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Cu-Catalyzed Arylation of Phenols: Synthesis of Sterically Hindered and Heteroaryl Diaryl Ethers

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Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
Cite this: J. Org. Chem. 2010, 75, 5, 1791–1794
Publication Date (Web):February 8, 2010
Copyright © 2010 American Chemical Society

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    Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K3PO4 with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.

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