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Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model

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Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, and Nanobiotechnology & Bioanalysis Group, Department of Chemical Engineering, Universitat Rovira i Virgili, 43007 Tarragona, Spain
§ Vascular Biology Laboratory, IMBECU-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, 5500 Mendoza, Argentina
Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain
Cite this: J. Agric. Food Chem. 2014, 62, 32, 8085–8093
Publication Date (Web):July 22, 2014
https://doi.org/10.1021/jf5014633
Copyright © 2014 American Chemical Society

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    Abstract

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    Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, transporting zinc cations through the plasma membrane. To prove this hypothesis, herein, we have demonstrated the capacity of QCT and epigallocatechin-gallate to rapidly increase labile zinc in mouse hepatocarcinoma Hepa 1-6 cells as well as, for the first time, in liposomes. In order to confirm that the polyphenols transport zinc cations across the plasma membrane independently of plasma membrane zinc transporters, QCT, epigallocatechin-gallate, or clioquinol (CQ), alone and combined with zinc, were added to unilamellar dipalmitoylphosphocholine/cholesterol liposomes loaded with membrane-impermeant FluoZin-3. Only the combinations of the chelators with zinc triggered a rapid increase of FluoZin-3 fluorescence within the liposomes, thus demonstrating the ionophore action of QCT, epigallocatechin-gallate, and CQ on lipid membrane systems. The ionophore activity of dietary polyphenols may underlay the raising of labile zinc levels triggered in cells by polyphenols and thus many of their biological actions.

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    30. Manjesh Saakre, Deepu Mathew, V. Ravisankar. Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2. Beni-Suef University Journal of Basic and Applied Sciences 2021, 10 (1) https://doi.org/10.1186/s43088-021-00107-w
    31. Oisín Kavanagh, Robert Elmes, Finbarr O’Sullivan, John Farragher, Shane Robinson, Gavin Walker. Investigating Structural Property Relationships to Enable Repurposing of Pharmaceuticals as Zinc Ionophores. Pharmaceutics 2021, 13 (12) , 2032. https://doi.org/10.3390/pharmaceutics13122032
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    45. Şeyma TAŞTEMUR, Hilmi ATASEVEN. Quercetin in the treatment and prevention of COVID-19. Cumhuriyet Medical Journal 2021, 43 (2) , 100-116. https://doi.org/10.7197/cmj.939856
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    47. Sima Heydarzadeh Asl, Sepideh Nikfarjam, Naime Majidi Zolbanin, Reza Nassiri, Reza Jafari. Immunopharmacological perspective on zinc in SARS-CoV-2 infection. International Immunopharmacology 2021, 96 , 107630. https://doi.org/10.1016/j.intimp.2021.107630
    48. Shital Balasaheb Palghadmal, Prajakta Shriram Kulkarni, Vishal Makadia, Mahesh Jagannath Deshmukh, Priyanka Satish Gondhale, Sriram Padmanabhan. Tackling Complications of Coronavirus Infection with Quercetin: Observations and Hypotheses. Exploratory Research and Hypothesis in Medicine 2021, 000 (000) , 000-000. https://doi.org/10.14218/ERHM.2021.00015
    49. Chandra K. Singh, Gagan Chhabra, Arth Patel, Hao Chang, Nihal Ahmad. Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management. Nutrients 2021, 13 (6) , 1867. https://doi.org/10.3390/nu13061867
    50. Felix Zulhendri, Kavita Chandrasekaran, Magdalena Kowacz, Munir Ravalia, Krishna Kripal, James Fearnley, Conrad O. Perera. Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review. Foods 2021, 10 (6) , 1360. https://doi.org/10.3390/foods10061360
    51. J. Adithya, Bhagyalakshmi Nair, T.S. Aishwarya, Lekshmi R. Nath. The Plausible Role of Indian Traditional Medicine in Combating Corona Virus (SARS-CoV 2): A Mini-Review. Current Pharmaceutical Biotechnology 2021, 22 (7) , 906-919. https://doi.org/10.2174/1389201021666200807111359
    52. Felix Zulhendri, Rafael Felitti, James Fearnley, Munir Ravalia. The use of propolis in dentistry, oral health, and medicine: A review. Journal of Oral Biosciences 2021, 63 (1) , 23-34. https://doi.org/10.1016/j.job.2021.01.001
    53. Anchalee Prasansuklab, Atsadang Theerasri, Panthakarn Rangsinth, Chanin Sillapachaiyaporn, Siriporn Chuchawankul, Tewin Tencomnao. Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection. Journal of Traditional and Complementary Medicine 2021, 11 (2) , 144-157. https://doi.org/10.1016/j.jtcme.2020.12.001
    54. Joseph Brewer, Juan Luis Gomez Marti, Adam Brufsky. Potential interventions for SARS‐CoV‐2 infections: Zinc showing promise. Journal of Medical Virology 2021, 93 (3) , 1201-1203. https://doi.org/10.1002/jmv.26523
    55. Cagla Celik, Ayse Gencay, Ismail Ocsoy. Can food and food supplements be deployed in the fight against the COVID 19 pandemic?. Biochimica et Biophysica Acta (BBA) - General Subjects 2021, 1865 (2) , 129801. https://doi.org/10.1016/j.bbagen.2020.129801
    56. Pierre Kory, G. Umberto Meduri, Jose Iglesias, Joseph Varon, Paul E. Marik. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. Journal of Intensive Care Medicine 2021, 36 (2) , 135-156. https://doi.org/10.1177/0885066620973585
    57. Nandeeta Samad, Temitayo Eniola Sodunke, Abdullahi Rabiu Abubakar, Iffat Jahan, Paras Sharma, Salequl Islam, Siddhartha Dutta, Mainul Haque. The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic. Journal of Inflammation Research 2021, Volume 14 , 527-550. https://doi.org/10.2147/JIR.S295377
    58. Alina Dima, Daniel Vasile Balaban, Ciprian Jurcut, Ioana Berza, Ruxandra Jurcut, Mariana Jinga. Perceptions of Romanian Physicians on Lockdowns for COVID-19 Prevention. Healthcare 2021, 9 (1) , 95. https://doi.org/10.3390/healthcare9010095
    59. Leon Margolin, Jeremy Luchins, Daniel Margolin, Michelle Margolin, Sanford Lefkowitz. 20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment. Journal of Evidence-Based Integrative Medicine 2021, 26 , 2515690X2110261. https://doi.org/10.1177/2515690X211026193
    60. Haruna Tamano, Haruna Tokoro, Daichi Murakami, Ryo Furuhata, Satoko Nakajima, Nana Saeki, Misa Katahira, Aoi Shioya, Yukino Tanaka, Mako Egawa, Atsushi Takeda. Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid β1-42-induced neurodegeneration via intracellular Zn2+ toxicity in the dentate gyrus. Experimental Animals 2021, 70 (4) , 514-521. https://doi.org/10.1538/expanim.21-0044
    61. Mohammed S. Razzaque. COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?. Computational and Structural Biotechnology Journal 2021, 19 , 1371-1378. https://doi.org/10.1016/j.csbj.2021.02.015
    62. Pawan K. Agrawal, Chandan Agrawal, Gerald Blunden. Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations. Natural Product Communications 2020, 15 (12) , 1934578X2097629. https://doi.org/10.1177/1934578X20976293
    63. Lise Alschuler, Andrew Weil, Randy Horwitz, Paul Stamets, Ann Marie Chiasson, Robert Crocker, Victoria Maizes. Integrative considerations during the COVID-19 pandemic. EXPLORE 2020, 16 (6) , 354-356. https://doi.org/10.1016/j.explore.2020.03.007
    64. Adeleh Sahebnasagh, Fatemeh Saghafi, Razieh Avan, Amirhosein Khoshi, Masoud Khataminia, Mohammadreza Safdari, Solomon Habtemariam, Hassan Rezai Ghaleno, Seyed Mohammad Nabavi. The prophylaxis and treatment potential of supplements for COVID-19. European Journal of Pharmacology 2020, 887 , 173530. https://doi.org/10.1016/j.ejphar.2020.173530
    65. Sabya S. Das, Afzal Hussain, Priya R. Prasad Verma, Syed S. Imam, Mohammad A. Altamimi, Sultan Alshehri, Sandeep Kumar Singh. Recent Advances in Liposomal Drug Delivery System of Quercetin for Cancer Targeting: A Mechanistic Approach. Current Drug Delivery 2020, 17 (10) , 845-860. https://doi.org/10.2174/1567201817666200415112657
    66. Christina B. Klouda, William L. Stone. Oxidative Stress, Proton Fluxes, and Chloroquine/Hydroxychloroquine Treatment for COVID-19. Antioxidants 2020, 9 (9) , 894. https://doi.org/10.3390/antiox9090894
    67. Yunlong Li, Daming Fan, Yueliang Zhao, Mingfu Wang. Effects of quercetin and cinnamaldehyde on the nutrient release from beef into soup during stewing process. LWT 2020, 131 , 109712. https://doi.org/10.1016/j.lwt.2020.109712
    68. Inga Wessels, Benjamin Rolles, Lothar Rink. The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in Immunology 2020, 11 https://doi.org/10.3389/fimmu.2020.01712
    69. Anatoly Skalny, Lothar Rink, Olga Ajsuvakova, Michael Aschner, Viktor Gritsenko, Svetlana Alekseenko, Andrey Svistunov, Demetrios Petrakis, Demetrios Spandidos, Jan Aaseth, Aristidis Tsatsakis, Alexey Tinkov. Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review). International Journal of Molecular Medicine 2020, https://doi.org/10.3892/ijmm.2020.4575
    70. Sabya Sachi Das, P. R. P. Verma, Sweta Kar, Sandeep Kumar Singh. Quercetin-Loaded Nanomedicine as Oncotherapy. 2020, 155-183. https://doi.org/10.1007/978-981-15-1664-1_5
    71. Sabya Sachi Das, P. R. P. Verma, Sandeep Kumar Singh. Quercetin-Loaded Nanomedicine as Nutritional Application. 2020, 259-301. https://doi.org/10.1007/978-981-15-1664-1_9
    72. Mika Turkia. MATH+ and I-MASK+ Protocols for Prevention and Treatment of All Phases of COVID-19 – A Short Review. SSRN Electronic Journal 2020, 10 https://doi.org/10.2139/ssrn.3723854
    73. Paula Fernández-Palanca, Flavia Fondevila, Carolina Méndez-Blanco, María J. Tuñón, Javier González-Gallego, José L. Mauriz. Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review. Nutrients 2019, 11 (12) , 2875. https://doi.org/10.3390/nu11122875
    74. Takaaki Aratake, Youichirou Higashi, Yusuke Ueba, Tomoya Hamada, Takahiro Shimizu, Shogo Shimizu, Toshio Yawata, Tetsuya Ueba, Motoaki Saito. The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia. Metallomics 2018, 10 (10) , 1501-1509. https://doi.org/10.1039/C8MT00248G
    75. Sarah Tomas‐Hernández, Jordi Blanco, Cristina Rojas, Joel Roca‐Martínez, María José Ojeda‐Montes, Raúl Beltrán‐Debón, Santiago Garcia‐Vallvé, Gerard Pujadas, Lluís Arola, Miquel Mulero. Resveratrol Potently Counteracts Quercetin Starvation‐Induced Autophagy and Sensitizes HepG2 Cancer Cells to Apoptosis. Molecular Nutrition & Food Research 2018, 62 (5) https://doi.org/10.1002/mnfr.201700610
    76. HyunTae V. Hwang, Darlene Thuy Tran, Michelle Nicole Rebuffatti, Chin-Shang Li, Anne A. Knowlton, . Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLOS ONE 2018, 13 (1) , e0190374. https://doi.org/10.1371/journal.pone.0190374
    77. Pawatsanai Samutprasert, Khajeelak Chiablaem, Chanon Teeraseranee, Punnawich Phaiyarin, Puttikorn Pukfukdee, Prompong Pienpinijtham, Jisnuson Svasti, Tanapat Palaga, Kriengsak Lirdprapamongkol, Supason Wanichwecharungruang. Epigallocatechin gallate-zinc oxide co-crystalline nanoparticles as an anticancer drug that is non-toxic to normal cells. RSC Advances 2018, 8 (14) , 7369-7376. https://doi.org/10.1039/C7RA10997K
    78. Marco Malavolta, Laura Costarelli, Robertina Giacconi, Andrea Basso, Francesco Piacenza, Elisa Pierpaoli, Mauro Provinciali, Ogo A. Ogo, Dianne Ford. Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. Experimental Gerontology 2017, 99 , 35-45. https://doi.org/10.1016/j.exger.2017.09.006
    79. Fang Dai, Wen-Jing Yan, Yu-Ting Du, Xia-Zhen Bao, Xiu-Zhuang Li, Bo Zhou. Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores. Free Radical Biology and Medicine 2017, 108 , 554-563. https://doi.org/10.1016/j.freeradbiomed.2017.04.023
    80. Gael Clergeaud, Husam Dabbagh-Bazarbachi, Mayreli Ortiz, Juan B. Fernández-Larrea, Ciara K. O’Sullivan. A simple liposome assay for the screening of zinc ionophore activity of polyphenols. Food Chemistry 2016, 197 , 916-923. https://doi.org/10.1016/j.foodchem.2015.11.057
    81. Yuri A. Kim, Yury S. Tarahovsky, Elena A. Yagolnik, Svetlana M. Kuznetsova, Eugeny N. Muzafarov. Integration of Quercetin-Iron Complexes into Phosphatidylcholine or Phosphatidylethanolamine Liposomes. Applied Biochemistry and Biotechnology 2015, 176 (7) , 1904-1913. https://doi.org/10.1007/s12010-015-1686-z
    82. Simona Piccolella, Severina Pacifico. Plant-Derived Polyphenols. 2015, 161-214. https://doi.org/10.1016/B978-0-12-802229-0.00005-0

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