Linear benzoadenine. Stretched-out analog of adenine

Nelson J. Leonard, Alan G. Morrice, and Mark A. Sprecker

J. Org. Chem., 1975, 40 (3), pp 356–363

DOI: 10.1021/jo00891a021

Publication Date: February 1975

Cite this:J. Org. Chem. 40, 3, 356-363

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Article

Linear benzoadenine. Stretched-out analog of adenine

Bicyclic and Tricyclic “Expanded” Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies

yDNA versus xDNA Pyrimidine Nucleobases: Computational Evidence for Dependence of Duplex Stability on Spacer Location

Fluorescence of Size-Expanded DNA Bases: Reporting on DNA Sequence and Structure with an Unnatural Genetic Set

Rational Design of Hetero-ring-Expanded Guanine Analogs with Enhanced Properties for Modified DNA Building Blocks

How Do Size-Expanded DNA Nucleobases Enhance Duplex Stability? Computational Analysis of the Hydrogen-Bonding and Stacking Ability of xDNA Bases

How Flexible Are Fleximer Nucleobases? A Computational Study

Toward a New Genetic System with Expanded Dimensions: Size-Expanded Analogues of Deoxyadenosine and Thymidine

Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 3. Replacement of Quinazoline Moiety and Improvement of Metabolic Polymorphism of 4-[4-(N-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives

“Fleximers”. Design and Synthesis of a New Class of Novel Shape-Modified Nucleosides¹

Synthesis and Antitumor Activity of Thieno-Separated Tricyclic Purines

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Concise Syntheses of the Novel 1H-Pyrrolo[3,2-g]quinazoline Ring System and its [2,3-f] Angular Isomer

Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase

Electronic probes of the mechanism of substrate oxidation by buttermilk xanthine oxidase: role of the active-site nucleophile in oxidation

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: a new fluorescence displacement titration technique for characterizing the nucleotide binding site on the catalytic subunit

Adenosine cyclic 3',5'-monophosphate-dependent protein kinase: Interaction of the catalytic subunit and holoenzyme with lin-benzoadenine nucleotides

Dimensional probes of enzyme-coenzyme binding sites

Dimensional probes of the enzyme binding sites of adenine nucleotides. Biological effects of widening the adenine ring by 2.4 Å

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Linear benzoadenine. Stretched-out analog of adenine

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