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Impact of Nanotechnology on Drug Delivery

The emergence of nanotechnology platforms can enable development and commercialization of entirely new classes of bioactive macromolecules that need precise intracellular delivery for bioactivity.

While both organic and inorganic technologies are under development, controlled-release polymer technologies and liposomes will likely continue to have the greatest clinical impact for the foreseeable future.

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† Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115
‡ MIT−Harvard Center for Cancer Nanotechnology Excellence
§ Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
* Address correspondence to [email protected], [email protected]
Cite this: ACS Nano 2009, 3, 1, 16–20
Publication Date (Web):January 27, 2009
https://doi.org/10.1021/nn900002m
Copyright © 2009 American Chemical Society
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    Abstract

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    Nanotechnology is the engineering and manufacturing of materials at the atomic and molecular scale. In its strictest definition from the National Nanotechnology Initiative, nanotechnology refers to structures roughly in the 1−100 nm size regime in at least one dimension. Despite this size restriction, nanotechnology commonly refers to structures that are up to several hundred nanometers in size and that are developed by top-down or bottom-up engineering of individual components. Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics.

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