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Organic Dots with Large π-Conjugated Planar for Cholangiography beyond 1500 nm in Rabbits: A Non-Radioactive Strategy
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    Organic Dots with Large π-Conjugated Planar for Cholangiography beyond 1500 nm in Rabbits: A Non-Radioactive Strategy
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    • Di Wu
      Di Wu
      Department of General Surgery, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
      More by Di Wu
    • Shunjie Liu
      Shunjie Liu
      Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science and State Key Laboratory of Molecular Neuroscience, and Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
      More by Shunjie Liu
    • Jing Zhou
      Jing Zhou
      State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, China
      More by Jing Zhou
    • Runze Chen
      Runze Chen
      State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, China
      More by Runze Chen
    • Yifan Wang
      Yifan Wang
      Department of General Surgery, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
      More by Yifan Wang
    • Zhe Feng
      Zhe Feng
      State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, China
      More by Zhe Feng
    • Hui Lin*
      Hui Lin
      Department of General Surgery, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
      *Email: [email protected]
      More by Hui Lin
    • Jun Qian*
      Jun Qian
      State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, China
      *Email: [email protected]
      More by Jun Qian
    • Ben Zhong Tang*
      Ben Zhong Tang
      Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science and State Key Laboratory of Molecular Neuroscience, and Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
      Center for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China
      HKUST-Shenzhen Research Institute, Nanshan, Shenzhen 518057, China
      *Email: [email protected]
    • Xiujun Cai*
      Xiujun Cai
      Department of General Surgery, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
      Key Laboratory of Laparoscopic Technology of Zhejiang Province; Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease; Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment, Zhejiang University Cancer Center, Hangzhou 310016, China
      *Email: [email protected]
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    ACS Nano

    Cite this: ACS Nano 2021, 15, 3, 5011–5022
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    https://doi.org/10.1021/acsnano.0c09981
    Published March 11, 2021
    Copyright © 2021 American Chemical Society

    Abstract

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    Iatrogenic extrahepatic bile duct injury remains a dreaded complication while performing cholecystectomy. Although X-ray based cholangiography could reduce the incidence of biliary tract injuries, the deficiencies including radiation damage and expertise dependence hamper its further clinical application. The effective strategy for intraoperative cholangiography is still urgently required. Herein, a fluorescence-based imaging approach for cholangiography in the near-infrared IIb window (1500–1700 nm) using TT3-oCB, a bright aggregation-induced emission luminogen with large π-conjugated planar unit, is reported. In phantom studies, TT3-oCB nanoparticles exhibit high near-infrared IIb emission and show better image clarity at varying penetrating depths. When intrabiliary injected into the gallbladder or the common bile duct of the rabbit, TT3-oCB nanoparticles enable the real-time imaging of the biliary structure with deep penetrating capability and high signal-to-background ratio. Moreover, the tiny iatrogenic biliary injuries and the gallstones in established disease models could be precisely diagnosed by TT3-oCB nanoparticle assisted near-infrared IIb imaging. In summary, we reported a feasible application for aggregation-induced emission dots as biliary contrast agent and realized high-quality cholangiography in the near-infrared IIb window with precise diagnostic ability and nonradioactive damage, which could possibly be applied for intraoperative diagnosis.

    Copyright © 2021 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.0c09981.

    • DLS profile in water, absorption spectra, NIR-IIb emission spectra, NIR-IIb fluorescence intensity measurement, ICG assisted NIR-IIb cholangiography, SBRs calculation, 3 mm adipose tissue phantom model, cell viability analysis, removal and clearance of TT3-oCB NPs, fluorescence intensity measurement of TT3-oCB NPs in organs, experimental methods (PDF)

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    This article is cited by 30 publications.

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    ACS Nano

    Cite this: ACS Nano 2021, 15, 3, 5011–5022
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsnano.0c09981
    Published March 11, 2021
    Copyright © 2021 American Chemical Society

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