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Role of Hydrophilicity and Length of Diblock Arms for Determining Star Polymer Physical Properties

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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Phys. Chem. B 2015, 119, 3, 944-957
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    Role of Hydrophilicity and Length of Diblock Arms for Determining Star Polymer Physical Properties
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    † ‡ § †Department of Chemical and Biomolecular Engineering, ‡Department of Chemistry, and §Department of Bioengineering, University of California Berkeley, Berkeley, California 94720, United States
    ∥ Chemical Sciences Division, Lawrence Berkeley National Laboratories, One Cyclotron Road, Berkeley, California 94720, United States
    IBM Almaden Research Center, IBM Research, 650 Harry Road, San Jose, California 95120, United States
    *E-mail: [email protected] (T.H.-G.).
    *E-mail: [email protected] (W.C.S.).
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    The Journal of Physical Chemistry B

    Cite this: J. Phys. Chem. B 2015, 119, 3, 944–957
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    https://doi.org/10.1021/jp506203k
    Published September 10, 2014
    Copyright © 2014 American Chemical Society
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    Abstract

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    We present a molecular simulation study of star polymers consisting of 16 diblock copolymer arms bound to a small adamantane core by varying both arm length and the outer hydrophilic block when attached to the same hydrophobic block of poly-δ-valerolactone. Here we consider two biocompatible star polymers in which the hydrophilic block is composed of polyethylene glycol (PEG) or polymethyloxazoline (POXA) in addition to a polycarbonate-based polymer with a pendant hydrophilic group (PC1). We find that the different hydrophilic blocks of the star polymers show qualitatively different trends in their interactions with aqueous solvent, orientational time correlation functions, and orientational correlation between pairs of monomers of their polymeric arms in solution, in which we find that the PEG polymers are more thermosensitive compared with the POXA and PC1 star polymers over the physiological temperature range we have investigated.

    Copyright © 2014 American Chemical Society

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    Supporting Information

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    Average radius of gyration for the complete star polymer and the hydrophobic core only, orientationally averaged mass density curves for each polymer, and depth profiles for interior water clusters. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cited By

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    This article is cited by 10 publications.

    1. In Chul Hwang, Steven W. Rick. The pH Response of a Peptoid Oligomer. The Journal of Physical Chemistry B 2023, 127 (12) , 2872-2878. https://doi.org/10.1021/acs.jpcb.3c00755
    2. Amber C. Carr, Victoria A. Piunova, Hasmerya Maarof, Julia E. Rice, William C. Swope. Influence of Solvent on the Drug-Loading Process of Amphiphilic Nanogel Star Polymers. The Journal of Physical Chemistry B 2018, 122 (21) , 5356-5367. https://doi.org/10.1021/acs.jpcb.7b10539
    3. Guangmin Wei and Vivek M. Prabhu , Victoria A. Piunova, Amber C. Carr, William C. Swope, and Robert D. Miller . Spatial Distribution of Hydrophobic Drugs in Model Nanogel-Core Star Polymers. Macromolecules 2017, 50 (24) , 9702-9712. https://doi.org/10.1021/acs.macromol.7b02061
    4. Amber C. Carr, Lisa E. Felberg, Victoria A. Piunova, Julia E. Rice, Teresa Head-Gordon, and William C. Swope . Effect of Hydrophobic Core Topology and Composition on the Structure and Kinetics of Star Polymers: A Molecular Dynamics Study. The Journal of Physical Chemistry B 2017, 121 (13) , 2902-2918. https://doi.org/10.1021/acs.jpcb.7b00865
    5. Tatyana Kirila, Alina Amirova, Alexey Blokhin, Andrey Tenkovtsev, Alexander Filippov. Features of Solution Behavior of Polymer Stars with Arms of Poly-2-alkyl-2-oxazolines Copolymers Grafted to the Upper Rim of Calix[8]arene. Polymers 2021, 13 (15) , 2507. https://doi.org/10.3390/polym13152507
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    7. Andrey V. Tenkovtsev, Alina I. Amirova, Alexander P. Filippov. Star‐shaped Poly(2‐alkyl‐2‐oxazolines): Synthesis and Properties. 2018, 67-92. https://doi.org/10.1002/9781119157830.ch3
    8. T. Yu. Kirila, M. P. Kurlykin, A. V. Tenkovtsev, A. P. Filippov. Behavior of Aqueous Solutions of Thermosensitive Starlike Polyalkyloxazolines with Different Arm Structures. Polymer Science, Series A 2017, 59 (6) , 826-838. https://doi.org/10.1134/S0965545X17060050
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    The Journal of Physical Chemistry B

    Cite this: J. Phys. Chem. B 2015, 119, 3, 944–957
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jp506203k
    Published September 10, 2014
    Copyright © 2014 American Chemical Society
    Request reuse permissions

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