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Atom Economy in the Metathesis Cross-Coupling of Alkenes and Alkynes

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Department of Chemistry, University at Buffalo, The State University of New York, Amherst, New York 14260, United States
[email protected]
Cite this: Org. Lett. 2011, 13, 11, 2896–2899
Publication Date (Web):May 11, 2011
https://doi.org/10.1021/ol200914j
Copyright © 2011 American Chemical Society
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    Abstract

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    A cross ene-yne metathesis has been achieved at a nearly 1:1 stoichiometry of the unsaturated reactants. This allowed the use of more complex alkene reactants without sacrificing excess alkene reactant. In the alkene, different allylic oxygen protecting groups were explored. Interestingly, alkenes containing the allylic hydroxyl group proved to be the most reactive.

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    17. Steven T. Diver, Justin R. Griffiths. Ene‐Yne Metathesis. 2014, 153-185. https://doi.org/10.1002/9781118711613.ch4
    18. S.T. Diver, J.R. Clark. 5.27 Ene–Yne Metathesis. 2014, 1302-1356. https://doi.org/10.1016/B978-0-08-097742-3.00528-0
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    23. Akio Saito, Yuji Hanzawa. Metathesis Reactions in Drug and Natural Product Synthesis. 2013, 1-46. https://doi.org/10.1002/9781118596784.ssd024
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    25. Joseph R. Clark, Steven T. Diver. ChemInform Abstract: Atom Economy in the Metathesis Cross‐Coupling of Alkenes and Alkynes.. ChemInform 2011, 42 (38) https://doi.org/10.1002/chin.201138045
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