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6,11-Dihydro-11-oxodibenz[b,e]oxepinacetic acids with potent antiinflammatory activity

Cite this: J. Med. Chem. 1976, 19, 7, 941–946
Publication Date (Print):July 1, 1976
https://doi.org/10.1021/jm00229a017
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    Cited By

    This article is cited by 20 publications.

    1. Chen-Xi Ye, Xiang Shen, Shuming Chen, Eric Meggers. Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids. Nature Chemistry 2022, 14 (5) , 566-573. https://doi.org/10.1038/s41557-022-00895-3
    2. Jimena Scoccia, M. Julia Castro, M. Belén Faraoni, Cecilia Bouzat, Víctor S. Martín, Darío C. Gerbino. Iron(II) promoted direct synthesis of dibenzo[b,e]oxepin-11(6H)-one derivatives with biological activity. A short synthesis of doxepin. Tetrahedron 2017, 73 (20) , 2913-2922. https://doi.org/10.1016/j.tet.2017.03.085
    3. Carmen Limban, Mariana Carmen Chifiriuc. Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents. International Journal of Molecular Sciences 2011, 12 (10) , 6432-6444. https://doi.org/10.3390/ijms12106432
    4. Jitendra Sainy, Ganesh P. Mishra, Rajesh Sharma, Subhash C. Chaturvedi. 2-Amino-5-sulfanyl-1,3,4-thiadiazoles: a novel series of anti-inflammatory and analgesic agents. Pharmaceutical Chemistry Journal 2009, 43 (1) , 19-24. https://doi.org/10.1007/s11094-009-0236-9
    5. . Heterocycles Fused to Two Aromatic Rings. 2008, 515-544. https://doi.org/10.1002/9780470399613.ch13
    6. Biswanath Das, Anjoy Majhi, Joydeep Banerjee, Nikhil Chowdhury, Harish Holla, Kankipati Harakishore, Upadhayula Suryanarayana Murty. An Efficient Synthesis of 2-Benzoxepines from Morita-Baylis-Hillman Adducts Using Heterogeneous Recyclable Catalysts. Chemical and Pharmaceutical Bulletin 2006, 54 (3) , 403-405. https://doi.org/10.1248/cpb.54.403
    7. . Oxepinac 55689‐65‐1. 2004https://doi.org/10.1002/0471701343.sdp19617
    8. Deevi Basavaiah, Duddu S. Sharada, Ainelly Veerendhar. A facile tandem construction of C–O and C–C bonds: a novel one-pot transformation of Baylis–Hillman adducts into 2-benzoxepines. Tetrahedron Letters 2004, 45 (15) , 3081-3083. https://doi.org/10.1016/j.tetlet.2004.02.107
    9. Thomas B.K. Lee, Andrew J. Tebben †, Franz J. Weiberth, George S.K. Wong †. An Expedient Large-Scale Preparation of a Dibenz[b,e]oxepinone Derivative. Synthetic Communications 1998, 28 (4) , 747-751. https://doi.org/10.1080/00397919808005948
    10. Bernard Bonnaud, Dennis Bigg, Jean‐François Patoiseau. Synthesis of novel indolizine derivatives. Journal of Heterocyclic Chemistry 1991, 28 (8) , 1927-1932. https://doi.org/10.1002/jhet.5570280820
    11. Toru Sugaya, Nobuyuki Kato, Shinji Tomioka, Kentaro Tamaki. Stereoselective Synthesis of Novel Thromboxane A2 Receptor Antagonists via Stereoselective 1-Azadiene Isomerization. Chemistry Letters 1990, 19 (12) , 2181-2182. https://doi.org/10.1246/cl.1990.2181
    12. Pietro Bollinger, Philip Cooper, Hans U. Gubler, Albert Leutwiler, Trevor Payne. (Benzo[4, 5]cyclohepta[l, 2‐b]thiophen‐4‐ylidene)acetic Acids: Novel Non‐ulcerogenic Antiinflammatory Agents. Helvetica Chimica Acta 1990, 73 (5) , 1197-1204. https://doi.org/10.1002/hlca.19900730507
    13. J. Elks, C. R. Ganellin. O. 1990, 892-927. https://doi.org/10.1007/978-1-4757-2085-3_15
    14. G. Bandoli, M. Nicolini, J. P. Tollenaere. Conformation of dibenzo[b,f]heteroepin drugs and related compounds. Journal of Crystallographic and Spectroscopic Research 1984, 14 (5) , 401-446. https://doi.org/10.1007/BF01160692
    15. D. H. Kim, C. G. Van Arman, D. Armstrong. The Chemistry of the Non-Steroidal Antipyretic Agents: Structure-Activity Relationships. 1982, 317-375. https://doi.org/10.1007/978-3-642-68569-9_12
    16. Joseph G. Lombardino. Chapter 18. New Agents for the Treatment of Inflammation and Arthritis. 1981, 189-198. https://doi.org/10.1016/S0065-7743(08)61285-3
    17. Hideo Hakusui, Wataru Suzuki, Mitsuji Sano. Quantitative analysis of oxepinac in human plasma, urine and saliva by gas chromatography—mass fragmentography. Journal of Chromatography B: Biomedical Sciences and Applications 1980, 182 (1) , 47-53. https://doi.org/10.1016/S0378-4347(00)81649-7
    18. Dimitri Gaitanopoulos, Martin Brenner. The Synthesis of Hydroxytrifluoromethyl 3H-Benzazepines. Synthetic Communications 1980, 10 (3) , 213-219. https://doi.org/10.1080/00397918008064224
    19. G. Dive, C. L. Lapière, G. Leroy. Analyse Conformationnelle des Dérivés Arylacétiques et Propioniques à Activité Antiinflammatoire. Bulletin des Sociétés Chimiques Belges 1977, 86 (1-2) , 73-80. https://doi.org/10.1002/bscb.19770860112
    20. K. UENO, S. KUBO, H. TAGAWA, T. YOSHIOKA, W. TSUKADA, M. TSUBOKAWA, H. KOJIMA, A. KASAHARA. ChemInform Abstract: 6,11‐DIHYDRO‐11‐OXODIBENZ(B,E)OXEPINACETIC ACIDS WITH POTENT ANTIINFLAMMATORY ACTIVITY. Chemischer Informationsdienst 1976, 7 (46) https://doi.org/10.1002/chin.197646261

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