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Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells

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Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, United States
Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States
§ Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States
Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, People's Republic of China
Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, United States
# Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States
*Address correspondence to [email protected]
Cite this: ACS Nano 2012, 6, 5, 4094–4103
Publication Date (Web):April 9, 2012
https://doi.org/10.1021/nn3004923
Copyright © 2012 American Chemical Society

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    Abstract

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    Human embryonic stem cells (hESCs) have great potentials for future cell-based therapeutics. However, their mechanosensitivity to biophysical signals from the cellular microenvironment is not well characterized. Here we introduced an effective microfabrication strategy for accurate control and patterning of nanoroughness on glass surfaces. Our results demonstrated that nanotopography could provide a potent regulatory signal over different hESC behaviors, including cell morphology, adhesion, proliferation, clonal expansion, and self-renewal. Our results indicated that topological sensing of hESCs might include feedback regulation involving mechanosensory integrin-mediated cell–matrix adhesion, myosin II, and E-cadherin. Our results also demonstrated that cellular responses to nanotopography were cell-type specific, and as such, we could generate a spatially segregated coculture system for hESCs and NIH/3T3 fibroblasts using patterned nanorough glass surfaces.

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