Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Flavonolignans and Other Constituents from Lepidium meyenii with Activities in Anti-inflammation and Human Cancer Cell Lines

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2015, 63, 9, 2458-2463
    Article

    Flavonolignans and Other Constituents from Lepidium meyenii with Activities in Anti-inflammation and Human Cancer Cell Lines
    Click to copy article linkArticle link copied!

    View Author Information
    † Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Pharmaceutical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi, China 710069
    ‡ Herbalife International, 950 West 190th Street, Torrance, California 90502, United States
    # Naturex SA, Site d’Agroparc B.P. 1218, 84911 Avignon Cedex 9, France
    § Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan
    *(N.B.) Phone: 0086-29-88305682. Fax: 0086-29-88302223. E-mail: [email protected]
    Other Access Options

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2015, 63, 9, 2458–2463
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.5b00219
    Published February 10, 2015
    Copyright © 2015 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    From the roots of Lepidium meyenii Walpers (Brassicaceae) have been isolated and identified 2 flavonolignans, tricin 4′-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (1) and tricin 4′-O-(erythro-β-guaiacyl-glyceryl) ether (2), along with 11 other known compounds, tricin (3), pinoresinol (4), 4-hydroxycinnamic acid (5), guanosine (6), glucotropaeolin (7), desulfoglucotropaeolin (8), 3-hydroxybenzylisothiocyanate (9), malic acid benzoate (10), 5-(hydroxymethyl)-2-furfural (11), d-phenylalanine (12), and vanillic acid 4-O-β-d-glucoside (13). Structures were elucidated on the basis of NMR and MS data. Some isolates and previously isolated lepidiline B (14) were tested for cytotoxicity in a small panel of human cancer cell lines (Hep G2, COLO 205, and HL-60) and for anti-inflammatory activities in LPS-treated RAW 264.7 macrophage. Among them, compounds 1 and 14 were modestly active for inhibiting nitrite production in macrophage. Compounds 1, 14, and 3 were demonstrated to be selectively active against HL-60 cells with IC50 values of 40.4, 52.0, and 52.1 μM, respectively.

    Copyright © 2015 American Chemical Society

    Subjects

    what are subjects

    Keywords

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 73 publications.

    1. Kartiko Arif Purnomo, Michal Korinek, Yi-Hong Tsai, Hao-Chun Hu, Yi-Hsuan Wang, Anders Backlund, Tsong-Long Hwang, Bing-Hung Chen, Shih-Wei Wang, Chin-Chung Wu, Fang-Rong Chang. Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti-inflammatory, Anti-thrombotic, and Pro-angiogenic Activities. Journal of Agricultural and Food Chemistry 2021, 69 (40) , 11856-11866. https://doi.org/10.1021/acs.jafc.1c03485
    2. Hung-Tse Huang, Chia-Ching Liaw, Chun-Tang Chiou, Yao-Haur Kuo, Kung-Ta Lee. Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway. Journal of Agricultural and Food Chemistry 2021, 69 (22) , 6271-6280. https://doi.org/10.1021/acs.jafc.1c01810
    3. Sihou Yang, Xiaochun Sun, Yumei Gao, Rui Chen. Differentiation of Lepidium meyenii (Maca) from Different Origins by Electrospray Ionization Mass Spectrometry with Principal Component Analysis. ACS Omega 2019, 4 (15) , 16493-16500. https://doi.org/10.1021/acsomega.9b02128
    4. Bini Wang, Yuanyuan Hui, Longgang Liu, Aiqing Zhao, Yi-Shiou Chiou, Fuxin Zhang, Min-Hsiung Pan. Optimized Extraction of Phenolics from Jujube Peel and Their Anti-inflammatory Effects in LPS-Stimulated Murine Macrophages. Journal of Agricultural and Food Chemistry 2019, 67 (6) , 1666-1673. https://doi.org/10.1021/acs.jafc.8b06309
    5. Min Zhou, Hang-Ying Ma, Zhi-Hua Liu, Guang-Yu Yang, Gang Du, Yan-Qing Ye, Gan-Peng Li, and Qiu-Fen Hu . (+)-Meyeniins A–C, Novel Hexahydroimidazo[1,5-c]thiazole Derivatives from the Tubers of Lepidium meyenii: Complete Structural Elucidation by Biomimetic Synthesis and Racemic Crystallization. Journal of Agricultural and Food Chemistry 2017, 65 (9) , 1887-1892. https://doi.org/10.1021/acs.jafc.6b05805
    6. Quan Liu, Chenghui Wu, Aifeng Peng, Kun Gao, Jianjun Chen, Ya Li, and Hua Fu . Flavonolignans from Elymus natans L. and Phytotoxic Activities. Journal of Agricultural and Food Chemistry 2017, 65 (7) , 1320-1327. https://doi.org/10.1021/acs.jafc.6b04162
    7. Mengmeng Zhang, Wenjia Wu, Yao Ren, Xiaofeng Li, Yuqian Tang, Tian Min, Furao Lai, and Hui Wu . Structural Characterization of a Novel Polysaccharide from Lepidium meyenii (Maca) and Analysis of Its Regulatory Function in Macrophage Polarization in Vitro. Journal of Agricultural and Food Chemistry 2017, 65 (6) , 1146-1157. https://doi.org/10.1021/acs.jafc.6b05218
    8. Mengmeng Zhang, Guang Wang, Furao Lai, and Hui Wu . Structural Characterization and Immunomodulatory Activity of a Novel Polysaccharide from Lepidium meyenii. Journal of Agricultural and Food Chemistry 2016, 64 (9) , 1921-1931. https://doi.org/10.1021/acs.jafc.5b05610
    9. Norka Ulloa del Carpio, Diego Alvarado-Corella, Dante M. Quiñones-Laveriano, Andrea Araya-Sibaja, José Vega-Baudrit, Maria Monagas-Juan, Mirtha Navarro-Hoyos, Martha Villar-López. Exploring the chemical and pharmacological variability of Lepidium meyenii: a comprehensive review of the effects of maca. Frontiers in Pharmacology 2024, 15 https://doi.org/10.3389/fphar.2024.1360422
    10. Haitham Al-Madhagi, Abd Alraouf Tarabishi. Nutritional aphrodisiacs: Biochemistry and Pharmacology. Current Research in Food Science 2024, 9 , 100783. https://doi.org/10.1016/j.crfs.2024.100783
    11. Carlos Henrique Corrêa dos Santos, Pauline Stark, Paride Rizzo, Katrin Franke, Ludger Wessjohann. Prenylated acylphloroglucinol alcohols and peroxides from Hypericum coris. Phytochemistry Letters 2023, 57 , 11-15. https://doi.org/10.1016/j.phytol.2023.07.011
    12. Naser-Aldin Lashgari, Nazanin M. Roudsari, Saeideh Momtaz, Amir H. Abdolghaffari, Stephen L. Atkin, Amirhossein Sahebkar. Regulatory Mechanisms of Vanillic Acid in Cardiovascular Diseases: A Review. Current Medicinal Chemistry 2023, 30 (22) , 2562-2576. https://doi.org/10.2174/0929867329666220831152608
    13. Shen Rao, Xin Cong, Haodong Liu, Yili Hu, Wei Yang, Hua Cheng, Shuiyuan Cheng, Yue Zhang. Revealing the Phenolic Acids in Cardamine violifolia Leaves by Transcriptome and Metabolome Analyses. Metabolites 2022, 12 (11) , 1024. https://doi.org/10.3390/metabo12111024
    14. Luz Quispe-Sanchez, Marilu Mestanza, Malluri Goñas, Elizabeth Renee Ambler Gill, Manuel Oliva-Cruz, Segundo G. Chavez. Physical, functional and sensory properties of bitter chocolates with incorporation of high nutritional value flours. Frontiers in Nutrition 2022, 9 https://doi.org/10.3389/fnut.2022.990887
    15. Mercedes Peña, Ana Guzmán, Rosario Martínez, Cristina Mesas, Jose Prados, Jesús M. Porres, Consolación Melguizo. Preventive effects of Brassicaceae family for colon cancer prevention: A focus on in vitro studies. Biomedicine & Pharmacotherapy 2022, 151 , 113145. https://doi.org/10.1016/j.biopha.2022.113145
    16. Olga Zaytseva, Meylin Terrel Gutierrez, Simone Graeff-Hönninger. Effect of Day Length on Growth and Root Morphology of Yellow Maca (Lepidium meyenii) Seedlings. International Journal of Plant Biology 2022, 13 (2) , 71-81. https://doi.org/10.3390/ijpb13020008
    17. Hanlei Wang, Ran Zhang, Kun Zhang, Xuelin Chen, Yumei Zhang. Antioxidant, Hypoglycemic and Molecular Docking Studies of Methanolic Extract, Fractions and Isolated Compounds from Aerial Parts of Cymbopogon citratus (DC.) Stapf. Molecules 2022, 27 (9) , 2858. https://doi.org/10.3390/molecules27092858
    18. Raquely M. Lenzi, Luciano H. Campestrini, Simone C. Semprebon, Jonas A.R. Paschoal, Monique A.G. Silva, Selma F. Zawadzki-Baggio, Mário S. Mantovani, Carmen L.O. Petkowicz, Juliana B.B. Maurer. Glucosinolate-Enriched Fractions from Maca ( Lepidium meyenii ) Exert Myrosinase-Dependent Cytotoxic Effects against HepG2/C3A and HT29 Tumor Cell Lines. Nutrition and Cancer 2022, 74 (4) , 1322-1337. https://doi.org/10.1080/01635581.2021.1952444
    19. Kainan Song, Meichen Li, Yuqian Yang, Zhe Zhang, Qing Zhu, Jianyu Liu, Andong Wang. Natural flavonolignans as potential therapeutic agents against common diseases. Journal of Pharmacy and Pharmacology 2022, 74 (3) , 337-350. https://doi.org/10.1093/jpp/rgab159
    20. Daniela Bizinelli, Fernanda Flores Navarro, Flavia Lima Costa Faldoni. Maca Root ( Lepidium meyenii ) Extract Increases the Expression of MMP-1 and Stimulates Migration of Triple-Negative Breast Cancer Cells. Nutrition and Cancer 2022, 74 (1) , 346-356. https://doi.org/10.1080/01635581.2021.1882511
    21. Velislava Todorova, Kalin Ivanov, Stanislava Ivanova. Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng). Plants 2022, 11 (1) , 64. https://doi.org/10.3390/plants11010064
    22. Rui Chen, Jinchao Wei, Yumei Gao. A review of the study of active components and their pharmacology value in Lepidium meyenii (Maca). Phytotherapy Research 2021, 35 (12) , 6706-6719. https://doi.org/10.1002/ptr.7257
    23. Serol KORKMAZ, Ayşe PARMAKSIZ, Ahmet SAİT, Burcu İrem OMURTAG KORKMAZ. The effects of solutions of maca (Lepidium meyenii) powder as a food/feed supplement on the viability of murine macrophage cells by digital image analysis. Journal of Advances in VetBio Science and Techniques 2021, 6 (2) , 116-120. https://doi.org/10.31797/vetbio.934630
    24. Xing-Rong Peng, Yan-Jie Huang, Jun-Hong Liu, Ran-Ran Zhang, Zhong-Rong Li, Lin Zhou, Ming-Hua Qiu. 1H qNMR-based quantitative analysis of total macamides in five maca (Lepidium meyenii Walp.) dried naturally. Journal of Food Composition and Analysis 2021, 100 , 103917. https://doi.org/10.1016/j.jfca.2021.103917
    25. Yue Cao, Yichao Zang, Xinyue Huang, Zhihong Cheng. Chemical constituents from Artemisia rupestris and their neuraminidase inhibitory activity. Natural Product Research 2021, 35 (11) , 1775-1782. https://doi.org/10.1080/14786419.2019.1639178
    26. Fatemeh Mirzaee, Hamidreza Mohammadi, Sahar Azarpeik, Fereshteh Talebpour Amiri, Somayeh Shahani. Attenuation of liver mitochondrial oxidative damage by the extract and desulfo glucosinolate fraction of Lepidium perfoliatum L. seeds. South African Journal of Botany 2021, 138 , 377-385. https://doi.org/10.1016/j.sajb.2021.01.011
    27. Consuelo J. Perez, Rodrigo S. Conceição, Demian R. Ifa. Chemical profiling and separation of bioactive secondary metabolites in Maca ( Lepidium peruvianum ) by normal and reverse phase thin layer chromatography coupled to desorption electrospray ionization‐mass spectrometry. Journal of Mass Spectrometry 2021, 56 (2) https://doi.org/10.1002/jms.4690
    28. Tingting Feng, Simin Qiu, Guiliang Tan, Dongmei Tian, Daming Wu, Lin Zhou, Maoxun Yang, Shuang Zhu. Identification of Suitable Barcodes for Specifically Detecting Adulterants of Turnip (Brassica rapa) and Radish (Raphanus sativus) in Maca (Lepidium meyenii). Food Analytical Methods 2021, 14 (1) , 66-73. https://doi.org/10.1007/s12161-020-01857-6
    29. Ling Fu, Jinchao Wei, Yumei Gao, Rui Chen. Antioxidant and antitumoral activities of isolated macamide and macaene fractions from Lepidium meyenii (Maca). Talanta 2021, 221 , 121635. https://doi.org/10.1016/j.talanta.2020.121635
    30. Ah-Reum Han, Yun-Seo Kil, Min Jeong Hong, Jisu Park, Hyeon Hwa Park, Chang Hyun Jin, Joo-Won Nam, Jin-Baek Kim. Anti-Inflammatory Flavonolignans from Triticum aestivum Linn. Hull. Applied Sciences 2020, 10 (23) , 8656. https://doi.org/10.3390/app10238656
    31. Giorgio Dell’Acqua, Aleksander Richards, M. Julie Thornton. The Potential Role of Nutraceuticals as an Adjuvant in Breast Cancer Patients to Prevent Hair Loss Induced by Endocrine Therapy. Nutrients 2020, 12 (11) , 3537. https://doi.org/10.3390/nu12113537
    32. Diana S. Antal, Florina Ardelean, Stefana Avram, Ioana Z. Pavel, Corina Danciu, Codruta Soica, Cristina Dehelean. Flavonolignans: One Step Further in the Broad-Spectrum Approach of Cancer. Anti-Cancer Agents in Medicinal Chemistry 2020, 20 (15) , 1817-1830. https://doi.org/10.2174/1871520620666200124112649
    33. Luz María Paucar-Menacho, Elena Peñas, Blanca Hernandez-Ledesma, Juana Frias, Cristina Martínez-Villaluenga. A comparative study on the phenolic bioaccessibility, antioxidant and inhibitory effects on carbohydrate-digesting enzymes of maca and mashua powders. LWT 2020, 131 , 109798. https://doi.org/10.1016/j.lwt.2020.109798
    34. Samantha Drouet, Duangjai Tungmunnithum, Éric Lainé, Christophe Hano. Gene Expression Analysis and Metabolite Profiling of Silymarin Biosynthesis during Milk Thistle (Silybum marianum (L.) Gaertn.) Fruit Ripening. International Journal of Molecular Sciences 2020, 21 (13) , 4730. https://doi.org/10.3390/ijms21134730
    35. Beatriz Pereira Moreno, Gislaine Cristiane Mantovanelli, Letycia Lopes Ricardo, Adriano Antônio Silva, Rubem Silvério De Oliveira, Emy Luiza Ishii‐Iwamoto, Maria Helena Sarragiotto, Debora Cristina Baldoqui. Chemical Characterization and Phytotoxic Effects of the Aerial Parts of Ruzigrass ( Urochloa ruziziensis ). Chemistry & Biodiversity 2020, 17 (3) https://doi.org/10.1002/cbdv.201900694
    36. Natália da Silva Leitão Peres, Letícia Cabrera Parra Bortoluzzi, Leila Larisa Medeiros Marques, Maysa Formigoni, Renata Hernandez Barros Fuchs, Adriana Aparecida Droval, Flávia Aparecida Reitz Cardoso. Medicinal effects of Peruvian maca ( Lepidium meyenii ): a review. Food & Function 2020, 11 (1) , 83-92. https://doi.org/10.1039/C9FO02732G
    37. Kamal Niaz, Fazlullah Khan. Analysis of polyphenolics. 2020, 39-197. https://doi.org/10.1016/B978-0-12-816455-6.00003-2
    38. Lan Li, Mei-Ping Xie, Hua Sun, An-Qi Lu, Bo Zhang, Dan Zhang, Su-Juan Wang. Bioactive phenolic acid-substituted glycoses and glycosides from rhizomes of Cibotium barometz. Journal of Asian Natural Products Research 2019, 21 (10) , 947-953. https://doi.org/10.1080/10286020.2018.1563076
    39. Yan-Qing Ye, Zu-Hong Ma, Qiao-Fen Yang, Yan-Qi Sun, Rui-Qi Zhang, Run-Fang Wu, Xin Ren, Li-Juan Mu, Zhi-Yong Jiang, Min Zhou. Isolation and synthesis of a new benzylated alkamide from the roots of Lepidium meyenii. Natural Product Research 2019, 33 (19) , 2731-2737. https://doi.org/10.1080/14786419.2018.1499633
    40. Siu W. Tang, Wayne H. Tang, Brian E. Leonard. Herbal medicine for psychiatric disorders: Psychopharmacology and neuroscience-based nomenclature. The World Journal of Biological Psychiatry 2019, 20 (8) , 586-604. https://doi.org/10.1080/15622975.2017.1346279
    41. Sunan Wang, Fan Zhu. Chemical composition and health effects of maca (Lepidium meyenii). Food Chemistry 2019, 288 , 422-443. https://doi.org/10.1016/j.foodchem.2019.02.071
    42. Wen-Da Duan, Gao-Hong Wang, Xiao-Feng Liu, Xin-Yi Huang, Dong Pei, Jian-Fei Liu, Duo-Long Di. Rapid screening and separating two radical scavengers in Lycium barbarum L. by DPPH-HPLC analysis-combined dual-mode high-speed countercurrent chromatography. Separation Science and Technology 2019, 54 (11) , 1787-1794. https://doi.org/10.1080/01496395.2018.1553979
    43. Meichen Li, Yanhua Fan, Ting Zhong, Ping Yi, Chengcheng Fan, Andong Wang, Jianyu Liu, Yongnan Xu. The protective effects of vernicilignan A, a new flavonolignan isolated from Toxicodendron vernicifluum on SH-SY5Y cells against oxidative stress-induced injury. Fitoterapia 2019, 134 , 81-87. https://doi.org/10.1016/j.fitote.2019.01.011
    44. Aya N. Talaat, Sherif S. Ebada, Rola M. Labib, Ahmed Esmat, Fadia S. Youssef, Abdel Nasser B. Singab. Verification of the anti-inflammatory activity of the polyphenolic-rich fraction of Araucaria bidwillii Hook. using phytohaemagglutinin-stimulated human peripheral blood mononuclear cells and virtual screening. Journal of Ethnopharmacology 2018, 226 , 44-47. https://doi.org/10.1016/j.jep.2018.07.026
    45. Yujuan Li, Yizhou Xin, Fangxue Xu, Mengmeng Zheng, Xiaozhi Xi, Xiaowei Cui, Hui Cao, Hong Guo, Chunchao Han. Maca polysaccharides: Extraction optimization, structural features and anti-fatigue activities. International Journal of Biological Macromolecules 2018, 115 , 618-624. https://doi.org/10.1016/j.ijbiomac.2018.04.063
    46. Hui-Chun Geng, Dong-Shun Yang, Xing-Lian Chen, Lu-Xiang Wang, Min Zhou, Wen-Quan Mei. Meyeniihydantoins A–C, three novel hydantoin derivatives from the roots of Lepidium meyenii Walp.. Phytochemistry Letters 2018, 26 , 208-211. https://doi.org/10.1016/j.phytol.2018.06.010
    47. XiaoXue Tian, XingRong Peng, MuYuan Yu, YanJie Huang, Xia Wang, Lin Zhou, Minghua Qiu. Hydantoin and thioamide analogues from Lepidium meyenii. Phytochemistry Letters 2018, 25 , 70-73. https://doi.org/10.1016/j.phytol.2018.03.011
    48. Yujuan Li, Fangxue Xu, Mengmeng Zheng, Xiaozhi Xi, Xiaowei Cui, Chunchao Han. Maca polysaccharides: A review of compositions, isolation, therapeutics and prospects. International Journal of Biological Macromolecules 2018, 111 , 894-902. https://doi.org/10.1016/j.ijbiomac.2018.01.059
    49. Sabrin R.M. Ibrahim, Hossam M. Abdallah, Ali M. El-Halawany, Ahmed Esmat, Gamal A. Mohamed. Thiotagetin B and tagetannins A and B, new acetylenic thiophene and digalloyl glucose derivatives from Tagetes minuta and evaluation of their in vitro antioxidative and anti-inflammatory activity. Fitoterapia 2018, 125 , 78-88. https://doi.org/10.1016/j.fitote.2017.12.024
    50. Janggyoo Choi, Kee Dong Yoon, Jinwoong Kim. Chemical constituents from Taraxacum officinale and their α-glucosidase inhibitory activities. Bioorganic & Medicinal Chemistry Letters 2018, 28 (3) , 476-481. https://doi.org/10.1016/j.bmcl.2017.12.014
    51. Quan Gao, Xia-Bing Li, Jia Sun, Er-Dong Xia, Feng Tang, Hai-Qun Cao, Hang Xun. Isolation and identification of new chemical constituents from Chinese chive (Allium tuberosum) and toxicological evaluation of raw and cooked Chinese chive. Food and Chemical Toxicology 2018, 112 , 400-411. https://doi.org/10.1016/j.fct.2017.02.011
    52. Daren Qiu, Jie Guo, Huimei Yu, Jiao Yan, Shengxiang Yang, Xiang Li, Yamei Zhang, Jinzhu Sun, Jie Cong, Shuliang He, Dongsheng Wei, Jian-Chun Qin. Antioxidant phenolic compounds isolated from wild Pyrus ussuriensis Maxim. fruit peels and leaves. Food Chemistry 2018, 241 , 182-187. https://doi.org/10.1016/j.foodchem.2017.08.072
    53. Min Zhou, Rui-Qi Zhang, Yan-Jun Chen, Ling-Min Liao, Yan-Qi Sun, Zu-Hong Ma, Qiao-Fen Yang, Ping Li, Yan-Qing Ye, Qiu-Fen Hu. Three new pyrrole alkaloids from the roots of Lepidium meyenii. Phytochemistry Letters 2018, 23 , 137-140. https://doi.org/10.1016/j.phytol.2017.12.002
    54. Caicai Kang, Liming Zhang, Limin Hao, Huanhuan Ge, Meng Xu, Jie Cao, Jianyong Yu, Yongwu Yang. Response Surface Methodology Optimization Extraction of Polysaccharides from Maca (Lepidium meyenii) Leaves and Primary Characterization. 2018, 213-224. https://doi.org/10.1007/978-981-10-4801-2_22
    55. Gustavo F. Gonzales, Dulce E. Alarcón-Yaquetto. Maca, A Nutraceutical From the Andean Highlands. 2018, 373-395. https://doi.org/10.1016/B978-0-12-811517-6.00012-X
    56. Wenwen Jin, Xuemin Chen, Qing Huo, Yajie Cui, Zejun Yu, Longjiang Yu. Aerial parts of maca ( Lepidium meyenii Walp.) as functional vegetables with gastrointestinal prokinetic efficacy in vivo. Food & Function 2018, 9 (6) , 3456-3465. https://doi.org/10.1039/C8FO00405F
    57. Yujuan Li, Shiyuan Wang, Yizhou Xin, Mengmeng Zheng, Fangxue Xu, Xiaozhi Xi, Hui Cao, Xiaowei Cui, Hong Guo, Chunchao Han. Maca Cosmetics: A Review on Constituents, Therapeutics and Advantages. Journal of Oleo Science 2018, 67 (7) , 789-800. https://doi.org/10.5650/jos.ess18012
    58. Jin-jin Chen, Qing-sheng Zhao, Yi-lan Liu, Peng-fei Gong, Li-li Cao, Xiao-dong Wang, Bing Zhao. Macamides present in the commercial maca ( Lepidium meyenii ) products and the macamide biosynthesis affected by postharvest conditions. International Journal of Food Properties 2017, 20 (12) , 3112-3123. https://doi.org/10.1080/10942912.2016.1274905
    59. Denisse Nuñez, Paola Olavegoya, Gustavo F. Gonzales, Cynthia Gonzales-Castañeda. Red Maca ( Lepidium meyenii ), a Plant from the Peruvian Highlands, Promotes Skin Wound Healing at Sea Level and at High Altitude in Adult Male Mice. High Altitude Medicine & Biology 2017, 18 (4) , 372-383. https://doi.org/10.1089/ham.2017.0038
    60. Rui Zheng, Shan Su, Jianbin Li, Zhengang Zhao, Juan Wei, Xiong Fu, Rui Hai Liu. Recovery of phenolics from the ethanolic extract of sugarcane (Saccharum officinarum L.) baggase and evaluation of the antioxidant and antiproliferative activities. Industrial Crops and Products 2017, 107 , 360-369. https://doi.org/10.1016/j.indcrop.2017.05.050
    61. Barbara Tenci, Lorenzo Di Cesare Mannelli, Mario Maresca, Laura Micheli, Giuseppe Pieraccini, Nadia Mulinacci, Carla Ghelardini. Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats. Zeitschrift für Naturforschung C 2017, 72 (11-12) , 449-457. https://doi.org/10.1515/znc-2016-0251
    62. Tao Zhou, Yanci Yang, Yiheng Hu, Xiao Zhang, Guoqing Bai, Guifang Zhao. Characterization of the complete chloroplast genome sequence of Lepidium meyenii (Brassicaceae). Conservation Genetics Resources 2017, 9 (3) , 405-408. https://doi.org/10.1007/s12686-017-0695-3
    63. Mu-Yuan Yu, Xu-Jie Qin, Xing-Rong Peng, Xia Wang, Xiao-Xue Tian, Zhong-Rong Li, Ming-Hua Qiu. Macathiohydantoins B–K, novel thiohydantoin derivatives from Lepidium meyenii. Tetrahedron 2017, 73 (30) , 4392-4397. https://doi.org/10.1016/j.tet.2017.05.096
    64. Chao-Bo Zhang, Yang Liu, Zheng-Fen Liu, Sheng-Zu Duan, Min-Yan Li, Wen Chen, Yan Li, Hong-Bin Zhang, Xiao-Dong Yang. Synthesis and cytotoxic activity of novel tetrahydrobenzodifuran–imidazolium salt derivatives. Bioorganic & Medicinal Chemistry Letters 2017, 27 (8) , 1808-1814. https://doi.org/10.1016/j.bmcl.2017.02.053
    65. Weiyi Wang, Shanshan Li, Zhuo Chen, Zengpeng Li, Yanyan Liao, Jianming Chen. Secondary Metabolites Produced by the Deep-Sea-Derived Fungus Engyodontium album. Chemistry of Natural Compounds 2017, 53 (2) , 224-226. https://doi.org/10.1007/s10600-017-1957-8
    66. Weimin Tang, Lu Jin, Lianghua Xie, Juqing Huang, Nan Wang, Bingquan Chu, Xulin Dai, Yu Liu, Rui Wang, Ying Zhang. Structural Characterization and Antifatigue Effect In Vivo of Maca ( Lepidium meyenii Walp) Polysaccharide. Journal of Food Science 2017, 82 (3) , 757-764. https://doi.org/10.1111/1750-3841.13619
    67. Yu Pan, Ji Zhang, Hong Li, Yuan‐Zhong Wang, Wan‐Yi Li. Characteristic fingerprinting based on macamides for discrimination of maca ( Lepidium meyenii ) by LC/MS/MS and multivariate statistical analysis. Journal of the Science of Food and Agriculture 2016, 96 (13) , 4475-4483. https://doi.org/10.1002/jsfa.7660
    68. Wenwen Jin, Xuemin Chen, Pengfei Dai, Longjiang Yu. Lepidiline C and D: Two new imidazole alkaloids from Lepidium meyenii Walpers (Brassicaceae) roots. Phytochemistry Letters 2016, 17 , 158-161. https://doi.org/10.1016/j.phytol.2016.07.001
    69. Yu Pan, Ji Zhang, Hong Li, Yuan-Zhong Wang, Wan-Yi Li. Simultaneous Analysis of Macamides in Maca (Lepidium meyenii) with Different Drying Process by Liquid Chromatography Tandem Mass Spectrometry. Food Analytical Methods 2016, 9 (6) , 1686-1695. https://doi.org/10.1007/s12161-015-0346-9
    70. Yousof Tahtah, Sileshi G. Wubshet, Kenneth T. Kongstad, Allison Maree Heskes, Irini Pateraki, Birger Lindberg Møller, Anna K. Jäger, Dan Staerk. High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography–high-resolution mass spectrometry–solid-phase extraction–nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extract of Eremophila lucida. Fitoterapia 2016, 110 , 52-58. https://doi.org/10.1016/j.fitote.2016.02.008
    71. Zhigang Yang, Ryo Nakabayashi, Tetsuya Mori, Satoshi Takamatsu, Susumu Kitanaka, Kazuki Saito. Metabolome Analysis of Oryza sativa (Rice) Using Liquid Chromatography-Mass Spectrometry for Characterizing Organ Specificity of Flavonoids with Anti-inflammatory and Anti-oxidant Activity. CHEMICAL & PHARMACEUTICAL BULLETIN 2016, 64 (7) , 952-956. https://doi.org/10.1248/cpb.c16-00180
    72. Jin-Jin CHEN, Qing-Sheng ZHAO, Yi-Lan LIU, Sheng-Hua ZHA, Bing ZHAO. Identification of maca (Lepidium meyenii Walp.) and its adulterants by a DNA-barcoding approach based on the ITS sequence. Chinese Journal of Natural Medicines 2015, 13 (9) , 653-659. https://doi.org/10.1016/S1875-5364(15)30062-5
    73. Hossam M. Abdallah, Fahad M. Almowallad, Ahmed Esmat, Ibrahim A. Shehata, Essam A. Abdel-Sattar. Anti-inflammatory activity of flavonoids from Chrozophora tinctoria. Phytochemistry Letters 2015, 13 , 74-80. https://doi.org/10.1016/j.phytol.2015.05.008
    Download PDF
    Go to Journal of Agricultural and Food Chemistry
    Get e-Alerts
    Get e-Alerts

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2015, 63, 9, 2458–2463
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.5b00219
    Published February 10, 2015
    Copyright © 2015 American Chemical Society
    Request reuse permissions

    Article Views

    1763

    Altmetric

    -

    Citations

    73
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.