Are Plant-Based Carbohydrate Nanoparticles Safe for Inhalation? Investigating Their Interactions with the Pulmonary Surfactant Using Langmuir MonolayersClick to copy article linkArticle link copied!
- Laurianne Gravel-TattaLaurianne Gravel-TattaDépartement de Chimie, Université de Montréal, Complexe des Sciences, C.P. 6128, Succursale Centre-ville, Montréal, Quebec H3C 3J7, CanadaFRQNT Centre Québécois sur les Matériaux Fonctionnels−Quebec Centre for Advanced Materials, McGill University, 845 Sherbrooke Street West, Montréal, Quebec H3A 0G4, CanadaMore by Laurianne Gravel-Tatta
- Christine DeWolf*Christine DeWolf*Email: [email protected]Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University, 7141 Sherbrooke Street West, Montréal, Quebec H4B 1R6, CanadaFRQNT Centre Québécois sur les Matériaux Fonctionnels−Quebec Centre for Advanced Materials, McGill University, 845 Sherbrooke Street West, Montréal, Quebec H3A 0G4, CanadaMore by Christine DeWolf
- Antonella Badia*Antonella Badia*Email: [email protected]Département de Chimie, Université de Montréal, Complexe des Sciences, C.P. 6128, Succursale Centre-ville, Montréal, Quebec H3C 3J7, CanadaFRQNT Centre Québécois sur les Matériaux Fonctionnels−Quebec Centre for Advanced Materials, McGill University, 845 Sherbrooke Street West, Montréal, Quebec H3A 0G4, CanadaMore by Antonella Badia
Abstract
Nanoparticle carriers show promise for drug delivery, including by inhalation, where the first barrier for uptake in the lungs is the monolayer pulmonary surfactant membrane that coats the air/alveoli interface and is critical to breathing. It is imperative to establish the fate of potential nanocarriers and their effects on the biophysical properties of the pulmonary surfactant. To this end, the impact of the nanoparticle surface charge on the lateral organization, thickness, and recompressibility of Langmuir monolayers of model phospholipid-only and phospholipid–protein mixtures was investigated using native and modified forms of nanophytoglycogen, a carbohydrate-based dendritic polymer extracted from corn as monodisperse nanoparticles. We show that the native (quasi-neutral) and anionic nanophytoglycogens have little impact on the phase behavior and film properties. By contrast, cationic nanophytoglycogen alters the film morphology and increases the hysteresis associated with the work of breathing due to its electrostatic interaction with the anionic phospholipids in the model systems. These findings specifically highlight the importance of surface charge as a selection criterion for inhaled nanoformulations.
Cited By
This article is cited by 2 publications.
- Panagiota Taktikakis, Mathieu Côté, Nivetha Subramaniam, Kailen Kroeger, Hala Youssef, Antonella Badia, Christine DeWolf. Understanding the Retention of Vaping Additives in the Lungs: Model Lung Surfactant Membrane Perturbation by Vitamin E and Vitamin E Acetate. Langmuir 2024, 40
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, 5651-5662. https://doi.org/10.1021/acs.langmuir.3c02952
- Dalia A. Ali, Laura Domínguez Mercado, Brandon L. Findlay, Antonella Badia, Christine DeWolf. Opposites Attract: Electrostatically Driven Loading of Antimicrobial Peptides into Phytoglycogen Nanocarriers. Langmuir 2023, 39
(1)
, 53-63. https://doi.org/10.1021/acs.langmuir.2c01794
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