Ultraflexible Neural Electrodes Enabled Synchronized Long-Term Dopamine Detection and Wideband Chronic Recording Deep in BrainClick to copy article linkArticle link copied!
- Xueying WangXueying WangState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Xueying Wang
- Mingliang XuMingliang XuShanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, ChinaSchool of Physical Sciences, University of Science and Technology of China, Hefei 230026, ChinaMore by Mingliang Xu
- Huiran YangHuiran YangState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Huiran Yang
- Wanqi JiangWanqi JiangState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Wanqi Jiang
- Jianbo JiangJianbo JiangState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Jianbo Jiang
- Dujuan ZouDujuan ZouSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, China2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaMore by Dujuan Zou
- Ziyi ZhuZiyi ZhuState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Ziyi Zhu
- Chen TaoChen TaoState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, ChinaMore by Chen Tao
- Siyuan NiSiyuan NiState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Siyuan Ni
- Zhitao ZhouZhitao ZhouState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Zhitao Zhou
- Liuyang SunLiuyang SunSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, China2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaMore by Liuyang Sun
- Meng LiMeng LiState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Meng Li
- Yanyan Nie
- Ying Zhao
- Fei He*Fei He*Email: [email protected]Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, ChinaMore by Fei He
- Tiger H. Tao*Tiger H. Tao*Email: [email protected]State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaCenter of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, ChinaCenter for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, ChinaNeuroxess Co., Ltd. (Jiangxi), Nanchang, Jiangxi 330029, ChinaGuangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, ChinaTianqiao and Chrissy Chen Institute for Translational Research, Shanghai 200031, ChinaMore by Tiger H. Tao
- Xiaoling Wei*Xiaoling Wei*Email: [email protected]State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaSchool of Graduate Study, University of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Xiaoling Wei
Abstract
Ultraflexible neural electrodes have shown superior stability compared with rigid electrodes in long-term in vivo recordings, owing to their low mechanical mismatch with brain tissue. It is desirable to detect neurotransmitters as well as electrophysiological signals for months in brain science. This work proposes a stable electronic interface that can simultaneously detect neural electrical activity and dopamine concentration deep in the brain. This ultraflexible electrode is modified by a nanocomposite of reduced graphene oxide (rGO) and poly(3,4-ethylenedioxythiophene):poly(sodium 4-styrenesulfonate) (rGO/PEDOT:PSS), enhancing the electrical stability of the coating and increasing its specific surface area, thereby improving the sensitivity to dopamine response with 15 pA/μM. This electrode can detect dopamine fluctuations and can conduct long-term, stable recordings of local field potentials (LFPs), spiking activities, and amplitudes with high spatial and temporal resolution across multiple regions, especially in deep brain areas. The electrodes were implanted into the brains of rodent models to monitor the changes in neural and electrochemical signals across different brain regions during the administration of nomifensine. Ten minutes after drug injection, enhanced neuronal firing activity and increased LFP power were detected in the motor cortex and deeper cortical layers, accompanied by a gradual rise in dopamine levels with 192 ± 29 nM. The in vivo recording consistently demonstrates chronic high-quality neural signal monitoring with electrochemical signal stability for up to 6 weeks. These findings highlight the high quality and stability of our electrophysiological/electrochemical codetection neural electrodes, underscoring their tremendous potential for applications in neuroscience research and brain–machine interfaces.
Cited By
This article has not yet been cited by other publications.
Article Views
Altmetric
Citations
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.