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Copper-Catalyzed Successive Radical Reactions of Glycine Derivatives
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    Copper-Catalyzed Successive Radical Reactions of Glycine Derivatives
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    • Youwan Ye
      Youwan Ye
      Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China
      More by Youwan Ye
    • Dongsheng Ji
      Dongsheng Ji
      Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China
      More by Dongsheng Ji
    • Chenxing Zhou
      Chenxing Zhou
      Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China
    • Yingpeng Su
      Yingpeng Su
      Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China
      More by Yingpeng Su
    • Xiazhen Bao
      Xiazhen Bao
      Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China
      More by Xiazhen Bao
    • Congde Huo*
      Congde Huo
      Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China
      *[email protected]
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    Organic Letters

    Cite this: Org. Lett. 2025, 27, 4, 1054–1059
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    https://doi.org/10.1021/acs.orglett.4c04707
    Published January 16, 2025
    Copyright © 2025 American Chemical Society

    Abstract

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    Here, we present a three-component successive radical addition strategy for the preparation of complex noncanonical α-amino acids from easily available glycine derivatives, alkenes, and aryl sulfonium salts via a copper-catalyzed photoredox-neutral catalytic cycle. The utility of this method is further demonstrated by its application in late-stage site-selective modifications of glycine residues in short peptides. It is worth noting that only 1 mol % copper catalyst is required in this reaction, demonstrating high catalytic efficiency.

    Copyright © 2025 American Chemical Society

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    Organic Letters

    Cite this: Org. Lett. 2025, 27, 4, 1054–1059
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.orglett.4c04707
    Published January 16, 2025
    Copyright © 2025 American Chemical Society

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