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Inhibitors of Aldose Reductase and Formation of Advanced Glycation End-Products in Moutan Cortex (Paeonia suffruticosa)

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    Inhibitors of Aldose Reductase and Formation of Advanced Glycation End-Products in Moutan Cortex (Paeonia suffruticosa)
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    College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea, National Institute of Medicinal Materials, 3B Quangtrung, Hoankiem, Hanoi, Vietnam, Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea, Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University of Iksan, Jeonbuk 570-749, Korea, KT&G Central Research Institute, Daejeon 305-805, Korea, and College of Pharmacy, Yeungnam University, Gyeongbuk 712-749, Korea
    * To whom correspondence should be addressed. Tel: +82-42-821-5925. Fax: +82-42-823-6566. E-mail: [email protected]
    †Chungnam National University.
    ‡National Institute of Medicinal Materials.
    §Korea Institute of Oriental Medicine.
    ⊥Wonkwang University of Iksan.
    ΔKT&G Central Research Institute.
    ○Yeungnam University.
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2009, 72, 8, 1465–1470
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    https://doi.org/10.1021/np9002004
    Published August 11, 2009
    Copyright © 2009 The American Chemical Society and American Society of Pharmacognosy
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    The methanol extract of Moutan cortex (Paeonia suffruticosa) afforded two new compounds, 8-O-benzoylpaeonidanin (1) and 5-hydroxy-3S-hydroxymethyl-6-methyl-2,3-dihydrobenzofuran (2), in addition to 4-O-butylpaeoniflorin (3) as an artifact of the separation, seven monoterpene glycosides (4−10), two monoterpenes (11, 12), four acetophenones (13−16), and two triterpenes (17, 18). The structures of the compounds were determined by spectroscopic methods, and the compounds were evaluated for inhibitory effects against rat lens aldose reductase (RLAR) and advanced glycation end-product (AGEs) formation. Compounds 17 and 18 showed the most potent inhibitory activity against RLAR, with IC50 values of 11.4 and 28.8 μM, respectively. Compounds 3 and 6 also inhibited RLAR with IC50 values of 36.2 and 44.6 μM, respectively. The positive control, 3,3-tetramethyleneglutamic acid, had an IC50 value of 31.8 μM. Compounds 3 and 6 inhibited AGE formation with IC50 values of 10.8 and 11.3 μM, respectively. Compound 2 had an IC50 value of 177.0 μM, whereas the positive control, aminoguanidine, had an IC50 value of 1026.8 μM.

    Copyright © 2009 The American Chemical Society and American Society of Pharmacognosy

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2009, 72, 8, 1465–1470
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np9002004
    Published August 11, 2009
    Copyright © 2009 The American Chemical Society and American Society of Pharmacognosy
    Request reuse permissions

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