ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Figure 1Loading Img

Imaging Pancreatic Cancer with a Peptide−Nanoparticle Conjugate Targeted to Normal Pancreas

View Author Information
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129
Cite this: Bioconjugate Chem. 2006, 17, 4, 905–911
Publication Date (Web):May 26, 2006
Copyright © 2006 American Chemical Society

    Article Views





    Other access options


    Designing molecules that bind to targets that become upregulated or overexpressed as normal cells become cancerous is an important strategy for both therapeutic and diagnostic drug design. We hypothesized that pancreatic ductal adenocarcinoma (PDAC) might be imaged with the inverse strategy, that is by the design of a nanoparticle−conjugate targeted to bombesin (BN) receptors present on normal acinar cells of the pancreas. Using the fluorescein hapten visualization method to assess the presence of bombesin (BN) receptors, we first demonstrated BN receptors in the normal mouse and human pancreas, but then the lack of BN binding receptors in 13 out of 13 specimens of PDAC. The BN peptide−nanoparticle conjugate, BN−CLIO(Cy5.5), was synthesized and accumulated in the mouse pancreas in receptor dependent fashion, but not in a receptor dependent fashion in other tissues, based on tissue fluorescence measurements. The BN−CLIO(Cy5.5) nanoparticle decreased the T2 of normal pancreas and enhanced the ability to visualize tumor in a model of pancreatic cancer by MRI. The use of BN−CLIO(Cy5.5) nanoparticle as a normal tissue-targeted, T2-reducing contrast agent offers a promising approach to imaging PDAC.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.


    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.


     Corresponding author. Fax:  617-726-5708. Phone:  617-726-5788. E-mail:  [email protected].

    Cited By

    This article is cited by 109 publications.

    1. Xin Yi Wong, Amadeo Sena-Torralba, Ruslan Álvarez-Diduk, Kasturi Muthoosamy, Arben Merkoçi. Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs. ACS Nano 2020, 14 (3) , 2585-2627.
    2. Sophie Richard, Ana Saric, Marianne Boucher, Christian Slomianny, Françoise Geffroy, Sébastien Mériaux, Yoann Lalatonne, Patrice X. Petit, and Laurence Motte . Antioxidative Theranostic Iron Oxide Nanoparticles toward Brain Tumors Imaging and ROS Production. ACS Chemical Biology 2016, 11 (10) , 2812-2819.
    3. Francesca Stanzione and Arthi Jayaraman . Computational Design of Oligopeptide Containing Poly(ethylene glycol) Brushes for Stimuli-Responsive Drug Delivery. The Journal of Physical Chemistry B 2015, 119 (42) , 13309-13320.
    4. Chengli Yang, Tingting Hu, Hua Cao, Lijing Zhang, Pengxiang Zhou, Gu He, Xiangrong Song, Aiping Tong, Gang Guo, Fan Yang, Xiaoning Zhang, Zhiyong Qian, Xiaorong Qi, Liangxue Zhou, and Yu Zheng . Facile Construction of Chloroquine Containing PLGA-Based pDNA Delivery System for Efficient Tumor and Pancreatitis Targeting in Vitro and in Vivo. Molecular Pharmaceutics 2015, 12 (6) , 2167-2179.
    5. Shou-Cheng Wu, Yu-Jen Chen, Yi-Jan Lin, Tung-Ho Wu, and Yun-Ming Wang . Development of a Mucin4-Targeting SPIO Contrast Agent for Effective Detection of Pancreatic Tumor Cells in Vitro and in Vivo. Journal of Medicinal Chemistry 2013, 56 (22) , 9100-9109.
    6. Cheng-An J. Lin, Wen-Kai Chuang, Zih-Yun Huang, Shih-Tsung Kang, Ching-Yi Chang, Ching-Ta Chen, Jhih-Liang Li, Jimmy K. Li, Hsueh-Hsiao Wang, Fu-Chen Kung, Ji-Lin Shen, Wen-Hsiung Chan, Chih-Kuang Yeh, Hung-I Yeh, Wen-Fu T. Lai, and Walter H. Chang . Rapid Transformation of Protein-Caged Nanomaterials into Microbubbles As Bimodal Imaging Agents. ACS Nano 2012, 6 (6) , 5111-5121.
    7. Carlos Tassa, Stanley Y. Shaw, and Ralph Weissleder . Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy. Accounts of Chemical Research 2011, 44 (10) , 842-852.
    8. Yang Xu, Alokita Karmakar, Daoyuan Wang, Meena W. Mahmood, Fumiya Watanabe, Yongbin Zhang, Ashley Fejleh, Phillip Fejleh, Zhongrui Li, Ganesh Kannarpady, Syed Ali, Alexandru R. Biris and Alexandru S. Biris . Multifunctional Fe3O4 Cored Magnetic-Quantum Dot Fluorescent Nanocomposites for RF Nanohyperthermia of Cancer Cells. The Journal of Physical Chemistry C 2010, 114 (11) , 5020-5026.
    9. Edyta Podstawka and Leonard M. Proniewicz . The Orientation of BN-Related Peptides Adsorbed on SERS-Active Silver Nanoparticles: Comparison with a Silver Electrode Surface. The Journal of Physical Chemistry B 2009, 113 (14) , 4978-4985.
    10. Ken-Tye Yong, Hong Ding, Indrajit Roy, Wing-Cheung Law, Earl J. Bergey, Anirban Maitra and Paras N. Prasad . Imaging Pancreatic Cancer Using Bioconjugated InP Quantum Dots. ACS Nano 2009, 3 (3) , 502-510.
    11. Sophie Laurent, Delphine Forge, Marc Port, Alain Roch, Caroline Robic, Luce Vander Elst and Robert N. Muller. Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications. Chemical Reviews 2008, 108 (6) , 2064-2110.
    12. Kevin J. Landmark, Stassi DiMaggio, Jesse Ward, Christopher Kelly, Stefan Vogt, Seungpyo Hong, Alina Kotlyar, Andrzej Myc, Thommey P. Thomas, James E. Penner-Hahn, James R. Baker, Jr., Mark M. Banaszak Holl and Bradford G. Orr . Synthesis, Characterization, and in Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers. ACS Nano 2008, 2 (4) , 773-783.
    13. Monu Kumar Shukla, Arpana Parihar, Chandrabose Karthikeyan, Deepak Kumar, Raju Khan. Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer. Nanoscale 2023, 15 (36) , 14698-14716.
    14. Beata Paulina Rurarz, Małgorzata Bukowczyk, Natalia Gibka, Agnieszka Wanda Piastowska-Ciesielska, Urszula Karczmarczyk, Piotr Ulański. Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor. International Journal of Molecular Sciences 2023, 24 (4) , 3455.
    15. Ehsan Ullah Rashid, Shahid Nawaz, Junaid Munawar, Aniruddha Sarker, Shahid Hussain, Hafiz M.N. Iqbal, Muhammad Bilal. Organic and inorganic nanoparticles. 2023, 93-119.
    16. S. Panda, S. Hajra, A. Kaushik, H.G. Rubahn, Y.K. Mishra, H.J. Kim. Smart nanomaterials as the foundation of a combination approach for efficient cancer theranostics. Materials Today Chemistry 2022, 26 , 101182.
    17. Mehdi Azizi, Hadi Kokabi, Hassan Dianat-Moghadam, Mohammad Mehrmohammadi. Tumor-specific imaging probes in preclinical applications and clinical trials. 2022, 49-138.
    18. Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md. Apamin-Conjugated Alendronate Sodium Nanocomplex for Management of Pancreatic Cancer. Pharmaceuticals 2021, 14 (8) , 729.
    19. Muhammad Shehroz Zeeshan, Zeeshan Ramzan. Current controversies and advances in the management of pancreatic adenocarcinoma. World Journal of Gastrointestinal Oncology 2021, 13 (6) , 472-494.
    20. Lala Sabir Gadzhiyeva, Gyul’tekin Dzhumzhud Abbasova, Gyunel’ Rovshan Safarli. STUDY OF STABLE STRUCTURES OF THE PENTAPEPTIDE MOLECULE. Chronos 2021, 6 (2(52)) , 5-9.
    21. Leela R. Jaidev, Laxmi S. Chede, Hemanth K. Kandikattu. Theranostic Nanoparticles for Pancreatic Cancer Treatment. Endocrine, Metabolic & Immune Disorders - Drug Targets 2021, 21 (2) , 203-214.
    22. Ahmad Amirshaghaghi, Zhiliang Cheng, Lee Josephson, Andrew Tsourkas. Magnetic Nanoparticles. 2021, 679-698.
    23. Dilip Kumar Patel, Roohi Kesharwani, Vikas Kumar. Nanoparticles: an emerging platform for medical imaging. 2021, 113-126.
    24. Jaspreet Kalra, Vandana Krishna, BollaReddy S.V. Reddy, Arti Dhar, Venkata V.K. Venuganti, Audesh Bhat. Nanoparticles in medical imaging. 2021, 175-210.
    25. Sameer Alshehri, Wei Fan, Wenting Zhang, Jered C. Garrison. In Vitro Evaluation and Biodistribution Studies of HPMA Copolymers Targeting the Gastrin Releasing Peptide Receptor in Prostate Cancer. Pharmaceutical Research 2020, 37 (11)
    26. Henry A. Adeola, Saheed Sabiu, Tayo A. Adekiya, Raphael T. Aruleba, Christiana E. Aruwa, Babatunji E. Oyinloye. Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers. Heliyon 2020, 6 (9) , e04890.
    27. Jin Hee Lee, Gun Gyun Kim, Sang Wook Kim, Joo-Hee Park. Zr-89 Labeled PAMAM Dendrimers 5G without a Chelator for a Cancer Diagnostic Agent. Journal of the Korean Physical Society 2020, 77 (5) , 409-413.
    28. E. M. N. Oliveira, G. I. Selli, A. von Schmude, C. Miguel, S. Laurent, M. R. M. Vianna, R. M. Papaléo. Developmental toxicity of iron oxide nanoparticles with different coatings in zebrafish larvae. Journal of Nanoparticle Research 2020, 22 (4)
    29. Anne C. Conibear, Alanca Schmid, Meder Kamalov, Christian F.W. Becker, Claudia Bello. Recent Advances in Peptide-Based Approaches for Cancer Treatment. Current Medicinal Chemistry 2020, 27 (8) , 1174-1205.
    30. G.Dzh. Abbasova, L.S. Gadzhieva. STUDY OF THE SPATIAL STRUCTURE OF THE MOLECULE CYS-ARG-GLU-LYS-ALA. Chronos Journal 2020, (2(41))
    31. Deep Pooja, Anusha Gunukula, Nitin Gupta, David J. Adams, Hitesh Kulhari. Bombesin receptors as potential targets for anticancer drug delivery and imaging. The International Journal of Biochemistry & Cell Biology 2019, 114 , 105567.
    32. Xiangjun Han, Ke Xu, Olena Taratula, Khashayar Farsad. Applications of nanoparticles in biomedical imaging. Nanoscale 2019, 11 (3) , 799-819.
    33. Ruma Rani, Khushboo Sethi, Geeta Singh. Nanomaterials and Their Applications in Bioimaging. 2019, 429-450.
    34. Sally A. El-Zahaby, Yosra S.R. Elnaggar, Ossama Y. Abdallah. Reviewing two decades of nanomedicine implementations in targeted treatment and diagnosis of pancreatic cancer: An emphasis on state of art. Journal of Controlled Release 2019, 293 , 21-35.
    35. Willemieke S. Tummers, Juergen K. Willmann, Bert A. Bonsing, Alexander L. Vahrmeijer, Sanjiv S. Gambhir, Rutger-Jan Swijnenburg. Advances in Diagnostic and Intraoperative Molecular Imaging of Pancreatic Cancer. Pancreas 2018, 47 (6) , 675-689.
    36. S. Zanganeh, J.Q. Ho, M. Aieneravaie, M. Erfanzadeh, M. Pauliah, R. Spitler. Drug Delivery. 2018, 247-271.
    37. Anupam Guleria, Kalpana Priyatharchini, Dinesh Kumar. Biomedical Applications of Magnetic Nanomaterials. 2018, 345-389.
    38. Pengcheng Zhang, Yonggang Cui, Caleb F. Anderson, Chunli Zhang, Yaping Li, Rongfu Wang, Honggang Cui. Peptide-based nanoprobes for molecular imaging and disease diagnostics. Chemical Society Reviews 2018, 47 (10) , 3490-3529.
    39. Pilar de la Puente, Abdel Kareem Azab. Nanoparticle delivery systems, general approaches, and their implementation in multiple myeloma. European Journal of Haematology 2017, 98 (6) , 529-541.
    40. Francisco Silva, Lurdes Gano, Maria Paula Cabral Campello, Rosa Marques, Isabel Prudêncio, Ajit Zambre, Anandhi Upendran, António Paulo, Raghuraman Kannan. In vitro/in vivo “peeling” of multilayered aminocarboxylate gold nanoparticles evidenced by a kinetically stable 99m Tc-label. Dalton Transactions 2017, 46 (42) , 14572-14583.
    41. Srinivas Patnaik. Nanomedicine Magic Bullet for Human Cancer. 2017, 382-407.
    42. Kristof Zarschler, Louise Rocks, Nadia Licciardello, Luca Boselli, Ester Polo, Karina Pombo Garcia, Luisa De Cola, Holger Stephan, Kenneth A. Dawson. Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications. Nanomedicine: Nanotechnology, Biology and Medicine 2016, 12 (6) , 1663-1701.
    43. Jing Huang, Yuancheng Li, Anamaria Orza, Qiong Lu, Peng Guo, Liya Wang, Lily Yang, Hui Mao. Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image‐Guided Approaches. Advanced Functional Materials 2016, 26 (22) , 3818-3836.
    44. Chongjie Zhang, Yuzhong Yan, Qi Zou, Jie Chen, Chunsheng Li. Superparamagnetic iron oxide nanoparticles for MR imaging of pancreatic cancer: Potential for early diagnosis through targeted strategies. Asia-Pacific Journal of Clinical Oncology 2016, 12 (1) , 13-21.
    45. Harshita Sharma, Krishan Kumar, Chetan Choudhary, Pawan K. Mishra, Bhuvaneshwar Vaidya. Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug. Artificial Cells, Nanomedicine, and Biotechnology 2016, 44 (2) , 672-679.
    46. Radhakrishnan Narayanaswamy, Samikannu Kanagesan, Ashokkumar Pandurangan, Parasuraman Padmanabhan. Basics to different imaging techniques, different nanobiomaterials for image enhancement. 2016, 101-129.
    47. Emir Baki Denkbaş, Ekin Çelik, Ebru Erdal, Doğa Kavaz, Öznur Akbal, Göknur Kara, Cem Bayram. Magnetically based nanocarriers in drug delivery. 2016, 285-331.
    48. Shyamasree Ghosh, Soham Saha, Abhinav Sur. Nanoparticles: Cancer Management Applications. 2015, 5510-5533.
    49. Wei Cao, Xiaowei Zeng, Gan Liu, Zhen Li, Xiaobin Zeng, Lijun Wang, Laiqiang Huang, Si-Shen Feng, Lin Mei. Porphine functionalized nanoparticles of star-shaped poly(ε-caprolactone)-b-D-α-tocopheryl polyethylene glycol 1000 succinate biodegradable copolymer for chemophotodynamic therapy on cervical cancer. Acta Biomaterialia 2015, 26 , 145-158.
    50. A. Mahajan, V. Goh, S. Basu, R. Vaish, A.J. Weeks, M.H. Thakur, G.J. Cook. Bench to bedside molecular functional imaging in translational cancer medicine: to image or to imagine?. Clinical Radiology 2015, 70 (10) , 1060-1082.
    51. Irene Ramos-Álvarez, Paola Moreno, Samuel A. Mantey, Taichi Nakamura, Bernardo Nuche-Berenguer, Terry W. Moody, David H. Coy, Robert T. Jensen. Insights into bombesin receptors and ligands: Highlighting recent advances. Peptides 2015, 72 , 128-144.
    52. Yolandy Lemmer, Lonji Kalombo, Ray-Dean Pietersen, Arwyn T. Jones, Boitumelo Semete-Makokotlela, Sandra Van Wyngaardt, Bathabile Ramalapa, Anton C. Stoltz, Bienyameen Baker, Jan A. Verschoor, Hulda S. Swai, Chantal de Chastellier. Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis. Journal of Controlled Release 2015, 211 , 94-104.
    53. Nina Raabe, Evelyn Forberich, Barbara Freund, Oliver T. Bruns, Markus Heine, Michael G. Kaul, Ulrich Tromsdorf, Lena Herich, Peter Nielsen, Rudolph Reimer, Heinrich Hohenberg, Horst Weller, U. Schumacher, Gerhard Adam, Harald Ittrich. Determination of liver‐specific r 2 * of a highly monodisperse USPIO by 59 Fe iron core‐labeling in mice at 3 T MRI. Contrast Media & Molecular Imaging 2015, 10 (2) , 153-162.
    54. Atefeh Jafari, Mojtaba Salouti, Saber Farjami Shayesteh, Zahra Heidari, Ahmad Bitarafan Rajabi, Komail Boustani, Ali Nahardani. Synthesis and characterization of Bombesin-superparamagnetic iron oxide nanoparticles as a targeted contrast agent for imaging of breast cancer using MRI. Nanotechnology 2015, 26 (7) , 075101.
    55. Laurent Vinet, Smaragda Lamprianou, Andrej Babič, Norbert Lange, Fabrizio Thorel, Pedro Luis Herrera, Xavier Montet, Paolo Meda. Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice. Diabetologia 2015, 58 (2) , 304-312.
    56. Vikas Nandwana, Mrinmoy De, Shihyao Chu, Manish Jaiswal, Matt Rotz, Thomas J. Meade, Vinayak P. Dravid. Theranostic Magnetic Nanostructures (MNS) for Cancer. 2015, 51-83.
    57. Xavier Montet, Smaragda Lamprianou, Laurent Vinet, Paolo Meda, Alfredo Fort. Approaches for Imaging Pancreatic Islets: Recent Advances and Future Prospects. 2015, 59-81.
    58. Srinivas Patnaik. Nanomedicine Magic Bullet for Human Cancer. 2015, 167-191.
    59. Oscar Bomati-Miguel, Nuria Miguel-Sancho, Ibane Abasolo, Ana Paula Candiota, Alejandro G. Roca, Milena Acosta, Simó Schwartz, Carles Arus, Clara Marquina, Gema Martinez, Jesus Santamaria. Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects. Journal of Nanoparticle Research 2014, 16 (3)
    60. Andrew Gdowski, Amalendu P. Ranjan, Anindita Mukerjee, Jamboor K. Vishwanatha. Nanobiosensors: Role in Cancer Detection and Diagnosis. 2014, 33-58.
    61. Xavier Montet, Smaragda Lamprianou, Laurent Vinet, Paolo Meda, Alfredo Fort. Approaches for Imaging Pancreatic Islets: Recent Advances and Future Prospects. 2014, 1-21.
    62. Xin Nie, Jiakun Zhang, Qing Xu, Xiaoguang Liu, Yaping Li, Yan Wu, Chunying Chen. Targeting peptide iRGD-conjugated amphiphilic chitosan-co-PLA/DPPE drug delivery system for enhanced tumor therapy. Journal of Materials Chemistry B 2014, 2 (21) , 3232.
    63. Gregory A. Coté, Jeffrey Smith, Stuart Sherman, Kimberly Kelly. Technologies for Imaging the Normal and Diseased Pancreas. Gastroenterology 2013, 144 (6) , 1262-1271.e1.
    64. Hongmin Chen, Zipeng Zhen, Trever Todd, Paul K. Chu, Jin Xie. Nanoparticles for improving cancer diagnosis. Materials Science and Engineering: R: Reports 2013, 74 (3) , 35-69.
    65. Raunak Varshney, Puja P. Hazari, P. Fernandez, J. Schulz, M. Allard, Anil K. Mishra. 68Ga-Labeled Bombesin Analogs for Receptor-Mediated Imaging. 2013, 221-256.
    66. Yonglan He, Wei Song, Jing Lei, Zhuo Li, Jian Cao, Shuai Huang, Jie Meng, Haiyan Xu, Zhengyu Jin, Huadan Xue. Anti-CXCR4 monoclonal antibody conjugated to ultrasmall superparamagnetic iron oxide nanoparticles in an application of MR molecular imaging of pancreatic cancer cell lines. Acta Radiologica 2012, 53 (9) , 1049-1058.
    67. Feng Yang, Chen Jin, Sabin Subedi, Chong Lek Lee, Qiang Wang, Yongjian Jiang, Ji Li, Yang Di, Deliang Fu. Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment. Cancer Treatment Reviews 2012, 38 (6) , 566-579.
    68. Pericles Pericleous, Maria Gazouli, Anna Lyberopoulou, Spyros Rizos, Nikolaos Nikiteas, Efstathios P Efstathopoulos. Quantum dots hold promise for early cancer imaging and detection. International Journal of Cancer 2012, 131 (3) , 519-528.
    69. Paul D Sykes, John P Neoptolemos, Eithne Costello, Christopher M Halloran. Nanotechnology advances in upper gastrointestinal, liver and pancreatic cancer. Expert Review of Gastroenterology & Hepatology 2012, 6 (3) , 343-356.
    70. Chao Ying Wu, Yu Pu, Gang Liu, Yang Shao, Qing Song Ma, Xiao Ming Zhang. MR imaging of human pancreatic cancer xenograft labeled with superparamagnetic iron oxide in nude mice. Contrast Media & Molecular Imaging 2012, 7 (1) , 51-58.
    71. Ruirui QIAO, Qiaojuan JIA, Jianfeng ZENG, Mingyuan GAO. Magnetic Iron Oxide Nanoparticles and Their Applications in Magnetic Resonance Imaging. ACTA BIOPHYSICA SINICA 2011, 27 (4) , 272-288.
    72. Omid Veiseh, Forrest M. Kievit, Richard G. Ellenbogen, Miqin Zhang. Cancer Cell Invasion: Treatment and Monitoring Opportunities in Nanomedicine. Advanced Drug Delivery Reviews 2011, 63 (8) , 582-596.
    73. Edyta Podstawka-Proniewicz, Yukihiro Ozaki, Younkyoo Kim, Yizhuang Xu, Leonard M. Proniewicz. Surface-enhanced Raman scattering studies on bombesin, its selected fragments and related peptides adsorbed at the silver colloidal surface. Applied Surface Science 2011, 257 (19) , 8246-8252.
    74. Gary R. Hutchison, Eva M. Malone. Nanotoxicity. 2011, 419-434.
    75. Morteza Mahmoudi, Shilpa Sant, Ben Wang, Sophie Laurent, Tapas Sen. Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy. Advanced Drug Delivery Reviews 2011, 63 (1-2) , 24-46.
    76. Wael R. Abd-Elgaliel, Zobeida Cruz-Monserrate, Craig D. Logsdon, Ching-Hsuan Tung. Molecular imaging of Cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe. Molecular BioSystems 2011, 7 (12) , 3207.
    77. Jason R. McCarthy, Jayeeta Bhaumik, Mark R. Karver, S. Sibel Erdem, Ralph Weissleder. Targeted nanoagents for the detection of cancers. Molecular Oncology 2010, 4 (6) , 511-528.
    78. Stephanie R. Lane, Prasanta Nanda, Tammy L. Rold, Gary L. Sieckman, Said D. Figueroa, Timothy J. Hoffman, Silvia S. Jurisson, Charles J. Smith. Optimization, biological evaluation and microPET imaging of copper-64-labeled bombesin agonists, [64Cu-NO2A-(X)-BBN(7–14)NH2], in a prostate tumor xenografted mouse model. Nuclear Medicine and Biology 2010, 37 (7) , 751-761.
    79. Jason H. Sakamoto, Anne L. van de Ven, Biana Godin, Elvin Blanco, Rita E. Serda, Alessandro Grattoni, Arturas Ziemys, Ali Bouamrani, Tony Hu, Shivakumar I. Ranganathan, Enrica De Rosa, Jonathan O. Martinez, Christine A. Smid, Rachel M. Buchanan, Sei-Young Lee, Srimeenakshi Srinivasan, Matthew Landry, Anne Meyn, Ennio Tasciotti, Xuewu Liu, Paolo Decuzzi, Mauro Ferrari. Enabling individualized therapy through nanotechnology. Pharmacological Research 2010, 62 (2) , 57-89.
    80. Amanda L. Martin, Jennifer L. Hickey, Amber L. Ablack, John D. Lewis, Leonard G. Luyt, Elizabeth R. Gillies. Synthesis of bombesin-functionalized iron oxide nanoparticles and their specific uptake in prostate cancer cells. Journal of Nanoparticle Research 2010, 12 (5) , 1599-1608.
    81. Omid Veiseh, Jonathan W. Gunn, Miqin Zhang. Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Advanced Drug Delivery Reviews 2010, 62 (3) , 284-304.
    82. Frank Alexis, Eric M. Pridgen, Robert Langer, Omid C. Farokhzad. Nanoparticle Technologies for Cancer Therapy. 2010, 55-86.
    83. Kenjiro Hanaoka. Development of Responsive Lanthanide-Based Magnetic Resonance Imaging and Luminescent Probes for Biological Applications. Chemical and Pharmaceutical Bulletin 2010, 58 (10) , 1283-1294.
    84. VickyV Mody, Rodney Siwale, Ajay Singh, HardikR Mody. Introduction to metallic nanoparticles. Journal of Pharmacy And Bioallied Sciences 2010, 2 (4) , 282.
    85. Timo Duchrow, Timur Shtatland, Daniel Guettler, Misha Pivovarov, Stefan Kramer, Ralph Weissleder. Enhancing navigation in biomedical databases by community voting and database-driven text classification. BMC Bioinformatics 2009, 10 (1)
    86. Mingming Huang, Zhongwei Qiao, Fei Miao, Nengqin Jia, Hebai Shen. Biofunctional magnetic nanoparticles as contrast agents for magnetic resonance imaging of pancreas cancer. Microchimica Acta 2009, 167 (1-2) , 27-34.
    87. Satish K Nune, Padmaja Gunda, Praveen K Thallapally, Ying-Ying Lin, M Laird Forrest, Cory J Berkland. Nanoparticles for biomedical imaging. Expert Opinion on Drug Delivery 2009, 6 (11) , 1175-1194.
    88. Caroline Wyss, Stephan C. Schaefer, Lucienne Juillerat-Jeanneret, Lucienne Lagopoulos, Hans-Anton Lehr, Christoph D. Becker, Xavier Montet. Molecular imaging by micro-CT: specific E-selectin imaging. European Radiology 2009, 19 (10) , 2487-2494.
    89. N. Alieva, D. Abbasova, N.M. Gojayev. Conformational and dynamical properties of the CREKA molecule. 2009, 1-5.
    90. U. Ayanthi Gunasekera, Quentin A. Pankhurst, Michael Douek. Imaging applications of nanotechnology in cancer. Targeted Oncology 2009, 4 (3) , 169-181.
    91. Yurii K. Gun'ko, Dermot F. Brougham. Magnetic Nanomaterials as MRI Contrast Agents. 2009
    92. Marites P. Melancon, Chun Li. Core–Shell Magnetic Nanomaterials in Medical Diagnosis and Therapy. 2009
    93. Wenbin Lin, Taeghwan Hyeon, Gregory M. Lanza, Miqin Zhang, Thomas J. Meade. Magnetic Nanoparticles for Early Detection of Cancer by Magnetic Resonance Imaging. MRS Bulletin 2009, 34 (6) , 441-448.
    94. Esmaiel Jabbari. Targeted Delivery with Peptidomimetic Conjugated Self-Assembled Nanoparticles. Pharmaceutical Research 2009, 26 (3) , 612-630.
    95. Manasi Das, Chandana Mohanty, Sanjeeb K Sahoo. Ligand-based targeted therapy for cancer tissue. Expert Opinion on Drug Delivery 2009, 6 (3) , 285-304.
    96. Guoxin Zhang, Yanbo Liu, Chunfu Zhang, Weiqing Hu, Wanbang Xu, Zheng Li, Sheng Liang, Jinquan Cao, Yongxian Wang. Aqueous immune magnetite nanoparticles for immunoassay. Journal of Nanoparticle Research 2009, 11 (2) , 441-448.
    97. Ken-Tye Yong. Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging. Nanotechnology 2009, 20 (1) , 015102.
    98. Ken-Tye Yong, Indrajit Roy, Mark T. Swihart, Paras N. Prasad. Multifunctional nanoparticles as biocompatible targeted probes for human cancer diagnosis and therapy. Journal of Materials Chemistry 2009, 19 (27) , 4655.
    99. Suelin Chen, Fred Reynolds, Lingtau Yu, Ralph Weissleder, Lee Josephson. A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles. Journal of Materials Chemistry 2009, 19 (35) , 6387.
    100. Edyta Podstawka. Structural properties of bombesin-like peptides revealed by surface-enhanced Raman scattering on roughened silver electrodes. Biopolymers 2008, 89 (11) , 980-992.
    Load all citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect