DABSO-Mediated Hydrosulfonylation of Activated AlkenesClick to copy article linkArticle link copied!
- Xiaoxiao YangXiaoxiao YangState Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430070, ChinaMore by Xiaoxiao Yang
- Shuaiqi LuShuaiqi LuState Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430070, ChinaMore by Shuaiqi Lu
- Yongxin ZhangYongxin ZhangState Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430070, ChinaMore by Yongxin Zhang
- Hui XuHui XuState Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430070, ChinaMore by Hui Xu
- Xiao CaiXiao CaiState Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430070, ChinaMore by Xiao Cai
- Chao Shu*Chao Shu*Email: [email protected]State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430070, ChinaMore by Chao Shu
Abstract
Highly functionalized sulfone containing scaffolds are ubiquitous and are attracting increasing interest in pharmaceutical and agrochemicals owing to their enhanced activities. Herein, we present an alternative protocol to access highly substituted sulfones from readily accessible olefin feedstocks and sulfinate salts through a DABSO enabled anti-Markovnikov hydrosulfonylation process. Notably, the practical procedure features excellent compatibility with various susceptible functional groups and a broad substrate scope under mild and operationally simple conditions. Gram-scale preparation, post-functionalization of complex molecules, and applications in the synthesis of bioactive compounds underscore the potential in drug discovery.
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This article is cited by 1 publications.
- Fanyuanhang Yang, Yuxin Yang, Yuxi Ren, Yuzhen Gao, Weiping Su. CO2-Promoted hydrosulfonylation of electron-deficient alkenes with sulfinates. Green Synthesis and Catalysis 2025, 36 https://doi.org/10.1016/j.gresc.2025.05.011
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