Exploration of Materials for Three-Dimensional NMR Microcoil Production via CNC Micromilling and Laser EtchingClick to copy article linkArticle link copied!
- Vincent Moxley-PaquetteVincent Moxley-PaquetteEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Vincent Moxley-Paquette
- Jacob PellizzariJacob PellizzariEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Jacob Pellizzari
- Daniel LaneDaniel LaneEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Daniel Lane
- Katrina SteinerKatrina SteinerEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Katrina Steiner
- Peter M. CostaPeter M. CostaEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Peter M. Costa
- William W. WolffWilliam W. WolffEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by William W. Wolff
- Daniel H. LysakDaniel H. LysakEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Daniel H. Lysak
- Rajshree Ghosh BiswasRajshree Ghosh BiswasEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Rajshree Ghosh Biswas
- Katelyn DowneyKatelyn DowneyEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Katelyn Downey
- Kiera RondaKiera RondaEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Kiera Ronda
- Ronald SoongRonald SoongEnvironmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by Ronald Soong
- Dmitri ZverevDmitri ZverevNSCNC Manufacturing LTD, 19358 96 Ave, Unit 150, Surrey, British Colombia V4N 4C1, CanadaMore by Dmitri Zverev
- Peter De CastroPeter De CastroBruker BioSpin AG, Industriestrasse 26, 8117 Fällanden, SwitzerlandMore by Peter De Castro
- Thomas Frei
- Danijela Al Adwan-StojilkovicDanijela Al Adwan-StojilkovicBruker BioSpin AG, Industriestrasse 26, 8117 Fällanden, SwitzerlandMore by Danijela Al Adwan-Stojilkovic
- Stephan Graf
- Simon Gloor
- Daniel SchmidigDaniel SchmidigBruker BioSpin AG, Industriestrasse 26, 8117 Fällanden, SwitzerlandMore by Daniel Schmidig
- Rainer KuemmerleRainer KuemmerleBruker BioSpin AG, Industriestrasse 26, 8117 Fällanden, SwitzerlandMore by Rainer Kuemmerle
- Till Kuehn
- Falko Busse
- Nathan HabererNathan HabererAidlab, 651 N., Broad St., Suite 201, Middletown, Delaware 19709, United StatesMore by Nathan Haberer
- Jakub DomaszewiczJakub DomaszewiczAidlab, 651 N., Broad St., Suite 201, Middletown, Delaware 19709, United StatesMore by Jakub Domaszewicz
- Ryan ScatenaRyan ScatenaThermal Conductive Bonding Inc., 6210 88th Street, Sacramento, California 95828, United StatesMore by Ryan Scatena
- Andressa LacerdaAndressa LacerdaSynex Medical, 2 Bloor Street E, Suite 310, Toronto, ON M4W 1A8, CanadaMore by Andressa Lacerda
- Ben NashmanBen NashmanSynex Medical, 2 Bloor Street E, Suite 310, Toronto, ON M4W 1A8, CanadaMore by Ben Nashman
- Jens Anders
- Marcel UtzMarcel UtzSchool of Chemistry, University of Southampton, Southampton SO17 1BJ, U.K.More by Marcel Utz
- André J. Simpson*André J. Simpson*Email: [email protected]Environmental NMR Center, University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, CanadaMore by André J. Simpson
Abstract
The excellent versatility of 5-axis computer numerical control (CNC) micromilling has led to its application for prototyping NMR microcoils tailored to mass-limited samples (reducing development time and cost). However, vibrations during 5-axis milling can hinder the creation of complex 3D volume microcoils (i.e., solenoids and saddle coils). To address these limitations, a high-resolution NSCNC ELARA 4-axis milling machine was developed with the extra precision required for making complex 3D volume microcoils. Upon investigating the performance of resonators made with various copper-coated dielectrics, resonators with poly(methyl methacrylate) (PMMA) provided the best SNR/line shape. Thus, complex 1.7 mm microcoil designs were machined from Cu-coated PMMA. A milled 6.4 mm solenoid also provided 6.6× the total carbon signal for a 13C-labeled broccoli seed compared to a commercial inverse 5 mm NMR probe (demonstrating potential for larger coil designs). However, the manufacture of coils <1.7 mm with copper-coated PMMA rods was challenging as ∼0.5 mm of remaining PMMA was needed to retain their structural integrity. To manufacture smaller microcoils, both a solenoid and saddle coil (both with 1 mm O.D., 0.1 mm thick walls) were etched from Cu-coated glass capillaries using a UV picosecond laser that was mounted onto an NSCNC 5-axis MiRA7L. Both resonators showed excellent signal and identified a wide range of metabolites in a 13C-labeled algae extract, while the solenoid was further tested on two copepod egg sacs (∼4 μg of total sample). In summary, the flexibility to prototype complex microcoils in-house allows laboratories to tailor microcoils to specific mass-limited samples while avoiding the costs of cleanrooms.
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