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Self-assembled Lyotropic Liquid Crystalline Phase Behavior of Monoolein–Capric Acid–Phospholipid Nanoparticulate Systems

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    Self-assembled Lyotropic Liquid Crystalline Phase Behavior of Monoolein–Capric Acid–Phospholipid Nanoparticulate Systems
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    † School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3000, Australia
    ‡ CSIRO Manufacturing, Clayton, Victoria 3168, Australia
    *(N.T.) School of Science, RMIT University, 124 La Trobe Street, Melbourne 3000, Victoria, Australia. Phone: +61 3 9925 2131. E-mail: [email protected]
    *(C.J.D.) School of Science, RMIT University, 124 La Trobe Street, Melbourne 3000, Victoria, Australia. Phone: +61 3 9925 4265. E-mail: [email protected]
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    Langmuir

    Cite this: Langmuir 2017, 33, 10, 2571–2580
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    https://doi.org/10.1021/acs.langmuir.6b04045
    Published February 13, 2017
    Copyright © 2017 American Chemical Society
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    Abstract

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    We report here the lyotropic liquid crystalline phase behavior of two lipid nanoparticulate systems containing mixtures of monoolein, capric acid, and saturated diacyl phosphatidylcholines dispersed by the Pluronic F127 block copolymer. Synchrotron small-angle X-ray scattering (SAXS) was used to screen the phase behavior of a library of lipid nanoparticles in a high-throughput manner. It was found that adding capric acid and phosphatidylcholines had opposing effects on the spontaneous membrane curvature of the monoolein lipid layer and hence the internal mesophase of the final nanoparticles. By varying the relative concentration of the three lipid components, we were able to establish a library of nanoparticles with a wide range of mesophases including at least the inverse bicontinuous primitive and double diamond cubic phases, the inverse hexagonal phase, the fluid lamellar phase, and possibly other phases. Furthermore, the in vitro cytotoxicity assay showed that the endogenous phospholipid-containing nanoparticles were less toxic to cultured cell lines compared to monoolein-based counterparts, improving the potential of the nonlamellar lipid nanoparticles for biomedical applications.

    Copyright © 2017 American Chemical Society

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.langmuir.6b04045.

    • Additional experimental methods for pH and particle size measurements; additional data include nanoparticle compositions, phase, and lattice parameter; pH measurement of nanoparticle solutions; nanoparticle hydrodynamic diameter in water and cell media; and representative SAXS profiles with peak identification method (PDF)

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    Langmuir

    Cite this: Langmuir 2017, 33, 10, 2571–2580
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.langmuir.6b04045
    Published February 13, 2017
    Copyright © 2017 American Chemical Society
    Request reuse permissions

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