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Synthesis of Unsymmetrical Pyrazines Based on α-Diazo Oxime Ethers
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    Synthesis of Unsymmetrical Pyrazines Based on α-Diazo Oxime Ethers
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    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616, Singapore
    Department of Chemistry, UNIST, UNIST-gil 50, Ulsan 689-798, Korea
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    Organic Letters

    Cite this: Org. Lett. 2015, 17, 3, 395–397
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    https://doi.org/10.1021/ol5034173
    Published January 15, 2015
    Copyright © 2015 American Chemical Society

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    Synthesis of unsymmetrically substituted pyrazines has been a challenge. The reactivity of α-imino carbenoids derived from α-diazo oxime ethers has been exploited for pyrazine synthesis, in which the reaction of α-diazo oxime ethers with 2H-azirines provides highly substituted pyrazines in good to excellent yields.

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    Organic Letters

    Cite this: Org. Lett. 2015, 17, 3, 395–397
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    https://doi.org/10.1021/ol5034173
    Published January 15, 2015
    Copyright © 2015 American Chemical Society

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