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Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders
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    Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders
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    • Biswajeet Acharya
      Biswajeet Acharya
      School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha 752050, India
    • Amulyaratna Behera*
      Amulyaratna Behera
      School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha 752050, India
      *Email: [email protected]
    • Suchismeeta Behera
      Suchismeeta Behera
      State Forensic Science Laboratory, Bhubaneswar, Odisha 751010, India
    • Srikanta Moharana*
      Srikanta Moharana
      Department of Chemistry, School of Applied Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha 752050, India
      *Email: [email protected]
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    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2024, 7, 3, 1336–1361
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    https://doi.org/10.1021/acsabm.3c01064
    Published February 27, 2024
    Copyright © 2024 American Chemical Society

    Abstract

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    Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers. Nanotechnology presents promising solutions to address these concerns by introducing innovative tools and techniques, facilitating early detection, targeted drug delivery, and improved imaging capabilities. Through the utilization of nanoscale materials and devices, researchers can craft treatments that are not only more precise but also more effective, significantly enhancing outcomes in reproductive healthcare. Looking forward, the future of nanotechnology in reproductive medicine holds immense potential for reshaping diagnostics, personalized therapies, and fertility preservation. The utilization of nanotechnology-driven drug delivery systems is anticipated to elevate treatment effectiveness, minimize side effects, and offer patients therapies that are not only more precise but also more efficient. This review aims to delve into the various types, properties, and preparation techniques of nanocarriers specifically designed for drug delivery in the context of reproductive disorders, shedding light on the current landscape and potential future directions in this dynamic field.

    Copyright © 2024 American Chemical Society

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    This article is cited by 13 publications.

    1. Tian Liu, Qi Lu, Hao Zhang, Fudan Dong, Zhonggui He, Jin Sun, Bingjun Sun. Biomimetic drug delivery for anticancer: Focusing on the relationship between drugs and biomimetic carriers. Coordination Chemistry Reviews 2025, 524 , 216328. https://doi.org/10.1016/j.ccr.2024.216328
    2. Gangaraju Gedda, Yoo-Jin Park, Myung-Geol Pang. Recent development of nanotechnology-based approaches for gynecologic cancer therapy. Obstetrics & Gynecology Science 2025, 68 (1) , 18-29. https://doi.org/10.5468/ogs.24180
    3. Biswajeet Acharya, Amulyaratna Behera, Kalim Deshmukh, Srikanta Moharana. Fluorescent carbon nanoparticles for drug delivery applications. 2025, 285-335. https://doi.org/10.1016/B978-0-443-13591-0.00018-8
    4. Biswajeet Acharya, Amulyaratna Behera, Kalim Deshmukh, Srikanta Moharana. Biocompatibility, biodegradability, and toxicity evaluations of chitosan nanoparticles. 2025, 139-187. https://doi.org/10.1016/B978-0-443-14088-4.00007-1
    5. Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Sakthi Sanjana Deenadhayalan, Elizabeth Rani Edwin, Preethi Harikrishnan, Prathiba Balaji. Nanoparticles in Hormonal Regulation of the Female Reproductive System. Journal of Bio-X Research 2025, 8 https://doi.org/10.34133/jbioxresearch.0027
    6. Mohammadreza Afshar, Alireza Afshar. Nanomedicine Approaches in Male Infertility Treatment: Targeted Drug Delivery and Sperm Function Enhancement. Journal of Infertility and Reproductive Biology 2024, 12 (4) , 31-44. https://doi.org/10.18502/jirb.v12i4.17976
    7. Ksheerabdhi Tanaya, Swati Mohapatra, Deviprasad Samantaray. Formulation of biogenic fluorescent pigmented PHB nanoparticles from Rhodanobacter sp. for drug delivery. Antonie van Leeuwenhoek 2024, 117 (1) https://doi.org/10.1007/s10482-024-01973-x
    8. Diya Pratish Chohan, Bipasa Dey, Arshia Tarkunde, Vaishnavi Vyas, Srijita De Sarkar, Babitha Kampa Sundara. Advancing Autonomous Nanomedicine: Bridging the Gap from Concept to Potential Clinical Studies. Journal of Cluster Science 2024, 35 (8) , 2607-2635. https://doi.org/10.1007/s10876-024-02691-0
    9. Aniseh Mardanpoor Moghadam, Mohammad Javad Javid-Naderi, Sonia Fathi-karkan, Fatemeh Tanhaye kalate Sabz, Zohreh Abbasi, Abbas Rahdar, Mehrab Pourmadadi, Sadanand Pandey. Nanoparticle-mediated L-carnitine delivery for improved male fertility. Journal of Drug Delivery Science and Technology 2024, 102 , 106420. https://doi.org/10.1016/j.jddst.2024.106420
    10. Gaurav Gopal Naik, Vijay A. Jagtap. Two heads are better than one: Unravelling the potential Impact of Artificial Intelligence in nanotechnology. Nano TransMed 2024, 3 , 100041. https://doi.org/10.1016/j.ntm.2024.100041
    11. Pei-Wei Weng, Chia-Hung Liu, Pei-Ru Jheng, Chia-Che Chiang, Yan-Ting Chen, Lekshmi Rethi, Yves S. Y. Hsieh, Andrew E.-Y. Chuang. Spermatozoon-propelled microcellular submarines combining innate magnetic hyperthermia with derived nanotherapies for thrombolysis and ischemia mitigation. Journal of Nanobiotechnology 2024, 22 (1) https://doi.org/10.1186/s12951-024-02716-w
    12. Anshuman Mishra, Temitayo Omoyeni, Pravin Kumar Singh, S. Anandakumar, Ashutosh Tiwari. Trends in sustainable chitosan-based hydrogel technology for circular biomedical engineering: A review. International Journal of Biological Macromolecules 2024, 276 , 133823. https://doi.org/10.1016/j.ijbiomac.2024.133823
    13. Biswajeet Acharya, Amulyaratna Behera, Suchismeeta Behera, Srikanta Moharana. Carbon quantum dots: A systematic overview of recent developments in synthesis, properties, and novel therapeutic applications. Inorganic Chemistry Communications 2024, 165 , 112492. https://doi.org/10.1016/j.inoche.2024.112492

    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2024, 7, 3, 1336–1361
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsabm.3c01064
    Published February 27, 2024
    Copyright © 2024 American Chemical Society

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