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Radiation-Sensitive Diselenide Block Co-polymer Micellar Aggregates: Toward the Combination of Radiotherapy and Chemotherapy

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Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China
School of Public Health, Jilin University, Changchun 130021, People’s Republic of China
§ Capital Medical University, Beijing 100069, People’s Republic of China
*E-mail: [email protected] (H.X.); [email protected] (X.Z.).
Cite this: Langmuir 2011, 27, 10, 5874–5878
Publication Date (Web):April 13, 2011
https://doi.org/10.1021/la2009682
Copyright © 2011 American Chemical Society

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    Abstract

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    We have developed a potential radiation-sensitive drug-delivery system using active diselenide-containing block co-polymer aggregates in aqueous solution that can load and release anticancer drugs. These aggregates were sensitive to even a low dose of γ-radiation, such as 5 Gy, which is close to the radiation dose received by patients during a single radiotherapy treatment. This line of research may open an avenue for the combination of radiotherapy and chemotherapy.

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