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Imaging Early Endothelial Inflammation Following Stroke by Core Shell Silica Superparamagnetic Glyconanoparticles That Target Selectin

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2014, 14, 4, 2130-2134
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    Imaging Early Endothelial Inflammation Following Stroke by Core Shell Silica Superparamagnetic Glyconanoparticles That Target Selectin
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    † Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité University Medicine, Charitéplatz 1, 10117 Berlin, Germany
    ‡ Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany
    § Institute of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany
    *E-mail: (P.H.S.) [email protected]
    *E-mail: (C.H.) [email protected]
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    Nano Letters

    Cite this: Nano Lett. 2014, 14, 4, 2130–2134
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    https://doi.org/10.1021/nl500388h
    Published February 25, 2014
    Copyright © 2014 American Chemical Society
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    Abstract

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    Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic.

    Copyright © 2014 American Chemical Society

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    Cite this: Nano Lett. 2014, 14, 4, 2130–2134
    Click to copy citationCitation copied!
    https://doi.org/10.1021/nl500388h
    Published February 25, 2014
    Copyright © 2014 American Chemical Society
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