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Synthesis and High Performance of Magnetofluorescent Polyelectrolyte Nanocomposites as MR/Near-Infrared Multimodal Cellular Imaging Nanoprobes
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    Synthesis and High Performance of Magnetofluorescent Polyelectrolyte Nanocomposites as MR/Near-Infrared Multimodal Cellular Imaging Nanoprobes
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    Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, Korea
    Division of MR Research, Korea Basic Science Institute, Cheongwon 363-883, Korea
    § Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul, and BioLeaders Corporation, Daejeon 305-500, Korea
    Viral Infectious Disease Research Centre, Korea Research Institute of Bioscience and Biotechnology, Korea
    Address correspondence to [email protected], [email protected]
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    ACS Nano

    Cite this: ACS Nano 2011, 5, 10, 8230–8240
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    https://doi.org/10.1021/nn202912b
    Published September 20, 2011
    Copyright © 2011 American Chemical Society

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    Here, we describe an easy but robust chemical strategy to synthesize high-performance magnetic resonance (MR)/near-infrared (NIR) multimodal imaging nanoprobes. Poly(γ-glutamic acid) was used for the convenient phase transfer of MnFe2O4 nanoparticles dispersed in organic solvents into aqueous solutions and facilitated further ionic gelation with poly(l-lysine). During the gelation process, MnFe2O4 nanoparticulate satellites were encapsulated in the ionic nanocomplex, which induced synergistic magnetism and resulted in huge T2 relaxivity (r2). The positively charged outer surfaces were assembled with other negatively charged NIR emitting fluorescent nanocrystals and enabled the highly efficient delivery of the magnetofluorescent polyelectrolyte nanocomposites (MagFL-PEN) into cancer cells. The enhancement of negative contrast of MagFL-PEN at 2 μg/mL concentration was similar to that of Resovist at 20 μg/mL concentration. The NIR fluorescence microscopy images of the MagFL-PEN-labeled cells even at 12.5 pM were able to be clearly observed. The labeling efficiency of MagFL-PEN was approximately 65-fold higher compared to that of the commercialized fluorescent nanocrystals, only after 3 h incubation period, even at the test concentration (100 pM). Due to the high-performance capabilities both in materials properties and cell labeling efficiency, the MagFL-PEN is expected to be used as a highly efficient MR/NIR dual-modality imaging nanoprobe in the detection of cancer cells and monitoring of therapeutic cells in vivo.

    Copyright © 2011 American Chemical Society

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    ACS Nano

    Cite this: ACS Nano 2011, 5, 10, 8230–8240
    Click to copy citationCitation copied!
    https://doi.org/10.1021/nn202912b
    Published September 20, 2011
    Copyright © 2011 American Chemical Society

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