One-Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from Curcusones A and B
- Xu-Yang Li
- Yuan-Feng Yang
- Xing-Rong Peng
- Ming-Ming Li
- Liang-Qun Li
- Xu Deng
- Hong-Bo Qin
- Jie-Qing Liu
- Ming-Hua Qiu
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† State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan People’s Republic of China
‡ University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China
*E-mail: [email protected] (M.-H. Qiu).
*E-mail: [email protected] (J.-Q. Liu).
*E-mail: [email protected] (H.-B. Qin).
Abstract
High contents of curcusones A and B and trace amounts of spirocurcasone exist in the roots of Jatropha curcas. Here, a one-step semisynthesis method of spirocurcasone and pyracurcasone was built, not only resulted an increased yield of spirocurcasone but also produced pyracurcasone, which exhibited greater cytotoxicity compared to curcusones A and B. The plausible mechanism of the formation of pyracurcasone was proposed, and the proposed biogenetic origin for spirocurcasone by Taglialatela-Scafati was confirmed.
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