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Design and Structure Analysis of Artificial Metalloproteins:  Selective Coordination of His64 to Copper Complexes with Square-Planar Structure in the apo-Myoglobin Scaffold

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    Design and Structure Analysis of Artificial Metalloproteins:  Selective Coordination of His64 to Copper Complexes with Square-Planar Structure in the apo-Myoglobin Scaffold
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    Department of Chemistry, Graduate School of Science, Department of Biotechnology, Graduate School of Engineering, High Intensity X-ray Diffraction Laboratory, and Research Center for Materials Science, Nagoya University, Nagoya 464-8602, Japan, and PRESTO, Japan Science and Technology Agency (JST), Saitama 332-0012, Japan
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    Inorganic Chemistry

    Cite this: Inorg. Chem. 2007, 46, 13, 5137–5139
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    https://doi.org/10.1021/ic070289m
    Published May 25, 2007
    Copyright © 2007 American Chemical Society
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    Abstract

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    apo-Myoglobin (apo-Mb) was reconstituted with three copper complexes:  CuII(Sal-Phe) (1; Sal-Phe = N-salicylidene-l-phenylalanato), CuII(Sal-Leu) (2; Sal-Leu = N-salicylidene-l-leucinato), and CuII(Sal-Ala) (3; Sal-Ala = N-salicylidene-l-alanato). The crystal structures of 1·apo-Mb (1.65 Å resolution) and 2·apo-Mb (1.8 Å resolution) show that the coordination geometry around the CuII atom in apo-Mb is distorted square-planar with tridentate Sal-X and a Nε atom of His64 in the apo-Mb cavity and the plane of these copper complexes is perpendicular to that of heme. These results suggest that the apo-Mb cavity can hold metal complexes with various coordination geometries.

    Copyright © 2007 American Chemical Society

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    †

     Department of Chemistry, Graduate School of Science, Nagoya University.

    ‡

     PRESTO, Japan Science and Technology Agency (JST), Japan.

    §

     Department of Biotechnology, Graduate School of Engineering, Nagoya University.

    ‖

     High Intensity X-ray Diffraction Laboratory, Nagoya University.

    *

     To whom correspondence should be addressed. E-mail:  yoshi@ nucc.cc.nagoya-u.ac.jp. Phone:  +81-52-789-3049. Fax:  +81-52-789-2953.

    ⊥

     Research Center for Materials Science, Nagoya University.

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    Inorganic Chemistry

    Cite this: Inorg. Chem. 2007, 46, 13, 5137–5139
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ic070289m
    Published May 25, 2007
    Copyright © 2007 American Chemical Society
    Request reuse permissions

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