Second Skin as Self-Protection Against γ-HydroxybutyrateClick to copy article linkArticle link copied!
- Gyeong-Ji KimGyeong-Ji KimSKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of KoreaMore by Gyeong-Ji Kim
- Seon Joo ParkSeon Joo ParkInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Seon Joo Park
- Lina KimLina KimInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Lina Kim
- Kyung Ho KimKyung Ho KimInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Kyung Ho Kim
- Soomin KimSoomin KimInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Soomin Kim
- Jai Eun AnJai Eun AnSKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of KoreaMore by Jai Eun An
- Chan Jae ShinChan Jae ShinSKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of KoreaMore by Chan Jae Shin
- Sung Eun SeoSung Eun SeoInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Sung Eun Seo
- Seongjae JoSeongjae JoInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Seongjae Jo
- Jinyeong KimJinyeong KimInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Jinyeong Kim
- Siyoung HaSiyoung HaDepartment of Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, United StatesMore by Siyoung Ha
- Hwi Won SeoHwi Won SeoInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaMore by Hwi Won Seo
- Mun-Chual RhoMun-Chual RhoFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of KoreaMore by Mun-Chual Rho
- Do Hyung KwonDo Hyung KwonBiotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of KoreaDepartment of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon 34113, Republic of KoreaMore by Do Hyung Kwon
- Woo-Keun KimWoo-Keun KimDepartment of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of KoreaMore by Woo-Keun Kim
- Gugin Jeong
- Jae Chun Ryu
- Jae Joon Kim*Jae Joon Kim*Email: [email protected] (J.J.K).Flexible Electronics Research Section, Reality Devices Research Division, Hyper-Reality Metaverse Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon 34129, Republic of KoreaMore by Jae Joon Kim
- Oh Seok Kwon*Oh Seok Kwon*Email: [email protected] (O.S.K).SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of KoreaDepartment of Nano Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of KoreaDepartment of Nano Science and Technology, Sungkyunkwan University (SKKU), Suwon 16419, Republic of KoreaMore by Oh Seok Kwon
Abstract
γ-Hydroxybutyrate (GHB), a date-rape drug, causes certain symptoms, such as amnesia, confusion, ataxia, and unconsciousness, when dissolved in beverages and consumed by a victim. Commonly, assailants use GHB in secret for the crime of drug-facilitated sexual assault because it is tasteless, odorless, and colorless when dissolved in beverages. Generally, GHB detection methods are difficult to use promptly and secretly in situ and in real life because of the necessary detection equipment and low selectivity. To overcome this problem, we have developed a fast, simple, and easy-to-use second skin platform as a confidential self-protection platform that can detect GHB in situ or in real life without equipment. The second skin platform for naked-eye detection of GHB is fabricated with poly(vinyl alcohol) (PVA), polyurethane (PU), and polyacrylonitrile (PAN) included in the chemical receptor 2-(3-bromo-4-hydroxystyryl)-3-ethylbenzothiazol-3-ium iodide (BHEI). PAN conjugated with BHEI nanofibers (PB NFs) has various characteristics, such as ease of use, high sensitivity, and fast color change. PB NFs rapidly detected GHB at 0.01 mg/mL. Furthermore, the second-skin platform attached to the fingertip and wrist detected both 1 and 0.1 mg/mL GHB in solution within 50 s. The color changes caused by the interaction of GHB and the second skin platform cannot be stopped due to strong chemical reactions. In addition, a second skin platform can be secretly utilized in real life because it can recognize fingerprints and object temperatures. Therefore, the second skin platform can be used to aid daily life and prevent drug-facilitated sexual assault crime when attached to the skin because it can be exposed anytime and anywhere.
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This article is cited by 2 publications.
- Chun Yang, Hongxian Yang, Zhen Yao, Taihong Liu. Recent advances in active chromophores for detecting gamma-hydroxybutyric acid (GHB)-related illicit drugs. The Analyst 2025, 150
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, 1972-1985. https://doi.org/10.1039/D5AN00167F
- Jordi Hernández-Contreras, Jordi Roig-Rubio, Margarita Parra, Salvador Gil, Pau Arroyo, José A. Sáez, Carlos Lodeiro, Pablo Gaviña. Green and real-time detection of GHB in soft drinks and alcoholic beverages using an eco-friendly cellulose paper-based fluorescent probe. Sensing and Bio-Sensing Research 2024, 46 , 100691. https://doi.org/10.1016/j.sbsr.2024.100691
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