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    Thermoelectric Nanoheterojunction-Mediated Multiple Energy Conversion for Enhanced Cancer Therapy
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    • Yanlin Zhu
      Yanlin Zhu
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      More by Yanlin Zhu
      Orcidhttps://orcid.org/0000-0003-0044-9433
    • Qingyu Hao
      Qingyu Hao
      Infectious Disease Hospital of Heilongjiang Province, Harbin 150500, P. R. China
      More by Qingyu Hao
    • Haixia Zhu
      Haixia Zhu
      Cancer Institute, Affiliated Tumor Hospital of Nantong University, Nantong 226631, P. R. China
      More by Haixia Zhu
    • Ruoxi Zhao
      Ruoxi Zhao
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      More by Ruoxi Zhao
    • Lili Feng*
      Lili Feng
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      *Email: [email protected]
      More by Lili Feng
      Orcidhttps://orcid.org/0000-0001-9459-6594
    • Song He
      Song He
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      More by Song He
    • Wenzhuo Wang
      Wenzhuo Wang
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      More by Wenzhuo Wang
    • Guanting He
      Guanting He
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      More by Guanting He
    • Bin Liu
      Bin Liu
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      More by Bin Liu
    • Piaoping Yang*
      Piaoping Yang
      Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
      *Email: [email protected]
      More by Piaoping Yang
      Orcidhttps://orcid.org/0000-0002-9555-1803
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    ACS Nano

    Cite this: ACS Nano 2024, 18, 50, 34257–34271
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    https://doi.org/10.1021/acsnano.4c12261
    Published December 4, 2024
    Copyright © 2024 American Chemical Society
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    Abstract

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    Electron–hole recombination and exogenous local hypoxia both impede the effectiveness of thermoelectric tumor catalytic therapy. Here, a thermoelectric heterojunction (Pt-TiO2–x/Ti3C2Tx-PEG) was developed to enhance charge carrier separation and alleviate tumor hypoxia. By incorporating titanium oxide with oxygen vacancies and platinum single atoms onto Ti3C2Tx MXene, we not only improve the charge separation efficiency but also prevent the recombination of positive and negative charges generated by the thermoelectric effect, leading to an increased production of reactive oxygen species (ROS). Furthermore, the Pt SAs exhibited excellent catalase-mimicking (CAT-mimicking) activity, catalyzing hydrogen peroxide to generate oxygen and alleviating the hypoxic tumor microenvironment. Titanium oxide with oxygen vacancies also serves as a sonosensitizer for sonodynamic therapy (SDT), enhancing ROS generation in collaboration with thermoelectric catalytic therapy. Moreover, the photothermal conversion efficiency of Pt-TiO2–x/Ti3C2Tx-PEG is augmented by Pt SAs with a surface plasmon resonance effect, further boosting CAT-mimicking activity and thermoelectric catalytic therapy efficacy. This tumor-specific thermoelectric heterojunction integrates thermoelectric therapy, SDT, and photothermal therapy, demonstrating excellent tumor suppression efficacy both in vitro and in vivo. Therefore, this study offers highly valuable and promising insights into utilizing photothermoelectric/ultrasound-mediated methods for cancer treatment.

    Copyright © 2024 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.4c12261.

    • Reagents; experimental apparatus; TEM images; PXRD patterns; AFM images; FTIR spectra; zeta potentials; hydrodynamic dimension; XPS spectra; UV–vis–NIR absorption spectra; infrared thermal images; EPR spectra; O2 generation; ESR spectra; degradation of MB; I–V curves; PF and thermal diffusivity; Mott–Schottky plots; energy bandgaps; confocal fluorescence images; relative cell viability; PA images of sO2; hemolysis analysis; in vivo thermal imaging; H&E-stained images; photothermal performance of various nanosystems; thermoelectric and electrical properties; and comparison of apoptosis ratio (PDF)

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    ACS Nano

    Cite this: ACS Nano 2024, 18, 50, 34257–34271
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsnano.4c12261
    Published December 4, 2024
    Copyright © 2024 American Chemical Society
    Request reuse permissions

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