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Monoamine Oxidase B and Free Radical Scavenging Activities of Natural Flavonoids in Melastoma candidum D. Don

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    Monoamine Oxidase B and Free Radical Scavenging Activities of Natural Flavonoids in Melastoma candidum D. Don
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    Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei 110, Taiwan, and Department of Internal Medicine, Taipei Municipal Ho-Ping Hospital, Taipei 100, Taiwan
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2001, 49, 11, 5551–5555
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    https://doi.org/10.1021/jf010622j
    Published October 13, 2001
    Copyright © 2001 American Chemical Society
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    Abstract

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    Monoamine oxidase type B (MAO-B) activity and free radicals are elevated in certain neurological diseases. Four natural flavonoids, quercitrin, isoquercitrin, rutin, and quercetin, were isolated for the first time from the leaves of Melastoma candidum D. Don. They exhibited an inhibitory effect on MAO-B. These potent flavonoids were purified using bioassay-guided fractionation and were separated by Diaion, Sephadex LH-20, and MCI CHP20P columns. The IC50 values of the four potent flavonoids, quercitrin, isoquercitrin, rutin, and quercetin on monoamine oxidase were 19.06, 11.64, 3.89, and 10.89 μM and enzyme kinetics analysis revealed apparent inhibition constants (Ki) of 21.01, 2.72, 1.83, and 7.95 μM, respectively, on the substrate, benzylamine. The four potent compounds also exhibited hydroxyl radical scavenging activity as determined using a spin trapping electron spin resonance method. This suggests that the four flavonoids from M.candidum possess both MAO-B inhibitory and free radical scavenging activities. These important properties may be used for preventing some neurodegenerative diseases in the future.

    Keywords: Melastoma candidum; monoamine oxidase B; quercitrin; isoquercitrin; quercetin; rutin; hydroxyl radical scavenging

    Copyright © 2001 American Chemical Society

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     Authors to whom correspondence should be addressed [(W.-C.H.) telephone 886 (2) 2736-1661, ext 676; e-mail [email protected]; (M.-H.L.) telephone 886 (2) 2736-1661, ext 675; e-mail [email protected]].

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     Taipei Medical University.

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     Taipei Municipal Ho-Ping Hospital.

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    Cite this: J. Agric. Food Chem. 2001, 49, 11, 5551–5555
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf010622j
    Published October 13, 2001
    Copyright © 2001 American Chemical Society
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