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Cytotoxic and Insecticidal Constituents of the Unripe Fruit of Persea americana
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    Cytotoxic and Insecticidal Constituents of the Unripe Fruit of Persea americana
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    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 1998, 61, 6, 781–785
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np9800304
    Published May 20, 1998
    Copyright © 1998 American Chemical Society and American Society of Pharmacognosy

    Abstract

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    Unripe avocado fruit (Persea americana) was subjected to a bioactivity-directed fractionation, as monitored via the brine shrimp lethality assay, to isolate three major bioactive constituents (13). Compounds 13 all have a 1,2,4-triol moiety and a long aliphatic chain that terminates as either an alkane, alkene, or alkyne, respectively; 1 is new, while 2 and 3 have been described previously but not as cytotoxic or pesticidal agents. All have activity against six human tumor cell lines in culture and show selectivity for human prostate adenocarcinoma (PC-3) cells with 3 being nearly as potent as adriamycin. Also, when tested against yellow fever mosquito larva, 3 was more effective than rotenone, a natural botanical insecticide and positive control.

    Copyright © 1998 American Chemical Society and American Society of Pharmacognosy

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     To whom correspondence should be addressed. jac@ pharmacy.purdue.edu, 765-494-1455, FAX 765-494-1414

    Cited By

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 1998, 61, 6, 781–785
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np9800304
    Published May 20, 1998
    Copyright © 1998 American Chemical Society and American Society of Pharmacognosy

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