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Bioactive Compounds from Bauhinia purpurea Possessing Antimalarial, Antimycobacterial, Antifungal, Anti-inflammatory, and Cytotoxic Activities

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Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand, Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand, and Chulabhorn Research Centre, Institute of Science and Technology for Research and Development, Mahidol University, Thailand
Cite this: J. Nat. Prod. 2007, 70, 5, 795–801
Publication Date (Web):May 5, 2007
https://doi.org/10.1021/np070010e
Copyright © 2007 American Chemical Society and American Society of Pharmacognosy

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    Abstract

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    Eleven new secondary metabolites (111), together with two known flavanones (12 and 13) and five known bibenzyls (1418), were isolated from the root extract of Bauhinia purpurea. New compounds include eight dihydrodibenzoxepins (18), a dihydrobenzofuran (9), a novel spirochromane-2,1‘-hexenedione (10), and a new bibenzyl (11). Antimycobacterial, antimalarial, antifungal, cytotoxic, and anti-inflammatory activities of the isolated compounds are reported, and biosynthetic pathways of these compounds are also discussed.

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     Chiang Mai University.

     Chulabhorn Research Institute.

    §

     Chulabhorn Research Centre, Mahidol University.

    *

     To whom correspondence should be addressed. Tel:  +66-(0)86-9755777. Fax:  +662-5740622, ext. 1513. E-mail:  prasatkittakoop@ yahoo.com.

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    1H and 13C NMR spectra of compounds 111. This material is available free of charge via the Internet at http://pubs.acs.org.

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