ACS Publications. Most Trusted. Most Cited. Most Read
Surface Coordination of Black Phosphorus with Modified Cisplatin

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Bioconjugate Chem. 2019, 30, 6, 1658-1664
    Article

    Surface Coordination of Black Phosphorus with Modified Cisplatin
    Click to copy article linkArticle link copied!

    • Jianing Zhang
      Jianing Zhang
      State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
      More by Jianing Zhang
    • Yue Ma
      Yue Ma
      State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
      More by Yue Ma
    • Kuan Hu
      Kuan Hu
      State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
      More by Kuan Hu
    • Yuan Feng
      Yuan Feng
      State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
      More by Yuan Feng
    • Si Chen
      Si Chen
      SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
      More by Si Chen
    • Xiaoyang Yang
      Xiaoyang Yang
      State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
      More by Xiaoyang Yang
    • Jacky Fong-Chuen Loo
      Jacky Fong-Chuen Loo
      Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, SAR 999077, China
      More by Jacky Fong-Chuen Loo
    • Han Zhang
      Han Zhang
      SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
      More by Han Zhang
      Orcidhttp://orcid.org/0000-0002-2197-7270
    • Feng Yin*
      Feng Yin
      State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
      *E-mail: [email protected]. (F.Y.)
      More by Feng Yin
    • Zigang Li*
      Zigang Li
      State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
      *E-mail: [email protected]. (Z.L.)
      More by Zigang Li
      Orcidhttp://orcid.org/0000-0002-3630-8520
    Other Access OptionsSupporting Information (1)

    Bioconjugate Chemistry

    Cite this: Bioconjugate Chem. 2019, 30, 6, 1658–1664
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.bioconjchem.9b00128
    Published May 9, 2019
    Copyright © 2019 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into PxOy species in ambient conditions largely limits its applications. In this study, modified cisplatin–Pt–NO3 [Pt(NH3)2(NO3)2] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.

    Copyright © 2019 American Chemical Society

    Subjects

    what are subjects

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.bioconjchem.9b00128.

    • Additional details on materials and methods. Figures showing HR-XPS spectra, SEM images, cell viability, Western blot, and apoptosis experimental results. Tables showing ssDNA and dsDNA sequences (PDF)

    Terms & Conditions

    Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 26 publications.

    1. Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti. Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids. RSC Medicinal Chemistry 2025, 16 https://doi.org/10.1039/D4MD00600C
    2. Haohao Zhang, Chaoyue Shan, Koulong Wu, Mingyuan Pang, Zhen Kong, Jiajia Ye, Wensi Li, Lei Yu, Zhao Wang, Yen Leng Pak, Juan An, Xing Gao, Jibin Song. Modification Strategies and Prospects for Enhancing the Stability of Black Phosphorus. ChemPlusChem 2024, 120 https://doi.org/10.1002/cplu.202400552
    3. Md Saiful Islam, Md. Thouhidul Islam, Md. Rakib Hossain. Phosphorene: A Novel Nanomaterial Revolutionizing Biomedicine. JCIS Open 2024, 306 , 100124. https://doi.org/10.1016/j.jciso.2024.100124
    4. Xinyu Cui, Xuefeng Tang, Yingying Niu, Lei Tong, Hanbing Zhao, Yong Yang, Ge Jin, Miaojing Li, Xiaojun Han. Functional phosphorene: Burgeoning generation, two-dimensional nanotherapeutic platform for oncotherapy. Coordination Chemistry Reviews 2024, 507 , 215744. https://doi.org/10.1016/j.ccr.2024.215744
    5. Christopher Igwe Idumah. Phosphorene polymeric nanocomposites for biomedical applications: a review. International Journal of Polymeric Materials and Polymeric Biomaterials 2024, 73 (4) , 292-309. https://doi.org/10.1080/00914037.2022.2158333
    6. Wanying Qi, Ru Zhang, Zaishang Wang, Haitao Du, Yiwu Zhao, Bin Shi, Yi Wang, Xin Wang, Ping Wang. Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering. Pharmaceuticals 2024, 17 (2) , 242. https://doi.org/10.3390/ph17020242
    7. Fei Kuang, Tiankun Hui, Yingjie Chen, Meng Qiu, Xiang Gao. Post‐Graphene 2D Materials: Structures, Properties, and Cancer Therapy Applications. Advanced Healthcare Materials 2024, 13 (5) https://doi.org/10.1002/adhm.202302604
    8. Kendahl L. Walz Mitra, Michael Riehs, Andrei Draguicevic, William A. Swann, Christina W. Li, Alexandra Velian. Reaction Chemistry at Discrete Organometallic Fragments on Black Phosphorus. Angewandte Chemie International Edition 2023, 62 (49) https://doi.org/10.1002/anie.202311575
    9. Kendahl L. Walz Mitra, Michael Riehs, Andrei Draguicevic, William A. Swann, Christina W. Li, Alexandra Velian. Reaction Chemistry at Discrete Organometallic Fragments on Black Phosphorus. Angewandte Chemie 2023, 135 (49) https://doi.org/10.1002/ange.202311575
    10. Siyang Gao, Yuelong Wang, Jianwei Sun, Zhihui Zhang. Recent development in black phosphorus nanomaterials for anticancer applications. Frontiers in Biomaterials Science 2023, 2 https://doi.org/10.3389/fbiom.2023.1172524
    11. Ajinkya Nene, Shengyong Geng, Wenhua Zhou, Xue-Feng Yu, Hongrong Luo, Seeram Ramakrishna. Black Phosphorous Aptamer-based Platform for Biomarker Detection. Current Medicinal Chemistry 2023, 30 (8) , 935-952. https://doi.org/10.2174/0929867329666220225110302
    12. Zhi Li, Jibin Song, Huanghao Yang. Emerging low-dimensional black phosphorus: from physical-optical properties to biomedical applications. Science China Chemistry 2023, 66 (2) , 406-435. https://doi.org/10.1007/s11426-022-1355-6
    13. Jinxing Liu, Chong Zhao, Wei R. Chen, Benqing Zhou. Recent progress in two-dimensional nanomaterials for cancer theranostics. Coordination Chemistry Reviews 2022, 469 , 214654. https://doi.org/10.1016/j.ccr.2022.214654
    14. Hongda Li, Chenpu Li, Hao Zhao, Boran Tao, Guofu Wang. Two-Dimensional Black Phosphorus: Preparation, Passivation and Lithium-Ion Battery Applications. Molecules 2022, 27 (18) , 5845. https://doi.org/10.3390/molecules27185845
    15. Yuan Zhang, Xiao Han, Yuan Liu, Shuang Wang, Xianlin Han, Cui Cheng. Research progress on nano-sensitizers for enhancing the effects of radiotherapy. Materials Advances 2022, 3 (9) , 3709-3725. https://doi.org/10.1039/D2MA00094F
    16. Yonghong Zeng, Zhinan Guo. Synthesis and stabilization of black phosphorus and phosphorene: Recent progress and perspectives. iScience 2021, 24 (10) , 103116. https://doi.org/10.1016/j.isci.2021.103116
    17. Dong An, Jianye Fu, Bin Zhang, Ni Xie, Guohui Nie, Hans Ågren, Meng Qiu, Han Zhang. NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges. Advanced Functional Materials 2021, 31 (32) https://doi.org/10.1002/adfm.202101625
    18. Leonardo Giusti, Vanessa R. Landaeta, Matteo Vanni, John A. Kelly, Robert Wolf, Maria Caporali. Coordination chemistry of elemental phosphorus. Coordination Chemistry Reviews 2021, 441 , 213927. https://doi.org/10.1016/j.ccr.2021.213927
    19. Yuanyuan Li, Jianming Xiong, Wenjing Guo, Yangye Jin, Wenjun Miao, Cong Wang, Hongman Zhang, Yi Hu, He Huang. Decomposable black phosphorus nano-assembly for controlled delivery of cisplatin and inhibition of breast cancer metastasis. Journal of Controlled Release 2021, 335 , 59-74. https://doi.org/10.1016/j.jconrel.2021.05.013
    20. Liping Yang, Ting Shen, Yew Von Lim, Mei Er Pam, Lu Guo, Yumeng Shi, Hui Ying Yang. Design of Black Phosphorous Derivatives with Excellent Stability and Ion-Kinetics for Alkali Metal-Ion Battery. Energy Storage Materials 2021, 35 , 283-309. https://doi.org/10.1016/j.ensm.2020.11.025
    21. Abhijeet Pandey, Ajinkya N. Nikam, Gasper Fernandes, Sanjay Kulkarni, Bharath Singh Padya, Ruth Prassl, Subham Das, Alex Joseph, Prashant K. Deshmukh, Pravin O. Patil, Srinivas Mutalik. Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications. Nanomaterials 2021, 11 (1) , 13. https://doi.org/10.3390/nano11010013
    22. Guodong Zeng, Yuping Chen. Surface modification of black phosphorus-based nanomaterials in biomedical applications: Strategies and recent advances. Acta Biomaterialia 2020, 118 , 1-17. https://doi.org/10.1016/j.actbio.2020.10.004
    23. Liang Cheng, Zhengwei Cai, Jingwen Zhao, Fei Wang, Min Lu, Lianfu Deng, Wenguo Cui. Black phosphorus-based 2D materials for bone therapy. Bioactive Materials 2020, 5 (4) , 1026-1043. https://doi.org/10.1016/j.bioactmat.2020.06.007
    24. Dong An, Jianye Fu, Zhongjian Xie, Chenyang Xing, Bin Zhang, Bing Wang, Meng Qiu. Progress in the therapeutic applications of polymer-decorated black phosphorus and black phosphorus analog nanomaterials in biomedicine. Journal of Materials Chemistry B 2020, 8 (32) , 7076-7120. https://doi.org/10.1039/D0TB00824A
    25. Haiguo Hu, Zhe Shi, Karim Khan, Rui Cao, Weiyuan Liang, Ayesha Khan Tareen, Ye Zhang, Weichun Huang, Zhinan Guo, Xiaoling Luo, Han Zhang. Recent advances in doping engineering of black phosphorus. Journal of Materials Chemistry A 2020, 8 (11) , 5421-5441. https://doi.org/10.1039/D0TA00416B
    26. Shameel Thurakkal, Xiaoyan Zhang. Recent Advances in Chemical Functionalization of 2D Black Phosphorous Nanosheets. Advanced Science 2020, 7 (2) https://doi.org/10.1002/advs.201902359
    Download PDF
    Go to Bioconjugate Chemistry
    Get e-Alerts
    Get e-Alerts

    Bioconjugate Chemistry

    Cite this: Bioconjugate Chem. 2019, 30, 6, 1658–1664
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.bioconjchem.9b00128
    Published May 9, 2019
    Copyright © 2019 American Chemical Society
    Request reuse permissions

    Article Views

    1290

    Altmetric

    -

    Citations

    26
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.