerker Fick, Tomas Brodin, Svante Winberg. Low concentrations of the benzodiazepine drug oxazepam induce anxiolytic effects in wild-caught but not in laboratory zebrafish. Science of The Total Environment 2020, 703 , 134701. https://doi.org/10.1016/j.scitotenv.2019.134701
  76. Xiaoxuan Yang, Anita Luethy, Honghai Zhang, Yan Luo, Qingsheng Xue, Buwei Yu, Han Lu. Mechanism and Development of Modern General Anesthetics. Current Topics in Medicinal Chemistry 2020, 19 (31) , 2842-2854. https://doi.org/10.2174/1568026619666191114101425
  77. Sarita Khandelwal, Yogesh Kumar Tailor, Esha Rushell, Mahendra Kumar. Use of sustainable organic transformations in the construction of heterocyclic scaffolds. 2020, 245-352. https://doi.org/10.1016/B978-0-12-817592-7.00009-5
  78. Qiaomei Jin, Dongjian Zhang, Jian Zhang. Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones via cyclization of N -alkoxy α-halogenoacetamides with N -(2-chloromethyl)aryl amides. Organic & Biomolecular Chemistry 2019, 17 (45) , 9708-9711. https://doi.org/10.1039/C9OB02260K
  79. Xinglin Ye, Zhiyuan Chen, Zhipeng Zhang, Yang Fu, Zhihong Deng, Yiyuan Peng. A convenient approach to 2,4-disubstituted quinazoline-3-oxides using active MnO 2 as the oxidant. Canadian Journal of Chemistry 2019, 97 (9) , 682-689. https://doi.org/10.1139/cjc-2018-0521
  80. Yun Yang, Yue Xu, Christopher R. Jones. A Ring Expansion Route to Benzofused N‐Heterocycles Through Aryne Insertion into 1,3‐Diaza‐heterocycles. European Journal of Organic Chemistry 2019, 2019 (31-32) , 5196-5200. https://doi.org/10.1002/ejoc.201900570
  81. Zahra Tashrifi, Mohammad Mohammadi-Khanaposhtani, Mahmood Biglar, Bagher Larijani, Mohammad Mahdavi. Isatoic Anhydride: A Fascinating and Basic Molecule for the Synthesis of Substituted Quinazolinones and Benzo di/triazepines. Current Organic Chemistry 2019, 23 (10) , 1090-1130. https://doi.org/10.2174/1385272823666190701142930
  82. Axel Kleemann. Anxiolytics (N05B). 2019, 1-7. https://doi.org/10.1002/14356007.p03_p01.pub2
  83. Virendra Prasad, Nidhi Mishra, Anand K. Agrahari, Sumit K. Singh, Prabhu P. Mohapatra, Vinod K. Tiwari. Cycloelimination-assisted Combinatorial Synthesis of Diverse Heterocyclic Scaffolds of Chemotherapeutic Values. Current Organic Chemistry 2019, 23 (7) , 768-808. https://doi.org/10.2174/1385272823666190405145805
  84. Zhongrong Meng, Weiran Yang, Jing Zheng. [4 + 3]-Cycloaddition of aza-o-quinone methides and azomethine imines to make 1,2,4-triazepines. Tetrahedron Letters 2019, 60 (27) , 1758-1762. https://doi.org/10.1016/j.tetlet.2019.05.038
  85. Samane Poursan, Somayeh Ahadi, Saeed Balalaie, Frank Rominger, Hamid Reza Bijanzadeh. Design and Synthesis of Novel Functionalized Fused Oxazepine and Diazepine Analogues Containing Coumarin Backbone through Domino Reaction. ChemistrySelect 2019, 4 (20) , 6403-6407. https://doi.org/10.1002/slct.201900918
  86. María Julia Amundarain, Juan Francisco Viso, Fernando Zamarreño, Alejandro Giorgetti, Marcelo Costabel. Orthosteric and benzodiazepine cavities of the α 1 β 2 γ 2 GABA A receptor: insights from experimentally validated in silico methods. Journal of Biomolecular Structure and Dynamics 2019, 37 (6) , 1597-1615. https://doi.org/10.1080/07391102.2018.1462733
  87. Elisabet Batlle, Enric Lizano, Miquel Viñas, Maria Dolors Pujol. 1,4-Benzodiazepines and New Derivatives: Description, Analysis, and Organic Synthesis. 2019https://doi.org/10.5772/intechopen.79879
  88. Terence Nguema Ongone, Redouane Achour, Mostafa El Ghoul, Latyfa El Ouasif, Meryem El Jemli, Laila Chemlal, Yahia Cherrah, Katim Alaoui, Amina Zellou. Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives. Journal of Chemistry 2019, 2019 , 1-7. https://doi.org/10.1155/2019/9043570
  89. Kenichi Tamama, Michael J. Lynch. Newly Emerging Drugs of Abuse. 2019, 463-502. https://doi.org/10.1007/164_2019_260
  90. Marc Vogel, Carlo Caflisch. Sedativa und Hypnotika. 2019, 259-278. https://doi.org/10.1016/B978-3-437-23021-9.00014-X
  91. Vitor Iglesias Mangolini, Laura Helena Andrade, Francisco Lotufo-Neto, Yuan-Pang Wang. Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence. Clinics 2019, 74 , e1316. https://doi.org/10.6061/clinics/2019/e1316
  92. Jonas Boström, Dean G. Brown, Robert J. Young, György M. Keserü. Expanding the medicinal chemistry synthetic toolbox. Nature Reviews Drug Discovery 2018, 17 (10) , 709-727. https://doi.org/10.1038/nrd.2018.116
  93. Marisa J. López Rivilli, Anahí V. Turina, Elena A. Bignante, Victor H. Molina, María A. Perillo, Margarita C. Briñon, Elizabeth L. Moyano. Synthesis and pharmacological evaluation of pyrazolo[4,3-c]quinolinones as high affinity GABAA-R ligands and potential anxiolytics. Bioorganic & Medicinal Chemistry 2018, 26 (14) , 3967-3974. https://doi.org/10.1016/j.bmc.2018.06.021
  94. Shaotong Zhu, Colleen M. Noviello, Jinfeng Teng, Richard M. Walsh, Jeong Joo Kim, Ryan E. Hibbs. Structure of a human synaptic GABAA receptor. Nature 2018, 559 (7712) , 67-72. https://doi.org/10.1038/s41586-018-0255-3
  95. Jessica E. Hill, Johnathan V. Matlock, Quentin Lefebvre, Katie G. Cooper, Jonathan Clayden. Consecutive Ring Expansion and Contraction for the Synthesis of 1-Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors. Angewandte Chemie 2018, 130 (20) , 5890-5893. https://doi.org/10.1002/ange.201802188
  96. Jessica E. Hill, Johnathan V. Matlock, Quentin Lefebvre, Katie G. Cooper, Jonathan Clayden. Consecutive Ring Expansion and Contraction for the Synthesis of 1-Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors. Angewandte Chemie International Edition 2018, 57 (20) , 5788-5791. https://doi.org/10.1002/anie.201802188
  97. Barbara Pem, Valerije Vrček. Substituent effects on the stability of 1,4-benzodiazepin-2-one tautomers: A density functional study. International Journal of Quantum Chemistry 2018, 118 (8) , e25523. https://doi.org/10.1002/qua.25523
  98. Kieran R. Manchester, Emma C. Lomas, Laura Waters, Fiona C. Dempsey, Peter D. Maskell. The emergence of new psychoactive substance (NPS) benzodiazepines: A review. Drug Testing and Analysis 2018, 10 (1) , 37-53. https://doi.org/10.1002/dta.2211
  99. Bjoern Moosmann, Volker Auwärter. Designer Benzodiazepines: Another Class of New Psychoactive Substances. 2018, 383-410. https://doi.org/10.1007/164_2018_154
  100. Zhoulong Fan, Heng Lu, Zhen Cheng, Ao Zhang. Ligand-promoted ruthenium-catalyzed meta C–H chlorination of arenes using N -chloro-2,10-camphorsultam. Chemical Communications 2018, 54 (47) , 6008-6011. https://doi.org/10.1039/C8CC03195A
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