logo

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Chem. Res. Toxicol. 2005, 18, 8, 1296-1305
RETURN TO ISSUEPREVArticleNEXT

Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase

View Author Information
Department of Medicinal Chemistry and Pharmacognosy and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231
Cite this: Chem. Res. Toxicol. 2005, 18, 8, 1296–1305
Publication Date (Web):July 12, 2005
https://doi.org/10.1021/tx050058x
Copyright © 2005 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
1290
Altmetric
-
Citations
146
LEARN ABOUT THESE METRICS

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.

Read OnlinePDF (185 KB)
SUBJECTS:

Abstract

Abstract Image

The female parts of hops (Humulus lupulus L.) show estrogenic effects as well as cancer chemopreventive potential. We analyzed the chemopreventive mechanism of hops by studying its antioxidative activities and its effect on the detoxification of a potentially toxic quinone (menadione). The detoxification enzyme quinone reductase [(NAD(P)H:quinone oxidoreductase, QR] protects against quinone-induced toxicity and has been used as a marker in cancer chemoprevention studies. Although the hop extract was only a weak quencher of free radicals formed from 1,1-diphenyl-2-picrylhydrazyl, it demonstrated strong QR induction in Hepa 1c1c7 cells. In addition, compounds isolated from hops including xanthohumol (XH) and 8-prenylnaringenin were tested for QR induction. Among these, XH was the most effective at inducing QR with a concentration required to double the specific activity of QR (CD value) of 1.7 ± 0.7 μM. In addition, pretreatment of Hepa1c1c7 cells with XH significantly inhibited menadione-induced DNA single-strand breaks. The QR inhibitor dicumarol reversed the protective effect of XH against menadione-induced DNA damage. Because the expression of QR and other detoxifying enzymes is known to be upregulated by binding of the transcription factor Nrf2 to the antioxidant response element (ARE), the reporter activity mediated by ARE in HepG2-ARE-C8 cells was investigated after incubation with XH for 24 h. Under these conditions, XH increased ARE reporter activity in a dose-dependent manner. One mechanism by which XH might induce QR could be through interaction with Keap1, which sequesters Nrf2 in the cytoplasm, so that it cannot activate the ARE. Using LC-MS-MS, we demonstrated that XH alkylates human Keap1 protein, most likely on a subset of the 27 cysteines of Keap1. This suggests that XH induces QR by covalently modifying the Keap1 protein. Therefore, XH and hops dietary supplements might function as chemopreventive agents, through induction of detoxification enzymes such as QR.

*

 To whom correspondence should be addressed. Tel:  312-996-5280. Fax:  312-996-7107. E-mail:  [email protected]

Cited By

This article is cited by 146 publications.

  1. Judy L. Bolton, Tareisha L. Dunlap, Atieh Hajirahimkhan, Obinna Mbachu, Shao-Nong Chen, Luke Chadwick, Dejan Nikolic, Richard B. van Breemen, Guido F. Pauli, Birgit M. Dietz. The Multiple Biological Targets of Hops and Bioactive Compounds. Chemical Research in Toxicology 2019, 32 (2) , 222-233. https://doi.org/10.1021/acs.chemrestox.8b00345
  2. Jiayuan Li, Ning Li, Xuezheng Li, Gang Chen, Cungang Wang, Bin Lin, and Yue Hou . Characteristic α-Acid Derivatives from Humulus lupulus with Antineuroinflammatory Activities. Journal of Natural Products 2017, 80 (12) , 3081-3092. https://doi.org/10.1021/acs.jnatprod.6b00921
  3. Birgit M. Dietz, Shao-Nong Chen, René F. Ramos Alvarenga, Huali Dong, Dejan Nikolić, Martin Biendl, Richard B. van Breemen, Judy L. Bolton, and Guido F. Pauli . DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women’s Health. Journal of Natural Products 2017, 80 (8) , 2284-2294. https://doi.org/10.1021/acs.jnatprod.7b00284
  4. Atieh Hajirahimkhan, Charlotte Simmler, Huali Dong, Daniel D. Lantvit, Guannan Li, Shao-Nong Chen, Dejan Nikolić, Guido F. Pauli, Richard B. van Breemen, Birgit M. Dietz, and Judy L. Bolton . Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A. Chemical Research in Toxicology 2015, 28 (11) , 2130-2141. https://doi.org/10.1021/acs.chemrestox.5b00310
  5. Juan Yao, Baoxin Zhang, Chunpo Ge, Shoujiao Peng, and Jianguo Fang . Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells. Journal of Agricultural and Food Chemistry 2015, 63 (5) , 1521-1531. https://doi.org/10.1021/jf505075n
  6. Dong Ho Suh, Sunmin Lee, Do Yeon Heo, Young-Suk Kim, Somi Kim Cho, Sarah Lee, and Choong Hwan Lee . Metabolite Profiling of Red and White Pitayas (Hylocereus polyrhizus and Hylocereus undatus) for Comparing Betalain Biosynthesis and Antioxidant Activity. Journal of Agricultural and Food Chemistry 2014, 62 (34) , 8764-8771. https://doi.org/10.1021/jf5020704
  7. Sarah Lee, Eun Sung Jung, Seon-Gil Do, Ga-young Jung, Gwanpil Song, Jung-min Song, and Choong Hwan Lee . Correlation between Species-Specific Metabolite Profiles and Bioactivities of Blueberries (Vaccinium spp.). Journal of Agricultural and Food Chemistry 2014, 62 (9) , 2126-2133. https://doi.org/10.1021/jf405272b
  8. Jia-Ni Lin, Hui-Yi Lin, Ning-Sun Yang, Yen-Hsien Li, Maw-Rong Lee, Chung-Hsiang Chuang, Chi-Tang Ho, Sheng-Chu Kuo, and Tzong-Der Way . Chemical Constituents and Anticancer Activity of Yellow Camellias against MDA-MB-231 Human Breast Cancer Cells. Journal of Agricultural and Food Chemistry 2013, 61 (40) , 9638-9644. https://doi.org/10.1021/jf4029877
  9. Sarah Lee, Seon-Gil Do, Sun Yeou Kim, Jinwan Kim, Yoojeong Jin, and Choong Hwan Lee . Mass Spectrometry-Based Metabolite Profiling and Antioxidant Activity of Aloe vera (Aloe barbadensis Miller) in Different Growth Stages. Journal of Agricultural and Food Chemistry 2012, 60 (45) , 11222-11228. https://doi.org/10.1021/jf3026309
  10. P. V. Narasimha Reddy, Katherine C. Jensen, Andrew D. Mesecar, Phillip E. Fanwick, and Mark Cushman . Design, Synthesis, and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues as Inhibitors of Quinone Reductase 2. Journal of Medicinal Chemistry 2012, 55 (1) , 367-377. https://doi.org/10.1021/jm201251c
  11. Horst Wolff, Magdalena Motyl, Claus Hellerbrand, Jörg Heilmann, and Birgit Kraus . Xanthohumol Uptake and Intracellular Kinetics in Hepatocytes, Hepatic Stellate Cells, and Intestinal Cells. Journal of Agricultural and Food Chemistry 2011, 59 (24) , 12893-12901. https://doi.org/10.1021/jf203689z
  12. Martin Conda-Sheridan, Laura Marler, Eun-Jung Park, Tamara P. Kondratyuk, Katherine Jermihov, Andrew D. Mesecar, John M. Pezzuto, Ratnakar N. Asolkar, William Fenical, and Mark Cushman . Potential Chemopreventive Agents Based on the Structure of the Lead Compound 2-Bromo-1-hydroxyphenazine, Isolated from Streptomyces Species, Strain CNS284. Journal of Medicinal Chemistry 2010, 53 (24) , 8688-8699. https://doi.org/10.1021/jm1011066
  13. Kang Mo Ku, Jiyoung Kim, Hye-Jin Park, Kwang-Hyeon Liu and Choong Hwan Lee . Application of Metabolomics in the Analysis of Manufacturing Type of Pu-erh Tea and Composition Changes with Different Postfermentation Year. Journal of Agricultural and Food Chemistry 2010, 58 (1) , 345-352. https://doi.org/10.1021/jf902818c
  14. Kang Mo Ku, Jung Nam Choi, Jiyoung Kim, Jeong Kee Kim, Lang Gook Yoo, Sang Jun Lee, Young-Shick Hong and Choong Hwan Lee . Metabolomics Analysis Reveals the Compositional Differences of Shade Grown Tea (Camellia sinensis L.). Journal of Agricultural and Food Chemistry 2010, 58 (1) , 418-426. https://doi.org/10.1021/jf902929h
  15. Andreas Hartkorn, Florian Hoffmann, Hussam Ajamieh, Susanne Vogel, Jörg Heilmann, Alexander L. Gerbes, Angelika M. Vollmar and Stefan Zahler. Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia−Reperfusion Injury. Journal of Natural Products 2009, 72 (10) , 1741-1747. https://doi.org/10.1021/np900230p
  16. Syed M. Qadri, Hasan Mahmud, Michael Föller and Florian Lang. Inhibition of Suicidal Erythrocyte Death by Xanthohumol. Journal of Agricultural and Food Chemistry 2009, 57 (16) , 7591-7595. https://doi.org/10.1021/jf900773w
  17. Vanda Mendes, Rosário Monteiro, Diogo Pestana, Diana Teixeira, Conceição Calhau and Isabel Azevedo . Xanthohumol Influences Preadipocyte Differentiation: Implication of Antiproliferative and Apoptotic Effects. Journal of Agricultural and Food Chemistry 2008, 56 (24) , 11631-11637. https://doi.org/10.1021/jf802233q
  18. Birgit M. Dietz, Dongting Liu, Ghenet K. Hagos, Ping Yao, Andreas Schinkovitz, Samuel M. Pro, Shixin Deng, Norman R. Farnsworth, Guido F. Pauli, Richard B. van Breemen and Judy L. Bolton . Angelica sinensis and Its Alkylphthalides Induce the Detoxification Enzyme NAD(P)H: Quinone Oxidoreductase 1 by Alkylating Keap1. Chemical Research in Toxicology 2008, 21 (10) , 1939-1948. https://doi.org/10.1021/tx8001274
  19. Susanne Vogel and Jörg Heilmann. Synthesis, Cytotoxicity, and Antioxidative Activity of Minor Prenylated Chalcones from Humulus lupulus. Journal of Natural Products 2008, 71 (7) , 1237-1241. https://doi.org/10.1021/np800188b
  20. Yan Luo, Aimee L. Eggler, Dongting Liu, Guowen Liu, Andrew D. Mesecar, Richard B. van Breemen. Sites of alkylation of human Keap1 by natural chemoprevention agents. Journal of the American Society for Mass Spectrometry 2007, 18 (12) , 2226-2232. https://doi.org/10.1021/jasms.8b02842
  21. Tareisha Dunlap, R. Esala P. Chandrasena, Zhiqiang Wang, Vaishali Sinha, Zhican Wang and Gregory R. J. Thatcher. Quinone Formation as a Chemoprevention Strategy for Hybrid Drugs: Balancing Cytotoxicity and Cytoprotection. Chemical Research in Toxicology 2007, 20 (12) , 1903-1912. https://doi.org/10.1021/tx7002257
  22. Guowen Liu,, Aimee L. Eggler,, Birgit M. Dietz,, Andrew D. Mesecar,, Judy L. Bolton,, John M. Pezzuto, and, Richard B. van Breemen. Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1. Analytical Chemistry 2005, 77 (19) , 6407-6414. https://doi.org/10.1021/ac050892r
  23. Hyang Seon Ro, Hyun Jun Jang, Gyu Rae Kim, Sang Jin Park, Hyeon Yong Lee. Enhancement of the Anti-Skin Wrinkling Effects of Aloe arborescens Miller Extracts Associated with Lactic Acid Fermentation. Evidence-Based Complementary and Alternative Medicine 2020, 2020 , 1-13. https://doi.org/10.1155/2020/2743594
  24. Alessandra Scagliarini, Aline Mathey, Virginie Aires, Dominique Delmas. Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent. Cells 2020, 9 (4) , 932. https://doi.org/10.3390/cells9040932
  25. Anita K. Ghosh, Vidhya R. Rao, Victoria J. Wisniewski, Alexandra D. Zigrossi, Jamie Floss, Peter Koulen, Evan B Stubbs, Simon Kaja. Differential Activation of Glioprotective Intracellular Signaling Pathways in Primary Optic Nerve Head Astrocytes after Treatment with Different Classes of Antioxidants. Antioxidants 2020, 9 (4) , 324. https://doi.org/10.3390/antiox9040324
  26. Temitope Isaac Adelusi, Lei Du, Meng Hao, Xueyan Zhou, Qian Xuan, Chowdhury Apu, Ying Sun, Qian Lu, Xiaoxing Yin. Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy. Biomedicine & Pharmacotherapy 2020, 123 , 109732. https://doi.org/10.1016/j.biopha.2019.109732
  27. Jan F. Stevens. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control. 2020,,, 319-350. https://doi.org/10.1007/978-3-030-39855-2_10
  28. Alejandro Bravo Iniguez, Mei-Jun Zhu. . Critical Reviews in Food Science and Nutrition 2020,,, 1. https://doi.org/10.1080/10408398.2020.1767537
  29. Maryam Majidinia, Anupam Bishayee, Bahman Yousefi. Polyphenols: Major regulators of key components of DNA damage response in cancer. DNA Repair 2019, 82 , 102679. https://doi.org/10.1016/j.dnarep.2019.102679
  30. Martin Ambrož, Kateřina Lněničková, Petra Matoušková, Lenka Skálová, Iva Boušová. Antiproliferative Effects of Hop-derived Prenylflavonoids and Their Influence on the Efficacy of Oxaliplatine, 5-fluorouracil and Irinotecan in Human ColorectalC Cells. Nutrients 2019, 11 (4) , 879. https://doi.org/10.3390/nu11040879
  31. Hyeon Yong Lee. Optimization of Cyanidin-3-O-galactoside Production from Aronia melanocarpa Elliot from Nonthermal Ultrasonic Extraction Process by Response Surface Methodology. Applied Sciences 2019, 9 (6) , 1203. https://doi.org/10.3390/app9061203
  32. Me-Mea Park, Eun-Young Yang, Dong-Ryeol Baek, Soo-Young Chae, Jung-Soo Lee, Yoon-Pyo Hong. Changes in physiological characteristics and functional compounds of ‘Kkwariput’, ‘Gilsang’ and ‘Cheongyang’ pepper fruit after harvest. Korean Journal of Food Preservation 2019, 26 (1) , 27-37. https://doi.org/10.11002/kjfp.2019.26.1.27
  33. Suyanee Thongchot, Malinee Thanee, Watcharin Loilome, Anchalee Techasen, Thidarat Boonmars, Prakasit Sa-Ngiamwibool, Attapol Titapun, Puangrat Yongvanit, Ciro Isidoro, Nisana Namwat. Curative effect of xanthohumol supplementation during liver fluke-associated cholangiocarcinogenesis: Potential involvement of autophagy. Journal of Traditional and Complementary Medicine 2019, https://doi.org/10.1016/j.jtcme.2019.02.001
  34. Hyeon Yong Lee. Improvement of skin barrier dysfunction by Scutellaria baicalensisGEOGI extracts through lactic acid fermentation. Journal of Cosmetic Dermatology 2019, 18 (1) , 183-191. https://doi.org/10.1111/jocd.12521
  35. Maša Knez Hrnčič, Eva Španinger, Iztok Košir, Željko Knez, Urban Bren. Hop Compounds: Extraction Techniques, Chemical Analyses, Antioxidative, Antimicrobial, and Anticarcinogenic Effects. Nutrients 2019, 11 (2) , 257. https://doi.org/10.3390/nu11020257
  36. Ines L. Paraiso, Layhna S. Plagmann, Liping Yang, Ryszard Zielke, Adrian F. Gombart, Claudia S. Maier, Aleksandra E. Sikora, Paul R. Blakemore, Jan F. Stevens. Reductive Metabolism of Xanthohumol and 8‐Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus. Molecular Nutrition & Food Research 2019, 63 (2) , 1800923. https://doi.org/10.1002/mnfr.201800923
  37. Ali M. El-Halawany, Hossam M. Abdallah, Ahmed R. Hamed, Hany Ezzat Khalil, Ameen M. Almohammadi. Phenolics from Barleria cristata var. Alba as carcinogenesis blockers against menadione cytotoxicity through induction and protection of quinone reductase. BMC Complementary and Alternative Medicine 2018, 18 (1) https://doi.org/10.1186/s12906-018-2214-9
  38. Woon Choi, Do Kang, Soo-Jin Heo, Hyeon Lee. Enhancement of the Neuroprotective Effect of Fermented Spirulina maxima Associated with Antioxidant Activities by Ultrasonic Extraction. Applied Sciences 2018, 8 (12) , 2469. https://doi.org/10.3390/app8122469
  39. Manuel Matzinger, Katrin Fischhuber, Elke H. Heiss. Activation of Nrf2 signaling by natural products-can it alleviate diabetes?. Biotechnology Advances 2018, 36 (6) , 1738-1767. https://doi.org/10.1016/j.biotechadv.2017.12.015
  40. Jinyong Park, Dong Ho Suh, Digar Singh, Sarah Lee, Jong Seok Lee, Choong Hwan Lee, . Systematic metabolic profiling and bioactivity assays for bioconversion of Aceraceae family. PLOS ONE 2018, 13 (6) , e0198739. https://doi.org/10.1371/journal.pone.0198739
  41. Soumya Nair, Sandra Suresh, Arya Kaniyassery, Panchami Jaya, Jayanthi Abraham. A review on melatonin action as therapeutic agent in cancer. Frontiers in Biology 2018, 13 (3) , 180-189. https://doi.org/10.1007/s11515-018-1503-5
  42. Jörg Heilmann. New Medical Applications of Plant Secondary Metabolites (From APR Volume 39). 2018,,, 348-380. https://doi.org/10.1002/9781119312994.apr0421
  43. Digar Singh, Choong H. Lee. Volatiles Mediated Interactions Between Aspergillus oryzae Strains Modulate Morphological Transition and Exometabolomes. Frontiers in Microbiology 2018, 9 https://doi.org/10.3389/fmicb.2018.00628
  44. Woon Choi, Hyeon Lee. Enhancement of Neuroprotective Effects of Spirulina platensis Extract from a High-Pressure Homogenization Process. Applied Sciences 2018, 8 (4) , 634. https://doi.org/10.3390/app8040634
  45. Keunho Ji, Youn Su Cho, Young Tae Kim. Tyrosinase Inhibitory and Anti-oxidative Effects of Lactic Acid Bacteria Isolated from Dairy Cow Feces. Probiotics and Antimicrobial Proteins 2018, 10 (1) , 43-55. https://doi.org/10.1007/s12602-017-9274-x
  46. Lars Porskjær Christensen. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress. 2018,,, 147-179. https://doi.org/10.1016/B978-0-12-813006-3.00013-1
  47. Woon Choi, Hyeon Lee. Enhancement of Chlorophyll a Production from Marine Spirulina maxima by an Optimized Ultrasonic Extraction Process. Applied Sciences 2018, 8 (1) , 26. https://doi.org/10.3390/app8010026
  48. Woon Choi, Hyeon Lee. Effect of Ultrasonic Extraction on Production and Structural Changes of C-Phycocyanin from Marine Spirulina maxima. International Journal of Molecular Sciences 2018, 19 (1) , 220. https://doi.org/10.3390/ijms19010220
  49. Hyeon Lee. Enhancement of Skin Anti-Inflammatory Activities of Eclipta prostrata L. from the Ultrasonic Extraction Process. Applied Sciences 2017, 7 (12) , 1227. https://doi.org/10.3390/app7121227
  50. Si Qin, De-Xing Hou. The Biofunctions of Phytochemicals and Their Applications in Farm Animals: The Nrf2/Keap1 System as a Target. Engineering 2017, 3 (5) , 738-752. https://doi.org/10.1016/J.ENG.2017.03.011
  51. T. Aydin, N. Bayrak, E. Baran, A. Cakir. Insecticidal effects of extracts of Humulus lupulus (hops) L. cones and its principal component, xanthohumol. Bulletin of Entomological Research 2017, 107 (4) , 543-549. https://doi.org/10.1017/S0007485317000256
  52. Guang Xin, Zeliang Wei, Chengjie Ji, Huajie Zheng, Jun Gu, Limei Ma, Wenfang Huang, Susan L. Morris-Natschke, Jwu-Lai Yeh, Rui Zhang, Chaoyi Qin, Li Wen, Zhihua Xing, Yu Cao, Qing Xia, Ke Li, Hai Niu, Kuo-Hsiung Lee, Wen Huang. Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release. Free Radical Biology and Medicine 2017, 108 , 247-257. https://doi.org/10.1016/j.freeradbiomed.2017.02.018
  53. Violetta Krajka-Kuźniak, Jarosław Paluszczak, Wanda Baer-Dubowska. The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment. Pharmacological Reports 2017, 69 (3) , 393-402. https://doi.org/10.1016/j.pharep.2016.12.011
  54. Xiangquan Mi, Chunming Wang, Chao Sun, Xu Chen, Xiang Huo, Yiming Zhang, Gang Li, Bo Xu, Jun Zhang, Jianxin Xie, Zhenhua Wang, Ji Li. Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway. Oncotarget 2017, 8 (19) , 31297-31304. https://doi.org/10.18632/oncotarget.16185
  55. Boguslawa Luzak, Hassan Kassassir, Edward Rój, Lidia Stanczyk, Cezary Watala, Jacek Golanski. Xanthohumol from hop cones ( Humulus lupulus L.) prevents ADP-induced platelet reactivity. Archives of Physiology and Biochemistry 2017, 123 (1) , 54-60. https://doi.org/10.1080/13813455.2016.1247284
  56. Tania Merinas-Amo, Inmaculada Tasset-Cuevas, Antonio M. Díaz-Carretero, Ángeles Alonso-Moraga, Fernando Calahorro. In vivo and in vitro studies of the role of lyophilised blond Lager beer and some bioactive components in the modulation of degenerative processes. Journal of Functional Foods 2016, 27 , 274-294. https://doi.org/10.1016/j.jff.2016.09.014
  57. Tiankui Qiao, Suchen Jiang, Ping Song, Xiaofeng Song, Qimin Liu, Lijuan Wang, Xuesi Chen. Effect of blending HA-g-PLLA on xanthohumol-loaded PLGA fiber membrane. Colloids and Surfaces B: Biointerfaces 2016, 146 , 221-227. https://doi.org/10.1016/j.colsurfb.2016.06.011
  58. Birgit M. Dietz, Atieh Hajirahimkhan, Tareisha L. Dunlap, Judy L. Bolton, . Botanicals and Their Bioactive Phytochemicals for Women’s Health. Pharmacological Reviews 2016, 68 (4) , 1026-1073. https://doi.org/10.1124/pr.115.010843
  59. Su Young Son, Na Kyung Kim, Sunmin Lee, Digar Singh, Ga Ryun Kim, Jong Seok Lee, Hee-sun Yang, Joohong Yeo, Sarah Lee, Choong Hwan Lee. Metabolite fingerprinting, pathway analyses, and bioactivity correlations for plant species belonging to the Cornaceae, Fabaceae, and Rosaceae families. Plant Cell Reports 2016, 35 (9) , 1917-1931. https://doi.org/10.1007/s00299-016-2006-y
  60. , Nam Young Kim, Jeong Min Lee, Jae Yong Lee, Hyeon Yong Lee. Enhancement of Anti-Obesity Activities of Aronia melanocarpa Elliot Extracts from Low Temperature Ultrasonification Process. Korean Journal of Medicinal Crop Science 2016, 24 (4) , 309-316. https://doi.org/10.7783/KJMCS.2016.24.4.309
  61. Si Qin, De-Xing Hou. Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals. Molecular Nutrition & Food Research 2016, 60 (8) , 1731-1755. https://doi.org/10.1002/mnfr.201501017
  62. Vlad Simon Luca, Anca Miron, Ana Clara Aprotosoaie. The antigenotoxic potential of dietary flavonoids. Phytochemistry Reviews 2016, 15 (4) , 591-625. https://doi.org/10.1007/s11101-016-9457-1
  63. Lidia Brodziak-Jarosz, Yuuta Fujikawa, Daniel Pastor-Flores, Sonay Kasikci, Petr Jirásek, Sebastian Pitzl, Robert W. Owen, Karel D. Klika, Clarissa Gerhäuser, Sabine Amslinger, Tobias P. Dick. A click chemistry approach identifies target proteins of xanthohumol. Molecular Nutrition & Food Research 2016, 60 (4) , 737-748. https://doi.org/10.1002/mnfr.201500613
  64. Byoung Ryong Jeong, Iyyakkannu Sivanesan. Direct adventitious shoot regeneration, in vitro flowering, fruiting, secondary metabolite content and antioxidant activity of Scrophularia takesimensis Nakai. Plant Cell, Tissue and Organ Culture (PCTOC) 2015, 123 (3) , 607-618. https://doi.org/10.1007/s11240-015-0864-6
  65. Heon Joong Lee, Dong Ho Suh, Eun Sung Jung, Hye Min Park, Ga-Young Jung, Seon-Gil Do, Choong Hwan Lee. Metabolomics of Lonicera caerulea fruit during ripening and its relationship with color and antioxidant activity. Food Research International 2015, 78 , 343-351. https://doi.org/10.1016/j.foodres.2015.09.017
  66. , Sung Kyeom Kim, Woo Moon Lee, Sang Gyu Lee, Hee Ju Lee, Chang Sun Choi, Sung Tae Park, Su Kim, Tae Sung Park. Variation of Antioxidant Activity and Bioactive Compounds Content in Cruciferae Seeds. Journal of Agriculture & Life Science 2015, 49 (5) , 103-115. https://doi.org/10.14397/jals.2015.49.5.103
  67. Nam Young Kim, Hyeon Yong Lee. Enhancement of Skin Whitening and Anti-wrinkle Activities of the Co-culture of Lactobacillus rhamnosus and Lactobacillus paracasei. Journal of the Society of Cosmetic Scientists of Korea 2015, 41 (3) , 253-261. https://doi.org/10.15230/SCSK.2015.41.3.253
  68. Ji Han, Sunmin Lee, Hyang Kim, Choong Lee. MS-Based Metabolite Profiling of Aboveground and Root Components of Zingiber mioga and Officinale. Molecules 2015, 20 (9) , 16170-16185. https://doi.org/10.3390/molecules200916170
  69. Hye-Kyung Na, Young-Joon Surh. Cancer Chemopreventive Phytochemicals Targeting NF-κB and Nrf2 Signaling Pathways. 2015,,, 102-121. https://doi.org/10.1002/9781118930458.ch9
  70. Gi Ru Shin, Sunmin Lee, Sarah Lee, Seon-Gil Do, Eunju Shin, Choong Hwan Lee. Maturity stage-specific metabolite profiling of Cudrania tricuspidata and its correlation with antioxidant activity. Industrial Crops and Products 2015, 70 , 322-331. https://doi.org/10.1016/j.indcrop.2015.01.048
  71. , Nam Young Kim, Dae Su Park, Hyeon Yong Lee. Effect of Anti-Skin Wrinkle and Antioxidant of Agastache rugosa Kentz through Fermentation Process of the lactic acid. Korean Journal of Medicinal Crop Science 2015, 23 (1) , 37-42. https://doi.org/10.7783/KJMCS.2015.23.1.37
  72. Ming Liu, Poul Hansen, Genzhu Wang, Lin Qiu, Jianjun Dong, Hua Yin, Zhonghua Qian, Mei Yang, Jinlai Miao. Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus). Molecules 2015, 20 (1) , 754-779. https://doi.org/10.3390/molecules20010754
  73. Jae Bin Sin, Woon Yong Choi, Do Hyung Kang, Hyeon Yong Lee. Comparison of Anti-Inflammatory Activity of Spirulina maxima Extract by Ultrasonication and Water Extraction Process. Journal of the Korean Society of Food Science and Nutrition 2014, 43 (12) , 1852-1857. https://doi.org/10.3746/jkfn.2014.43.12.1852
  74. Wooseok Choi, Ra Hwan No, Hee-Souk Kwon, Hyeon Yong Lee. Enhancement of skin anti-inflammatory activities of Scutellaria baicalensis extract using a nanoencapsulation process. Journal of Cosmetic and Laser Therapy 2014, 16 (6) , 271-278. https://doi.org/10.3109/14764172.2014.946051
  75. Wooseok Choi, Hee-Souk Kwon, Hyeon Yong Lee. Enhancement of anti-skin inflammatory activities of Scutellaria baicalensis using an alkaline reduced water extraction process. Food Science and Biotechnology 2014, 23 (6) , 1859-1866. https://doi.org/10.1007/s10068-014-0254-6
  76. Richard B. van Breemen, Yang Yuan, Suzanne Banuvar, Lee P. Shulman, Xi Qiu, René F. Ramos Alvarenga, Shao-Nong Chen, Birgit M. Dietz, Judy L. Bolton, Guido F. Pauli, Elizabeth Krause, Marlos Viana, Dejan Nikolic. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Molecular Nutrition & Food Research 2014, 58 (10) , 1962-1969. https://doi.org/10.1002/mnfr.201400245
  77. Ga Kim, Eun Jung, Sarah Lee, Sun-Hyung Lim, Sun-Hwa Ha, Choong Lee. Combined Mass Spectrometry-Based Metabolite Profiling of Different Pigmented Rice (Oryza sativa L.) Seeds and Correlation with Antioxidant Activities. Molecules 2014, 19 (10) , 15673-15686. https://doi.org/10.3390/molecules191015673
  78. Nam Young Kim, Jeung Hoan Kim, Geun Pyo Choi, Hyeon Yong Lee. Comparison of Anti-Skin Wrinkle Activities of Aronia melanocarpa Extracts by Extraction Methods. Korean Journal of Medicinal Crop Science 2014, 22 (3) , 217-222. https://doi.org/10.7783/KJMCS.2014.22.3.217
  79. Elizabeth Krause, Yang Yuan, Atieh Hajirahimkhan, Huali Dong, Birgit M. Dietz, Dejan Nikolic, Guido F. Pauli, Judy L. Bolton, Richard B. van Breemen. Biological and chemical standardization of a hop ( Humulus lupulus ) botanical dietary supplement. Biomedical Chromatography 2014, 28 (6) , 729-734. https://doi.org/10.1002/bmc.3177
  80. K.M. Maria John, Muthu Thiruvengadam, Gansukh Enkhtaivan, Doo Hwan Kim. Variation in major phenolic compounds and quality potential of CTC black tea elicited by Saccharomyces cercevisiae and its correlation with antioxidant potential. Industrial Crops and Products 2014, 55 , 289-294. https://doi.org/10.1016/j.indcrop.2014.02.006
  81. Yang Yuan, Xi Qiu, Dejan Nikolić, Shao-Nong Chen, Ke Huang, Guannan Li, Guido F. Pauli, Richard B. van Breemen. Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols. European Journal of Pharmaceutical Sciences 2014, 53 , 55-61. https://doi.org/10.1016/j.ejps.2013.12.003
  82. Liyan Yu, Fuxian Zhang, Zhijuan Hu, Hui Ding, Huifang Tang, Zhongjun Ma, Xiaofeng Zhao. Novel prenylated bichalcone and chalcone from Humulus lupulus and their quinone reductase induction activities. Fitoterapia 2014, 93 , 115-120. https://doi.org/10.1016/j.fitote.2013.12.019
  83. Lars Porskjær Christensen, Kathrine Bisgaard Christensen. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress. 2014,,, 289-309. https://doi.org/10.1016/B978-0-12-398456-2.00023-2
  84. Min Ju Kim, K.M. Maria John, Jung Nam Choi, Sarah Lee, Ah Jin Kim, Young Mi Kim, Choong Hwan Lee. Changes in secondary metabolites of green tea during fermentation by Aspergillus oryzae and its effect on antioxidant potential. Food Research International 2013, 53 (2) , 670-677. https://doi.org/10.1016/j.foodres.2012.12.053
  85. Andrew V. Stachulski, Thomas A. Baillie, B. Kevin Park, R. Scott Obach, Deepak K. Dalvie, Dominic P. Williams, Abhishek Srivastava, Sophie L. Regan, Daniel J. Antoine, Christopher E. P. Goldring, Alvin J. L. Chia, Neil R. Kitteringham, Laura E. Randle, Hayley Callan, J. Luis Castrejon, John Farrell, Dean J. Naisbitt, Martin S. Lennard. The Generation, Detection, and Effects of Reactive Drug Metabolites. Medicinal Research Reviews 2013, 33 (5) , 985-1080. https://doi.org/10.1002/med.21273
  86. Eun Sung Jung, Sarah Lee, Sun-Hyung Lim, Sun-Hwa Ha, Kwang-Hyeon Liu, Choong Hwan Lee. Metabolite profiling of the short-term responses of rice leaves (Oryza sativa cv. Ilmi) cultivated under different LED lights and its correlations with antioxidant activities. Plant Science 2013, 210 , 61-69. https://doi.org/10.1016/j.plantsci.2013.05.004
  87. Birgit Dietz, Judy Bolton. Anti-Inflammatory Botanical Dietary Supplements for Women’s Health. 2013,,, 529-548. https://doi.org/10.1201/b15323-37
  88. Atieh Hajirahimkhan, Charlotte Simmler, Yang Yuan, Jeffrey R. Anderson, Shao-Nong Chen, Dejan Nikolić, Birgit M. Dietz, Guido F. Pauli, Richard B. van Breemen, Judy L. Bolton, . Evaluation of Estrogenic Activity of Licorice Species in Comparison with Hops Used in Botanicals for Menopausal Symptoms. PLoS ONE 2013, 8 (7) , e67947. https://doi.org/10.1371/journal.pone.0067947
  89. Jay S. Kirkwood, LeeCole L. Legette, Cristobal L. Miranda, Yuan Jiang, Jan F. Stevens. A Metabolomics-driven Elucidation of the Anti-obesity Mechanisms of Xanthohumol. Journal of Biological Chemistry 2013, 288 (26) , 19000-19013. https://doi.org/10.1074/jbc.M112.445452
  90. Birgit M. Dietz, Ghenet K. Hagos, Jillian N. Eskra, Gihani T. Wijewickrama, Jeffrey R. Anderson, Dejan Nikolic, Jian Guo, Brian Wright, Shao-Nong Chen, Guido F. Pauli, Richard B. van Breemen, Judy L. Bolton. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops ( Humulus lupulus ) in vitro and in vivo. Molecular Nutrition & Food Research 2013, 57 (6) , 1055-1066. https://doi.org/10.1002/mnfr.201200534
  91. Ahmed Kamal, Methuku Kashi Reddy, Arutla Viswanath. The design and development of imidazothiazole–chalcone derivatives as potential anticancer drugs. Expert Opinion on Drug Discovery 2013, 8 (3) , 289-304. https://doi.org/10.1517/17460441.2013.758630
  92. Ji Seon Kim, Ji Woong Kim, Hee Seok Kwon, Hye Won Lim, Hyeon Yong Lee. Screening of Skin Whitening Activity of Codonopsis lanceolata Extract by Complex Steaming Process. Korean Journal of Medicinal Crop Science 2013, 21 (1) , 54-60. https://doi.org/10.7783/KJMCS.2013.21.1.54
  93. Violetta Krajka-Kuźniak, Jarosław Paluszczak, Wanda Baer-Dubowska. Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro. Toxicology in Vitro 2013, 27 (1) , 149-156. https://doi.org/10.1016/j.tiv.2012.10.008
  94. Ohn-Soon Kim, Ye-Ji Kim, Hyeun-Kyoo Shin. Anti-atherosclerotic Effects of Herbal Formulas for Sasang Constitutional Medicine. Journal of Sasang Constitutional Medicine 2012, 24 (4) , 51-61. https://doi.org/10.7730/JSCM.2012.24.4.51
  95. Ciska Wyns, Katleen van Steendam, Barbara Vanhoecke, Dieter Deforce, Marc Bracke, Arne Heyerick. Prenylated chalcone xanthohumol associates with histones in breast cancer cells-a novel target identified by a monoclonal antibody. Molecular Nutrition & Food Research 2012, 56 (11) , 1688-1696. https://doi.org/10.1002/mnfr.201200030
  96. Chi-Ho Song, Yong-Chang Seo, Woon-Yong Choi, Choon-Geun Lee, Do-Un Kim, Jae-Youn Chung, Hee-Chul Chung, Dong-Sik Park, Choong-Je Ma, Hyeon-Yong Lee. Enhancement of Antioxidative Activity of Codonopsis lanceolata by Stepwise Steaming Process. Korean Journal of Medicinal Crop Science 2012, 20 (4) , 238-244. https://doi.org/10.7783/KJMCS.2012.20.4.238
  97. Courtney S. Snelten, Birgit Dietz, Judy L. Bolton. Modulation of estrogen chemical carcinogenesis by botanical supplements used for postmenopausal women's health. Drug Discovery Today: Disease Mechanisms 2012, 9 (1-2) , e47-e54. https://doi.org/10.1016/j.ddmec.2012.11.001
  98. LeeCole Legette, Lian Ma, Ralph L. Reed, Cristobal L. Miranda, John Mark Christensen, Rosita Rodriguez-Proteau, Jan F. Stevens. Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Molecular Nutrition & Food Research 2012, 56 (3) , 466-474. https://doi.org/10.1002/mnfr.201100554
  99. Olga Viegas, Bojana Žegura, Marko Pezdric, Matjaž Novak, Isabel M.P.L.V.O. Ferreira, Olívia Pinho, Metka Filipič. Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells. Food and Chemical Toxicology 2012, 50 (3-4) , 949-955. https://doi.org/10.1016/j.fct.2011.11.031
  100. Il-Hwan Ryu, Tae-Oh Kwon. The Antioxidative Effect and Ingredients of Oil Extracted from Schizandra chinensis Seed. Korean Journal of Medicinal Crop Science 2012, 20 (1) , 63-71. https://doi.org/10.7783/KJMCS.2012.20.1.063
  101. Volodymyr I. Lushchak. Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions. Journal of Amino Acids 2012, 2012 , 1-26. https://doi.org/10.1155/2012/736837
  102. Marc Birringer. Hormetics: Dietary Triggers of an Adaptive Stress Response. Pharmaceutical Research 2011, 28 (11) , 2680-2694. https://doi.org/10.1007/s11095-011-0551-1
  103. Takeshi Kokubo, Yoshimasa Taniguchi, Masaya Kanayama, Masako Shimura, Yutaka Konishi, Hirokazu Kawagishi, Masayuki Yamamoto, Kazutoshi Shindo, Aruto Yoshida. Extract of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2. Food Chemistry 2011, 129 (1) , 92-99. https://doi.org/10.1016/j.foodchem.2011.04.031
  104. Sung-Yeoun Hwang, Seong-Hun Ahn. Biological Activities and Cell Proliferation effects of Red Ginseng Ethanol Extracts. Journal of Pharmacopuncture 2011, 14 (3) , 55-61. https://doi.org/10.3831/KPI.2011.14.3.055
  105. Mee-Kyung Kim, Jin-Sung Kim, Bun-Sung Jo, Jeung-Hoan Kim, In-Cheol Lee, Myung-Sup Lee, Young-Je Cho. Functional Properties of Walnut in Cosmetics. Journal of Life Science 2011, 21 (6) , 858-864. https://doi.org/10.5352/JLS.2011.21.6.858
  106. Jie Ding, Qi Zhao, Lei Sun, Lan Ding, Nanqi Ren. Magnetic mixed hemimicelles solid-phase extraction of xanthohumol in beer coupled with high-performance liquid chromatography determination. Journal of Separation Science 2011, 34 (12) , 1463-1468. https://doi.org/10.1002/jssc.201000930
  107. Birgit M. Dietz, Judy L. Bolton. Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chemico-Biological Interactions 2011, 192 (1-2) , 72-80. https://doi.org/10.1016/j.cbi.2010.10.007
  108. Jiyoung KIM, Jung Nam CHOI, Kang Mo KU, Daejung KANG, Jong Sang KIM, Jung Han Yoon PARK, Choong Hwan LEE. A Correlation between Antioxidant Activity and Metabolite Release during the Blanching of Chrysanthemum coronarium L.. Bioscience, Biotechnology, and Biochemistry 2011, 75 (4) , 674-680. https://doi.org/10.1271/bbb.100799
  109. Jiyoung KIM, Jung Nam CHOI, Daejung KANG, Gun Hee SON, Young-Suk KIM, Hyung-Kyoon CHOI, Dae Young KWON, Choong Hwan LEE. Correlation between Antioxidative Activities and Metabolite Changes during Cheonggukjang Fermentation. Bioscience, Biotechnology, and Biochemistry 2011, 75 (4) , 732-739. https://doi.org/10.1271/bbb.100858
  110. Ye-Sook Jeon, Mi-Won Kim. The Antioxidative Effects and Isolation and Characterization of the Extracts from Morus alba L.. The Korean Journal of Food And Nutrition 2011, 24 (1) , 94-100. https://doi.org/10.9799/ksfan.2011.24.1.094
  111. Claus Jacob, Vincent Jamier, Lalla Aicha Ba. Redox active secondary metabolites. Current Opinion in Chemical Biology 2011, 15 (1) , 149-155. https://doi.org/10.1016/j.cbpa.2010.10.015
  112. Ik-Soo Lee, Juhee Lim, Jiyeong Gal, Jeen Chu Kang, Hyun Jung Kim, Bok Yun Kang, Hyun Jin Choi. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochemistry International 2011, 58 (2) , 153-160. https://doi.org/10.1016/j.neuint.2010.11.008
  113. João R. Araújo, Pedro Gonçalves, Fátima Martel. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutrition Research 2011, 31 (2) , 77-87. https://doi.org/10.1016/j.nutres.2011.01.006
  114. Rakesh Sharma, Jose Katz. Bioactive Foods in Cancer Prevention. 2010,,, 143-180. https://doi.org/10.1201/b10330-12
  115. Sung-Chul Kim, Geun-Young Seo, Sung-Won Lee, Sung-Joo Park, Jae-Hyo Kim, Seong-Hun Ahn, Sung-Yeoun Hwang. Biological Activities of Scolopendrid Pharmacopuncture. Journal of Pharmacopuncture 2010, 13 (3) , 5-13. https://doi.org/10.3831/KPI.2010.13.3.005
  116. Franziska Ferk, Wolfgang W. Huber, Metka Filipič, Julia Bichler, Elisabeth Haslinger, Miroslav Mišík, Armen Nersesyan, Bettina Grasl-Kraupp, Bojana Žegura, Siegfried Knasmüller. Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-f]quinoline (IQ). Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2010, 691 (1-2) , 17-22. https://doi.org/10.1016/j.mrfmmm.2010.06.006
  117. Nguyen Thi Xuan, Ekaterina Shumilina, Erich Gulbins, Shuchen Gu, Friedrich Götz, Florian Lang. Triggering of dendritic cell apoptosis by xanthohumol. Molecular Nutrition & Food Research 2010, 54 (S2) , S214-S224. https://doi.org/10.1002/mnfr.200900324
  118. Branislav Radović, Ragna Hussong, Clarissa Gerhäuser, Walter Meinl, Norbert Frank, Hans Becker, Josef Köhrle. Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism. Molecular Nutrition & Food Research 2010, 54 (S2) , S225-S235. https://doi.org/10.1002/mnfr.200900489
  119. Christoph Dorn, Frauke Bataille, Erwin Gaebele, Jörg Heilmann, Claus Hellerbrand. Xanthohumol feeding does not impair organ function and homoeostasis in mice. Food and Chemical Toxicology 2010, 48 (7) , 1890-1897. https://doi.org/10.1016/j.fct.2010.04.030
  120. Geun-Young Seo, Sung-Won Lee, Sung -Joo Park, Sung-Chul Kim, In-Chul Sohn, Sung-Yeoun Hwang, Seong-Hun Ahn. Biological Activities of Hominis Placenta Herbal Acupuncture prepared by Hydrochloric Acid Hydrolysis. Journal of Pharmacopuncture 2010, 13 (2) , 5-12. https://doi.org/10.3831/KPI.2010.13.2.005
  121. Young-Chang Cho, Sung-Kyun You, Hyun Jung Kim, Cheong-Weon Cho, Ik-Soo Lee, Bok Yun Kang. Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis. International Immunopharmacology 2010, 10 (5) , 556-561. https://doi.org/10.1016/j.intimp.2010.02.002
  122. Kang-Mo Ku, Young-Hwa Kang. Antioxidant and Quinone Reductase Inductive Activities of Various Organs of Pepper. Journal of Applied Biological Chemistry 2010, 53 (1) , 31-36. https://doi.org/10.3839/jabc.2010.006
  123. Jörg Heilmann. New Medical Applications of Plant Secondary Metabolites. 2010,,, 348-380. https://doi.org/10.1002/9781444318876.ch5
  124. Jürgen Behr, Rudi F. Vogel. Mechanisms of Hop Inhibition Include the Transmembrane Redox Reaction. Applied and Environmental Microbiology 2010, 76 (1) , 142-149. https://doi.org/10.1128/AEM.01693-09
  125. Xiaohua Gao, Dorrah Deeb, Yongbo Liu, Sarita Gautam, Scott A. Dulchavsky, Subhash C. Gautam. Immunomodulatory activity of xanthohumol: inhibition of T cell proliferation, cell-mediated cytotoxicity and Th1 cytokine production through suppression of NF-κB. Immunopharmacology and Immunotoxicology 2009, 31 (3) , 477-484. https://doi.org/10.1080/08923970902798132
  126. Norman R. Farnsworth, Gail B. Mahady. Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: Black cohosh from the field to the clinic. Pharmaceutical Biology 2009, 47 (8) , 755-760. https://doi.org/10.1080/13880200902988637
  127. Srujana Rayalam, Jeong-Yeh Yang, Mary Anne Della-Fera, Hea Jin Park, Suresh Ambati, Clifton A. Baile. Anti-Obesity Effects of Xanthohumol Plus Guggulsterone in 3T3-L1 Adipocytes. Journal of Medicinal Food 2009, 12 (4) , 846-853. https://doi.org/10.1089/jmf.2008.0158
  128. Kang-Mo Ku, He-Sook Kim, Byung-Su Kim, Young-Hwa Kang. Antioxidant Activities and Antioxidant Constituents of Pepper Leaves from Various Cultivars and Correlation between Antioxidant Activities and Antioxidant Constituents. Journal of Applied Biological Chemistry 2009, 52 (2) , 70-76. https://doi.org/10.3839/jabc.2009.013
  129. Paulo J. Magalhães, Daniel O. Carvalho, José M. Cruz, Luís F. Guido, Aquiles A. Barros. Fundamentals and Health Benefits of Xanthohumol, a Natural Product Derived from Hops and Beer. Natural Product Communications 2009, 4 (5) , 1934578X0900400. https://doi.org/10.1177/1934578X0900400501
  130. Kuzhuvelil B. Harikumar, Ajaikumar B. Kunnumakkara, Kwang S. Ahn, Preetha Anand, Sunil Krishnan, Sushovan Guha, Bharat B. Aggarwal. Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB–regulated gene products and potentiation of apoptosis in leukemia cells. Blood 2009, 113 (9) , 2003-2013. https://doi.org/10.1182/blood-2008-04-151944
  131. Jin Myung Choi, Hyun Jung Kim, Kwang Youl Lee, Hyun Jin Choi, Ik-Soo Lee, Bok Yun Kang. Increased IL-2 production in T cells by xanthohumol through enhanced NF-AT and AP-1 activity. International Immunopharmacology 2009, 9 (1) , 103-107. https://doi.org/10.1016/j.intimp.2008.10.011
  132. . Human ACAT Inhibitory Effects of Flavonoids from Sophora flavescens. Bulletin of the Korean Chemical Society 2008,,, 2287-2290. https://doi.org/10.5012/bkcs.2008.29.11.2287
  133. Regina Brigelius-Flohé, Antje Banning. Dietary Factors in the Regulation of Selenoprotein Biosynthesis. 2008,,https://doi.org/10.1201/9780849381492.ch10
  134. Tareisha Dunlap, Samer O. Abdul-Hay, R. Esala P. Chandrasena, Ghenet K. Hagos, Vaishali Sinha, Zhiqiang Wang, Huali Wang, Gregory R.J. Thatcher. Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: In vitro evidence querying the NO donor functionality. Nitric Oxide 2008, 19 (2) , 115-124. https://doi.org/10.1016/j.niox.2008.04.013
  135. Jeong-Yeh Yang, Mary Anne Della-Fera, Srujana Rayalam, Clifton A. Baile. Enhanced Effects of Xanthohumol Plus Honokiol on Apoptosis in 3T3-L1 Adipocytes. Obesity 2008, 16 (6) , 1232-1238. https://doi.org/10.1038/oby.2008.66
  136. C. B. Castro, L. D. Whittock, S. P. Whittock, G. Leggett, A. Koutoulis. DNA Sequence and Expression Variation of Hop (Humulus lupulus) Valerophenone Synthase (VPS), a Key Gene in Bitter Acid Biosynthesis. Annals of Botany 2008, 102 (2) , 265-273. https://doi.org/10.1093/aob/mcn089
  137. Susanne Vogel, Susanne Ohmayer, Gabi Brunner, Jörg Heilmann. Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity. Bioorganic & Medicinal Chemistry 2008, 16 (8) , 4286-4293. https://doi.org/10.1016/j.bmc.2008.02.079
  138. Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park. The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity. Toxicology 2008, 246 (1) , 24-33. https://doi.org/10.1016/j.tox.2007.10.029
  139. Janja Plazar, Metka Filipič, Geny M.M. Groothuis. Antigenotoxic effect of Xanthohumol in rat liver slices. Toxicology in Vitro 2008, 22 (2) , 318-327. https://doi.org/10.1016/j.tiv.2007.09.009
  140. Norman R Farnsworth, Elizabeth C Krause, Judy L Bolton, Guido F Pauli, Richard B van Breemen, James G Graham. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use. The American Journal of Clinical Nutrition 2008, 87 (2) , 504S-508S. https://doi.org/10.1093/ajcn/87.2.504S
  141. Sung Ho Lee, Hyun Jung Kim, Jung Sun Lee, Ik-Soo Lee, Bok Yun Kang. Inhibition of topoisomerase I activity and efflux drug transporters’ expression by xanthohumol from hops. Archives of Pharmacal Research 2007, 30 (11) , 1435-1439. https://doi.org/10.1007/BF02977368
  142. Jeong-Yeh Yang, Mary Anne Della-Fera, Srujana Rayalam, Clifton A. Baile. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis 2007, 12 (11) , 1953-1963. https://doi.org/10.1007/s10495-007-0130-4
  143. Janja Plazar, Bojana Žegura, Tamara T. Lah, Metka Filipič. Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2007, 632 (1-2) , 1-8. https://doi.org/10.1016/j.mrgentox.2007.03.013
  144. Rosário Monteiro, Ana Faria, Isabel Azevedo, Conceição Calhau. Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids. The Journal of Steroid Biochemistry and Molecular Biology 2007, 105 (1-5) , 124-130. https://doi.org/10.1016/j.jsbmb.2006.11.026
  145. Emily C. Colgate, Cristobal L. Miranda, Jan F. Stevens, Tammy M. Bray, Emily Ho. Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Letters 2007, 246 (1-2) , 201-209. https://doi.org/10.1016/j.canlet.2006.02.015
  146. Yan Pang, Dejan Nikolic, Dongwei Zhu, Lucas R. Chadwick, Guido F. Pauli, Norman R. Farnsworth, Richard B. van Breemen. . Molecular Nutrition & Food Research 2007,,, 872. https://doi.org/10.1002/mnfr.200600252

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

OOPS

You have to login with your ACS ID befor you can login with your Mendeley account.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE