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Surface-Grafted Zwitterionic Polymers Improve the Efficacy of a Single Antibiotic Injection in Suppressing Staphylococcus aureus Periprosthetic Infections

  • Ben Zhang
    Ben Zhang
    Department of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts 01655, United States
    More by Ben Zhang
  • Jordan D. Skelly
    Jordan D. Skelly
    Department of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts 01655, United States
  • Benjamin M. Braun
    Benjamin M. Braun
    Department of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts 01655, United States
  • David C. Ayers
    David C. Ayers
    Department of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts 01655, United States
  • , and 
  • Jie Song*
    Jie Song
    Department of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts 01655, United States
    *Email: [email protected]
    More by Jie Song
Cite this: ACS Appl. Bio Mater. 2020, 3, 9, 5896–5904
Publication Date (Web):September 2, 2020
https://doi.org/10.1021/acsabm.0c00600
Copyright © 2020 American Chemical Society

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    Abstract

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    Implant-associated bacterial infections are difficult to treat because of the tendency of biofilm formation on implant surfaces, which protects embedded pathogens from host defense and impedes antibiotic penetration, rendering systemic antibiotic injections ineffective. Here, we test the hypothesis that implant coatings that reduce bacterial colonization would make planktonic bacteria within the periprosthetic environment more susceptible to conventional systemic antibiotic treatment. We covalently grafted zwitterionic polymer brushes poly(sulfobetaine methacrylate) from the Ti6Al4V surface to increase the substrate surface hydrophilicity and reduce Staphylococcus aureus adhesion. Using a mouse femoral intramedullary (IM) canal infection model, we showed that the antifouling coating applied to Ti6Al4V IM implants, when combined with a single vancomycin systemic injection, significantly suppressed both the bacterial colonization on implant surfaces and the periprosthetic infections, outperforming either treatment alone. This work supports the hypothesis that grafting antifouling polymers to implant surfaces improves the efficacy of systemic antibiotic injections to combat periprosthetic infections.

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    Cited By

    This article is cited by 8 publications.

    1. Xin Xu, Yixin Chang, Yutong Gong, Yuhao Zhang, Ye Yu, Hui Peng, Changkui Fu. Recent Advances in Antifouling Surface Polymer Brushes. ACS Applied Polymer Materials 2024, 6 (1) , 1-27. https://doi.org/10.1021/acsapm.3c02150
    2. Chloe K. Herczeg, Jie Song. Sterilization of Polymeric Implants: Challenges and Opportunities. ACS Applied Bio Materials 2022, 5 (11) , 5077-5088. https://doi.org/10.1021/acsabm.2c00793
    3. Ananta Ghimire, Jie Song. Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings. ACS Applied Materials & Interfaces 2021, 13 (18) , 20921-20937. https://doi.org/10.1021/acsami.1c01389
    4. Xikuang Yao, Chao Qi, Changrui Sun, Fengwei Huo, Xiqun Jiang. Poly(ethylene glycol) alternatives in biomedical applications. Nano Today 2023, 48 , 101738. https://doi.org/10.1016/j.nantod.2022.101738
    5. Paolo Canepa, Danijela Gregurec, Nara Liessi, Silvia Maria Cristina Rotondi, Sergio Enrique Moya, Enrico Millo, Maurizio Canepa, Ornella Cavalleri. Biofunctionalization of Porous Titanium Oxide through Amino Acid Coupling for Biomaterial Design. Materials 2023, 16 (2) , 784. https://doi.org/10.3390/ma16020784
    6. Jingwei Yu, Minghao Zhou, Luxuan Zhang, Hongbo Wei. Antibacterial Adhesion Strategy for Dental Titanium Implant Surfaces: From Mechanisms to Application. Journal of Functional Biomaterials 2022, 13 (4) , 169. https://doi.org/10.3390/jfb13040169
    7. Brinta Bhattacharjee, Sreyan Ghosh, Dipanjana Patra, Jayanta Haldar. Advancements in release‐active antimicrobial biomaterials: A journey from release to relief. WIREs Nanomedicine and Nanobiotechnology 2022, 14 (1) https://doi.org/10.1002/wnan.1745
    8. Stefania Scialla, Giorgia Martuscelli, Francesco Nappi, Sanjeet Singh Avtaar Singh, Adelaide Iervolino, Domenico Larobina, Luigi Ambrosio, Maria Grazia Raucci. Trends in Managing Cardiac and Orthopaedic Device-Associated Infections by Using Therapeutic Biomaterials. Polymers 2021, 13 (10) , 1556. https://doi.org/10.3390/polym13101556

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