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Electrospinning: An Efficient Biopolymer-Based Micro- and Nanofibers Fabrication Technique

  • Tara Chand Yadav
    Tara Chand Yadav
    Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
  • Amit Kumar Srivastava
    Amit Kumar Srivastava
    Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
  • Purusottam Mishra
    Purusottam Mishra
    Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
  • Divya Singh
    Divya Singh
    Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
    More by Divya Singh
  • Navdeep Raghuwanshi
    Navdeep Raghuwanshi
    Vaccine Formulation & Research Center, Gennova (Emcure) Biopharmaceuticals Limited, Pune - 411057, Maharashtra, India
  • Nitin Kumar Singh
    Nitin Kumar Singh
    Department of Environment Science and Engineering, Marwadi Education Foundations Group of Institutions, Rajkot - 360003, Gujarat, India
  • Amit Kumar Singh
    Amit Kumar Singh
    Department of Biochemistry, University of Allahabad, Allahabad, 211002 India
  • Saurabh Kumar Tiwari
    Saurabh Kumar Tiwari
    Department of Chemistry, University of Allahabad, Allahabad, 211002 India
  • Ramasare Prasad*
    Ramasare Prasad
    Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
    *E-mail: Ramasare Prasad: [email protected]
  • , and 
  • Vikas Pruthi*
    Vikas Pruthi
    Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
    *E-mail: Vikas Pruthi: [email protected], [email protected]
    More by Vikas Pruthi
DOI: 10.1021/bk-2019-1329.ch010
    Publication Date (Web):December 3, 2019
    Copyright © 2019 American Chemical Society.
    Next Generation Biomanufacturing Technologies
    Chapter 10pp 209-241
    ACS Symposium SeriesVol. 1329
    ISBN13: 9780841235007eISBN: 9780841234949

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    Abstract

    Electrospinning, an electrostatic fiber fabrication method, has emerged as an invincible technique for the production of micro- to nanofibers-based polymeric scaffolds. It has gained significant attention and interest in recent years because of its simplicity, scalability, versatility, and potential application in soft-tissue engineering, biosensors, wound dressings, drug delivery, filtration, and enzyme immobilization. Polymeric solution under the influence of a strong electric field produces fibers of nanoscale dimension. The polymeric scaffold and nonwoven nanofibers produced by electrospinning more closely mimic components of extracellular matrix as compared with conventional methods. Submicron-range electrospun fibers manufactured by the electrospinning process offer unrivaled advantages such as high surface-area-to-volume ratio, tunable porosity, and the ability to sway nanofibers composition to obtain anticipated property and function accompanying tailored morphology and orientation. This chapter aims to briefly discuss the basic concepts of electrospinning and its potential application along with solvent properties, solution parameters, and processing conditions, which considerably affect the morphology and orientation of produced nanofibers. This chapter also intends to highlight advancements, challenges, and various applications along with future prospects of the fabricated natural biopolymer-based electrospun scaffolds produced by this invincible technology.

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