Selenium-Enriched Black Soybean Protein Prevents Benzo(a)pyrene-Induced Pyroptotic Colon Damage and Gut DysbacteriosisClick to copy article linkArticle link copied!
- Zhulin WangZhulin WangEngineering Research Center of High Value Utilization of Western China Fruit Resources, Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, People’s Republic of ChinaMore by Zhulin Wang
- Lin ShiLin ShiEngineering Research Center of High Value Utilization of Western China Fruit Resources, Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, People’s Republic of ChinaMore by Lin Shi
- Hao LiHao LiEngineering Research Center of High Value Utilization of Western China Fruit Resources, Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, People’s Republic of ChinaMore by Hao Li
- Wei SongWei SongEngineering Research Center of High Value Utilization of Western China Fruit Resources, Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, People’s Republic of ChinaMore by Wei Song
- Jianke Li*Jianke Li*Email: [email protected]Engineering Research Center of High Value Utilization of Western China Fruit Resources, Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, People’s Republic of ChinaMore by Jianke Li
- Li Yuan*Li Yuan*Email: [email protected]Engineering Research Center of High Value Utilization of Western China Fruit Resources, Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, People’s Republic of ChinaMore by Li Yuan
Abstract
Selenium-enriched black soybean protein (SeBSP) is a kind of high-quality selenium resource with many physiological functions. Benzo(a)pyrene (BaP) is a well-known injurant that widely exists in high-temperature processed food and has been previously found to cause colon injury. In this study, the effects of SeBSP on colonic damage induced by BaP in BALB/C mice were investigated by comparing it with normal black soybean protein (BSP). SeBSP inhibited the BaP-induced reductions on body weight, food intake, and water intake. Moreover, metabolic enzymes, including AhR, CYP1A1, CYP1B1, and GST-P1, that were promoted by BaP were downregulated by SeBSP, reducing oxidative damage caused by BaP in the metabolic process. The classical pyroptosis indexes (i.e., NLRP3, ASC, Caspase-1, GSDMD) and inflammatory factors (i.e., TNF-α, IL-1β, IL-18, iNOS, COX-2) were downregulated by SeBSP in BaP-treated mice, suggesting the benefits of SeBSP in reducing colonic toxicity. Notably, SeBSP enhanced microbial diversity of gut microbiota and increased relative abundances of prebiotic bacteria, for example, Lactobacillus reuteri, Bacteroides thetaiotaomicron, and genera Bifidobacterium, and Blautia, along with the promotion of short-chain fatty acids. Integrative analysis showed strong links between the antioxidant and anti-inflammatory effects of SeBSP and its altered gut microbiota. Collectively, our study demonstrates the pronounced benefits of Se-enriched black soybean in preventing the colonic toxicity of BaP, and such effects could be mediated by gut microbiota.
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