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Label-Free Detection of Single Protein Using a Nanoplasmonic-Photonic Hybrid Microcavity

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† Microparticle Photophysics Lab, Polytechnic Institute of NYU, Brooklyn, New York 11201, United States
‡ Department of Physics, Fordham University, Bronx, New York 10458, United States
§ Department of Biological Sciences, NYC College of Technology, Brooklyn, New York 11201, United States
*E-mail: [email protected]
Cite this: Nano Lett. 2013, 13, 7, 3347–3351
Publication Date (Web):June 18, 2013
https://doi.org/10.1021/nl401633y
Copyright © 2013 American Chemical Society
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    Recently we reported the detection and sizing of the smallest RNA virus MS2 with a mass of 6 ag from the resonance frequency shift of a whispering gallery mode-nanoshell hybrid resonator (WGM-h) upon adsorption on the nanoshell and anticipated that single protein above 0.4 ag should be detectable but with considerably smaller signals. Here, we report the detection of single thyroid cancer marker (Thyroglobulin, Tg) and bovine serum albumin (BSA) proteins with masses of only 1 ag and 0.11 ag (66 kDa), respectively. However, the wavelength shifts are enhanced beyond those anticipated in our earlier work by 240% for Tg and 1500% for BSA. This surprising sensitivity is traced to a short-range reactive field near the surface of our Au nanoshell receptor due to intrinsic random bumps of protein size, leading to an unanticipated increase in sensitivity to single protein, which grows larger as the protein diminishes in size. As a consequence of the largest signal-to-noise ratio in our BSA experiments (S/N ≈ 13), we conservatively estimated a new protein limit of detection for our WGM-h of 5 kDa.

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    3. Martin. D. Baaske, Nasrin Asgari, Patrick Spaeth, Subhasis Adhikari, Deep Punj, Michel Orrit. Photothermal Spectro-Microscopy as Benchmark for Optoplasmonic Bio-Detection Assays. The Journal of Physical Chemistry C 2021, 125 (45) , 25087-25093. https://doi.org/10.1021/acs.jpcc.1c07592
    4. Shuai Zhang, Xiaoyu Shi, Shaoxin Yan, Xiao Zhang, Kun Ge, Chang Bao Han, Tianrui Zhai. Single-Mode Lasing in Plasmonic-Enhanced Woven Microfibers for Multifunctional Sensing. ACS Sensors 2021, 6 (9) , 3416-3423. https://doi.org/10.1021/acssensors.1c01278
    5. Swati Tanwar, Vishaldeep Kaur, Gagandeep Kaur, Tapasi Sen. Broadband SERS Enhancement by DNA Origami Assembled Bimetallic Nanoantennas with Label-Free Single Protein Sensing. The Journal of Physical Chemistry Letters 2021, 12 (33) , 8141-8150. https://doi.org/10.1021/acs.jpclett.1c02272
    6. Teresa Staniszewska, Maciej Szkulmowski, Seweryn Morawiec. Computational Optimization of the Size of Gold Nanorods for Single-Molecule Plasmonic Biosensors Operating in Scattering and Absorption Modes. The Journal of Physical Chemistry C 2021, 125 (27) , 14765-14777. https://doi.org/10.1021/acs.jpcc.1c02510
    7. Subhasis Adhikari, Patrick Spaeth, Ashish Kar, Martin Dieter Baaske, Saumyakanti Khatua, Michel Orrit. Photothermal Microscopy: Imaging the Optical Absorption of Single Nanoparticles and Single Molecules. ACS Nano 2020, 14 (12) , 16414-16445. https://doi.org/10.1021/acsnano.0c07638
    8. Martin Dieter Baaske, Peter Sebastian Neu, Michel Orrit. Label-Free Plasmonic Detection of Untethered Nanometer-Sized Brownian Particles. ACS Nano 2020, 14 (10) , 14212-14218. https://doi.org/10.1021/acsnano.0c07335
    9. Feng Pan, Kevin C. Smith, Hoang L. Nguyen, Kassandra A. Knapper, David J. Masiello, Randall H. Goldsmith. Elucidating Energy Pathways through Simultaneous Measurement of Absorption and Transmission in a Coupled Plasmonic–Photonic Cavity. Nano Letters 2020, 20 (1) , 50-58. https://doi.org/10.1021/acs.nanolett.9b02796
    10. Levi T. Hogan, Erik H. Horak, Jonathan M. Ward, Kassandra A. Knapper, Síle Nic Chormaic, Randall H. Goldsmith. Toward Real-Time Monitoring and Control of Single Nanoparticle Properties with a Microbubble Resonator Spectrometer. ACS Nano 2019, 13 (11) , 12743-12757. https://doi.org/10.1021/acsnano.9b04702
    11. Thomas Jollans, Martin D. Baaske, Michel Orrit. Nonfluorescent Optical Probing of Single Molecules and Nanoparticles. The Journal of Physical Chemistry C 2019, 123 (23) , 14107-14117. https://doi.org/10.1021/acs.jpcc.9b00843
    12. Yin Yin, Jinbo Pang, Jiawei Wang, Xueyi Lu, Qi Hao, Ehsan Saei Ghareh Naz, Xinxing Zhou, Libo Ma, Oliver G. Schmidt. Graphene-Activated Optoplasmonic Nanomembrane Cavities for Photodegradation Detection. ACS Applied Materials & Interfaces 2019, 11 (17) , 15891-15897. https://doi.org/10.1021/acsami.9b00733
    13. Tian Zhao, Megan A. Steves, Brian S. Chapman, Joseph B. Tracy, Kenneth L. Knappenberger, Jr.. Quantification of Interface-Dependent Plasmon Quality Factors Using Single-Beam Nonlinear Optical Interferometry. Analytical Chemistry 2018, 90 (22) , 13702-13707. https://doi.org/10.1021/acs.analchem.8b04101
    14. Yin Yin, Jiawei Wang, Xueyi Lu, Qi Hao, Ehsan Saei Ghareh Naz, Chuanfu Cheng, Libo Ma, Oliver G. Schmidt. In Situ Generation of Plasmonic Nanoparticles for Manipulating Photon–Plasmon Coupling in Microtube Cavities. ACS Nano 2018, 12 (4) , 3726-3732. https://doi.org/10.1021/acsnano.8b00957
    15. Niket Thakkar, Morgan T. Rea, Kevin C. Smith, Kevin D. Heylman, Steven C. Quillin, Kassandra A. Knapper, Erik H. Horak, David J. Masiello, and Randall H. Goldsmith . Sculpting Fano Resonances To Control Photonic–Plasmonic Hybridization. Nano Letters 2017, 17 (11) , 6927-6934. https://doi.org/10.1021/acs.nanolett.7b03332
    16. Adam B. Taylor and Peter Zijlstra . Single-Molecule Plasmon Sensing: Current Status and Future Prospects. ACS Sensors 2017, 2 (8) , 1103-1122. https://doi.org/10.1021/acssensors.7b00382
    17. Hugo M. Doeleman, Ewold Verhagen, and A. Femius Koenderink . Antenna–Cavity Hybrids: Matching Polar Opposites for Purcell Enhancements at Any Linewidth. ACS Photonics 2016, 3 (10) , 1943-1951. https://doi.org/10.1021/acsphotonics.6b00453
    18. Kai Sun, Ying Tang, Qiong Li, Shengyan Yin, Weiping Qin, Jiangbo Yu, Daniel T. Chiu, Yubin Liu, Zhen Yuan, Xuanjun Zhang, and Changfeng Wu . In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer. ACS Nano 2016, 10 (7) , 6769-6781. https://doi.org/10.1021/acsnano.6b02386
    19. Feng Liang and Qimin Quan . Detecting Single Gold Nanoparticles (1.8 nm) with Ultrahigh-Q Air-Mode Photonic Crystal Nanobeam Cavities. ACS Photonics 2015, 2 (12) , 1692-1697. https://doi.org/10.1021/acsphotonics.5b00602
    20. Michael A. Beuwer, Menno W. J. Prins, and Peter Zijlstra . Stochastic Protein Interactions Monitored by Hundreds of Single-Molecule Plasmonic Biosensors. Nano Letters 2015, 15 (5) , 3507-3511. https://doi.org/10.1021/acs.nanolett.5b00872
    21. Euan McLeod, Chau Nguyen, Patrick Huang, Wei Luo, Muhammed Veli, and Aydogan Ozcan . Tunable Vapor-Condensed Nanolenses. ACS Nano 2014, 8 (7) , 7340-7349. https://doi.org/10.1021/nn502453h
    22. Sirirat Panich, Kerry A. Wilson, Philippa Nuttall, Christopher K. Wood, Tim Albrecht, and Joshua B. Edel . Label-Free Pb(II) Whispering Gallery Mode Sensing Using Self-Assembled Glutathione-Modified Gold Nanoparticles on an Optical Microcavity. Analytical Chemistry 2014, 86 (13) , 6299-6306. https://doi.org/10.1021/ac500845h
    23. Kevin D. Heylman, Kassandra A. Knapper, and Randall H. Goldsmith . Photothermal Microscopy of Nonluminescent Single Particles Enabled by Optical Microresonators. The Journal of Physical Chemistry Letters 2014, 5 (11) , 1917-1923. https://doi.org/10.1021/jz500781g
    24. Yanran Wu, Bing Duan, Changhong Li, Daquan Yang. Multimode sensing based on optical microcavities. Frontiers of Optoelectronics 2023, 16 (1) https://doi.org/10.1007/s12200-023-00084-1
    25. Wenbo Mao, Yihang Li, Xuefeng Jiang, Zhiwen Liu, Lan Yang. A whispering-gallery scanning microprobe for Raman spectroscopy and imaging. Light: Science & Applications 2023, 12 (1) https://doi.org/10.1038/s41377-023-01276-2
    26. Ning An, Yiwei Li, Hao Zhang, Yupei Liang, Teng Tan, Yongzheng Guo, Zihan Liu, Mingyu Liu, Yanhong Guo, Yu Wu, Bo Peng, Yunjiang Rao, Guangming Zhao, Baicheng Yao. Brillouin lasers in a graphene microresonator for multispecies and individual gas molecule detection. APL Photonics 2023, 8 (10) https://doi.org/10.1063/5.0164107
    27. Chenyu Dong, Yifan Wang, Xiaoyan Zhao, Jie Bian, Weihua Zhang. Chemical Sensing and Analysis with Optical Nanostructures. Chemosensors 2023, 11 (9) , 497. https://doi.org/10.3390/chemosensors11090497
    28. Hong Dang, Huanhuan Liu, Linqi Cheng, Yuqi Tian, Jinna Chen, Kunpeng Feng, Jiwen Cui, Perry Ping Shum. Deconvolutional Suppression of Resolution Degradation in Coherent Optical Spectrum Analyzer. Journal of Lightwave Technology 2023, 41 (13) , 4430-4436. https://doi.org/10.1109/JLT.2023.3237926
    29. Yuchen Wang, Yiwei Li, Yicheng Li, Hao zhang, Zihan Liu, Yanhong Guo, Zeping Wang, Jun He, Xuhan Guo, Yiping Wang, Baicheng Yao. Noise canceled graphene-microcavity fiber laser sensor for ultrasensitive gas detection. Photonics Research 2023, https://doi.org/10.1364/PRJ.492473
    30. Yun Peng, Yong Zhao. Microfiber quantum sensors for protein measurement with quantum N00N state. Sensors and Actuators B: Chemical 2023, 383 , 133616. https://doi.org/10.1016/j.snb.2023.133616
    31. Wei Wang, You-Ling Chen, Zheng-Zheng Shen, Ke Yang, Meng-Wei Sheng, You-Zeng Hao, Yue-de Yang, Jin-Long Xiao, Yong-Zhen Huang. Unidirectional light emission in a deformed circular-side triangular microresonator. Optics Express 2023, 31 (9) , 14560. https://doi.org/10.1364/OE.485160
    32. Aoxiang Xiao, Jiaying Zheng, Xiaolan Wu, Wei Cui, Pengwei Chen, Jiaxuan Liang, Junyang Zhong, Yugang Huang, Yunyun Huang, Bai‐Ou Guan. Ultrasensitive Detection and Cellular Photothermal Therapy via a Self‐Photothermal Modulation Biosensor. Advanced Optical Materials 2023, 11 (8) https://doi.org/10.1002/adom.202202711
    33. Yaping Wang, Marion C. Lang, Jinsong Lu, Mingqian Suo, Mengcong Du, Yubin Hou, Xiu-Hong Wang, Pu Wang. Demonstration of intracellular real-time molecular quantification via FRET-enhanced optical microcavity. Nature Communications 2022, 13 (1) https://doi.org/10.1038/s41467-022-34547-4
    34. Amartya Mandal, Pragya Tiwari, Paul K. Upputuri, Venkata R. Dantham. Characteristic parameters of photonic nanojets of single dielectric microspheres illuminated by focused broadband radiation. Scientific Reports 2022, 12 (1) https://doi.org/10.1038/s41598-021-03610-3
    35. Larnii S. Booth, Eloise V. Browne, Nicolas P. Mauranyapin, Lars S. Madsen, Shelley Barfoot, Alan Mark, Warwick P. Bowen. Modelling of the dynamic polarizability of macromolecules for single-molecule optical biosensing. Scientific Reports 2022, 12 (1) https://doi.org/10.1038/s41598-022-05586-0
    36. Shuting Shen, Jingyu Wang, Yuezhou Zhu, Weimin Yang, Renxian Gao, Jian-Feng Li, Guoya Sun, Yang Zhilin. Large-area metal-dielectric heterostructures for surface-enhanced raman scattering. Optics Express 2022, 30 (21) , 38256. https://doi.org/10.1364/OE.464631
    37. Stephen T. Hsieh, Joseph E. Cheeney, Xi Ding, Nosang V. Myung, Elaine D. Haberer. Near-field electrospinning of polymer/phage whispering gallery mode microfiber resonators for label-free biosensing. Sensors and Actuators B: Chemical 2022, 367 , 132062. https://doi.org/10.1016/j.snb.2022.132062
    38. Nicolas P. Mauranyapin, Alex Terrasson, Warwick P. Bowen. Quantum Biotechnology. Advanced Quantum Technologies 2022, 5 (9) https://doi.org/10.1002/qute.202100139
    39. Ben Niu, Xiaoyu Shi, Kun Ge, Jun Ruan, Dan Guo, Tianrui Zhai. Microfluidic flowmeter based on tunable polymer WGM laser. Organic Electronics 2022, 107 , 106563. https://doi.org/10.1016/j.orgel.2022.106563
    40. Kun Ge, Zhiyang Xu, Dan Guo, Ben Niu, Jun Ruan, Libin Cui, Tianrui Zhai. RGB WGM lasing woven in fiber braiding cavity. Science China Information Sciences 2022, 65 (8) https://doi.org/10.1007/s11432-022-3436-y
    41. Yu-Wei Lu, Wen-Jie Zhou, Yongyao Li, Runhua Li, Jing-Feng Liu, Lin Wu, Haishu Tan. Unveiling atom-photon quasi-bound states in hybrid plasmonic-photonic cavity. Nanophotonics 2022, 11 (14) , 3307-3317. https://doi.org/10.1515/nanoph-2022-0162
    42. Kousik Mukherjee, Paresh Chandra Jana. Inseparability in parity-time-symmetric microcavities: power spectrum. Journal of Optics 2022, 51 (2) , 216-226. https://doi.org/10.1007/s12596-021-00783-y
    43. Zhonghua Gong, Hao Zhang, Miaosen Fan, Wei Lin, Bo Liu, Haifeng Liu. Light-Controlled Exceptional Point Sensor Based on Azo-Functionalized Whispering Gallery Mode Microcavity. IEEE Sensors Journal 2022, 22 (11) , 10485-10491. https://doi.org/10.1109/JSEN.2022.3168129
    44. Ningtao Cheng, Bin Lou, Hongyang Wang. An intelligent serological SERS test toward early-stage hepatocellular carcinoma diagnosis through ultrasensitive nanobiosensing. Nano Research 2022, 15 (6) , 5331-5339. https://doi.org/10.1007/s12274-022-4114-z
    45. Giuseppe Brunetti, Nicola Sasanelli, Mario Nicola Armenise, Caterina Ciminelli. Nanoscale Optical Trapping by Means of Dielectric Bowtie. Photonics 2022, 9 (6) , 425. https://doi.org/10.3390/photonics9060425
    46. Gang Li, Yi Wu, Yan Lei Zhang, Bing He, Qing Lin. Ultra-high resolution mass sensing based on an optomechanical nonlinearity. Optics Express 2022, 30 (10) , 15858. https://doi.org/10.1364/OE.454812
    47. Bryan C. Paulus, Jenny K. Banh, Kirk D. Rector, Benjamin W. Stein, Laura M. Lilley. Whispering gallery mode resonators in continuous flow: spectral assignments and sensing with monodisperse microspheres. Analytical Methods 2022, 14 (17) , 1690-1697. https://doi.org/10.1039/D2AY00181K
    48. Keisuke Watanabe, Hsin‐Yu Wu, Jolly Xavier, Lovleen Tina Joshi, Frank Vollmer. Single Virus Detection on Silicon Photonic Crystal Random Cavities. Small 2022, 18 (15) https://doi.org/10.1002/smll.202107597
    49. Xiao-Chong Yu, Shui-Jing Tang, Wenjing Liu, Yinglun Xu, Qihuang Gong, You-Ling Chen, Yun-Feng Xiao. Single-molecule optofluidic microsensor with interface whispering gallery modes. Proceedings of the National Academy of Sciences 2022, 119 (6) https://doi.org/10.1073/pnas.2108678119
    50. Shuo Yang, Yunqi Wang, Ye Kong, Gaoshan Huang, Zhe Zhao, Yang Wang, Borui Xu, Jizhai Cui, Yongfeng Mei. Enhanced Evanescent Field Coupling of Smart Particles in Tubular Optical Microcavity for Sensing Application. Advanced Optical Materials 2022, 10 (4) https://doi.org/10.1002/adom.202102158
    51. Martin D. Baaske, Nasrin Asgari, Deep Punj, Michel Orrit. Nanosecond time scale transient optoplasmonic detection of single proteins. Science Advances 2022, 8 (2) https://doi.org/10.1126/sciadv.abl5576
    52. Wenyan Yu, Wei C. Jiang, Qiang Lin, Tao Lu. Optomechanical Sensing. 2022, 127-161. https://doi.org/10.1007/978-3-030-90339-8_4
    53. Stephen Arnold, Jiachen Wan, Kaitlynn M. Snyder, Mohammed Ali Miri. Interaction Between a Plasmonic Nano-Resonator and a Whispering Gallery Mode Photonic Resonator Described Through Coupled Mode Theory and Experiment. 2022, 59-69. https://doi.org/10.1007/978-94-024-2138-5_4
    54. Jingyi Zhao, Weidong Zhang, Te Wen, Lulu Ye, Hai Lin, Jinglin Tang, Qihuang Gong, Guowei Lyu. Controlled plasmon-enhanced fluorescence by spherical microcavity*. Chinese Physics B 2021, 30 (11) , 114215. https://doi.org/10.1088/1674-1056/ac0daa
    55. João M. Maia, Vítor A. Amorim, Duarte Viveiros, P. V. S. Marques. Femtosecond laser micromachining of an optofluidics-based monolithic whispering-gallery mode resonator coupled to a suspended waveguide. Scientific Reports 2021, 11 (1) https://doi.org/10.1038/s41598-021-88682-x
    56. Deshui Yu, Matjaž Humar, Krista Meserve, Ryan C. Bailey, Síle Nic Chormaic, Frank Vollmer. Whispering-gallery-mode sensors for biological and physical sensing. Nature Reviews Methods Primers 2021, 1 (1) https://doi.org/10.1038/s43586-021-00079-2
    57. Anton V. Saetchnikov, Elina A. Tcherniavskaia, Vladimir A. Saetchnikov, Andreas Ostendorf. Intelligent Optical Microresonator Imaging Sensor for Early Stage Classification of Dynamical Variations. Advanced Photonics Research 2021, 2 (12) https://doi.org/10.1002/adpr.202100242
    58. Yi Zihan, Lecler Sylvain. Whispering gallery mode resonance contribution in photonic nanojet simulation. Optics Express 2021, 29 (24) , 39249. https://doi.org/10.1364/OE.443546
    59. Zhe Zhang, Leona Nest, Suo Wang, Si-Yi Wang, Ren-Min Ma. Lasing-enhanced surface plasmon resonance spectroscopy and sensing. Photonics Research 2021, 9 (9) , 1699. https://doi.org/10.1364/PRJ.431612
    60. Pragya Tiwari, Amartya Mandal, Venkata Ramanaiah Dantham. Sensitivity of whispering gallery modes with different physical parameters of hollow microspheres: a theoretical study. Journal of the Optical Society of America B 2021, 38 (8) , 2312. https://doi.org/10.1364/JOSAB.428749
    61. Zhe Wang, Arun Kumar Mallik, Fangfang Wei, Zhuochen Wang, Anuradha Rout, Qiang Wu, Yuliya Semenova. Thermo-optic tuning of a nematic liquid crystal-filled capillary whispering gallery mode resonator. Optics Express 2021, 29 (15) , 23569. https://doi.org/10.1364/OE.432103
    62. Yongpeng Chen, Yin Yin, Libo Ma, Oliver G. Schmidt. Recent Progress on Optoplasmonic Whispering‐Gallery‐Mode Microcavities. Advanced Optical Materials 2021, 9 (12) https://doi.org/10.1002/adom.202100143
    63. Philipp Grimm, Gary Razinskas, Jer-Shing Huang, Bert Hecht. Driving plasmonic nanoantennas at perfect impedance matching using generalized coherent perfect absorption. Nanophotonics 2021, 10 (7) , 1879-1887. https://doi.org/10.1515/nanoph-2021-0048
    64. Arash Darafsheh. Photonic nanojets and their applications. Journal of Physics: Photonics 2021, 3 (2) , 022001. https://doi.org/10.1088/2515-7647/abdb05
    65. Pengwei Chen, Yunyun Huang, Ye Bo, He Liang, Aoxiang Xiao, Bai-Ou Guan. 3D nanointerface enhanced optical microfiber for real-time detection and sizing of single nanoparticles. Chemical Engineering Journal 2021, 407 , 127143. https://doi.org/10.1016/j.cej.2020.127143
    66. Tom Lenkiewicz Abudi, Mark Douvidzon, Baheej Bathish, Tal Carmon. Resonators made of a disk and a movable continuous-membrane. APL Photonics 2021, 6 (3) , 036105. https://doi.org/10.1063/5.0041315
    67. Huanzhu Lv, Kefei Zhang, Xiaocui Ma, Wenbo Zhong, Yaxin Wang, Xiang Gao. Optimum design of the surface plasmon resonance sensor based on polymethyl methacrylate fiber. Physics Open 2021, 6 , 100054. https://doi.org/10.1016/j.physo.2020.100054
    68. Chen Chen, Xun Hou, Junsheng Wang. A Novel Hybrid Plasmonic Resonator With High Quality Factor and Large Free Spectral Range. IEEE Sensors Journal 2021, 21 (2) , 1644-1654. https://doi.org/10.1109/JSEN.2020.3017647
    69. S Mahmoud Ashrafi, R Malekfar, A R Bahrampour, Johannes Feist. Long-distance heat transfer between molecular systems through a hybrid plasmonic-photonic nanoresonator. Journal of Optics 2021, 23 (1) , 015003. https://doi.org/10.1088/2040-8986/abcfd6
    70. Yuye Wang, Shuwen Zeng, Georges Humbert, Ho‐Pui Ho. Microfluidic Whispering Gallery Mode Optical Sensors for Biological Applications. Laser & Photonics Reviews 2020, 14 (12) https://doi.org/10.1002/lpor.202000135
    71. Hua-Jun Chen. Ultrasensitive and high resolution mass sensor by photonic-molecule optomechanics with phonon pump. Laser Physics 2020, 30 (11) , 115203. https://doi.org/10.1088/1555-6611/abbe0e
    72. Pragya Tiwari, Gour Mohan Das, Venkata Ramanaiah Dantham. Optical Properties of Au-Ag Bimetallic Nanoparticles of Different Shapes for Making Efficient Bimetallic-Photonic Whispering Gallery Mode Hybrid Microresonators. Plasmonics 2020, 15 (5) , 1251-1260. https://doi.org/10.1007/s11468-020-01141-7
    73. Ran Zhang, Yilin Liu, Qing Liu, Yueyue Zhang, Xing Ma, Qinghai Song, Huanhuan Feng. Facile microfluidic fabrication of monodispersed self‐coupling microcavity with fine tunability. ELECTROPHORESIS 2020, 41 (16-17) , 1418-1424. https://doi.org/10.1002/elps.201900281
    74. Daquan Yang, Bing Duan, Aiqiang Wang, Yijie Pan, Chuan Wang, Yuefeng Ji, Jin-hui Chen. Packaged Microbubble Resonator for Versatile Optical Sensing. Journal of Lightwave Technology 2020, 38 (16) , 4555-4559. https://doi.org/10.1109/JLT.2020.2988206
    75. Qinglan Huang, Nantao Li, Hanyuan Zhang, Congnyu Che, Fu Sun, Yanyu Xiong, Taylor D. Canady, Brian T. Cunningham. Critical Review: digital resolution biomolecular sensing for diagnostics and life science research. Lab on a Chip 2020, 20 (16) , 2816-2840. https://doi.org/10.1039/D0LC00506A
    76. Yun Peng, Yong Zhao, Xu-guang Hu, Yang Yang. Optical fiber quantum biosensor based on surface plasmon polaritons for the label-free measurement of protein. Sensors and Actuators B: Chemical 2020, 316 , 128097. https://doi.org/10.1016/j.snb.2020.128097
    77. Xuefeng Jiang, Abraham J. Qavi, Steven H. Huang, Lan Yang. Whispering-Gallery Sensors. Matter 2020, 3 (2) , 371-392. https://doi.org/10.1016/j.matt.2020.07.008
    78. Ping Zhang, Dongyue He, Chen Zhang, Zhiruo Yan. FDTD Simulation: Simultaneous Measurement of the Refractive Index and the Pressure Using Microdisk Resonator with Two Whispering-Gallery Modes. Sensors 2020, 20 (14) , 3955. https://doi.org/10.3390/s20143955
    79. Zhihe Guo, Yingchun Qin, Peizong Chen, Jinliang Hu, Yi Zhou, Xuyang Zhao, Zhiran Liu, Yiyan Fei, Xiaoshun Jiang, Xiang Wu. Hyperboloid‐Drum Microdisk Laser Biosensors for Ultrasensitive Detection of Human IgG. Small 2020, 16 (26) https://doi.org/10.1002/smll.202000239
    80. Jiawei Wang, Mariana Medina Sanchez, Yin Yin, Raffael Herzer, Libo Ma, Oliver G. Schmidt. Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap. Advanced Materials Technologies 2020, 5 (6) https://doi.org/10.1002/admt.201901138
    81. Shubhayan Bhattacharya, Aneesh V. Veluthandath, Ganapathy Senthil Murugan, Prem B. Bisht. Temperature dependence of whispering gallery modes of quantum dot-doped microbottle resonators. Journal of Luminescence 2020, 221 , 117050. https://doi.org/10.1016/j.jlumin.2020.117050
    82. Shawana Tabassum, Ratnesh Kumar. Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing. Advanced Materials Technologies 2020, 5 (5) https://doi.org/10.1002/admt.201900792
    83. Daquan Yang, Aiqiang Wang, Jin-Hui Chen, Xiao-Chong Yu, Chuwen Lan, Yuefeng Ji, Yun-Feng Xiao. Real-time monitoring of hydrogel phase transition in an ultrahigh Q microbubble resonator. Photonics Research 2020, 8 (4) , 497. https://doi.org/10.1364/PRJ.380238
    84. Lev Deych, Lan Yang. Effects of the magnetodipole corrections on the spectra of spheroidal whispering gallery mode resonators interacting with a dielectric nanoparticle. Optics Letters 2020, 45 (6) , 1435. https://doi.org/10.1364/OL.385993
    85. Chen Chen, Junsheng Wang. Optical biosensors: an exhaustive and comprehensive review. The Analyst 2020, 145 (5) , 1605-1628. https://doi.org/10.1039/C9AN01998G
    86. Namik Akkilic, Stefan Geschwindner, Fredrik Höök. Single-molecule biosensors: Recent advances and applications. Biosensors and Bioelectronics 2020, 151 , 111944. https://doi.org/10.1016/j.bios.2019.111944
    87. Kousik Mukherjee, Paresh Chandra Jana. Controlled optical bistability in parity-time-symmetric coupled micro-cavities: Possibility of all-optical switching. Physica E: Low-dimensional Systems and Nanostructures 2020, 117 , 113780. https://doi.org/10.1016/j.physe.2019.113780
    88. Pragya Tiwari, Venkata Ramanaiah Dantham. Effect of different plasmonic nanoparticles on the reactive shift of nanoplasmonic-whispering gallery mode hybrid microresonator. 2020, 050018. https://doi.org/10.1063/5.0001703
    89. Amartya Mandal, V. R. Dantham. Elongated photonic nanojets generated by spherical shaped single dielectric core-shell microparticles. 2020, 020162. https://doi.org/10.1063/5.0005350
    90. Xiao-Chong Yu, Shui-Jing Tang, Yun-Feng Xiao. Opto-plasmonic microfluidic sensor for molecular detection. 2020, S3I.7. https://doi.org/10.1364/ACPC.2020.S3I.7
    91. Sujan Kasani, Kathrine Curtin, Nianqiang Wu. A review of 2D and 3D plasmonic nanostructure array patterns: fabrication, light management and sensing applications. Nanophotonics 2019, 8 (12) , 2065-2089. https://doi.org/10.1515/nanoph-2019-0158
    92. Chenyi Zhang, Jinxin Li, Jin Gyu Park, Yi-Feng Su, Robert E. Goddard, Ryan M. Gelfand. Optimization of metallic nanoapertures at short-wave infrared wavelengths for self-induced back-action trapping. Applied Optics 2019, 58 (35) , 9498. https://doi.org/10.1364/AO.58.009498
    93. Hongtao Li, Yunyun Huang, Guanhua Hou, Aoxiang Xiao, Pengwei Chen, He Liang, Yugang Huang, Xiaotian Zhao, Lili Liang, Xinhuan Feng, Bai-Ou Guan. Single-molecule detection of biomarker and localized cellular photothermal therapy using an optical microfiber with nanointerface. Science Advances 2019, 5 (12) https://doi.org/10.1126/sciadv.aax4659
    94. Zunaid Omair, Muhammad Anisuzzaman Talukder. Sensitivity Analysis of Gold Nanorod Biosensors for Single Molecule Detection. Plasmonics 2019, 14 (6) , 1611-1619. https://doi.org/10.1007/s11468-019-00946-5
    95. Guo-Qing Qin, Min Wang, Jing-Wei Wen, Dong Ruan, Gui-Lu Long. Brillouin cavity optomechanics sensing with enhanced dynamical backaction. Photonics Research 2019, 7 (12) , 1440. https://doi.org/10.1364/PRJ.7.001440
    96. R. V. William, G. M. Das, V. R. Dantham, R. Laha. Enhancement of Single Molecule Raman Scattering using Sprouted Potato Shaped Bimetallic Nanoparticles. Scientific Reports 2019, 9 (1) https://doi.org/10.1038/s41598-019-47179-4
    97. Jhen-Hong Yang, Min-Wen Yu, Kuo-Ping Chen. Absorption avoided resonance crossing of hybridization of silicon nanoparticles and gold nanoantennas. Scientific Reports 2019, 9 (1) https://doi.org/10.1038/s41598-019-48135-y
    98. Yan Hong, Björn M Reinhard. Optoplasmonics: basic principles and applications. Journal of Optics 2019, 21 (11) , 113001. https://doi.org/10.1088/2040-8986/ab490d
    99. Isabelle M. Palstra, Hugo M. Doeleman, A. Femius Koenderink. Hybrid cavity-antenna systems for quantum optics outside the cryostat?. Nanophotonics 2019, 8 (9) , 1513-1531. https://doi.org/10.1515/nanoph-2019-0062
    100. Cheng Li, Lei Chen, Euan McLeod, Judith Su. Dark mode plasmonic optical microcavity biochemical sensor. Photonics Research 2019, 7 (8) , 939. https://doi.org/10.1364/PRJ.7.000939
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