Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Tug-of-War between Covalent Binding and Electrostatic Interaction Effectively Killing E. coli without Detectable Resistance

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2021, 13, 48, 56838-56849
    Biological and Medical Applications of Materials and Interfaces

    Tug-of-War between Covalent Binding and Electrostatic Interaction Effectively Killing E. coli without Detectable Resistance
    Click to copy article linkArticle link copied!

    • Haili Wang
      Haili Wang
      The Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Haili Wang
    • Xuan Nie
      Xuan Nie
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Xuan Nie
      Orcidhttps://orcid.org/0000-0002-7757-9538
    • Wei You
      Wei You
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Wei You
    • Weiqiang Huang
      Weiqiang Huang
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Weiqiang Huang
      Orcidhttps://orcid.org/0000-0002-2660-1117
    • Guang Chen
      Guang Chen
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Guang Chen
      Orcidhttps://orcid.org/0000-0002-2965-2614
    • Fan Gao
      Fan Gao
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Fan Gao
    • Lei Xia
      Lei Xia
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Lei Xia
    • Lei Zhang*
      Lei Zhang
      The Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China
      *Email: [email protected]
      More by Lei Zhang
    • Longhai Wang
      Longhai Wang
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      More by Longhai Wang
    • Ai-Zong Shen*
      Ai-Zong Shen
      The Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China
      *Email: [email protected]
      More by Ai-Zong Shen
    • Kai-Le Wu*
      Kai-Le Wu
      Department of Otolaryngology Head & Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China
      *Email: [email protected]
      More by Kai-Le Wu
    • Sheng-Gang Ding*
      Sheng-Gang Ding
      Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China
      *Email: [email protected]
      More by Sheng-Gang Ding
    • Ye-Zi You*
      Ye-Zi You
      The Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China
      Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
      *Email: [email protected]
      More by Ye-Zi You
      Orcidhttps://orcid.org/0000-0003-0319-4165
    Other Access OptionsSupporting Information (1)

    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2021, 13, 48, 56838–56849
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.1c15868
    Published November 24, 2021
    Copyright © 2021 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    Antimicrobial resistance in Gram-negative bacteria has become one of the leading causes of morbidity and mortality and a serious worldwide public health concern due to the fact that Gram-negative bacteria have an additional outer membrane protecting them from an unwanted compound invading. It is still very difficult for antimicrobials to reach intracellular targets and very challenging to treat Gram-negative bacteria with the current strategies. Here, we found that (o-(bromomethyl)phenyl)boronic acid was incorporated into poly((2-N,N-diethyl)aminoethyl acrylate) (PDEA), forming a copolymer (poly(o-Bn-DEA)) having both phenylboronic acid (B) and ((2-N,N-diethyl)amino) (DEA) units. Poly(o-Bn-DEA) exhibits very strong intramolecular B–N coordination, which could highly promote the covalent binding of phenylboronic acid with lipopolysaccharide (LPS) on the outer membrane of E. coli and lodge poly(o-Bn-DEA) on the LPS layer on the surface of E. coli. Meanwhile, the strong electrostatic interaction between poly(o-Bn-DEA) and the negatively charged lipid preferred tugging the poly(o-Bn-DEA) into the lipid bilayer of E. coli. The combating interactions between covalent binding and electrostatic interaction form a tug-of-war action, which could trigger the lysis of the outer membrane, thereby killing Gram-negative E. coli effectively without detectable resistance.

    Copyright © 2021 American Chemical Society

    Subjects

    what are subjects

    Keywords

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.1c15868.

    • Experimental details, materials, and methods; characterization of PDEA and cationic copolymers; 1H NMR and 11B NMR spectra; dose-dependent growth inhibition and killing assays of E. coli; SEM images of E. coli biofilms; dose- and time-dependent antibiofilm effects; hematology and blood biochemistry analysis (PDF)

    Terms & Conditions

    Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 7 publications.

    1. Christian K. O. Dzuvor, Hsin-Hui Shen, Victoria S. Haritos, Lizhong He. Coassembled Multicomponent Protein Nanoparticles Elicit Enhanced Antibacterial Activity. ACS Nano 2024, 18 (5) , 4478-4494. https://doi.org/10.1021/acsnano.3c11179
    2. João Pedro dos S. Silva, Raphael C. Costa, Bruna E. Nagay, Maria H. R. Borges, Catharina M. Sacramento, Nilson C. da Cruz, Elidiane C. Rangel, Carlos A. Fortulan, José H. D. da Silva, Karina G. S. Ruiz, Valentim A. R. Barão. Boosting Titanium Surfaces with Positive Charges: Newly Developed Cationic Coating Combines Anticorrosive and Bactericidal Properties for Implant Application. ACS Biomaterials Science & Engineering 2023, 9 (9) , 5389-5404. https://doi.org/10.1021/acsbiomaterials.3c00491
    3. Evgeniya A. Saverina, Nikita A. Frolov, Olga A. Kamanina, Vyacheslav A. Arlyapov, Anatoly N. Vereshchagin, Valentine P. Ananikov. From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs). ACS Infectious Diseases 2023, 9 (3) , 394-422. https://doi.org/10.1021/acsinfecdis.2c00469
    4. Ke Huang, Wei Liu, Fang‐Jie Zhao. Methylarsenite is a broad‐spectrum antibiotic disrupting cell wall biosynthesis and cell membrane potential. Environmental Microbiology 2023, 25 (2) , 562-574. https://doi.org/10.1111/1462-2920.16309
    5. Haili Wang, Wei You, Fan Gao, Lei Zhang, Aizong Shen, Fei Wang, Guang Chen, Xuan Nie, Lei Xia, Wei-Qiang Huang, Wen-Jian Zhang, Long-Hai Wang, Chun-Yan Hong, Ze Zhang, Ye-Zi You. Direct cytosolic delivery of DNA by creating fast closable holes in the cell membrane. Chemical Engineering Journal 2023, 455 , 140962. https://doi.org/10.1016/j.cej.2022.140962
    6. Ning Guo, Yu Xia, Weishen Zeng, Jia Chen, Quanxin Wu, Yaxin Shi, Guoying Li, Zhuoyi Huang, Guanhai Wang, Yun Liu. Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy. Drug Delivery 2022, 29 (1) , 1086-1099. https://doi.org/10.1080/10717544.2022.2058650
    7. Haili Wang, Wei You, Bin Wu, Xuan Nie, Lei Xia, Changhui Wang, Ye-Zi You. Phenylboronic acid-functionalized silver nanoparticles for highly efficient and selective bacterial killing. Journal of Materials Chemistry B 2022, 10 (15) , 2844-2852. https://doi.org/10.1039/D2TB00320A
    Download PDF
    Go to ACS Applied Materials & Interfaces
    Get e-Alerts
    Get e-Alerts

    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2021, 13, 48, 56838–56849
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.1c15868
    Published November 24, 2021
    Copyright © 2021 American Chemical Society
    Request reuse permissions

    Article Views

    1146

    Altmetric

    -

    Citations

    7
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.