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Biomimetic Dendritic Cell-Based Nanovaccines for Reprogramming the Immune Microenvironment to Boost Tumor Immunotherapy

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    Biomimetic Dendritic Cell-Based Nanovaccines for Reprogramming the Immune Microenvironment to Boost Tumor Immunotherapy
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    • Weizhong Wang
      Weizhong Wang
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
      More by Weizhong Wang
    • Cheng Zou
      Cheng Zou
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Cheng Zou
    • Xiao Liu
      Xiao Liu
      Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
      More by Xiao Liu
      Orcidhttps://orcid.org/0000-0003-1490-3836
    • Lei He
      Lei He
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Lei He
    • Zhengcong Cao
      Zhengcong Cao
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Zhengcong Cao
    • Maorong Zhu
      Maorong Zhu
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Maorong Zhu
    • Yuxin Wu
      Yuxin Wu
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Yuxin Wu
    • Xiaolin Liu
      Xiaolin Liu
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Xiaolin Liu
    • Jiying Ma
      Jiying Ma
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Jiying Ma
    • Yaoliang Wang
      Yaoliang Wang
      Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
      More by Yaoliang Wang
    • Yile Zhang
      Yile Zhang
      Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
      More by Yile Zhang
    • Kuo Zhang
      Kuo Zhang
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Kuo Zhang
    • Shuning Wang
      Shuning Wang
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Shuning Wang
    • Wangqian Zhang
      Wangqian Zhang
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Wangqian Zhang
    • Wei Liu
      Wei Liu
      Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
      More by Wei Liu
    • Wei Lin
      Wei Lin
      Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
      More by Wei Lin
    • Yingqi Zhang
      Yingqi Zhang
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      More by Yingqi Zhang
    • Qingdong Guo*
      Qingdong Guo
      Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
      *E-mail: [email protected]
      More by Qingdong Guo
    • Meng Li*
      Meng Li
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      *E-mail: [email protected]
      More by Meng Li
    • Jintao Gu*
      Jintao Gu
      Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
      *E-mail: [email protected]
      More by Jintao Gu
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    ACS Nano

    Cite this: ACS Nano 2024, 18, 50, 34063–34076
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    https://doi.org/10.1021/acsnano.4c09653
    Published December 3, 2024
    Copyright © 2024 American Chemical Society
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    Abstract

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    Although dendritic cell (DC)-mediated immunotherapies are effective options for immunotherapy, traditional DC vaccines are hampered by a variety of drawbacks such as insufficient antigen delivery, weak lymph node homing, and the risk of living cell transfusion. To address the above-mentioned issues, we developed a personalized DC-mimicking nanovaccine (HybridDC) that enhances antigen presentation and elicits effective antitumor immunity. The biomimetic nanovaccine contains cell membranes derived from genetically engineered DCs, and several cellular components are simultaneously anchored onto these membranes, including CC-chemokine receptor 7 (CCR7), tumor-associated antigenic (TAA) peptide/tumor-derived exosome (TEX), and relevant costimulatory molecules. Compared with previous vaccines, the HybridDC vaccine showed an increased ability to target lymphoid tissues and reshape the immune landscape in the tumor milieu. HybridDC demonstrated significant therapeutic and prophylactic efficacy in poorly immunogenic, orthotopic models of glioma. Furthermore, the HybridDC vaccine potentiates the therapeutic efficacy of immune checkpoint blockade (ICB) therapy, providing a potential combination strategy to maximize the efficacy of ICB. Specifically, HybridDC can induce long-term protective immunity in memory T cells. Overall, the HybridDC vaccine is a promising platform for personalized cancer vaccines and may offer a combinational modality to improve current immunotherapy.

    Copyright © 2024 American Chemical Society

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    ACS Nano

    Cite this: ACS Nano 2024, 18, 50, 34063–34076
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsnano.4c09653
    Published December 3, 2024
    Copyright © 2024 American Chemical Society
    Request reuse permissions

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