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Heck Couplings at Room Temperature in Nanometer Aqueous Micelles

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Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106
Cite this: Org. Lett. 2008, 10, 7, 1329–1332
Publication Date (Web):March 12, 2008
Copyright © 2008 American Chemical Society

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    A nonionic amphiphile such as Triton X-100 or the vitamin E-based PTS, both of which form nanomicelles in water, promotes Heck cross-couplings of non-water-soluble partners at ambient temperatures. These are the first examples of Heck reactions conducted in water (as the only solvent) at room temperature.

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     Dedicated with greatest respect and admiration to Professor E. J. Corey, Nobel Laureate, on the occasion of his 80th birthday.


    In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

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