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Overlooked Iodo-Disinfection Byproduct Formation When Cooking Pasta with Iodized Table Salt
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    Contaminants in Aquatic and Terrestrial Environments

    Overlooked Iodo-Disinfection Byproduct Formation When Cooking Pasta with Iodized Table Salt
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    • Huiyu Dong
      Huiyu Dong
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
      Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
      More by Huiyu Dong
    • Ilona D. Nordhorn
      Ilona D. Nordhorn
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
      Institute of Inorganic and Analytical Chemistry, University of Muenster, Muenster D-48149, Germany
    • Karsten Lamann
      Karsten Lamann
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
      Institute of Inorganic and Analytical Chemistry, University of Muenster, Muenster D-48149, Germany
    • Danielle C. Westerman
      Danielle C. Westerman
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
    • Hannah K. Liberatore
      Hannah K. Liberatore
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
      Currently at Center for Environmental Measurement and Modeling, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park North Carolina 27711, United States
    • Alexandria L. B. Forster
      Alexandria L. B. Forster
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
    • Md. Tareq Aziz
      Md. Tareq Aziz
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
    • Susan D. Richardson*
      Susan D. Richardson
      Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States
      *Email: [email protected]. Tel: +1-803-777-6932.
    Other Access OptionsSupporting Information (1)

    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2023, 57, 9, 3538–3548
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    https://doi.org/10.1021/acs.est.2c05234
    Published February 20, 2023
    Copyright © 2023 American Chemical Society

    Abstract

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    Iodized table salt provides iodide that is essential for health. However, during cooking, we found that chloramine residuals in tap water can react with iodide in table salt and organic matter in pasta to form iodinated disinfection byproducts (I-DBPs). While naturally occurring iodide in source waters is known to react with chloramine and dissolved organic carbon (e.g., humic acid) during the treatment of drinking water, this is the first study to investigate I-DBP formation from cooking real food with iodized table salt and chloraminated tap water. Matrix effects from the pasta posed an analytical challenge, necessitating the development of a new method for sensitive and reproducible measurements. The optimized method utilized sample cleanup with Captiva EMR-Lipid sorbent, extraction with ethyl acetate, standard addition calibration, and analysis using gas chromatography (GC)–mass spectrometry (MS)/MS. Using this method, seven I-DBPs, including six iodo-trihalomethanes (I-THMs) and iodoacetonitrile, were detected when iodized table salt was used to cook pasta, while no I-DBPs were formed with Kosher or Himalayan salts. Total I-THM levels of 11.1 ng/g in pasta combined with cooking water were measured, with triiodomethane and chlorodiiodomethane dominant, at 6.7 and 1.3 ng/g, respectively. Calculated cytotoxicity and genotoxicity of I-THMs for the pasta with cooking water were 126- and 18-fold, respectively, compared to the corresponding chloraminated tap water. However, when the cooked pasta was separated (strained) from the pasta water, chlorodiiodomethane was the dominant I-THM, and lower levels of total I-THMs (retaining 30% of the I-THMs) and calculated toxicity were observed. This study highlights an overlooked source of exposure to toxic I-DBPs. At the same time, the formation of I-DBPs can be avoided by boiling the pasta without a lid and adding iodized salt after cooking.

    Copyright © 2023 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.est.2c05234.

    • Additional details on evaluation and determination of matrix effects, MRM parameters, I-THM physicochemical constants, calculated cytotoxicity and genotoxicity of I-THMs, I-THM structures, effect of quenching agent on I-THM concentrations, GC-MS chromatograms, effect of solvent on extract cleanup, I-THM peak area under SIM and MRM, quantification curves and results by standard addition approach, I-THM distribution, and decrease of I-THMs during heating water, with accompanying texts, tables, and figures (PDF)

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    Cited By

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    This article is cited by 5 publications.

    1. Shunke Ding, Zhenqi Du, Ruixin Qu, Menglin Wu, Rong Xiao, Pin Wang, Xiaoyan Chen, Wenhai Chu. Reactivity, Pathways, and Iodinated Disinfection Byproduct Formation during Chlorination of Iodotyrosines Derived from Edible Seaweed. Environmental Science & Technology 2024, 58 (40) , 17999-18008. https://doi.org/10.1021/acs.est.4c03542
    2. Susan D. Richardson, Tarek Manasfi. Water Analysis: Emerging Contaminants and Current Issues. Analytical Chemistry 2024, 96 (20) , 8184-8219. https://doi.org/10.1021/acs.analchem.4c01423
    3. Li Mou, Daguang Sun, Jiayuan Qu, Xiaoyin Tan, Suli Wang, Qiang Zeng, Changjiang Liu. GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline. Journal of Hazardous Materials 2024, 476 , 135101. https://doi.org/10.1016/j.jhazmat.2024.135101
    4. Yan Liu, Jia Ni, Kai Ye, Guiying He, Zan Sheng, Yang Pan, Mengting Yang. DBPs in Food and Cooking. 2024, 333-356. https://doi.org/10.1007/698_2024_1162
    5. Yuan Zhuang, Yujia Gao, Baoyou Shi. Iron particles lower than 10 μm in drinking water dominate particle catalysis effect on disinfection byproduct formation. Water Research 2023, 245 , 120634. https://doi.org/10.1016/j.watres.2023.120634

    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2023, 57, 9, 3538–3548
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.est.2c05234
    Published February 20, 2023
    Copyright © 2023 American Chemical Society

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