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On-Demand Aligned DNA Hydrogel Via Light Scanning

  • Juri Kim
    Juri Kim
    Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
    More by Juri Kim
  • Yun-Seok Choi
    Yun-Seok Choi
    Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos 87545, New Mexico, USA
  • Geonhyeong Park
    Geonhyeong Park
    Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
  • Mingeun Kim
    Mingeun Kim
    Chemical Materials Solutions Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea
    More by Mingeun Kim
  • Jin Suk Myung
    Jin Suk Myung
    Chemical Materials Solutions Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea
  • Woo Jin Choi
    Woo Jin Choi
    Chemical Materials Solutions Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea
    More by Woo Jin Choi
  • Soon Mo Park*
    Soon Mo Park
    Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
    Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca 14853, New York, USA
    *Soon Mo Park ─ Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea; Email: [email protected]
    More by Soon Mo Park
  • , and 
  • Dong Ki Yoon*
    Dong Ki Yoon
    Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
    Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
    *Dong Ki Yoon ─ Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea; Email: [email protected]
    More by Dong Ki Yoon
Cite this: ACS Nano 2023, 17, 22, 22778–22787
Publication Date (Web):November 10, 2023
https://doi.org/10.1021/acsnano.3c07493
Copyright © 2023 American Chemical Society

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    Supporting Info (4)»

    Abstract

    Abstract Image

    DNA is an anisotropic, water-attracting, and biocompatible material, an ideal building block for hydrogel. The alignment of the anisotropic DNA chains is essential to maximize hydrogel properties, which has been little explored. Here, we present a method to fabricate the anisotropic DNA hydrogel that allows precise control for the polymerization process of photoreactive cationic monomers. Scanning ultraviolet light enables the uniaxial alignment of DNA chains through the polymerization-induced diffusive mass flow using a concentration gradient. While studying anisotropic mechanical properties and orientation recovery according to the DNA chain alignment direction, we demonstrate the potential of directionally controlled DNA hydrogels as smart materials.

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.3c07493.

    • Schematic illustration of UV scanning setup (S1); Images of UV projection for whole window irradiation (S2); Photographs of the fabricated hydrogels (S3); SEM images of the fabricated hydrogels (S4); Orientation of DNA and cationic polymer in line scanning irradiated hydrogel characterized by polarized FT-IR (S5); Effects of UV intensity and scanning rate on molecular alignment (S6); Rheological analysis of precursor solution and polymerized gel (S7); Comparison of molecular diffusion in a precursor solution and polymerized gel (S8); FT-IR spectra of pristine DNA and DNA based hydrogel (S9); UV scanning using negative charged or neutral monomers (S10); Pictures of programming shape and orientation in DNA hydrogel (S11) (PDF)

    • Image input to DMD for line scanning process (MP4)

    • Photo of UV projection for line scanning process (MP4)

    • Real time observation of gelation process by light scanning (MP4)

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