Organocatalytic Enantioselective Arylation to Access Densely Aryl-Substituted P-Stereogenic CentersClick to copy article linkArticle link copied!
- Hui-Lin HuHui-Lin HuKey Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaMore by Hui-Lin Hu
- Siqiang FangSiqiang FangKey Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaMore by Siqiang Fang
- Xingjie LuoXingjie LuoKey Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaMore by Xingjie Luo
- Jiajia HeJiajia HeKey Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaMore by Jiajia He
- Jia-Hong WuJia-Hong WuKey Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaMore by Jia-Hong Wu
- Zhishan SuZhishan SuKey Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaMore by Zhishan Su
- Zhipeng Xu*Zhipeng Xu*[email protected]College of Water Resource and Hydropower, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. ChinaMore by Zhipeng Xu
- Tianli Wang*Tianli Wang*[email protected]Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaMore by Tianli Wang
Abstract

Although methods for synthesizing chiral phosphorus scaffolds are available, the potential of this molecular chirality remains largely unexplored. Herein, we present a remote desymmetrization of prochiral biaryl phosphine oxides through an organocatalytic asymmetric arylation. This metal-free approach enables the efficient synthesis of a wide range of densely functionalized P(V)-stereogenic compounds with good to excellent yields and satisfactory enantioselectivities. Mechanistic studies reveal that hydrogen bonding and ion-pairing interactions are crucial for achieving precise stereocontrol in this transformation.
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