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LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2014, 14, 5, 2636-2641
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    LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum
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    † ICFO - Institut de Ciencies Fotoniques, Mediterranean Technology Park, 08860 Castelldefels (Barcelona), Spain
    ‡ Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Route Cantonale, 1015 Lausanne, Switzerland
    § ICREA - Institució Catalana de Recerca i Estudis Avançats, Passeig de Lluís Companys, 23, 08010 Barcelona, Spain
    *E-mail: (M.P.K.) [email protected]
    *E-mail: (R.Q.) [email protected]
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    Nano Letters

    Cite this: Nano Lett. 2014, 14, 5, 2636–2641
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    https://doi.org/10.1021/nl500574n
    Published April 14, 2014
    Copyright © 2014 American Chemical Society
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    Abstract

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    Label-free biosensing based on metallic nanoparticles supporting localized surface plasmon resonances (LSPR) has recently received growing interest (Anker, J. N., et al. Nat. Mater.2008, 7, 442–453). Besides its competitive sensitivity (Yonzon, C. R., et al. J. Am. Chem. Soc.2004, 126, 12669–12676; Svendendahl, M., et al. Nano Lett.2009, 9, 4428–4433) when compared to the surface plasmon resonance (SPR) approach based on extended metal films, LSPR biosensing features a high-end miniaturization potential and a significant reduction of the interrogation device bulkiness, positioning itself as a promising candidate for point-of-care diagnostic and field applications. Here, we present the first, paralleled LSPR lab-on-a-chip realization that goes well beyond the state-of-the-art, by uniting the latest advances in plasmonics, nanofabrication, microfluidics, and surface chemistry. Our system offers parallel, real-time inspection of 32 sensing sites distributed across 8 independent microfluidic channels with very high reproducibility/repeatability. This enables us to test various sensing strategies for the detection of biomolecules. In particular we demonstrate the fast detection of relevant cancer biomarkers (human alpha-feto-protein and prostate specific antigen) down to concentrations of 500 pg/mL in a complex matrix consisting of 50% human serum.

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    Cite this: Nano Lett. 2014, 14, 5, 2636–2641
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