Insights into Single-Electron-Transfer Processes in Frustrated Lewis Pair Chemistry and Related Donor–Acceptor Systems in Main Group Chemistry

The activation and utilization of substrates mediated by Frustrated Lewis Pairs (FLPs) was initially believed to occur solely via a two-electron, cooperative mechanism. More recently, the occurrence of a single-electron transfer (SET) from the Lewis base to the Lewis acid was observed, indicating that mechanisms that proceed via one-electron-transfer processes are also feasible. As such, SET in FLP systems leads to the formation of radical ion pairs, which have recently been more frequently observed. In this review, we aim to discuss the seminal findings regarding the recently established insights into the SET processes in FLP chemistry as well as highlight examples of this radical formation process. In addition, applications of reported main group radicals will also be reviewed and discussed in the context of the understanding of SET processes in FLP systems.


INTRODUCTION
In 1942, Brown and co-workers were the first to observe the influence of steric hindrance on the interaction between Lewis acids and Lewis bases. 1 They showed that the combination of trimethyl borane and lutidine are unable to form a classic Lewis acid−base adduct, even at temperatures as low as −80°C (Scheme 1A). The authors explained these findings by suggesting that steric hindrance prevents the formation of the Lewis adduct. Decades later, in 2006, the group of Stephan et al. showed for the first time that a combination of sterically encumbered Lewis acids and bases can also induce intriguing reactivity. 2 They demonstrated that phosphine borane 1 can bind dihydrogen and release it again upon heating (Scheme 1B). A year later, Stephan et al. introduced the term Frustrated Lewis Pairs (FLPs) to highlight cases in which the Lewis acid and base are unable to form a classical Lewis adduct. 3 Since these seminal reports, the use of FLPs has been widely explored and rejuvenated the field of main group chemistry and catalysis. 4−7 Typically, the reactivity of FLP systems is described by twoelectron chemistry, where the Lewis acid and base act cooperatively. 8,9 In this mechanism, it is now recognized that the Lewis acid and base first form a so-called encounter complex EDA, as shown in Scheme 2A. 10,11 Next, the substrate is heterolytically activated by simultaneous donation of electron density from the Lewis base lone pair into an antibonding orbital of the substate (e.g., the H−H σ*-orbital of H 2 ) and the acceptance of electron density from a bonding orbital of the substrate (e.g., the H−H σ-orbital of H 2 ) by the Lewis acid. In addition to these early reports, Piers et al. postulated in 2011 that FLPs can also react via one-electron pathways. 12 For the activation of dihydrogen by the P t Bu 3 / B(C 6 F 5 ) 3 FLP, the authors envisioned that one-electron oxidation of the phosphine by the borane via a single-electron transfer (SET) event occurs as the first reaction step, yielding the radical ion pair P t Bu 3 •+ /B(C 6 F 5 ) 3 •− 2 (Scheme 2B). Subsequently, dihydrogen is activated homolytically to yield the same phosphonium borohydride salt [ t Bu 3 PH][HB-(C 6 F 5 ) 3 ] as obtained via the heterolytic cleavage of the H− H bond. Piers et al. presumed that reaction progress through this radical mechanism was unlikely to be the major contribution due to the large disparity in redox potentials between the P t Bu 3 (0.90 V vs Fc/Fc + in MeCN 13 ) and B(C 6 F 5 ) 3 (−1.79 V vs Fc/Fc + in DCM 14 ). This difference results in only a small amount of the intermediate radical ion pair 2 being present in solution, which does not correlate with the observation that P t Bu 3 /B(C 6 F 5 ) 3 promptly reacts with dihydrogen. 15 Later, Slootweg and co-workers showed with ultrafast transient absorption spectroscopy that the lifetime of the radical ion pair P t Bu 3 •+ /B(C 6 F 5 ) 3 •− 2 is very short (6 ps) due to rapid back electron transfer to the ground-state electron donor−acceptor (EDA) complex [P t Bu 3 , B(C 6 F 5 ) 3 ], which prevents subsequent radical reactivity. 16 Therefore, in this case, dihydrogen is solely activated heterolytically. 17 Two years after the proposal of radical ion pairs in FLP chemistry by Piers et al., the Wang group provided the first direct experimental evidence of SET between a Lewis base and Lewis acid. 18 Namely, upon mixing arylamine 3 and B(C 6 F 5 ) 3 and stirring for 3 days at room temperature, the authors obtained a deep blue solution due to the formation of the amine radical cation 4, which they proved using electron paramagnetic resonance (EPR) spectroscopy (Scheme 2C; Figure 1; see Table 1 for parameters). The corresponding Isotropic CW X-band EPR spectra of radicals 4 and B(C 6 F 5 ) 3 •− ; simulated using data reported in Table 1.
borane radical anion B(C 6 F 5 ) 3 •− was however not observed, which is associated with its facile decomposition. Yet, the EPR spectrum of the B(C 6 F 5 ) 3 •− radical anion has been previously reported at low temperatures and is characterized by a rich hyperfine structure originating from the nuclear spin-active 10,11 B isotopes and fluorine substituents at all positions on the phenyl ring ( Figure 1; see Table 1 for parameters). 14,19−21 To date, three different approaches for the formation of radicals in FLP chemistry have been identified. 22−25 First, the FLP can react with a radical substrate X, such as nitric oxide, to yield a "trimer" radical of the form LA−X−LB 5 (Scheme 3A). 26−31 The second route involves the use of a transitionmetal-based electron donor, such as ferrocene or cobaltocene, to reduce the Lewis acid to the corresponding radical anion (Scheme 3B). 23 Finally, the generation of radical ion pairs (RIPs) can proceed via direct SET between a Lewis base and Lewis acid that function as an electron donor and electron acceptor, respectively (Scheme 3C). These RIPs were coined Frustrated Radical Pairs (FRPs) by Stephan et al. Notably, the radical ion pair can be converted back to the closed-shell FLP system via back electron transfer (BET), 32 depending on the relative energies of the two states. In this review, to support discussion of the three alternative approaches to radical formation in FLP chemistry, we shall highlight selected main-group chemistry examples where we believe SET mechanisms are prevalent and focus on the mechanistic details of the SET process and the corresponding spectroscopic findings.

PHOTOINDUCED SINGLE-ELECTRON TRANSFER
In 2020, Slootweg et al. reported on key insights into the mechanism of SET in FLP chemistry. 16 Prior to this contribution, Stephan et al. had observed only the phosphine radical cation for the PMes 3 /B(C 6 F 5 ) 3 combination in chlorobenzene. 33 In-line with the findings of Piers et al., Slootweg et al. concluded that thermally activated SET for this combination of Lewis acid and base is not feasible. Namely, DFT calculations at the SCRF (toluene)/ωB97X-D/6-311+G-(d,p) level of theory showed that the electron affinity of B(C 6 F 5 ) 3 is 3.03 eV (conversion factor: 1.00 eV = 23.0621 kcal/mol), while the ionization energy of PMes 3 is 5.54 eV, resulting in an energy difference between the closed shell PMes 3 /B(C 6 F 5 ) 3 and the radical ion pair PMes 3   3 •− RIP was found due to the reduced stabilization of the phosphorus radical cation. 20,21,32 These energy differences indicate that whereas SET is unlikely to be induced by a thermal reaction, interaction with visible light (λ = 400−800 nm, ΔE = 71.4−35.7 kcal/mol) is however feasible.
Inspired by the pioneering work of Mulliken and Kochi et al., 34,35 Slootweg et al. realized that the Mulliken theory can be used to explain the observation of these radical ion pairs. 16 Namely, an electron donor and an electron acceptor (classified as Lewis base and Lewis acid in Frustrated Lewis Pair chemistry) can combine to form an electron donor−acceptor (EDA) complex, which is visualized in Scheme 2A as the encounter complex EDA. 34,35 This EDA complex can be characterized by UV−vis spectroscopy 36 and shows a new absorption band at longer wavelengths compared to the absorptions of the individual FLP components. Irradiation of the FLP system using selective wavelengths that align with the absorption band of the EDA leads to a photoinduced SET from the electron donor to the acceptor.
The reported UV−vis spectra of the PMes 3 /B(C 6 F 5 ) 3 (violet) and P t Bu 3 /B(C 6 F 5 ) 3 (pale yellow) FLPs in toluene showed a new absorption band to be present for both (at λ max = 534 nm and λ max ≈ 400 nm, respectively; see Figure 3). 16 Time-dependent DFT (TD-DFT) calculations also predicted the presence of these new absorption bands [PMes 3 /B(C 6 F 5 ) 3 : 439 nm (f osc = 0.0184); and P t Bu 3 /B(C 6 F 5 ) 3 : 400 nm (f osc = 0.0719)]. Analysis of the frontier molecular orbitals showed that the donor orbital (HOMO) contains the phosphine lone pair, while the acceptor is the empty orbital (LUMO) located on B(C 6 F 5 ) 3 , underlining that FLP systems are ideally suited for single-electron-transfer processes.
To confirm that the SET in these phosphine/borane systems is photoinduced, EPR spectroscopy was performed in toluene at 30 K. 16 When measuring the samples in the dark, no signals were observed in the EPR spectra, highlighting that the color of the solution stems from the closed-shell EDA complex and not from the presence of radicals. On the other hand, upon irradiation with visible light (390−500 nm), SET was promoted to form the corresponding RIP, as evidenced by the observation of two separate signals in the EPR spectra ( Figure 4), which could be assigned for the first time to both the phosphine radical cation and the borane radical anion. Subsequently, by using transient absorption spectroscopy, the lifetime of the radical ion pair state in toluene at room temperature could be determined to be 237 and 6 ps for PMes 3 /B(C 6 F 5 ) 3 and P t Bu 3 /B(C 6 F 5 ) 3 , respectively. These results indicate that BET occurs quickly after SET, leading to an equilibrium between the ground state and the radical state, which lies heavily on the side of the EDA complex, as shown in Scheme 4. These results prove that the color of these solutions (in the dark) is due to the existence of a chargetransfer band, in contrast to earlier reports where typically the color was assigned to the presence of radicals. 33 Similarly, an equimolar mixture of Mes 3 P and Al(C 6 F 5 ) 3 in dry toluene or chlorobenzene was reported by Stephan et al. to yield, without exclusion of light, a distinctly purple-colored solution. 33 The room-temperature EPR spectrum of the reaction mixture showed a doublet resonance with a hyperfine coupling constant of 23.8 mT centered at g iso = 2.0089, Figure 2. Energy required for the formation of a radical ion pair can be estimated from the electron donor's ionization energy (IE) and the electron acceptor's electron affinity (EA). 16 Calculations at the SCRF/ωB97X-D/6-311+G(d,p) (solvent = toluene) level of theory.   Table 1. assigned to PMes 3 •+ of the corresponding radical ion pair PMes 3 •+ /Al(C 6 F 5 ) 3 •− (Figure 4). 17 No evidence of the radical anion Al(C 6 F 5 ) 3 •− could be observed via EPR, analogous to the boron-based radical anion. 33 Based on the findings of the photoinduced SET, we expect the formation of PMes 3 •+ in this case is due to irradiation of the charge-transfer band by visible light and that the charge-transfer band causes the purple color. Similar to B(C 6 F 5 ) 3 •− , the absence of Al(C 6 F 5 ) 3 •− can be explained by facile decomposition.
Subsequently, Marques and Ando investigated photoinduced SET in FLP chemistry using resonance Raman spectroscopy aided by supporting DFT calculations. 37 Resonance Raman spectroscopy of the archetypal PMes 3 /B(C 6 F 5 ) 3 system employing 457 nm excitation to overlap with the chargetransfer band showed the increase in signal intensity of specific signals compared to the normal Raman spectra (excitation at 1064 nm). The excitation in resonance with the charge-transfer band causes greater changes in the polarizability tensor of the vibrational modes associated with the EDA complex [PMes 3 , B(C 6 F 5 ) 3 ] and hence selective enhancement of Raman bands that were specifically attributed to the radical ion pair PMes 3 . The author's experimental results were supported by complementary DFT calculations, leading to the important conclusion that the enhancement of intensity in Raman signals originated from vibrations in both B(C 6 F 5 ) 3 and PMes 3 . The involvement of both components of the FLP system further confirms the occurrence of SET between Lewis base and acid upon irradiation of the charge-transfer band in the EDA.
As the concept of photoinduced SET in FLP chemistry is now well recognized within the literature as demonstrated here, the following sections highlight examples to showcase the potential applications accessible via these remarkable oneelectron processes.

Application of Photoinduced Single-Electron Transfer: Utilization in Materials Science
In search of multicomponent polymers with new properties, Meijer et al. reported on the photophysical properties of a copolymer consisting of stacked boranes and amines as monomers ( Figure 5). 38,39 For a combination of 6 and 7, the authors observed a new absorption band in the UV−vis spectrum upon mixing the two components in decaline (λ abs ∼500 nm). 38 As neither of the individual LA or LB components absorb above 500 nm, this absorption band was assigned to the charge-transfer band of the encounter complex [6,7]. To explore the emission properties of the corresponding radical ion pair 7 •+ /6 •− formed upon excitation, photoluminescence spectroscopy was employed. Excitation (λ ex = 387 nm) of the FLP resulted in an additional emission band at 550 nm, which was not observed in corresponding measurements of the individual components even though both components have absorption bands at the selected excitation wavelength. The authors assigned this long wavelength emission to BET from the borane to the amine. The emission decay was characterized by two different lifetimes of ∼96 ns and ∼6 μs, which the authors assigned to decay of the singlet and triplet (caused by two electrons with the same spin in close proximity) states. Similar emission spectroscopy results were also reported by the authors for the combination 6 and 8, although it should be noted that no UV−vis spectrum of the combination was reported to confirm the presence of a chargetransfer band.
In a subsequent study, the authors used EPR spectroscopy to characterize the combination of arylamine 8 and B(C 6 F 5 ) 3 in a stacked copolymer. 39 Complementary UV−vis spectroscopy showed no evidence of a charge-transfer band for this combination, although this could be due to the relatively low concentration of the components used in this study (both 25 μM). Despite this, two signals were observed in the lowtemperature EPR spectra upon 320−390 nm irradiation of the copolymer, at g = 2.0 and g = 4.2 ( Figure 6). The signal at g = 2.0 was weakly observed in the dark and grew in intensity upon irradiation, therefore indicating the formation of a low population of doublet-state isolated radical ions upon lowtemperature excitation. The signal at g = 4.2 is characteristic of a triplet state (S = 1), arising from two coupled electrons of the same spin being localized in close proximity, likely arising from an N-to-B SET process. However, the individual components do also absorb the 320−390 nm light, therefore making it possible that these EPR results are due to absorption by one of the individual components.
In search of photoluminescent aryl boranes as novel optoelectronic materials, the Wagner group synthesized a doubly Ph 2 P-substituted dihydrodiborapentacene 9. 40 This compound is an air-stable solid in the dark, but when a DCM solution was exposed to ambient light, quantitative yield of the  . CW X-band EPR spectra of two independent EPR signals originating from low-and high-spin systems of a copolymer radical. oxidized product 10 was obtained within 10 h (Scheme 5). The authors related this to a photoinduced, intramolecular charge transfer from the phosphine toward the borane backbone, yielding the corresponding radical ion pair. Phosphorus radical cations are known to react readily with oxygen to yield the corresponding phosphine oxide, just as the authors observed. 40 The photoinduced SET is further supported by the calculation of the IE (5.50 eV) and EA (−2.79 eV) with DFT (SCF/B3LYP-D4/def2TZVP(-f) with SMD treatment of DCM). 40 This results in the radical ion pair state calculated to be 2.71 eV (458 nm) higher in energy, which is comparable to the longest wavelength absorption band reported in benzene solution (470 nm, ε = 20800 mol −1 dm 3 cm −1 ). TD-DFT also predicted the possibility of a photoinduced SET where electron density is moved from the phosphorus centers to the boranes (2.86 eV, 433 nm, f osc = 0.186). It is important to note that the TD-DFT calculations (at the OT-LRC-ωPBEh/def2-TZVP level of theory with pt(SS+LR)-PCM treatment of toluene) also predicts other charge-transfer states in close proximity. For these excitations, the electron density is transferred from the anthracene toward the borane centers.

Photoinduced Single-Electron Transfer: Utilization in Synthesis
As previously noted, dihydrogen activation was one of the first examples of an FLP-induced chemical modification. 2 In this reaction, as clearly evidenced by Piers and co-workers, both radical (SET) and two-electron-transfer mechanisms can be envisioned (Scheme 6). 12 In order to elucidate the prevalent reaction pathway, Slootweg et al. further investigated the PMes 3 /B(C 6 F 5 ) 3 combination. 17 As shown above, the formation of the RIP PMes 3 •− via SET for this FLP pair occurs only under the influence of light. However, irradiation (534 nm, 2.2 W) was reported to have no significant influence on the reaction kinetics of H 2 activation. Therefore, it was concluded that the radical pathway plays an insignificant role due to the transient nature of the RIP PMes 3 •+ /B(C 6 F 5 ) 3 •− and rather the major contribution to this reaction chemistry is via a two-electron-transfer mechanism.
Using photoinduced single-electron transfer employing B(C 6 F 5 ) 3 as the electron acceptor and catalyst, Tang et al. reported the sulfenylation of 2-phenyl indoles (Scheme 7A). 41 UV−vis spectroscopy showed the formation of a chargetransfer band around 430 nm for the EDA [2-phenyl indole, B(C 6 F 5 ) 3 ]. Irradiation of this band with 455−460 nm light resulted in single-electron transfer from the indole to the borane, yielding the radical ion pair 2-phenyl indole •+ / B(C 6 F 5 ) 3 •-(11), as confirmed by the observation of a signal in the EPR spectrum, characterized by g iso = 2.00296 with no resolved hyperfine structure. The narrow spectral width of the signal (∼1.7 mT) precludes the assignment of this signal to the B(C 6 F 5 ) 3 •− anion (ΔB = 8 mT); therefore, this signal likely originates from the indole radical cation. The 2.4 V (517 nm) energy difference between indole oxidation (0.6 V vs Fc/Fc + in acetonitrile 42 ) and borane reduction (−1.79 V vs Fc/Fc + in DCM 14 ) confirms the feasibility of a photoinduced single- The formation of the thiyl radical is suggested to occur concomitantly during oxidation of the borane radical anion using oxygen as an oxidant. Furthermore, this process closes the borane catalytic cycle with selective oxidation of the reactive borane radical anion, achieving a high turnover number (TON) of 19 for B(C 6 F 5 ) 3 . Liu, Wu, and co-workers also used the photoinduced formation of a borane radical anion in the hydroboration of alkenes (Scheme 7B). 43 The reaction begins with SET from ethyl di-iso-propyl amine to BX 3 (with X = Cl or Br) to form the corresponding radical ion pair i Pr 2 NEt •+ /BX 3 •− , which was calculated via DFT to be 3.40 eV (78.3 kcal/mol) higher in energy than the closed shell pair, hence requiring photoinduced SET for its formation. TD-DFT calculations of Liu et al. also predict a charge-transfer band at 323 nm for SET from the amine to borane. After the formation of the RIP, the authors propose that the borane radical anion adds to the alkene, yielding radical intermediate 13, based on more DFT calculations. After hydrogen atom abstraction from the amine radical cation and halogen loss from 13, the final product 14 is obtained. To determine the proton source, deuterium-labeling experiments were performed using d 8 -styrene and d 2 -dichloromethane. For both deuterium sources, no d-incorporation was observed in the β-position of the product. Instead, the presence of an iminium cation was confirmed by observation of a resonance at 152.6 ppm in the 13 C NMR spectra and by ESI-MS analysis (128.1435 (observed) vs 128.1434 (calculated)), indicating the amine radical cation to be the hydrogen atom source. Further mechanistic studies regarding halogen loss indicated the formation of BBr 4 − by the observation of a peak at −24.32 ppm in the 11 B-NMR spectrum. An inhibition of the reaction was observed in the presence of radical scavengers like 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) Besides the typical borane Lewis acids as electron acceptors, there are also reports of using sulfonium salts as the acceptor in combination with, among others, amines or sulfur-based electron donors. 44 45,46 Mixing 15 with the arene gave the adduct 16, which together with the amine 17 formed EDA complex [17,16], which is characterized by a small red-shifted absorption in the UV−vis spectrum. The subsequent photoinduced SET (λ em = 456 nm) led to the formation of both the amine radical cation 18 and the sulfur radical 19, of which the latter undergoes homolytic bond cleavage to yield the sp 2 -arene radical 20. Next, this radical is trapped by the nucleophile t Bu-isocyanide (route a) or an enol silane (route b) to yield the functionalized arene radical 21. Oxidation of this radical by the amine radical cation 18 or sulfonium cation 15 yields the corresponding arene cation 22. The final product is obtained after elimination of the t Bu cation (route a) or silyl cation (route b). With this one-pot procedure, the authors were able to obtain a wide range of αarylated carbonyl compounds using route a 47,48 and cyanated arenes with route b, 49,50 which are hard to prepare in the absence of transition-metal catalysts, organometallic reagents, and toxic cyanides.

THERMAL SINGLE-ELECTRON TRANSFER
As shown in section 2, for SET to be induced with visible light, the energy gap between the ionization energy of the Lewis base and the electron affinity of the Lewis acid should be in the range 1.5−3.1 eV. It is also possible to thermally induce SET by reducing the energy difference between IE and EA, and as such reducing the energy difference between the ground state EDA complex and the corresponding radical ion pair. This will lead to an equilibrium between the closed shell and radical states as shown in Scheme 9.   16 since concentrations as low as the 10 −10 M region can be detected. 51 In the following sections several FLP and main group systems will be discussed to highlight the feasibility of a thermal SET.

Evidence of Thermal Single-Electron Transfer
Riedel et al. recently reported thermal SET using the fluorinated trityl cation [C(C 6 F 5 ) 3 ][Al(OTeF 5 ) 4 ] (23). 52 This substituted carbon-based Lewis acid was determined to have an increased electron affinity compared to the nonfluorinated trityl cation (CPh 3 + ) (−7.33 eV vs −5.86 eV, respectively). This is in agreement with trends in the oxidation potential, which increases from −0.11 V vs Fc/Fc + in MeCN for CPh 3 Addition of tris(p-bromophenyl)amine (0.74 V vs Fc/Fc + in DCM) to the fluorinated trityl cation 23 led to the formation of the radical pair (pBr-Ph) 3 • (24), as directly evidenced by the observation of both radical ions in the EPR spectrum as broad, featureless overlapping singlets characterized by g iso ∼ 2.0031 and g iso ∼ 2.012 for the perfluorinated trityl and arylamine radical cation, respectively (Scheme 10A). As the redox potential of the fluorinated trityl cation is 0.4 V higher than the redox potential of the amine, thermal SET is indeed possible for this combination of electron donor and acceptor.
The group of Gianetti studied the reactivity between trioxatriangulenium (TOTA + , 25) with 1,3-di-tert-butylimidazol-2-ylidene (I t Bu, 26; Scheme 10B). 53 Mixing the two compounds in toluene or acetonitrile gave directly a green solution, which is an indication of possibly a SET event. The corresponding radicals TOTA • 27 and I t Bu •+ 28 were not observed via EPR spectroscopy, either directly or via trapping experiments with TEMPO and benzoyl peroxide. However, the formation of TOTA-dimers 29 and 30 as components of the product mixture suggested the presence of radical intermediates. The calculated electron affinity of TOTA + (−7.41 eV, PCM/CAM-B3LYP/6-311G(d,p) in acetonitrile) and the ionization energy of I t Bu (5.59 eV) support the premise that a thermal SET mechanism is possible. As a final proof for the occurrence of a thermal SET, the authors studied the properties of the TOTA dimer. Upon measuring a solution of the dimer in m-xylene, the TOTA monomer radical could be observed at temperatures above 340 K with EPR spectroscopy and was identified by a multiline EPR signal characterized by g iso = 2.005, a iso ( 1 H n=6 ) = 0.091 mT and a iso ( 1 H n=3 ) = 0.328 mT ( Figure 7).
The reduction of metals by pyridine scaffolds was observed by Boẗtcher et al. during their attempts of coordinating paraborane-substituted pyridines 31 and 31 F (Scheme 10C) to metal centers. 54 To study the SET process in more detail, they mixed 31 with the trityl cation (CPh 3 + ) in DCM. The obtained products were the protonated pyridine 33 and Gomberg's dimer, 34. Detection of the Gomberg dimer indicates the occurrence of SET, and indeed the redox potentials (0.56 V vs Fc + /Fc for 31, and 0.66 V vs Fc + /Fc for the trityl cation) show that a thermal SET is feasible. The authors proposed that  (Figure 7). Independent generation of the radical 37 from the diazonium-phosphine adduct 35 with various reducing agents (Cp 2 Co, potassium, and PhSNa) suggest that 35 is reduced during the cleavage of the disulfide bond. The reported redox potential of the diazonium-phosphine adduct 35 (E red = −0.91 V vs Fc/Fc + in MeCN) is in accordance with a possible thermal SET using P t Bu 3 as the oxidant (E ox = 0.90 V vs Fc + / Fc in MeCN) yields an energy gap of ΔE ox-red = −0.01 V. 13

Reactions with a Thermal Single-Electron-Transfer Step
Melen's group reported on the use of diaryl esters (38, Scheme 12) for the formation of C−C bonds in the presence of the PMes 3 /B(C 6 F 5 ) 3 FLP system, providing both experimental and computational details to support proposed reaction mechanisms. 56,57 The reaction proceeds initially with the coordination of B(C 6 F 5 ) 3 to the ester 38 (Scheme 12A) to form adduct 39, followed by heterolytic cleavage of the C−O bond, yielding the borane 40 and carbocation 41. The carbocation can undergo a reversible one-electron reduction by PMes 3 to the radical 42 (Scheme 12B), as evidenced by room temperature EPR spectroscopy ( Figure 9). The authors found that this radical state is only 6.9 kcal/mol (0.30 eV) higher in energy than the ion pair, making a thermally induced SET indeed feasible. The absence of the carbon radical 40 was justified by its quick decomposition. It should be noted that Melen et al. were able to observe a weak signal in the EPR spectrum assigned to a more sterically encumbered carbon radical for a related system, confirming the formation of a radical pair. 56 Continuing from the equilibrium between cation 41 and radical 42, the reaction can proceed via two alternative pathways. 57 The radical mechanism continues from the radical 42 by addition to the alkyne to give 43 as an intermediate, as shown in Scheme 12B. After hydrogen atom abstraction by the phosphine radical cation, the final product 44 is obtained. Alternatively, the diamagnetic pathway proceeds with the addition of both the carbocation 41 and phosphine to phenylacetylene (Scheme 12C). The product 44 is obtained after elimination of PMes 3 from the intermediate 45.
To probe the operative mechanism, the authors determined the Hammett parameter ρ by doing competition experiments with para-substituted phenyl acetylenes. They found values for ρ of −6.6 ± 1.7 experimentally and −5.7 ± 0.8 computationally, which indicates the buildup of a positive charge during the reaction. These results are consistent with the diamagnetic mechanism. DFT calculations of the energy surface show that for electron-donating para-substitutions on the phenylacety- Chemical Reviews pubs.acs.org/CR Review lene, the reaction barrier of the radical mechanism is up to 18.8 kcal/mol (for p-NMe 2 phenyl acetylene) higher in energy than the barrier in the diamagnetic pathway. The difference between the radical and diamagnetic mechanism is however smaller when utilizing electron-withdrawing substituents. For example, the difference is only 0.7 kcal/mol for p-NO 2 phenyl acetylene, indicating that the radical mechanism can be (partly) operative with electron-poor substrates. Very recently, Malischewski's group increased the EA of free TCNQ from experimentally determined 3.38 eV for the first oxidation to 6.04 eV upon addition of four equivalents of B(C 6 F 5 ) 3 , as determined by DFT calculations at the B3LYP-D3(BJ)/Def2-SVP level of theory. 58 Also the EA of the second oxidation of 3.21 eV was found to be more facile than the first oxidation of free TCNQ. The authors showed that TCNQ-(B(C 6 F 5 ) 3 ) 4 is capable of oxidizing both pBrPh 3 N and thianthrene in DCM (upper reactions in Scheme 13) by observation of two partly overlapping singlets in either case. In the case of pBrPh 3 N, the authors assigned the singlet at g iso = 2.0143 to the pBrPh 3 N •+ radical cation and for the TCNQ-(B(C 6 F 5 ) 3 ) 4 •− radical anion a signal at g iso = 2.0026. In the case of employing thianthrenium, the radical anion was observed at the same position and the thianthrenium radical cation at g iso = 2.00788. Independent generation of the monoanion with ferrocene showed a broad singlet at g iso = 2.00238, confirming the assignment of the radical anion.
Furthermore, for both pBrPh 3 N and thianthrenium the authors were able to obtain crystal structures in combination with TCNQ-(B(C 6 F 5 ) 3 ) 4 , which showed the coordination of the boranes to each of the cyanides of TCNQ.
Formation of the dianion [TCNQ-(B(C 6 F 5 ) 3 ) 4 ] 2− was achieved with ferrocene (Fc) and decamethylcobaltocene (Cp* 2 Co) (bottom reactions in Scheme 13). 59 X-ray diffraction confirmed again the coordination of the boranes to the cyanides of TCNQ. The dianion also made it feasible for the authors to measure the oxidation potential of the dianion and monoanion.  4 ] as the major product (Scheme 14). 13 The reaction was predicted to proceed through the formation of the radical salt intermediate [P t Bu 3 ] •+ [BF 4 ] − as the oxidation potential of P t Bu 3 (0.90 V vs Fc/Fc + in MeCN) is in the range of a thermal SET. The generated phosphorus radical cation readily abstracts a proton from the acetonitrile solvent and subsequent decomposition affords the phosphonium borate product. Using EPR studies, a small side reaction was found to occur as the authors found a six-line pattern characterized by g iso = 2.0071, a iso ( 14 N) = 1.05 mT, and a iso ( 31 P) = 1.21 mT (Figure 8). They assigned this to the formation of the nitrosyl−phosphine adduct t Bu 3 P−NO • , which can be established by trapping the in situ generated NO • by residual P t Bu 3 .
An exciting example of SET has recently been reported by Muller et al., in which they described the coordination of B(C 6 F 5 ) 3 to the germanium-centered Lewis base 46 (Scheme 15). 60 During the reaction, the toluene solution turns into a deep purple color (λ max = 544 nm), eventually turning colorless when the reaction is completed. Room temperature EPR spectra were recorded on reaction aliquots during the course of the reaction, in which the authors observed the formation of two different radical species (Figure 9). The first paramagnetic species was identified as the hafnium-based radical cation 47′ (g iso = 1.9881, a iso (Hf) = 8.5 mT), which the authors propose to be in equilibrium with 47. The authors propose that the formation of 47 occurs from 46 by a SET toward B(C 6 F 5 ) 3 . Cyclic voltammetry showed indeed an irreversible oxidation ability of compound 46 (−0.51 V vs Fc + /Fc). Furthermore, oxidizing 46 with [Ph 3 C][B(C 6 F 5 ) 4 ] showed the formation of the same hafnium radical 47′ that could be detected together with the trityl radical, showing the occurrence of a SET with 46 as the reductant. The radical 47′ was also observed with EPR spectroscopy when a silyl cation was employed as the oxidant.
Besides the hafnium radical 47′, the authors observed a second, featureless radical in the EPR spectrum when performing the reaction. They assigned it to the formation of the B(C 6 F 5 ) 3 •− radical anion and also proposed that this radical is responsible for the absorption at 544 nm, even though they mention that the B(C 6 F 5 ) 3 •− radical anion is highly unstable (t 1/2 ≈ 5−10 min at 0°C in THF). 19 Furthermore, based on the reported reduction potential of B(C 6 F 5 ) 3 (−1.79 V vs Fc/Fc + in DCM), a thermal SET seems unlikely due to the large energy gap (approximately 1.3 V). Therefore, we note here that a photoinduced SET cannot be excluded, where the observed deep purple color of the reaction mixture stems from the EDA complex [46, B(C 6 F 5 ) 3 ] that features a charge-transfer band in the UV/vis spectrum at λ max = 544 nm. A similar misinterpretation was found for the observed purple color in the case of PMes 3 /B(C 6 F 5 ) 3 in chlorobenzene. 33 For this FLP combination, the purple color was first thought to be indicative of the presence of radicals, but has since been shown to arise from the formation of the EDA complex [PMes 3 , B(C 6 F 5 ) 3 ]. 16

CONSEQUENCES OF RADICAL DECOMPOSITION IN RADICAL PAIRS GENERATED VIA SET
There are cases where a thermally induced SET can be observed even though the energy gap between the closed shell state and the radical (ion) pair is more than 0.4 eV. This can be attributed to the subsequent reaction of one of the radicals in a consecutive step (for example, hydrogen atom abstraction), as illustrated in Scheme 16. Further involvement of the radical in subsequent reactions will shift the SET equilibrium toward the radical products and thus increase the  Figure 8. CW X-band EPR spectra of substituted nitroxyl; simulated using values listed in Table 1.

Scheme 15. Proposed Generation of Radical Ion Pair
Species from a Germanium-Centered Lewis Base with B(C 6 F 5 ) 3 and a Control Reaction Using the Trityl Cation as a One-Electron Oxidant for the Lewis Base  Table 1.

Chemical Reviews
pubs.acs.org/CR Review concentration of the more persistent radical, according to Le Chatelier's principle. 61 The consequence of this reactivity is that only one of the two radicals can be directly observed, instead of observing both radicals simultaneously as would be the case if both radicals are persistent. Furthermore, the decomposition of one of the two radicals can also occur after a photoinduced SET. BET is then not feasible anymore, leading to an increasing concentration of the persistent radical upon prolonged irradiation. The next sections contain reports where the decomposition of either of the formed radicals is required to observe radicals or where this is utilized in synthesis (Scheme 16). 17A). 20,62 Both tris-2,4,6-triiso-propylphenyl phosphine (PTipp 3 ) and PMes 3 led to a SET event as both phosphine radical cations were observed by EPR (see Table 1 for details). The sum of the electron affinity and ionization energies were calculated as 0.07 and 0.33 eV (SCRF/M06-2X/6-311+G(d,p) in chlorobenzene), respectively, indicating that a SET thermal process was feasible for these phosphine derivatives. Later, Slootweg and co-workers showed that this is indeed the case as the radicals are formed in the dark. 16 For P t Bu 3 , the sum of the electron affinity and ionization energy is 0.67 eV, which is typically too large to observe a thermal SET with EPR. 20 However, the authors reported the presence of the trityl radical in the EPR spectrum. The 31 P( 1 H) NMR spectrum showed the formation of tri-tert-butyl phosphonium salt, which was postulated to be formed by hydrogen abstraction by the phosphine radical cation. Therefore, it was postulated that decomposition of the phosphine radical cation leads to an increased concentration of the more persistent trityl radical, and hence increases the likelihood for experimental observa-tion with EPR spectroscopy. The authors also studied the combination [Ph 3 C][B(C 6 F 5 ) 4 ] with PoTol 3 , for which the calculated energy gap (1.04 eV) completely precluded a thermal SET, as confirmed by the absence of detectable radicals in the EPR spectrum; hence, no radicals were available for subsequent reactivity. Klare and Muller et al. have also studied silylium ions as the choice of electron acceptor (Scheme 17B). 20 The silylium ions are weaker electron acceptors than the trityl cation, resulting in the IE/EA sum to be larger than 0.4 eV in all cases, which normally would make the observations of radicals with EPR spectroscopy impossible. However, the obtained silyl radicals are known to be highly unstable and can quickly decompose upon formation, 63 pushing the equilibrium in favor of the phosphine radical cation. We suggest that this decomposition therefore results in the enhanced ability of the authors to observe in certain cases the partner phosphine radical cation. For example, for the silylium cation [(Me 5 C 6 ) 3 Si][B(C 6 F 5 ) 4 ] in combination with PTipp 3 or PMes 3 , the IE/EA sum is 0.92 and 1.18 eV, respectively, but the phosphine radical cation is clearly visible in the resulting EPR spectrum. 20,62 In contrast, no EPR signals were observed for either the P t Bu 3 and PoTol 3 systems, which the authors explained as arising from the energy gap being too large to be thermally overcome for the radical state to be accessed. Furthermore, the phosphine radical cations of P t Bu 3 and PoTol 3 are both thermally unstable, further reducing the possibility of observation of any radicals via EPR spectroscopy as both components, the electron donor and acceptor, are unstable in their corresponding radical state.

Klare et al. and Schilter et al. studied the reactivity of [Ph 3 C][B(C 6 F 5 ) 4 ] with different phosphines (Scheme
Severin et al. reported the use of N-heterocyclic carbenes (NHCs) as electron donors in toluene. 64 Upon mixing the NHC IDipp (49 with R = 2,6-di-iso-propylphenyl) and the trityl cation (see Scheme 18A), a short-lived purple solution was obtained. Both the resulting room temperature EPR spectrum and UV−vis spectroscopy measurements (revealing an absorption band at 343 nm) showed evidence of the trityl radical. The IDipp radical cation 50 was not observed by EPR, presumably due to its facile decomposition. On the other hand, the authors were able to assign an absorption band at 591 nm to the IDipp radical cation 50, which was observed during the early stages of the reaction. The authors supported this assignment by independently oxidizing IDipp with [NO][PF 6 ], which showed the same short-lived purple color as observed for the FLP solution. Trapping the IDipp radical cation 50   53 Typically, this is too high in energy to observe any radical species, but we suggest that the rapid decomposition of the NHC radical cation 50 allows a buildup in concentration of the trityl radical, making its experimental observation with EPR spectroscopy (g iso = 2.0025, a iso (o-H) = 0.26 mT, a iso (m-H) = 0.11 mT, a iso (p-H) = 0.28 mT) possible.

For a SET between Np-Tol 3 or NPh 3 and [CPh 3 ]
[B(C 6 F 5 ) 4 ] (IE/EA sum = 0.43 and 0.7 eV, respectively, at SCRF/ωB97X-D/6-311+G(d,p) in toluene), the radical pair state is too high in energy to observe any radical formation by EPR. 16 However, Slootweg et al. showed that the dimerization of the trityl radical toward Gomberg's dimer drives the equilibrium toward the radical state (Scheme 18B). This increases the concentration of the amine radical cations, making it possible to observe these radicals in toluene solution at room temperature with EPR spectroscopy.

Formation of a Single Radical Species after Photoinduced Single-Electron Transfer
It should again be noted that decomposition of one of the radicals can occur after photoinduced SET. Slootweg et al.   3 •− is 2.91 eV (67.1 kcal/mol) higher in energy than the ground state (SCRF/ωB97X-D/6-311+G(d,p) in toluene). 16 Upon irradiation of a mixture of both the donor and acceptor in DCM for 3 h, a red solution was obtained, and the presence of the thermally stable borane radical anion was confirmed by a signal (with some hyperfine features, presumably due to coupling with the boron center) in the EPR spectrum. The red color of the borane radical anion solution was persistent, as BET was prevented by the rapid decomposition of the phosphine radical cation.

Utilization of Radical Reactivity in Synthesis
Hong's group reported recently the C−H functionalization of pyridinium salts using alcohols and thiols. 65 This reaction was proven to proceed via both a dark reaction and a photoinduced pathway, as evidenced by the results that a 72% yield was obtained in the absence of irradiation, which improved slightly to 84% upon irradiation (λ = 467 nm). The reaction started with an initiation, which the authors proposed for the dark reaction to be a SET between P t Bu 3 and the pyridinium salt 52 (Scheme 19A). This yielded a radical pair consisting of P t Bu 3 •+ and radical 53. Upon the formation of radical 53, homolytic bond cleavage occurred toward aminyl radical 54 and pyridine. The photoinduced reaction was also proposed to be initiated by the formation of radical 53. The authors showed the presence of a new broad absorption band around 550 nm, which was formed upon mixing pyridinium salt 52 and the in situ formed xanthate anion 55. Irradiation of this band led to SET and via the formation of radical 53 toward aminyl radical 54, which was also obtained in the dark initiation reaction.
The authors proposed the same catalytic cycle for both the dark and light reaction, as shown in Scheme 19B for the formation of the product. 65 Initially, the aminyl radical 54 undergoes SET with the xanthate anion 55, to obtain the amide anion 59 and xanthate radical 57. The isolation of Ph 3 P = S (over 95% yield) showed that the phosphoranyl radical 58 was formed in a reaction between P t Bu 3 and the xanthate radical in the next step. The phosphoranyl radical undergoes βscission, yielding the phosphine sulfide and an alkyl radical. In the last step of the catalytic cycle, the alkyl radical reacts with the pyridinium salt, forming the product and regenerating the aminyl radical 54. This example of chemical synthesis illustrates that high conversions of the starting material can be obtained if one of the radicals is reactive, even if the equilibrium does not favor the radical state.

SINGLE-ELECTRON TRANSFER FACILITATED BY LEWIS ACID COORDINATION
As shown in the previous sections, the electron affinity of the Lewis acid and ionization energy of the Lewis base are of fundamental importance for the possibility of SET events. A possible synthetic strategy to widen the range of electron acceptor affinities is the coordination of Lewis acids. An example is the reduction potential of ferrocyanide as reported by the group of Gray et al. 66 The authors showed that the reduction potential could be altered by as much as 2 V by the coordination of a different number of boranes to the metal (Scheme 20) . More examples are abound in organometallic chemistry. 67,68 Herein, we will present several examples in which the electron affinity of an organic substrate is increased by the coordination of a Lewis acid.

Observations of Single-Electron Transfer Induced by Lewis Acid Coordination
Stephan and co-workers found that the FLP systems consisting of B(C 6 F 5 ) 3 or Al(C 6 F 5 ) 3 as a Lewis acid and P t Bu 3 or PMes 3 as a Lewis base can readily reduce tetrachloro-p-benzoquinone (Scheme 21A). 33 Using equimolar equivalents of P t Bu 3 in toluene at −78°C, the adduct 60 was found as the product, in which the phosphine forms a covalent bond with the quinone. On the other hand, when PMes 3 was added in excess, the dianionic bis-B(C 6 F 5 ) 3 /Al(C 6 F 5 ) 3 adduct 62 resulted, with 2 equiv of the phosphine radical cation as the counterion that was characterized by an absorption at 573 nm in the UV−vis spectrum.
In 2020, Slootweg et al. set out to explore the mechanistic details of these reductions. 17 They found that both the quinone (EA = 4.45 eV, SCRF/ωB97X-D/6-311+G(d,p) in chlorobenzene) and B(C 6 F 5 ) 3 (EA = 3.31 eV) are clearly not strong enough to oxidize PMes 3 (5.25 eV) thermally, yet they observed that the reaction proceeds in the dark (ΔE = 0.80 eV for p-benzoquinone and ΔE = 1.94 eV for B(C 6 F 5 ) 3 ). Encouraged by the report of the groups of Nocera, Jacobsen, and co-workers on the increased electron affinity of quinones by the formation of hydrogen bonds, 69 Slootweg et al. calculated the electron affinity of the quinone-B(C 6 F 5 ) 3 adduct 60 (Scheme 21A), 17 which increased by 1.12 to 5.57 eV compared to that of the parent quinone. This electron affinity is now large enough to induce a thermal SET using either P t Bu 3 or PMes 3 as the Lewis base. Furthermore, the calculations showed that the coordination of a second equivalent of B(C 6 F 5 ) 3 enhances the electron-accepting ability even further, such that a second reduction event can occur with both PMes 3 and P t Bu 3 . In the case of P t Bu 3 , the second reduction is prevented by the barrierless formation of the 61 adduct from the semiquinone fragment.
Slootweg et al. also performed spectroscopic studies on the deep purple reaction mixture of PMes 3 /B(C 6 F 5 ) 3 (color comes from EDA complex [PMes 3 , B(C 6 F 5 ) 3 ]) with 0.5 equiv of tetrachloro-1,4-benzoquinone (TCQ) in the dark. 17 For this reaction, Stephan et al. had previously reported the presence of the PMes 3 radical cation. 33 Slootweg et al. confirmed this by the observation of a doublet signal in the EPR spectrum (g iso = 2.0050; a iso = 23.9 mT) and a triplet multiplet pattern assigned to the formation of the (PMes 3 ) 2 •+ (g iso = 2.0060; a iso = 16.6 mT); Figure 4). In addition, an undefined featureless signal (g iso = 2.0058) was observed, which was assigned to the TCQ centered radical anion, TCQ−B(C 6 F 5 ) 3   70 By employing TEMPO and the trityl radical or decamethylferrocene (FeCp* 2 ) as electron donors, they obtained the radical anion bis-B(C 6 F 5 ) 3 adduct 63 (Scheme 21B). Using 2 equiv of the trityl radical, the quinone could be readily reduced to the dianion. However, in the absence of the Lewis acid, none of the electron donors could reduce the quinone moiety. The authors also employed anthraquinone, phenanthrenequinone, and acenaphthenequinone, which all showed similar reactivity to p-benzoquinone, although TEMPO was not always a potent enough reductant for these quinones.
Regarding the mechanism for the formation of 63, the authors found that the reduction of the quinone was reversible, as the addition of THF or DMSO resulted in the backward reaction toward the formation of the quinone. 70 The addition of these coordinating solvents led to the decoordination of B(C 6 F 5 ) 3 from the quinone and the formation of a Lewis adduct between B(C 6 F 5 ) 3 and THF or DMSO. Consequently, the quinone became less electron accepting and thus induced a BET to yield the quinone.
The reduction of dioxygen has been reported by Henthorn and Agapie 71 and Erker's group. 72 First, Henthorn and Agapie showed that even though ferrocene (FeCp 2 ) is inert to oxygen, in the presence of 2 equiv of B(C 6 F 5 ) 3 in DCM-d 2 , oxygen (1 atm) can be reduced to obtain [(F 5 C 6 ) 3 B−O 2 −B(C 6 F 5 ) 3 ] 2− (64) in several hours (Scheme 22A). The nature of the product was confirmed by X-ray diffraction, and the control reaction of ferrocene and B(C 6 F 5 ) 3 showed no oxidation of ferrocene, indicating the requirement of both oxygen and B(C 6 F 5 ) 3 . In light of the discussed literature, we support the suggestion of the authors that B(C 6 F 5 ) 3 facilities the reduction of oxygen, presumably via coordination in a first step to obtain a strong enough electron donor to be reduced by ferrocene. This is in accordance with the mismatched reduction potentials of ferrocene and O 2 − /O 2 (−1.18 V vs Fc/Fc + in DMSO). 73 In the subsequent study of Erker et al., the reduction of oxygen (1.5 bar) in DCM-d 2 is achieved using TEMPO as an oxidant in the presence of 2 equiv of B(C 6 F 5 ) 3 . 72 Instead of obtaining the dianion product, TEMPO can achieve only a single reduction toward the [(F 5 C 6 ) 3 B−O 2 −B(C 6 F 5 ) 3 ] •− radical anion (65). This radical was characterized by a seven-line signal at g iso = 2.01101 due to hyperfine coupling of both borane nuclei (a ( 11 B) iso = 0.323 mT). Trapping the B(C 6 F 5 ) 3 with THF or DMSO leads to BET, as observed by the formation of the TEMPO radical and liberation of presumably oxygen gas. As further proof of the feasibility of SET from TEMPO toward the (F 5 C 6 ) 3 B−O 2 −B(C 6 F 5 ) 3 adduct, the authors recorded the redox potential of the [(F 5 C 6 ) 3 B−O 2 −B(C 6 F 5 ) 3 ] − /[(F 5 C 6 ) 3 B−O 2 −B(C 6 F 5 ) 3 ] 2− couple to be +0.22 V vs Fc/Fc + in DCM, which is similar to the TEMPO/TEMPO + redox potential (+0.24 V vs Fc/Fc + in DCM).
Thompson and Heiden also studied the influence of Lewis acids on the reduction of quinones (Lewis acid coordination is shown in Scheme 22B). 74 Through detailed DFT calculations (SMD/M06-2X/6-311++G(d,p) in acetonitrile), they determined that the reduction potential of quinones can be increased by 0.5−1.5 V upon the coordination of a Lewis acid, dependent on the strength of the Lewis acid. For example, the coordination of B(C 6 F 5 ) 3 increased the computed first redox potential by 1.14 V. A further increase of the reduction potential by 0.7−1.6 V was possible by the coordination of a second Lewis acid. In the case of the coordination of 2 equiv of B(C 6 F 5 ) 3 , the computed redox potential is 1.16 V compared to −0.96 V for the parent quinone. These results indicate that the electron affinity of quinones can be tuned over a wide range by the addition of Lewis acids, thus facilitating SET processes.
Interested in obtaining an intermolecular SET induced by Lewis acid coordination, Wang's group investigated the combination of amines as electron donors for borane-activated quinones. 75 Coordination of the borane to the amine quinone   76 Upon mixing amine 69 and 9,10anthraquinone (Scheme 23B) with 2 equiv of B(C 6 F 5 ) 3 in DCM, the authors obtained a dark blue solution from which they could obtain deep purple crystals. UV−vis spectroscopy of 70 in DCM showed two absorption bands at 570 and 620 nm, which were assigned to the amine radical cation. The crystal structure revealed elongation of several quinone bonds, in tandem with the shortening of amine bonds upon addition, attributed to electron transfer to obtain the quinone radical anion and amine radical cation. The presence of the radical cation and anion were confirmed by the observation of two signals in the EPR spectra ( Figure 10). The quinone radical anion gave a featureless signal at g iso = 2.0040, while the amine radical cation was observed by a multiplet signal centered at g iso = 2.0034 with hyperfine splitting originating from coupling to proton and nitrogen nuclei [a iso ( 1 H) = 0.195 and 0.655 mT, and a iso ( 14 N) = 0.700 mT]. Half-field signals were observed for solid samples (both at room temperature and 88 K), indicating magnetic exchange couplings to be present. SQUID measurements confirmed the relatively strong antiferromagnetic exchange coupling.
In contrast, for the combination of amine 71 and pbenzoquinone with 2 equiv of B(C 6 F 5 ) 3 , the SQUID measurements showed only weak antiferromagnetic interaction (Scheme 23C). 76 The authors explained this by the large distance between the cation and anion in the crystal structure. Another difference observed between 69 and 72 was observed in the EPR spectrum. Unlike 69, for 72 only the radical cation could be observed with a characteristic nitrogen hyperfine  (Figure 10). The presence of the amine radical cation was further confirmed by UV−vis spectroscopy of a DCM solution of 72, in which a broad absorption band around 1500 nm was observed that was earlier already ascribed to the amine radical cation using spectroelectrochemistry. 77 The authors suggest that the lack of observation of the quinone radical anion of 72 was due to a low coupling constant or weak signal intensity. 76 These results make us on the other hand speculate whether a second reduction of the quinone occurred, yielding a quinone dianion that also could explain the absence of a signal in the EPR spectrum.
Stephan et al. showed the cleavage of the O−O bond of benzoyl peroxides 73 using the FLP system PMes 3 /B(C 6 F 5 ) 3 (Scheme 24). 78 Previously, the authors observed that B(C 6 F 5 ) 3 coordinates readily to peroxides. 79 Using Cp* 2 Fe as reductant, it was possible to cleave the O−O bonds of these peroxides. Upon employment of PMes 3 /B(C 6 F 5 ) 3 in combination with 0.5 equiv of (ArCOO) 2 in DCM, immediately an extremely deep purple solution was obtained containing the salt [PMes 3 ] •+ [RCOOB(C 6 F 5 ) 3 ] − (R = Ph, p-BrC 6 H 5 , p-CH 3 C 6 H 5 ). The characteristic doublet signal in the EPR spectrum and the absorption maximum at 572 nm further confirmed [PMes 3 ] •+ formation. The authors proposed the mechanism to start with the coordination of B(C 6 F 5 ) 3 to the ketone moiety of benzoyl peroxide 73, forming adduct 74. 78 Next, the reduction occurred using PMes 3 as the electron donor. We expect that the increase of the electron affinity of the benzoyl peroxide due to B(C 6 F 5 ) 3 coordination is required to enable the use of PMes 3 as a one-electron donor.
Recently, Warren et al. presented the reduction of the nitrite anion using strong Lewis acids, such as B(C 6 F 5 ) 3    . The EPR spectrum for 79 attained the expected isotropic three-line pattern rising from 14 N hyperfine coupling, with an isotropic hyperfine coupling of 1.57 mT at room temperature. This study showed that besides influencing the redox potential of electron acceptors, also the stability can be influenced at the same time.

Influence of Lewis Acid Coordination on the Photoinduced SET
Interested in fluorescence properties of organic donor− acceptor diads, Abe's group studied the influence of B(C 6 F 5 ) 3 coordination. 81 The commercial fluorescence dye 80 has an absorption band in DCM at 422 nm (2.94 eV) for the photoinduced SET from the coumarin core toward the pyridyl group. The fluorescence emission after excitation of the absorption band is at 481 nm (2.58 eV). Upon coordination of B(C 6 F 5 ) 3 as illustrated in Scheme 24, the dye 81 is obtained where the B(C 6 F 5 ) 3  These results demonstrate that the coordination of a Lewis acid to the electron acceptor changes the required wavelength in the case of a photoinduced SET. Besides being reflected in orbital energies and redox potentials, also the fluorescence, likely from BET, moves toward a longer wavelength upon coordination of a Lewis acid. Besides dye 80, the authors observed similar results for the coordination of B(C 6 F 5 ) 3 to the dyes 82 and 83 (Scheme 26).

Lewis-Acid Catalyzed Single-Electron Transfer: Utilization in Synthesis
Ooi's group exploited the use of SET for the formation of C− C bonds between amines and vinyl ketones, catalyzed by B(C 6 F 5 ) 3 . 82 The authors evidenced that thermal SET occurs with B(C 6 F 5 ) 3 and the TMS amine 84 as the amine radical cation 85 could be observed by EPR spectroscopy both in the presence and in the absence of light (characterized by g iso = 2.0033 and hyperfine coupling originating from the amine nitrogen and ring protons Figure 11 and Table 1). Upon addition of methyl vinyl ketone, the formation of the addition product 86 was observed (Scheme 27A). The authors purported that this formed via the loss of the TMS cation before the addition of the ketone. Employing the less electronrich amine 87 (oxidation potential 0.50 V vs Fc/Fc + , compared to 0.23 V vs Fc/Fc + for 84, R = Br in both cases), the authors found that light (405 nm) was required for a reversible SET to occur, as the radical 88 was observed only by EPR upon irradiation with 405 nm (Figure 11 and Table 1). TD-DFT Figure 10. CW X-band EPR spectrum of the individual radical components of 70 (i.e., amine-radical cation 70 •+ and quinone radical anion 70 •− ), and the radical ion pair 72; simulated using values listed in Table 1.   83 The Lewis acid first coordinates to the aldehyde 90, which is subsequently able to form an EDA complex with amine 91 (Scheme 27B). The authors proved this using UV−vis spectroscopy, which showed a new absorption peak (a broad peak around 430 nm) in the presence of all three components. Irradiation of this band with 456 nm light promoted photoinduced SET in EDA complex [91, 89] and yielded the RIP consisting of the amine radical cation 93 and the radical anion 92. The amine radical cation 93 subsequently eliminates the TMS cation, yielding an α-alkyl radical, which couples with the radical anion 92 to obtain the product 94 in good yield (up to 94%) (Scheme 27B). The obtained enantioselectivity (up to 95% ee) further proves that Lewis acid coordination to the aldehyde is required to induce SET.

CONCLUSION AND OUTLOOK
Since the first report on the simultaneous activation of hydrogen by a Lewis acid and Lewis base, a rise of interest in the chemistry of FLP systems has developed, rejuvenating the field of main group chemistry and catalysis. At first, the reactivity with H 2 was solely explained via two-electrontransfer pathways, where simultaneous donation and accepting of electron density in the encounter complex occurs. More recently, reports of radicals in FLP chemistry have been appearing. Here, we set out to review the different mechanisms of SET between Lewis base and acid to understand the underlying fundamental processes of radical formation.
One possible way for a SET to occur is photoinduced. In these cases, the absorption of light by the EDA or encounter complex leads to the formation of the radical pair. Light energy is required as the radical state is significantly higher in energy than the ground state electron donor−acceptor complex, which cannot be reached with common thermal means of heating the reaction mixture. Visible-light energy can be used to accomplish a single-electron shift to form transient radical pairs, which are 1.5−3.1 eV higher in energy than the ground state. If the radical state becomes more stable, the SET could occur thermally. For radical states not more than 0.4 eV higher in energy than the ground state, the radicals can potentially be observed in the reaction mixture with EPR spectroscopy at ambient temperature. Larger energy differences will lead to such small quantities of the radical state following the Boltzmann distribution, which makes their detection with, for example, EPR spectroscopy impossible. Yet, at low temperatures (e.g., 30 K) and upon direct irradiation of the sample in the EPR spectrometer, transient high-energy radical ion pairs like PMes 3 •+ /B(C 6 F 5 ) 3 •− have been detected. Indeed, there are cases where one of the radicals formed following SET is thermally labile and decomposes during the reaction under ambient temperatures, making it only possible to observe the persistent radicals. A consequence of this decomposition is that the equilibrium between the ground state EDA complex and the radical pair shifts toward the radical state. As such, it could be possible to observe radicals even if the radical pairs are too high in energy to be typically observed. In particular, in the case of photoinduced SET, the partial decomposition of the radical pair prevents BET, leading to a buildup of radical concentration. The formation of radicals by SET and subsequent observation can also be facilitated by Lewis acid coordination to the substrate, which acts to increase the electron affinity of the substrate, making the SET event more feasible.
We hope this review leads to more insights and understanding of the SET process in FLP chemistry and related Scheme 25. Reduction of Nitrite Anion Using Lewis Acid to Produce Capped Nitrite Mono-and Dianions Scheme 26. Abe's Group 81 Studied Donor−Acceptor Dyes and the Influence of Coordination of B(C 6 F 5 ) 3 at the Acceptor Side Figure 11. CW X-band EPR spectra of amine radical cations 85 and 88; simulated using data listed in Table 1.

Chemical Reviews
pubs.acs.org/CR Review donor−acceptor systems in main group chemistry, which can aid the design of new chemical conversions previously unknown in the two-electron paradigm. During correction of the proofs, the article of Lin et al. was published that highlighted the potential of in-situ generated radical pairs for the regioselective aliphatic C−H functionalization. 85 More understanding of the fundamental radical steps should help to stir the development of radical mechanisms, ultimately also leading to more selective pathways or higher reaction rates as typical single-electron-transfer steps and radical mechanisms have low energy barriers. It is especially noteworthy that employing irradiation can potentially lead to increased reaction rates through photoinduced SET events. The occurrence of SET in FLP chemistry could also lead to the activation of thus far unreactive substrates or lead to new synthesis pathways.

AUTHOR INFORMATION Corresponding Authors
Electron Paramagnetic Resonance, including advanced angularselective hyperfine techniques to investigate electron-transfer processes in hetero-/homogeneous catalysis. She has a particular interest in the application of first-row complexes and main group systems as sustainable congeners of precious metal alternatives. Emma is coauthor of the popular Oxford University Press textbook "Electron Paramagnetic Resonance".
Rebecca Melen started her independent career as a lecturer at Cardiff University in 2014 following postdoctoral stays at the University of Toronto and the University of Heidelberg. She was promoted to full professor in 2021. In 2018, she was awarded an EPSRC early career fellowship to investigate main group catalysis. Her research group's interest lies in developing catalytic systems based upon the p-block elements and exploring their catalytic activity. A key part of her research program involves understanding reaction mechanisms and how ligand design can help tune catalytic activity.
Chris Slootweg started his independent scientific career in 2006 at Vrije Universiteit Amsterdam. He was promoted to Associate Professor in 2014 and moved to the University of Amsterdam in 2016. The mission of his laboratory is to educate students at the intersection of fundamental physical organic chemistry, main group chemistry, and circular chemistry. Chris is cofounder and scientific advisor of SusPhos BV, a pioneering company focused on upcycling of phosphate-rich waste streams to generate high-quality alternatives to replace current fossil-sourced products.