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Redox-Neutral α-Cyanation of Amines
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    Redox-Neutral α-Cyanation of Amines
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    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2012, 134, 37, 15305–15308
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    https://doi.org/10.1021/ja308009g
    Published September 10, 2012
    Copyright © 2012 American Chemical Society

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    α-Aminonitriles inaccessible by traditional Strecker chemistry are obtained in redox-neutral fashion by direct amine α-cyanation/N-alkylation or alternatively, α-aminonitrile isomerization. These unprecedented transformations are catalyzed by simple carboxylic acids.

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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2012, 134, 37, 15305–15308
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja308009g
    Published September 10, 2012
    Copyright © 2012 American Chemical Society

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